Frontiers in Bioengineering and Biotechnology
·
2025
·
IF 4.8
Xiping Jiang,Hui Xu,Xinyue Sun,Xuefan Yang,Yuxuan Xia,Wen Xue,Yaohua He
Introduction: The high rate of retear following rotator cuff repair is largely attributed to the absence of a fibrocartilage layer and limited bone regeneration capacity. We aim to evaluate a bioadhesive derived from decellularized porcine annulus fibrosus extracellular matrix, loaded with zeolitic imidazolate framework-8 (ZIF-8), and to promote rotator cuff tendon–bone healing.Methods: Three adhesive formulations were developed: (1) silk fibroin/tannic acid (ST group), (2) ST combined with decellularized porcine annulus fibrosus extracellular matrix (ST/dECM group), and (3) ST/dECM supplemented with ZIF-8 (ST/dECM/ZIF-8 group). Optimal component ratios were determined using lap shear strength testing. The microstructure, Fourier transform infrared (FTIR) spectra, swelling behavior, and degradation properties of the materials were characterized. In vitro studies assessed the adhesives’ effects on cytotoxicity, proliferation, and the chondrogenic and osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells (BMSCs). A rat rotator cuff repair model was used to evaluate in vivo anti-inflammatory effects, fibrocartilage and bone regeneration, and biomechanical performance.Results: All adhesive formulations exhibited comparable tissue adhesion strength and biocompatibility. Both the ST/dECM and ST/dECM/ZIF-8 groups enhanced BMSC chondrogenic differentiation compared to the ST group, with the ST/dECM/ZIF-8 group showing superior osteogenic induction. In vivo, the ST/dECM/ZIF-8 hydrogel effectively reduced interfacial inflammation and promoted fibrocartilage and bone regeneration. Biomechanical testing demonstrated significantly higher ultimate load, tensile stress, and stiffness in all adhesive-treated groups compared to untreated controls.Conclusion: The ST/dECM/ZIF-8 bioadhesive hydrogel promotes fibrocartilage and bone regeneration. These findings highlight its potential as a promising biomaterial-based strategy to enhance tendon-to-bone interface healing following rotator cuff repair.
研究领域:
生物材料
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组织工程
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骨科手术
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再生医学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED ORGANOMETALLIC CHEMISTRY
·
2022
·Vol. 36
·期 12
·e6888
·
IF 4.072
Tiedong Sun,Zhengya Yue,Yan Song,Jiatong Ni,Wenxin Wang,Junge Zhao,Jialun Li,Yuan Sun,Bin Li
Chemodynamic therapy (CDT) is a highly effective clinical treatment strategy based on the Fenton or Fenton-like responses. However, its efficacy has been greatly limited by the complex tumor microenvironment, TME, such as the low levels of H 2 O 2 and the overexpression of the glutathione (GSH). Polyoxometalates (POMs) are compounds that consist of anionic transition metal oxide clusters, such as tungsten (W) and molybdenum (Mo), and notably, these compounds have excellent redox properties in biological systems that can be utilized therapeutically. Therefore, POM-CaO 2 @ZIF-8 nanoparticles (NPs) have been synthesized and used as a mediator to develop an electrically enhanced CDT strategy. It is hoped that the simultaneous modulation of endogenous (the H 2 O 2 generated by CaO 2 NPs and GSH depletion by POM) and exogenous (Electric, E) stimulation enhanced Fenton-like responses will lead to better therapeutic results. Such a treatment strategy has shown excellent tumor cell killing effects in both in vitro and in vivo studies.
