LUMINESCENCE
·
2021
·Vol. 36
·期 7
·1584-1591
·
IF 2.464
Yaning Qin,Zhaoyue Yan,Rui Liu,Chaojie Qu,Haichen Mao,Lingbo Qu,Ran Yang
In this work, novel types of nitrogen-doped carbon dots (N-CDs) were prepared from citric acid and glycine (GLY) as precursors through a simple pyrolysis method. The GLY-CDs showed strong fluorescence with a fluorescence quantum yield as high as 33.34% and good water solubility. The fluorescence of GLY-CDs could be selectively quenched by iron(III) ion (Fe 3+ ) resulting in the non-fluorescent complex. Due to the high affinity of Fe 3+ to adenosine-5′-triphosphate (ATP), the fluorescence of the GLY-CDs in GLY-CDs-Fe 3+ could be recovered by ATP. Thereby, quantitatively fluorescent turn-on detection of ATP could be achieved. The fluorescence recovery ratio was linearly proportional to the concentration of ATP with a detection limit as low as 15.0 nM, indicating the CDs have high sensitivity. The GLY-CDs were successfully employed in the detection of ATP in serum and cell lysates.
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BIOELECTROCHEMISTRY
·
2021
·
IF 5.373
Rui Li,Huanru Liang,Mingfang Zhu,Mushen Lai,Shumei Wang,Hongwu Zhang,Hongqing Ye,Rongkun Zhu,Wenhao Zhang
A highly sensitive electrochemical sensor for the simultaneous dual signal determination of dopamine (DA), uric acid (UA) and glucose (Glu) has been obtained using nanocomposites based on the copper and cerium bimetallic nanoparticles and carbon nanomaterials of graphene and single-walled carbon nanotubes in the presence of Tween 20 (GR-SWCNT-Ce-Cu-Tween 20) modified glassy carbon electrode. The surface morphology of the nanocomposites was characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD), and the electrochemical behavior of the sensor was investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) with potassium ferricyanide as probe. In the coexistence system of DA, UA and Glu, three clear and well-isolated voltammetric peaks were obtained by CV and differential pulse voltammetry (DPV), and oxidation peak currents of DA and UA are positively correlated with their concentrations respectively, while the peak current of Glu is negatively correlated with its concentration. Linearity was obtained in the ranges of 0.1–100 µM for dopamine, 0.08–100 µM for uric acid and 1–1000 µM for glucose with DPV, and the detection limits (S/N = 3) of 0.0072 µM, 0.0063 µM, and 0.095 µM for DA, UA and Glu, respectively. The method was successfully applied to the determination of DA, UA and Glu in blood serum samples, which provided a reference for further sensor research.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Amjad Farid,Lujun Pan,Muhammad Usman,I.A. Khan,Abdul Sammed Khan,Aqrab ul Ahmad,Muhammad Javid
The combination of transition-metals with chalcogens provide a platform for developing highly sensitive and stable electro-catalyst materials possessing excellent electrochemical features regarding glucose oxidation . The growth of porous cobalt telluride (CoTe 2 ) nanosheets (NSs) on a three-dimension (3D) nickel foam (NF) scaffold via anion-exchange transformation is achieved by employing low temperature scalable hydrothermal process. Being an active catalyst material for glucose detection, the CoTe 2 NSs/NF electrode demonstrates an ultra-prompt response time of 0.1 s, boosting sensitivity of 168000 μA mM −1 cm −2 , low limit of detection of 0.59 μM along with excellent anti-interference ability and favorable stability. Besides, the effective electrochemical performance of sensing electrode is recognized with respect to the glucose detection in real human blood serum. Overall, this material guarantees free-standing 3D architecture, interconnected porous NSs morphology, large specific surface area, high conductivity, and appealing electro-catalytic activity. Therefore, the porous CoTe 2 NSs/NF binder-free electrode has a great application prospect as a promising biomimetic catalyst material for highly sensitive and efficient non-enzymatic glucose sensor.
