FOOD CHEMISTRY
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2025
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IF 9.8
Wanyue Pang,Ruoyu Cao,Shuaijie Guo,Shuo Wang,Xuelian Hu,Yiwei Tang,Xiuying Liu
A versatile fluorescent molecularly imprinted nanosensor (MIPs@O-CDs) for profiling ciprofloxacin (CIP) was innovatively developed using a controllable post-imprinting modification strategy. High-affinity molecularly imprinted polymers (MIPs) as recognition elements granted nanosensor favorable anti-interference. Bright orange-emission carbon dots (O-CDs) as signal transducers demonstrated prominent reverse fluorescence response to CIP due to inner filter effect, ameliorating detection sensitivity and accuracy. Benefiting from inherent advantages, MIPs@O-CDs accomplished selectivity and ultrasensitive ratiometric fluorescence detection of CIP with a linear range of 0.025–6.000 μg mL −1 , a detection line (6.858 ng mL −1 ), a rapid response time (1.5 min) and a distinguishable color transformation (orange-pink-purple). Additionally, a portable optosensing platform has been triumphantly established by integrating MIPs@O-CDs and smartphone-assisted detectors, which achieved precise on-site determination of CIP in milk with satisfactory recoveries (88.185–93.267 %) and a relative standard deviation below 3.960 %. Accordingly, MIPs@O-CDs-based platform demonstrated portability, feasibility, selectivity, and sensitivity, presenting a powerful tool for real-time food safety assessment.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2025
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IF 4.1
Zhansong Zhu,Kaiqiang Sun,Linlin Han,Zhencui Wang
Kanamycin is an antibiotic commonly used for the prevention and treatment of infections. The monitoring of kanamycin is of vital significance for maintaining food safety and safeguarding public health. However, the sensitive and reliable detection of kanamycin under visible light irradiation still presents significant challenges. In this study, a self–supported electrode was fabricated from a titanium dioxide nanowire array modified with gold nanoparticles, utilizing a straightforward and controllable electrochemical deposition method. The synthesized photoanode exhibited enhanced photoelectrochemical performance under visible light, which can be attributed to the localized surface plasmon resonance effect of Au nanoparticles. Kanamycin aptamers served as recognition elements, immobilized on the TiO₂/Au nanowires through Au S bonds. The specific recognition and high affinity between the aptamers and kanamycin contributed to the excellent sensitivity of the photoelectrochemical aptasensor. The sensor demonstrated a linear range of 1–500 nM, with a limit of detection as low as 0.42 nM (S/N = 3). Furthermore, the sensor exhibited remarkable anti–interference capability in the presence of other contaminants and maintained excellent stability. It has been successfully applied for the analysis of kanamycin in real milk samples. The simple, efficient, highly sensitive, selective, and reproducible detection platform for kanamycin developed in this study offers significant potential for a wide range of applications.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Feiyan He,Jilai Gong,Juan Li,Jun Zhao,Huaiyang Zhou,Yewei Wang,Yanzhao Hu
Nanofiltration (NF) membranes are part of the promising technologies for treating antibiotic wastewater. However, current NF membranes are constrained by the trade-off between the water permeability and selectivity. To address this challenge, a (2-Hydroxypropyl)-β-cyclodextrin (OH-β-CD) incorporated into nitrogen-doped quantum dots (N-GQDs) aqueous phase to form the membrane (N-CD 0.1 ). The integration of the OH-β-CD manipulated the structural properties of selective layer and improved the water permeability. This was attributed to the fact that OH-β-CD not only provided an additional priority water channel, but also regulated the interfacial polymerization process of the membrane by slowing down the diffusion rate of N-GQDs. In addition, the hydrophilicity and electronegativity of the membrane were optimized by OH-β-CD. The results showed that the N-CD 0.1 membrane achieved a high antibiotic rejection (Ciprofloxacin: 98.28 %, Norfloxacin: 97.9 % and Ofloxacin: 97.46 %). The N-CD 0.1 membrane had a remarkable water permeability of 15.82 L⋅m −2 ⋅h −1 ⋅bar −1 , which was 2.05-fold that of the N-GQDs membrane. Furthermore, the N-CD 0.1 membrane exhibited good high-pressure stability. When the operating pressure was 3 ∼ 7 bar, the N-CD 0.1 membrane still had a high Ciprofloxacin rejection (> 97 %). Therefore, by the addition of OH-β-CD, the water permeability of NF membrane could be further improved almost without sacrificing the rejection of Ciprofloxacin, which provided a green and efficient strategy for the fabrication of high-performance NF membranes.