研究领域:
纳米医学
·
癌症治疗
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材料科学
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生物医学工程
✓ 已验证
DOI
高影响因子
Membranes
·
2025
·Vol. 15
·期 9
·277
·
IF 3.6
Lei Ni,Qiancheng Cui,Zhe Wang,Xueting Zhang,Jun Ma,Wenjuan Zhang,Caihong Liu
The inherent hydrophobicity of poly(vinylidene fluoride) (PVDF) ultrafiltration membranes leads to severe membrane fouling when processing proteinaceous solutions and organic contaminants, significantly limiting their practical applications. This study presents a novel metal-ion mediated co-deposition strategy for fabricating high-performance antifouling poly(vinylidene fluoride) (PVDF) hollow fiber ultrafiltration membranes. Through Zn2+coordination-driven self-assembly, a uniform and stable composite coating of dopamine (DA), tannic acid (TA), and ZIF-8 nanoparticles was successfully constructed on the membrane surface under mild conditions. The modified membrane exhibited significantly enhanced hydrophilicity, with a water contact angle of 21° and zeta potential of −29.68 mV, facilitating the formation of a dense hydration layer that effectively prevented protein adhesion. The membrane demonstrated exceptional separation performance, achieving a pure water permeability of 771 L/(m2∙h∙bar) and bovine serum albumin (BSA) rejection of 97.7%. Furthermore, it showed outstanding antifouling capability with flux recovery rates exceeding 83.6%, 74.7%, and 71.5% after fouling by BSA, lysozyme, and ovalbumin, respectively. xDLVO analysis revealed substantially increased interfacial free energy and stronger repulsive interactions between the modified surface and protein foulants. The antifouling mechanism was attributed to the synergistic effects of hydration layer formation, optimized pore structure, additional water transport pathways from ZIF-8 incorporation, and electrostatic repulsion from negatively charged surface groups. This work provides valuable insights into the rational design of high-performance antifouling membranes for sustainable water treatment and protein separation applications.
研究领域:
膜科学与技术
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环境工程
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材料化学
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分离科学
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水处理技术
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生物材料
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纳米材料应用
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界面工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2025
·
IF 7.4
Biyu Huang,Haopeng Zhang,Jirui Qu,Gaoyuan Li,Hongbo Zhao,Lei Liu,Chuanmei Jiao,Xilei Chen
Exceptional fire safety, mechanical flexibility, ultraviolet (UV) resistance, and transparency are critical characteristics for thermoplastic polyurethane (TPU) materials in rapidly evolving industrial applications. Nevertheless, achieving a harmonious balance among these properties remains a significant challenge. In this paper, bio-based phytic acid/chitosan intumescent flame retardant (CaCS@PA) and cobalt metal-organic framework (ZIF-67) were incorporated into TPU, forming a densely crosslinked network through non-covalent interactions including hydrogen bonding and π-π stacking. The resulting TPU/ZIF-67-CaCS@PA composites show significant fire safety performance, with a 49.8% reduction in peak heat release rate and a 30.0% decrease in peak smoke production. Analysis of the condensed and gas phases indicated that the flame-retardant mechanism of ZIF-67-CaCS@PA primarily relies on the ability of ZIF-67 to influence the migration of intumescent flame retardant (IFR) gases and catalyze carbonization. This process accelerates the formation of a highly graphitized, thermally stable, and compact char layer, which acts as an effective protective barrier. Owing to the synergistic effect of supramolecular interactions, the tensile strength and elongation at break of the TPU composites were significantly enhanced to 39.6 MPa and 787.4%, representing increases of 155.6% and 27.7% prior to the pure TPU, respectively. Additionally, TPU/ZIF-67-CaCS@PA displays excellent transparency and UV resistance, effectively mitigating aging, yellowing, and strength degradation under UV exposure. This study successfully achieved a desirable balance between fire safety, mechanical performance, UV shielding, and transparency in TPU composites, offering valuable insights and potential advancements for both industrial applications and academic research.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 5
·1-11
·
IF 2.8
Su Hao,Wang Qing,Dai Jianfeng,Li Weixue
Rational design of electrode materials is an important means to improve the performance of supercapacitors. In this paper, CoMoO 4 @Co 3 O 4 composite is prepared by hydrothermal treatment and sintering treatment using ZIF-67 as a self-supporting template. The CoMoO 4 @Co 3 O 4 electrode shows an excellent specific capacity of 2003 F g −1 at a current density of 1 A g −1 , and the capacity retention after 5000 cycles can reach 68% at a current density of 10 A g −1 . In addition, the asymmetric supercapacitor composed of CoMoO 4 @Co 3 O 4 composite and activated carbon (AC) shows an energy density of 56 Wh kg −1 at a power density of 750 W kg −1 and the capacity retention of 80% after 15,000 cycles at a current density of 10 A g −1 . The excellent electrochemical performance is attributed to the use of ZIF-67 as a self-supporting template to suppress the volume expansion and fragmentation of the CoMoO 4 @Co 3 O 4 electrode during charge and discharge.