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Polymers
·
2020
·Vol. 12
·期 10
·2419
·
IF 3.426
Fang Wang,Sheng Hu,Fengna Shi,Kexin Huang,Jiarui Li
Herein, a composite structure, consisting of Cu nanoparticles (NPs) deposited onto carbon nanotubes and modified with ferrocene-branched chitosan, was prepared in order to develop a nonenzymatic electrochemical glucose biosensor ferrocene-chitosan/carbon nanotube@ Cu (Fc-CHIT/CNT@Cu). The elemental composition of the carbon nanohybrids, morphology and structure were characterized by various techniques. Electrochemical impedance spectroscopy (EIS) was used to study the interfacial properties of the electrodes. Cyclic voltammetry (CV) and chronoamperometry methods in alkaline solution were used to determine glucose biosensing properties. The synergy effect of Cu NPs and Fc on current responses of the developed electrode resulted in good glucose sensitivity, including broad linear detection between 0.2 mM and 22 mM, a low detection limit of 13.52 μM and sensitivity of 1.256 μA mM−1cm−2. Moreover, the modified electrode possessed long-term stability and good selectivity in the presence of ascorbic acid, dopamine and uric acid. The results indicated that this inexpensive electrode had potential application for non-enzymatic electrochemical glucose detection.Keywords:carbon nanotube;chitosan;copper nanoparticles;ferrocene;electrochemical sensor;glucose;non-enzymatic
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Nanomaterials
·
2020
·Vol. 10
·期 8
·1513
·
IF 4.324
Venkata Narayana Palakollu,Rajshekhar Karpoormath,Lei Wang,Jiao-Ning Tang,Chen Liu
The excessive intake of chlorpromazine (CPZ) adversely affects human health profoundly, leading to a series of severe diseases such as hepatomegaly and dyskinesia. The rapid and precise detection of CPZ in real samples is of great significance for its effective surveillance. Herein, a versatile and sensitive electrochemical sensor was developed for the detection of antipsychotic drug CPZ based on a Nafion (Nf)-supported nitrogen-doped carbon dots/cuprous oxide (N-CDs/Cu2O) composite. The as-synthesized N-CDs/Cu2O composite was systematically characterized using various physicochemical techniques. The developed composite-based sensor displayed excellent performance towards CPZ determination in a dynamic linear range of 0.001–230 µM with the detection limit of 25 nM. Remarkably, the developed sensor displayed good performance in terms of sensitivity and selectivity. Furthermore, good anti-interference properties toward CPZ determination were attained despite the presence of highly concentrated interfering compounds. Therefore, this composite could be a notable potential modifier to enhance electrocatalytic activity onto the surface of the electrode. Finally, N-CDs/Cu2O/Nf-based sensor was effectively applied for quantification of CPZ in human urine and pharmaceutical formulation samples.Keywords:electrochemical sensor;carbon dots;cuprous oxide;chlorpromazine;antipsychotic drug;pharmaceutical formulations
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MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Long Yan,Pengcheng Ma,Yichen Liu,Xiaoyan Ma,Fang Chen,Mengqi Li
The three-dimensional (3D) coral-like gold/carbon paper (Au/CP) electrode was prepared by a simple one-step electrodeposition procedure assisted by hydrogen evolution without any additive, and used as a support of glucose oxidase (GOx). GOx was immobilized onto the 3D porous electrode Au/CP in a process combining covalent attachment and cross-linking enzyme aggregates to fabricate the biosensor GOx EA -Au/CP. The structure and electrochemical properties of prepared electrodes were tested and characterized by scanning electron microscopy (SEM), chronocoulometry, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The gold coating with coral-like morphology can be found on the Au/CP surface, and the biosensor we fabricated exhibits high sensitivity (96.27 μA mM −1 cm −2 ) to glucose with a considerably wide linear response range (0.002–21.97 mM) as well as a low detection limit (0.6 μM) for glucose detection. In human serum samples, the detection of glucose based on this sensor has high detection stability and recovery, which means the as-prepared electrode is expected to be served as a competitive candidate for developing enzymatic glucose biosensors.