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CHIRALITY
·
2025
·Vol. 37
·期 8
·e70050
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IF 3
Xiangwen Chen,Xuan Chen,Juan Pan,Shuqi Deng,Qiubing Qin,Qiang Fu,Jiliang Cao
In this work, the silica gel bonded amylose[( S )-α-methylbenzyl carbamate] (CHIRALPAK IH) was chosen as the chiral stationary phase (CSP) for the separation of five quinolone enantiomers by high-performance liquid chromatography (HPLC), namely, ofloxacin, flumequine, nadifloxacin, lomefloxacin, and clinafloxacin. The mobile phase composition, organic modifier, and acid–base additive were systematically investigated for the baseline separation of these five interested quinolones. The optimized mobile phases were n -hexane–ethanol–acetic acid–diethylamine (60:40:0.2:0.2, v / v / v / v ) for ofloxacin and nadifloxacin, n -hexane–ethanol–acetic acid–diethylamine (60:40:0.2:0.2, v / v / v / v ) for flumequine, n -hexane–isopropanol–acetic acid–diethylamine (60:40:0.3:0.3, v / v / v / v ) for lomefloxacin, and n -hexane–ethanol–acetic acid–diethylamine (70:30:0.3:0.3, v / v / v / v ) for clinafloxacin. The interaction forces between the amylose CSP and target quinolones were simulated by computerized molecular docking to study their enantiorecognition mechanisms. The results indicated that hydrogen bonding, π–π stacking, and hydrophobic interactions collectively contributed to the stereoselective binding. The differences in these interaction forces between the quinolone enantiomers, particularly the greater contribution of hydrogen bonding in one enantiomer compared to the other, led to a significant difference in binding energy. This differential binding energy ultimately governed the elution order and enabled chiral recognition of the five quinolone enantiomers.
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APPLIED CLAY SCIENCE
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2025
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IF 5.8
Yuqi Zhang,Yunan Zhong,Pengfei Zhang,Yang Zheng,Chunfang Du
Halloysite nanotubes (HNTs) served as the support and aluminum source for in-situ synthesizing CoAl 2 O 4 /HNTs (CAO/HNTs), which acted as an effective catalyst to activate peroxymonosulfate (PMS) for degrading tetracycline hydrochloride (TC). To achieve the optimal removal performance, various parameters were optimized. The final CAO/HNTs demonstrated a high degradation efficiency of 88 % toward TC within 40 min, which was 1.69 times as high as that of pure CAO. The existence of HNTs made CAO highly dispersed, increasing the number of exposed active sites and the contact opportunities between CAO and TC molecules, which enabled CAO to participate in the reaction more effectively and thus improved the degradation efficiency. Additionally, the formation of Co-O-Al bonds facilitated the growth of CAO into a three-dimensional (3D) spherical structure with more active sites other than the tetrahedral structure on HNTs. In the CAO/HNTs/PMS system, O 2 •– and 1 O 2 contributed mostly to the catalytic process. This work not only provides a novel catalyst for the treatment of antibiotic pollution, but also offers an innovative strategy for fabricating functional materials on the basis of chemical composition and morphology characteristics of natural minerals.
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MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Shuyuan Guo,Miao Liu,Hanlin Liu,Jingru Mao,Yongfeng Zou,Li-Peng Sun,Yan Huang,Dandan Sun,Jie Ma
A reflective microfiber biosensor with fiber Bragg grating (FBG) is presented for detecting flumequine (Flu) concentration through successive surface modification with polydopamine (PDA) and europium-incorporated covalent organic framework (Eu@COF). The detection mechanism relies on refractive index (RI) changes induced by Flu adsorption, which are monitored by tracking of interference wavelength shifts. Experimental results demonstrate that the sensor exhibits a significant response within a concentration range of 0.1–100 μM, achieving a sensitivity of 0.732 nm/μM in the 0.1–1 μM range with a limit of detection (LOD) of 0.1 μM. Furthermore, the biosensor demonstrates the exceptional specificity for Flu detection among various quinolone antibiotics, while delivering reliable detection in real samples. With the integrated advantages of high sensitivity, superior selectivity, and long-term stability, this sensing platform shows the promising potential for on-site monitoring applications in food safety supervision and veterinary drug residue analysis.