研究领域:
材料科学
·
电化学
·
能量存储
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuyu Peng,Yina Jiang,Chunyan Wang,Kelei Pang,Xiwang Li,Xiaofeng Zhou,Zhengjie Wang
Surface-enhanced Raman scattering (SERS) technique has significant advantages in the detection of gaseous small molecules, but it still faces challenges such as low adsorption capacity of gaseous small molecules on the surface of the SERS substrate, and low detection sensitivity due to the small Raman scattering cross section. In this paper, a nucleophilic addition strategy based on Ag@Au@4-nitrophenylhydrazine (4-NPH) @zeolite imidazolium ester backbone material-8 (ZIF-8) is proposed for achieving highly sensitive SERS detection of gaseous acetone. The SERS sensing platform was constructed by synthesizing Ag@Au nanoparticles with a core-shell structure modified with 4-NPH as a Raman reporter molecule, which was then encapsulated in a ZIF-8 porous framework. The nucleophilic addition reaction mechanism between acetone and 4-NPH was systematically investigated using density-functional theory (DFT), which revealed the changes in Raman spectra of 4-NPH due to the reaction and provided a theoretical basis for the specific detection of acetone. In addition, the charge transfer effect of more adsorption sites between the reaction product and the nanogold surface further enhanced the SERS signal. The constructed SERS substrate was demonstrated to have a low relative standard deviation (RSD) as low as 4.8 % for the detection of gaseous acetone, which ensured high sensitivity and reliability, and could detect at a concentration of 100 ppb. The method's excellent immunity to interference in complex exhaled gases gives it the potential to be applied to the non-invasive diagnosis of diabetes, demonstrating significant clinical applications.
研究领域:
分析化学
·
纳米技术
·
光谱学
·
化学传感
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理论化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2025
·
IF 7.4
Jing Wang,Wei Liu,Xinyi He,Yingjie Li,Fukai Chu,Yanbei Hou,Weizhao Hu,Lei Song,Yuan Hu
Conventional intumescent flame retardants typically generate localized hypoxic environments within the char layer, leading to incomplete carbonization and substantial CO emission, particularly in intrinsically flammable polyolefins. Metal oxides, owing to their high catalytic activity and tunable redox states, have emerged as promising additives for smoke suppression and toxicity mitigation in polyolefin systems. However, excessive catalytic activity can concurrently accelerate oxidative decomposition of the protective char. Inspired by the protective architecture and stimuli-responsive release of natural seeds, we report a bioinspired interfacial chemical engineering strategy to construct a core–shell Co 3 O 4 @ZIF-8 catalyst. This confinement architecture enables spatiotemporal decoupling of char formation and CO oxidation. During early combustion, the catalyst facilitates the rapid formation of a compact char barrier serving as an efficient thermal shield. Upon reaching elevated temperatures, Co 3 O 4 becomes exposed via the ZIF-8 carrier, efficiently catalyzing CO oxidation and markedly reducing toxic emissions. This strategy achieves a 91.7% reduction in the peak heat release rate (PHRR), 83.9% decrease in total heat release (THR), and 54.1% reduction in CO emission, while delivering outstanding flame-retardant performance (LOI=32%, UL-94 V-0 rating). Collectively, this work establishes a bioinspired core–shell confined catalyst for simultaneous fire safety and toxicity suppression in flame-retardant polypropylene.