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JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2020
·
IF 3.209
Congcong Yu,Qingpeng Cao,Tingting Tu,Yu Cai,Lu Fang,Xuesong Ye,Bo Liang
As a vital therapeutic agent for Parkinson's disease, dosage control of levodopa has always been a major obstacle in ensuring efficacy and curbing side effects. Simple and fast electrochemical detection methods are the main force in this field. Here, we presented a differential dual-strip method based on the coulometry for high accuracy determination of levodopa. The difference between the two strip signals with or without the tyrosinase extracted the levodopa signal from the samples. The Prussian Blue modified carbon screen-printed electrode was used to convert and amplify the electrochemical signal upon the presence of levodopa. The system exhibited a linear behavior in the 0–10 μM concentration range and a detection limit of 0.25 μM. Furthermore, it was proved to be stable in effectively distinguishing levodopa from complex samples through anti-interference experiments and serum tests. We demonstrated the superiority of dual-strip differential coulometry for the determination of levodopa towards Parkinson’s disease clinical management.
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DYES AND PIGMENTS
·
2020
·
IF 4.613
Qingxiao An,Qinlu Lin,Xiaohui Huang,Rongju Zhou,Xin Guo,Weizhen Xu,Suyan Wang,Dong Xu,Huan-Tsung Chang
Preparation of carbon dots (C dots) with strong emission at long wavelengths is an ongoing goal to their advanced applications, especially in bioanalysis. For sensing Fe 3+ and ascorbic acid (AA), we prepared C dots with a large Stokes shift using o- phenylenediamine (OPD) as the carbon source through an electrochemical method . During the electrolysis, OPD undergoes polymerization, carbonization , and passivation at the platinum anode to form C dots. These C dots were characterized by UV–Vis spectroscopy, transmission electron microscopy , Raman spectroscopy , X-ray photoelectron spectroscopy (XPS), and FT-IR spectroscopy. They are composed of C, N, O, H elements, having a maximum of emission at 570 nm and a supreme excitation at 261 nm, with a Stokes shift of 309 nm. A new emission at 350 nm emerged with their exposure to Fe 3+ and the intensity rises upon increasing Fe 3+ , while the emission intensity at 570 nm decreases. Thus, dissimilar to the usual quenching strategy, a novel ratiometric fluorescent sensor based on the fluorescence intensity ratio (F 350 /F 570 ) of the C dots at 350 nm and 570 nm has been developed for quantitation of Fe 3+ with a limit of detection (LOD) of 0.16 μM and high selectivity toward Fe 3+ against K + , Cu 2+ , and Fe 2+ . With evidence of decreased C–N C and C–O/N–O in XPS and increased content of C O/N O and N–H, we suggested the complexation of Fe 3+ with the surface groups led to the changes in chemical bonds accounting for their optical property variation. Furthermore, AA can quench the fluorescence of C dots at 570 nm and Fe 3+ -treated C dots (incubated with 50 μM Fe 3+ ) at 350 nm by a static mechanism. Accordingly, two assays toward AA were developed with LODs of 0.12 μM and 0.32 μM by using C dots and Fe 3+ -treated C dots, respectively. Especially, both AA assays exhibited excellent selectivity under various substances including those with strong reducing ability such as pyrogallic acid, sodium citrate, tea polyphenol, and dithiothreitol. The applications of the assays were validated with the quantitation of Fe 3+ in urine and AA in beverages. Electrochemical method is a significant approach to develop novel C dots even using the same carbon sources as in other methods.
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ANALYST
·
2020
·Vol. 146
·期 1
·207-212
·
IF 3.978
Wenjie Jing,Xiangkun Cui,Fanbo Kong,Wei Wei,Yunchao Li,Louzhen Fan,Xiaohong Li
Identifying the species and concentrations of antioxidants is really important because antioxidants play important roles in various biological processes and numerous diseases. Compared with an individual sensor detecting a single antioxidant with limited specificity, a sensor array could simultaneously identify various antioxidants, in which 3–5 types of nanomaterials with peroxidase-like activity are absolutely necessary. Herein, as a single-atom nanozyme, Fe–N/C with oxidase-mimicking activity was applied to construct a triple-channel colorimetric sensor array: (1) Fe–N/C catalytically oxidized three substrates 3,3′,5,5′-tetramethylbenzidine (TMB), 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) and o-phenylenediamine (OPD) to produce blue oxidized TMB (oxTMB), green oxidized ABTS (oxABTS) and yellow oxidized OPD (oxOPD), respectively; (2) with oxTMB, oxABTS and oxOPD as three sensing channels, a colorimetric sensor array was constructed for simultaneously discriminating glutathione (GSH), L-cysteine (L-Cys), ascorbic acid (AA), uric acid (UA), and melatonin (MT), even quantifying concentrations (with GSH as a model analyst). The performance of the sensor array was validated through accurately identifying 15 blind samples containing GSH, L-Cys, AA, UA and MT in buffer solution and human serum samples, and also in binary and ternary mixtures. This work proved that fabricating a single nanozyme-based sensor array was a simplified and reliable strategy for simultaneously probing multiple antioxidants.
