JOURNAL OF ORGANIC CHEMISTRY
·
2020
·
IF 4.335
Shimin Xie,Lebin Su,Min Mo,Wang Zhou,Yongbo Zhou,Jianyu Dong
An alternative thioesterification reaction via copper-catalyzed oxidative coupling of readily available aroylhydrazides with disulfides is developed, in which oxidative expulsion of N2 overcomes the activation barrier between the carboxylic acid derivatives and the products. The reaction produces various thioesters in good to excellent yields with good functional group tolerance. In the reaction, stable and easily available aroylhydrazides are used as acyl sources and the relatively odorless disulfides are used as S sources. Mechanistic investigations demonstrate that the reaction of copper salt and oxidant (NH4)2S2O8 allows for achievement of tandem processes, including deprotonation, free-radical-mediated denitrogenation, and C–S bond formation.
研究领域:
有机化学
·
催化反应
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DOI
高影响因子
Journal of Materials Chemistry C
·
2024
·Vol. 12
·期 39
·15903-15914
·
IF 5.7
Mengyuan Niu,Yuliang Yang,Yue Sun,Yu Hu,Kaiyue Song,Xiaoxia Sun
A novel chiral fluorescent probe, tetraphenylvinyltriazole-ribosyl ribose derivative (β,D)-RIB-TPE, was prepared by Click reaction. It can self-assemble into amphiphilic micron vesicles in methanol solution. (β,D)-RIB-TPE has good AIE properties with a large Stokes shift (redshift 61.8 nm), self-assembles into J-aggregates in a mixed solution with 98% water content, and exhibits a relative fluorescence intensity αAIE = 24, emitting bright blue fluorescence. In addition to the micron vesicles, (β,D)-RIB-TPE self-assembled into J-aggregates in different mixtures, showing different morphologies, such as a cross-linked network structure and an irregular bulk stacking structure. The fluorescent probe (β,D)-RIB-TPE could achieve high efficiency and rapid multi-channel detection of clopidogrel S-(+)-sulfate by fluorescence chromatography and CD spectroscopy. Infrared, nuclear magnetic titration, scanning electron microscopy and DFT calculations confirmed that the probe (β,D)-RIB-TPE recognized S-(+)-clopidogrel sulfate by an ICT mechanism. (β,D)-RIB-TPE and S-(+)-clopidogrel sulfate were co-assembled in methanol to form single-target drug-carrying micron vesicles with a smaller particle size than the self-assembled (β,D)-RIB-TPE vesicles and good drug embedding capacity.
研究领域:
材料科学
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生物医学工程
·
药学
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DOI
高影响因子
ENVIRONMENTAL HEALTH PERSPECTIVES
·
2025
·Vol. 133
·期 5
·057009
·
IF 9.8
Shiqi Li,Yun Fan,Min Tang,Xiaorong Wu,Shengjun Bai,Xiancheng Yang,Xueer Zhang,Chuncheng Lu,Chenbo Ji,Paul A Wade,Xu Wang,Wei Gu,Guizhen Du,Yufeng Qin
Background: Bisphenol S (BPS) is a substitute for bisphenol A in various commercial products and is increasingly used globally due to restrictions on bisphenol A usage. Consequently, there are increasing public health concerns that substantial effects mediated by synthetic chemicals may impact human health. Recently, epidemiology studies reported associations between bisphenol exposure and nonalcoholic fatty liver disease [metabolic dysfunction-associated steatotic liver disease (MASLD)]. However, the causal relationship and the molecular mechanisms affecting hepatocellular functions are still unknown. Objectives: Our study aimed to understand the molecular mechanism by which BPS exposure caused hepatic lipid deposition. Methods: C57BL/6J mice were exposed to BPS for 3 months, and its effects were assessed by histology. RNA sequencing (RNA-seq), assay for transposase-accessible chromatin with high-throughout sequencing (ATAC-seq), and cleavage under targets and tagmentation (CUT&Tag) were used to investigate mechanistic details. ATF3 liver-specific knockout mice and cells were used to validate its functions in BPS-induced hepatotoxicity. Results: Here, mice that were chronically exposed to BPS showed significant lipid deposition in the liver and dyslipidemia and were predisposed to MASLD, accompanied with a reprogrammed liver transcriptional network and chromatin accessibility that was enriched for the Atf3 binding motif. Comparing to the control group, we identified numerous differential Atf3 binding sites associated with signaling pathways integral to lipid catabolism and synthesis in the BPS exposure group, resulting in a drastic surge in lipid accumulation. Moreover, knocking out Atf3 in vitro and in vivo significantly attenuates BPS-induced hepatic lipid accumulation via the regulation of chromatin accessibility and gene expression. Besides, inhibiting JunB also eliminates BPS-induced Atf3 upregulation and lipid accumulation. Conclusion: Our study reveals a novel mechanism, through which BPS upregulates JunB and Atf3 to impair hepatic lipid metabolism, and provides new insights into the hepatotoxicity of BPS. https://doi.org/10.1289/EHP17057