研究领域:
材料科学
·
高分子化学
·
火灾安全工程
·
纳米技术
·
催化
✓ 已验证
产品关联
DOI
高影响因子
Molecular Catalysis
·
2025
·
IF 4.9
Huan-huan Fan,Wei Su,Jing-zhi Wu,Wen-long Liu,Chu-an Lin,Qing-yun Li,You-yan Liu,Ai-xing Tang
This study addresses challenges in the chemoenzymatic epoxidation of α-pinene, such as lipase deactivation, carrier decomposition in acidic environments, and product ring-opening side reactions, by developing a core-shell structured metal-organic framework (MOF)-based immobilized enzyme catalyst, CALB@ZIF-8@Zn-BTC. Candida antarctica lipase B (CALB) was encapsulated into ZIF-8 channels via in situ encapsulation. Trisodium citrate was introduced to accelerate the aggregation and co-precipitation of ZIF-8, while 1,3,5-benzenetricarboxylic acid (H₃BTC) coordinated with surface zinc ions of ZIF-8 to form a core-shell composite with enzyme protection and acid-buffering functionalities. Experimental results demonstrated that sodium citrate significantly enhanced acid scavenging capacity, suppressing acidic side reactions and achieving 96.6 % epoxidation selectivity. The Zn-BTC shell improved ZIF-8 stability in acidic systems, retaining over 60 % activity after 7 cycles. Under optimized conditions (3.35 mol/L ethyl acetate, 0.5 mol/L H₂O₂, 0.1 g sodium citrate), α-pinene conversion reached 83.1 %. Compared to the commercial catalyst Novozym435, CALB@ZIF-8@Zn-BTC exhibited superior catalytic efficiency, selectivity, and reusability. Structural characterization (FESEM, EDS, nitrogen adsorption) confirmed enhanced mass transfer and stability due to the composite’s unique architecture and uniformly distributed sodium citrate. This work provides an innovative solution for green and efficient α-pinene epoxidation and offers theoretical and practical insights for designing MOF-based catalysts in acidic environments.
研究领域:
催化
·
绿色化学
·
酶固定化
·
金属有机框架材料
·
有机合成
·
化学反应工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Huanhuan Li,Yu Wu,Xorlali Nunekpeku,Yuhan Yang,Jingsa Zhao,Wei Sheng,Yuexia Wang
The increasing presence of Aflatoxin B 1 (AFB 1 ) residues in food continues to raise significant public health concerns. Herein, we designed an upconversion-based sensor integrated into an alginate-polyacrylamide (SA-PAM) hydrogel for on-site AFB 1 detection in food. First, core-shell upconversion nanoparticles (CSUCNPs) with enhanced fluorescence were modified with complementary DNA (cDNA), forming signal probes known as CSUCNPs-cDNA. Simultaneously, NH 2 -ZIF-8@Cu 2+ with a high surface area and specific affinity for aptamer was synthesized using a one-pot method. This was then modified with an AFB 1 -specific aptamer, forming the capture probe Apt-ZIF-8@Cu 2+ . Using base pairing, CSUCNPs-cDNA and Apt-ZIF-8@Cu 2+ were hybridized into sensing probes (CSUCNPs-ZIF-8@Cu 2+ ), which were embedded into SA-PAM hydrogels as stable sensor carrier. Furthermore, the SA-PAM hydrogel showed a reduced swelling ratio of 1.68–1.80 in water and phosphate buffer solution(s) (PBS), which improves stability. In the presence of AFB 1 , the aptamer selectively binds the AFB 1 , increasing electrostatic repulsion between CSUCNPs-cDNA and Apt-ZIF-8@Cu 2+ . This disrupts Förster resonance energy transfer (FRET), resulting in a pronounced “signal-on” fluorescence. This sensor achieves AFB 1 diffusion through the SA-PAM hydrogel, FRET disruption and upconversion signal stabilization within 18 min, faster than traditional methods. Under optimized conditions, the sensor exhibited a clear linear correlation between fluorescence intensity and the logarithm of AFB 1 concentration ranging from 0.1 to 100 µg/kg ( R ² = 0.994), with a detection limit as low as 0.08 µg/kg. Besides, its performance was further validated through tests on spiked wheat, corn, peanut, and water, demonstrating high accuracy and reproducibility with relative standard deviation (RSD) below 3.63 % and recoveries of 85.88–98.04 %.