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Science China-Technological Sciences
·
2020
·Vol. 64
·期 1
·65-70
·
IF 2.302
Chen Fang,Shao Bo,Zhai Wei,Ma XiaoYan
The fabrication of high performance CuO based glucose sensors remains a great challenge due to the “trade-off effect” between sensitivity and linear range. In this study, a hierarchical CuO nanostructure with a great number of firecracker-shaped nanorods along the ligament and three-dimensional interconnected nanoporous is obtained by dealloying and post oxidation process of Al-33.3 wt% Cu eutectic alloy ribbons. Because of the precise structural design, not only the number of active sites for glucose electro-oxidation is significantly increased but also the glucose diffusion under high concentration is greatly accelerated, leading to a high sensitivity of 1.18 mA cm −2 mM −1 and a wider linear range up to 5.53 mM for glucose detection. This work provides a potential approach to design hierarchical nanostructure for other metal oxides with desirable properties for electrocatalytic applications.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2020
·Vol. 412
·期 26
·7275-7283
·
IF 3.637
Shi Weishan,Li Jing,Wu Jie,Wei Qianying,Chen Cuili,Bao Ning,Yu Chunmei,Gu Haiying
The amounts of uric acid (UA) in non-invasive biological samples, such as saliva, are critical for diagnosis and therapy of gout, hyperuricemia, Lesch–Nyhan syndrome, and several other diseases. Here, disposable UA biosensors were fabricated with the screen printing technique on the substrate of flexible PET. The working electrode was modified with carbon nanotubes followed by uricase for UA detection with excellent selectivity. The biosensor showed good electrocatalytic activity toward UA with high sensitivity, low detection limit, and wide linear range, which covers the full range of UA levels in human saliva. We demonstrate that UA can be directly detected in human saliva with the biosensor and the experimental data were consistent with the clinical analysis. This study indicated that the non-invasive biosensor is an attractive and possible approach for the monitoring of salivary UA.
A disposable uric acid biosensor modified with carbon nanotubes followed by uricase was fabricated on flexible PET and applied for the monitoring of salivary uric acid in human saliva
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2020
·
IF 3.807
Liping Hao,Shan-Shan Li,Jin Wang,Yang Tan,Lu Bai,Aihua Liu
Functional nanostructured transition metal oxides hold great promise in catalysis based sensors due to their superb catalytic activity, good stability, ease of preparation and cost-effectiveness. In this work, MnO 2 nanowires and MnO 2 /multi-walled carbon nanotubes (MWCNTs) nanocomposite were prepared via a simple hydrothermal method . The MnO 2 /MWCNTs nanocomposite was developed by deposition of MnO 2 on MWCNTs surface, which have abundant hydrophilic groups facilitating ion-adsorption and nucleation process. The MWCNTs/MnO 2 exhibited higher catalytic activity upon hydrogen peroxide (H 2 O 2 ) electrooxidation , with reduced overpotential by 100 mV and 220 mV in contrast to those values of MWCNTs and MnO 2 nanowires, respectively. Thus the MnO 2 /MWCNTs nanocomposite modified glass carbon electrode (GCE) enabled to detect H 2 O 2 sensitively. Moreover, by incorporation of glucose oxidase (GOx), a glucose biosensor GOx/MnO 2 /MWCNTs/GCE was prepared. The as-proposed biosensor had wide linear range (5–200 μM and 0.2–1 mM) and a low detection limit of 2 μM (S/N = 3), which could be applicable to detect real sample with satisfying accuracy and reproducibility. Due to the superb electrochemical properties, the as-developed MnO 2 /MWCNTs nanocomposite is prospected in electrochemical sensor, electrocatalysis and supercapacitor .
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