研究领域:
毒理学
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环境健康
·
分子生物学
·
肝脏病学
·
表观遗传学
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DOI
PubMed
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2026
·Vol. 109
·期 6
·e70939
·
IF 4.2
Houcai Kan,Jianjun Chen,Hao Chen,Qingfeng Zeng
The widespread industrial adoption of carbon fiber-reinforced silicon carbide (C f /SiC) composites is currently hindered by the long processing cycles and high energy consumption of traditional fabrication methods. This study presents a novel ultrafast pressure sintering method for fabricating C f /SiC composites. Densified C f /SiC ceramic matrix composites (CMCs) were achieved in 60 s by using borosilicate as a liquid-phase sintering aid. Under optimal processing conditions, the resulting composites exhibited a bulk density of 2.06 g/cm 3 , open porosity of 2.64%, flexural strength of 188.1 ± 15.5 MPa, and fracture toughness of 5.96 ± 0.11 MPa·m 1/2 . This work presents a facile and ultrafast technique that significantly reduces the manufacturing time of C f /SiC composites, paving the way for their broader industrial applications.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Lei Wu,Ruiting Xue,Sujing Zou,Xiqiang Mao,Jun Li,Yang Li,Jian Yang,Ximei Fan
Plasmonic/semiconductor heterojunctions have shown remarkable potential for advancing photochemical reactions, yet the reliance on noble metals in conventional plasmonic systems imposes prohibitive costs for solar-driven applications. Herein, we report the plasmonic semiconductor (WO 3 -OV) with full spectral response by pre-irradiation for the first time. The near-infrared light effectively excites the surface plasmon resonance (SPR) of WO 3 -OV, generating high-energy hot electrons capable of multi-electron transfer processes. Coupling WO 3 -OV with a band-matched semiconductor (TiO 2 ) establishes an internal electric field (IEF) at the heterointerface, which synergistically enhances charge separation and prolongs carrier lifetimes. Crucially, oxygen vacancies (OVs) in WO₃-OV serve dual roles: (1) as plasmonic centers for NIR photon harvesting and (2) as catalytic active sites for toluene oxidation. The synergistic effect of heterojunction and plasmonic was elucidated through comprehensive in situ characterization and theoretical calculation. The rational integration of LSPR, defect engineering, and interfacial charge control provides a universal framework for designing high-efficiency photocatalytic systems for environmental remediation and energy conversion.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Xi Yamin,Zhang Chaoqi,Bao Tong,Liu Suzhao,Wang Tianxiang,Tu Wenjing,Guo Yuntian,Zou Yingying,Yu Chengzhong,Liu Chao
Photocatalytic nitrate reduction reaction coupled carbon dioxide reduction reaction holds great promise for sustainable urea synthesis, the design of photocatalysts with efficient C-N coupling and charge separation is crucial yet challenging. Herein, we report the synthesis of a novel MOF-on-MOF S-scheme heterojunction photocatalyst with interfacial dual active sites for efficient urea production via nitrate reduction reaction coupled carbon dioxide reduction reaction. The integration of semiconducting Zr-MOF and Co-MOF produces interfacial Co and Zr dual sites for NO 3 - activation and CO 2 adsorption, synergistically promoting C-N coupling with reduced energy barriers. Besides, the S-scheme heterojunction enables the strong redox capability and facilitates the charge transfer. Consequently, the rationally designed MOF-on-MOF heterojunction achieves a high urea yield of 3523.4 μg g⁻¹ h⁻¹ and an apparent quantum yield of 1.16% at 365 nm in the absence of sacrificial agents. This work paves the way for the development of high-performance photocatalysts for urea production.