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WATER RESEARCH
·
2025
·
IF 12.4
Fang Zhao,Zhao Yang,Yifan Xiao,Ganghua Han,Kim R. Hardie,Mark Bartlam,Yingying Wang
The stereochemistry of antibiotics significantly affects resistance development. With rising antibiotic resistance, nanotechnology is emerging as a promising solution, potentially increasing the likelihood of nanoparticle coexistence with antibiotics in wastewater treatment plants (WWTPs). However, the influence of nanoparticles on chiral antibiotics induced resistance remains unclear. This study employed chemical characterization, metagenomics, and molecular docking to comprehensively elucidate the resistance mechanisms induced by the combination of silver nanoparticles (AgNPs) and chiral antibiotics (ofloxacin: OFL and levofloxacin: LEV). AgNPs significantly altered the abundance and composition of antibiotic and metal resistance genes, as well as the conjugative transfer of the RP4 plasmid among activated sludge communities, with the OFL_AgNPs combination exhibiting a higher resistance potential than LEV_AgNPs. Mechanistic studies revealed that chiral antibiotics selectively interact with AgNPs, promoting Ag + release, enhancing antibiotic uptake, and forming stable complexes. These interactions reshaped microbial functions, including cell membrane permeability, oxidative stress response, quorum sensing, and extracellular secretion, thereby shaping resistance profiles. This study reveals previously overlooked enantiomer-specific risks associated with nanoparticle-antibiotic interactions and provides a foundation for strategies to mitigate ARG dissemination in wastewater treatment and broader environmental systems.
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ENVIRONMENTAL POLLUTION
·
2025
·
IF 7.3
Jianyi Wu,Xinlin Huang,Miao Chen,Lingxuan Li,Wenhui Zhao,Wenqing Tu
Quinolone antibiotic pollution (QAP) introduced by irrigation may cause the release of per- and polyfluoroalkyl substances (PFASs) at the soil-water interface in paddy fields, endangering the growth of rice crops and the security of human food sources. Thus, the comprehensive investigation of the joint and individual effects of quinolone antibiotics with environment-relevant concentrations on the soil PFASs migration were conducted. Results showed that the QAP dose of 1 μg/L had the highest activation for the release of PFASs into the overlying water, resulting in the highest net concentration of 99.32 μg/L. Structural equation modeling revealed that the QAP-mediated microbial adsorption was the hub transition for PFASs migration ( p < 0.001). The PFASs re-partitioning after QAP was primarily driven by physicochemistry and nutrient cycling variations induced by QAP, which was facilitated by soil microbial urease and acid phosphatase. The soil microbial genes nasC , nasE , phnG , nasD , napD , phnA , nirK , nosZ , and nasB were identified as the critical regulators of PFASs migration under QAP by the aggregate boosted tree modeling. Molecularly, the soil microbial metabolisms of Galactosylglycerol and 3-beta-D-Galactosyl-sn-glycerol were responsible for PFASs release under the QAP level of 1 μg/L ( p < 0.001). These findings were beneficial in elucidating the ecological risks of bioavailable PFASs in paddy fields subjected to the integrated pollution of quinolone antibiotics.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Yixuan Liang,Hanbing Li,Yaming Li,Lei Yan,Sumei Li,Xiaowei Wang,Danyang Li,Sha Chen
Environmental challenges of antibiotics contamination have emerged to address severe impacts on ecological stability and human health. Active sampling methods are not well-fitted to study the emerging pollutants since complicated and unstable enrichment devices/chemicals are significantly required for measurements. Diffusive gradients in thin-films (DGT) are proved to be useful for organic compound detection, but limited by its non-specificity for quinolones (QNs) and tetracyclines (TCs) in waters. Consequently, a metal-organic framework derived carbon specific to QNs and TCs was used as binding agent to develop selective DGT (qt-DGT) in this study. qt-DGT had highly selective adsorption capacity for QNs at 85.45–112.59 μg and TCs at 79.19–85.92 μg in a pH range of 4–9 and ionic strength from 0.001 to 0.05 M. Masses of antibiotics accumulated by qt-DGT increased linearly with time in 24 h. After the deployment in a wastewater treatment plant (WWTP) of Beijing, the qt-DGT exhibited stable and selective uptake of QNs and TCs in comparison with traditional HLB-DGT and active sampling methods. With qt-DGT measurements, QNs and TCs up to 1202.3 ng/L from influent forced WWTP became the major sink of antibiotics, and 830.1–966.3 ng/L from effluent warned the inefficient treatment leading to elevated threats on natural waters.