研究领域:
食品安全
·
分析化学
·
纳米技术
·
生物传感器
·
毒素检测
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Jinhuai Hua,Rui Yao,Haonan Xu,Wenbin Zhao,Yuping Zhou,Hua Jin,Yanshuo Li
This study addresses the challenges of bio-butanol recovery by synergizing innovative module design with advanced mixed matrix membranes (MMMs) for enhanced pervaporation (PV) efficiency. ZIF-8 nanoparticles (14–120 nm) were integrated into a polymethylphenylsiloxane (PMPS) matrix to fabricate ZIF-8/PMPS MMMs on flat-sheet Al 2 O 3 supports, for efficient n-butanol separation via pervaporation. The optimized 14 nm-ZIF-8/PMPS MMMs (13.0 wt% loading) exhibited optimal performance, achieving a total flux of 925.86 g m −2 h −1 and a separation factor of 37.65 for 1 wt% n-butanol/water mixtures at 40 °C, enabling stable operation over 600 h. Key factors included the improved hydrophobicity, reduced interfacial voids, and enhanced surface roughness. A novel plate-and-frame module was engineered to address scalability challenges, increasing packing density from 5 to 55 m 2 /m 3 while mitigating concentration polarization and enhancing mass transfer under dynamic flow conditions. The module's compact design, combined with the mechanical robustness of Al 2 O 3 supports and the compatibility of ZIF-8/PMPS membranes, demonstrates industrial viability.
研究领域:
化学工程
·
材料科学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2020
·
IF 16.683
Haimin Liu,Mengmeng Jin,Da Zhan,Jinming Wang,Xiaoyi Cai,Yongting Qiu,Linfei Lai
Structure modulation of transition metal phosphides at the atomic scale can significantly modify their catalytic properties. Herein, stacking faults abundant Ni 2 P/Co 2 P electrocatalysts with outstanding bifunctional oxygen evolution and hydrogen evolution property have been prepared. The stacking faults are formed by slow dissolution of Ni substrate by Mo 6+ and further redeposition of Ni 2+ during the growth of Co(OH)F crystals. Unprecedentedly, the distinct mechanistic etching-redeposition pathway dictated by the stacking faults, heterostructures and crystal lattice deformation leads to lattice expansion of Co 2 P and enables preferred reactants adsorption. Electrolysis cell employing Ni 2 P/Co 2 P electrocatalysts as a bifunctional catalyst for both the cathode and the anode delivers a current density of 10 mA cm −2 at a cell voltage of 1.57 V, which is comparable to the integrated Pt/C and IrO 2 counterparts. The exceptional electrocatalytic performance of Co 2 P/Ni 2 P-x%Mo indicates the redeposition mechanism a new methodology to modulate the structure and surface reactivity of electrocatalysts.
研究领域:
材料科学
·
电化学
·
催化
·
纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 53
·期 15
·10772-10783
·
IF 2.993
Liu Guangyang,Li Lingyun,Huang Xiaodong,Zheng Shuning,Xu Xiaomin,Liu Zhongxiao,Zhang Yanguo,Wang Jing,Lin Huan,Xu Donghui
In this study, the functional adsorbent metal–organic framework ZIF-8/magnetic multi-walled carbon nanotubes (M-M-ZIF-8) was successfully prepared for removal of eight organophosphorus pesticides from environmental water and soil samples. The M-M-ZIF-8 was characterized and their adsorption capacity was evaluated based on their isothermal adsorption curves. The results suggest that ZIF-8 particles are deposited on the surface of the magnetic MWCNTs via coordination–polymerization strategy. In addition, M-M-ZIF-8 has high static adsorption capacities for organophosphorus pesticides because of its high specific surface area and porous structure. The static adsorption data fit the Freundlich adsorption model better than the Langmuir model. Under the optimized conditions, M-M-ZIF-8 was successfully applied to remove the eight organophosphorus pesticides from environmental water and soil samples. A possible mechanism is valence-electron-driven adsorption by sharing or exchanging of electrons between the organophosphorus pesticide molecules and the vacant active sites of M-M-ZIF-8. Therefore, M-M-ZIF-8 is a promising hybrid adsorbent for adsorption and removal of organic pollutions from the environment.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）