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DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2020
·
IF 7.097
Meng Yuan,Xiaobing Chen,Yitang Sun,Li Jiang,Zhongni Xia,Kaixiong Ye,Hong Jiang,Bo Yang,Meidan Ying,Ji Cao,Qiaojun He
The membrane protein claudin-3 (CLDN3) is critical for the formation and maintenance of tight junction and its high expression has been implicated in dictating malignant progression in various cancers. However, the post-translational modification of CLDN3 and its biological function remains poorly understood. Here, we report that CLDN3 is positively correlated with ovarian cancer progression both in vitro and in vivo. Of interest, CLDN3 undergoes S -palmitoylation on three juxtamembrane cysteine residues, which contribute to the accurate plasma membrane localization and protein stability of CLDN3 . Moreover, the deprivation of S -palmitoylation in CLDN3 significantly abolishes its tumorigenic promotion effect in ovarian cancer cells. By utilizing the co-immunoprecipitation assay, we further identify ZDHHC12 as a CLDN3-targating palmitoyltransferase from 23 ZDHHC family proteins. Furthermore, the knockdown of ZDHHC12 also significantly inhibits CLDN3 accurate membrane localization, protein stability and ovarian cancer cells tumorigenesis . Thus, our work reveals S -palmitoylation as a novel regulatory mechanism that modulates CLDN3 function, which implies that targeting ZDHHC12-mediated CLDN3 S -palmitoylation might be a potential strategy for ovarian cancer therapy.
研究领域:
癌症生物学
·
细胞生物学
·
分子生物学
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DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Wang Kuiyou,Li Guanwu,Zhang Yunfeng,Xu Hechao,Zhao Bo,Wei Jianshuang,Kang Wenbin,Wang Dong,Song Lixian,Zheng Weitao,Song Yingze,Sun Jingyu
Li‒S batteries offer a transformative alternative to present energy storage technologies. However, their practical viability is impeded by polysulfide shuttling and lithium dendrite formation. Electrolyte engineering seeks to solve these thorny issues, yet conventional approaches rely on internal, static or invasive modifications. Here we report an acoustic-induced entropy-driven electrolyte design to steer Li‒S chemistry, realizing enhanced sulfur conversion kinetics and sustained lithium working interface. With the aid of comprehensive instrumental and computational toolbox, it is shown that the entropy-driven state of the electrolyte propels the homogeneous nucleation of both sulfur and lithium species, along with dictating Li-ion desolvation process. The designed electrolyte at a lean dosage of 2.9 µL mg –1 readily enables a 1.1 Ah-level pouch cell with a delivered specific energy of 404.1 Wh kg -1 without packaging. Our electrolyte formulation concept using external field modulation offers an appealing solution to overcome key hurdles in Li–S technology toward high-performance devices.