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ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2025
·
IF 11.3
Xiaozhen Lu,Lin Wang,Hong Peng,Xuewu Zhu,Zhe Yang,Jiashuai Wei,Bin Liu
Polyamide (PA) nanofiltration (NF) membranes represent a promising approach to safe drinking water production. Yet, selective removal of contaminants while retaining essential minerals remains a critical challenge for cost-effective water treatment processes. Here, we employed ammonia bicarbonate (AB) as an economical additive to modify interfacial polymerization (IP) for developing high-performance NF membranes suitable for drinking water applications. Comprehensive characterization coupled with molecular dynamics simulations demonstrate that AB modulates the IP process through three mechanisms: (1) controlling the diffusion kinetics of piperazine (PIP) at the aqueous–organic interface, (2) the reaction between HCO3– and H+ produced by IP achieves nanofoaming, and (3) the thermal decomposition of AB releases additional gaseous products (NH3 and CO2), enhancing the dual nanofoaming effect. This controlled reaction kinetics and increased nanobubble formation produced a thinner, more wrinkled PA selective layer with an optimized microstructure. The optimized NF-AB-8 membrane demonstrated enhanced permeance (28.5 LMH/bar) during actual surface water purification, while maintaining selective separation between minerals and dissolved organic matter (KCa2+/DOM = 34.5). In addition, the improved microstructure and separation performance enhanced the antiscaling and antifouling properties of the NF membrane. This study explored the application of dual-nanofoaming mechanisms in NF membranes, providing insights for designing NF membranes that simultaneously improve permeance and selectivity, which may promote the preparation of high-performance NF membranes and their application in drinking water production.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Yilong Zhu,Ping Chen,Jianjun Yu,Xueyan Zheng,Haichao Xu,Sainan Sun,Xinyun Li,Jiahong Pan,Shi-Wen Lv
Developing novel technique for effective degradation of fluorinated antibiotic is of great significance. Herein, we adopt a simple ship-in-a-bottle strategy to prepare Co(OH) 2 /C composite with hollow structure. Notably, spatial confinement effect triggered by carbon sphere can promote the mass transfer process between PMS and Co(OH) 2 /C, so Co(OH) 2 /C displays high efficiency of PMS activation. As guessed, the Co(OH) 2 /C-mediated PMS system can realize effective degradation of ofloxacin in a short time, and observed rate constant is as high as 1.32 min −1 . Because of large layer spacing and amphoteric attribute of Co(OH) 2 , interestingly, the Co(OH) 2 /C-mediated PMS system also exhibits superb anti-interference ability for inorganic ions and acid fluctuation. More importantly, in-situ characterization analyses reveal that the formation of Co(OH) 2 /C-PMS* complex is the first step during the process of PMS over Co(OH) 2 /C, and the Co(OH) 2 /C-PMS* complex is then decomposed into ≡Co 4+ = O and H • , thereby achieving high removal efficiency of total organic carbon and satisfactory defluorination rate. In addition, pathways of ofloxacin degradation and toxicity of degradation intermediates are investigated in detailed. To sum up, current work offers a promising technique for effective treatment of wastewater containing fluorinated antibiotic.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Cailiang Yue,Yukun Tian,Linlin Zhu,Nan Sun,Zhiqi Zhou,Fuqiang Liu,Yifei Sun
Photocatalytic 1 O 2 generation has emerged as a promising technology for environmental remediation and organics synthesis. Nevertheless, the efficiency of photocatalytic 1 O 2 generation via O 2 activation through charge-transfer mechanism remains challenging in carbon nitride due to the weak dielectric screening effect. Herein, series of uric acid (UA)-modified ultrathin carbon nitride nanosheets (UCN-x) were fabricated by the simple supramolecular self-assembly process. Comprehensive characterizations revealed that the incorporation of UA pigment would induce purine structure into heptazine skeleton. Photocatalytic experiments showed that the modification of UA greatly enhanced photocatalytic 1 O 2 generation ability. The optimal UCN-2 exhibited superior photocatalytic degradation of tetracycline (TC) with the normalized TC degradation rate up to 10.03 mg TC g cat −1 min −1 , which was 2.1–31.1 times as high as that of reported photocatalysts. What's more, UCN-2 exhibited excellent photocatalytic TC degradation across diverse aqueous conditions, demonstrating significant potential in environmental remediation. Time-dependent density functional theory (TD-DFT) calculation revealed that the doping of UA could trigger the spatial separation of h + /e − distribution, with h + concentrated in UA pigment and e − concentrated in adjacent heptazine ring. The engineered adjacent redox sites were precisely tailored to align with the charge-transfer mechanism for photocatalytic 1 O 2 generation. This work established a fundamental framework for designing highly efficient photocatalysts with manipulated O 2 activation.
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