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DOI
PubMed
高影响因子
POLYMER INTERNATIONAL
·
2013
·Vol. 63
·期 3
·537-545
·
IF 2.125
Yewei Xu,Xiangwang Cui,Fanghua Zhu,Xuan Luo,Qiang Yin,Lin Zhang
Six new bis(benzimidazolyl) monomers containing ether, sulfonyl and ketone groups were synthesized efficiently. A series of poly( N -arylenebenzimidazole)s were prepared using an aromatic nucleophilic displacement reaction that removed the N–H sites from the novel bis(benzimidazolyl) derivatives with activated aromatic difluorides in sulfolane. The reaction was carried out at 210 °C in the presence of anhydrous potassium carbonate. All resulting polymers showed essentially amorphous patterns. This was consistent with the calculated results. Differential scanning calorimetry and thermogravimetric measurements showed that the polymers had high glass transition temperatures (>240 °C), good thermostability and high decomposition temperatures (>400 °C). These novel polymers also showed easy solubility. © 2013 Society of Chemical Industry
研究领域:
高分子化学
·
材料科学
·
有机合成
·
热分析
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Meng Dai,Zuoli He,Peng Zhang,Xin Li,Shuguang Wang
The recombination of photogenerated electrons and holes is a crucial factor limiting photocatalytic H 2 evolution. The S-scheme ZnWO 4 -ZnIn 2 S 4 heterojunction with 2D coupling interfaces was successfully synthesized using a simple solvothermal method. An effective S-scheme interfacial charge migration route at the S-scheme heterogeneous interface was determined by energy band structure analyses (such as UPS, Mott-Schottky and XPS plots), which facilitates the separation of photoexcited carriers. It is worth noting that the optimal ZnWO 4 -ZnIn 2 S 4 composite has an H 2 evolution activity of 4925.3 μmol g −1 h −1 with favourable photostability and stability. Meanwhile, the ZnWO 4 -ZnIn 2 S 4 heterojunction exhibits the maximum optical response value (2.8 mA cm −2 ) in the initial stage, effectively promoting the separation and migration of photogenerated carriers. The establishment of the built-in electric field direction at the interface can effectively promote the space charge separation between the ZnWO 4 and ZnIn 2 S 4 nanosheets, which is favorable to the photocatalytic H 2 evolution. This work provides valuable guidance for designing S-scheme heterojunction photocatalysts composed of two n-type semiconductors for energy and environmental applications.
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高影响因子
Nano Research
·
2021
·Vol. 15
·期 3
·1809-1816
·
IF 8.897
Geng Shuo,Tian Fenyang,Li Menggang,Liu Yequn,Sheng Jie,Yang Weiwei,Yu Yongsheng,Hou Yanglong
The hydrogen evolution reaction (HER) of molybdenum disulfide (MoS 2 ) is limited in alkaline and acid solution because the active sites are on the finite edge with extended basal plane remaining inert. Herein, we activated the interfacial S sites by coupling with Ru nanoparticles on the inert basal plane of MoS 2 nanosheets. The density functional theory (DFT) calculation and experimental results show that the interfacial S electronic structure was modulated. And the results of Δ G H* demonstrate that the adsorption of H on the MoS 2 was also optimized. With the advantage of interfacial S sites activation, the Ru-MoS 2 needs only overpotential of 110 and 98 mV to achieve 10 mA·cm −2 in both 0.5 M H 2 SO 4 and 1 M KOH solution, respectively. This strategy paves a new way for activating the basal plane of other transition metal sulfide electrocatalysts for improving the HER performance.
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高影响因子
Environmental Science & Technology Letters
·
2021
·
IF 7.653
Wenjuan Zhang,Yue Gao,Cheng Chen,Aijing Li,Xuerui Ma,Yong Liang,Xinglei Yao,Maoyong Song,Guibin Jiang
Bisphenol S (BPS) is a bisphenol A (BPA) replacement that is widely present in the environment and in humans. The association between obesity and BPS has been reported in epidemiological studies; however, the obesogenic effect and related mechanism of BPS remain poorly understood. In this study, high-resolution microcomputed tomography analysis showed that the volume of visceral fat was significantly increased in BPS-treated mice. Moreover, BPS showed a higher potency to induce visceral fat formation in mice than BPA at the exposure concentration of 5 mg/kg/day for 14 days. Nontargeted metabolomic analysis showed that BPS exposure induced multiple metabolic disorders in the livers of BPS-treated mice. Interestingly, the body weight and volumes of visceral fat returned to normal by co-treatment with succinate in BPS-treated mice, suggesting that succinate might be the key molecule for the link between BPS and visceral obesity. Our findings highlight that BPS may act as an environmental obesogen to promote obesity.
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高影响因子
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