Advanced Science
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2026
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IF 14.1
Jilong Wang,Ning Lu,Zhuo Yan,Luyi Ye,Luyao Bai,Shanshan Yuan,Yuting Zhu,Yiru Xiong,Yongheng Bai,Yaping Chen,Junjie Deng
Macrophage-based immunotherapy holds great promise for solid tumors but is limited by impaired phagocytosis and unstable M1-type polarization due to immunosuppressive tumor microenvironments. Here, we develop engineered macrophages by conjugating oncolytic adenovirus (OA)-loaded zeolitic imidazolate framework-8 (ZIF-8) onto macrophage surfaces via bioorthogonal chemistry (ZIFOA-M). This platform leverages localized viral delivery to selectively downregulate “don't eat me” signals (CD47 and CD24) on tumor cells, thereby restoring macrophage phagocytic capacity. Moreover, viral replication within tumors induces immunogenic cell death, releasing major damage-associated molecular patterns (DAMPs) that sustain M1-type polarization and promote durable antitumor immunity. ZIFOA-M also enhances tumor antigen presentation, eliciting robust tumor-specific T cell responses. Our strategy integrates phagocytosis restoration, microenvironment remodeling, and adaptive immune activation in a single, localized platform. ZIFOA-M offers a complementary and translatable approach to overcome key barriers in macrophage-based cancer immunotherapy.
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ANALYTICAL SCIENCES
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2026
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IF 2
Deng Hualong,Jiang Chaoyong,Deng Huaxin,Li Yaohua,Zhang Baoliang
Osteoarthritis (OA) is a leading cause of chronic pain and disability in the elderly. The lack of sensitive diagnostic methods for early OA remains a major clinical challenge. Synovial fluid contains exosomes (SF-exosomes) that carry disease-specific biomolecules, making them promising targets for early diagnosis. However, efficient isolation of SF-exosomes with high purity is technically demanding. This study aimed to develop phosphatidylserine-based molecularly imprinted polymers (P-MIPs) for the efficient enrichment of SF-exosomes and to discover potential protein biomarkers for early OA diagnosis using proteomic analysis. P-MIPs can specifically recognize phosphatidylserine on the extracellular vesicle membrane, thereby achieving highly selective enrichment of extracellular vesicles. P-MIPs were synthesized via a reverse microemulsion system. The binding capacity, specificity, and enrichment efficiency of P-MIPs were characterized. SF-exosomes from 6 OA patients and 6 healthy controls were enriched using P-MIPs and analyzed by LC–MS/MS proteomics. Differentially expressed proteins (DEPs) were subjected to bioinformatics analysis. The diagnostic value of hub genes was validated by ROC analysis in an independent cohort. The results showed that the binding capacity (Qmax) of P-MIPs was 129.71 µmol/g, and the cross-reactivity with sphingomyelin (SM), phenylphosphonic acid (PYP), and tyrosine phosphopeptides was less than 3.5%. The purity of enriched SF-exosomes was 82.6%. A total of 40 DEPs were identified, of which 28 were upregulated and 12 were downregulated in OA. PPI network analyses identified 10 hub genes: IL6, IL1B, MYC, CD4, MMP9, PTPRC, CXCL8, PPARG, ICAM1 , and STAT3 . ROC analysis showed that among the top five hub genes ranked by degree, MYC (AUC = 0.741) and IL6 (AUC = 0.735) exhibited good diagnostic performance. A combined biomarker panel comprising the top five hub genes achieved an even higher diagnostic accuracy, with an AUC of 0.899. The P-MIPs-based SF-exosome enrichment strategy is efficient and selective. MYC and IL6 are potential diagnostic biomarkers for early OA, and the identified DEPs provide insights into OA pathogenesis. Furthermore, this strategy can be extended for the recognition and enrichment of exosomes in other biological fluid matrices, facilitating the discovery of novel disease biomarkers and therapeutic targets. Graphical abstract
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2026
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IF 9.6
Xiangkun Li,Zhonghui Ma,Jiarong Liang,Shikang Liu,Si Wang,Fei Kuang,Luozhen Jiang,Zhiyi Wang
The unique electronic structure of spin-polarized Co nanoparticles enables superior ·OH generation. • Cu-mediated GSH depletion suppresses ROS scavenging and amplifies oxidative damage. • Y6-enabled PTT accelerates catalytic kinetics and induces tumor cell apoptosis. • A combined CDT/PTT nanoplatform achieves effective tumor inhibition. Chemodynamic therapy (CDT) relies on Fenton-like catalysis to convert endogenous H 2 O 2 into cytotoxic reactive oxygen species (ROS). However, its efficacy is limited by the sluggish catalytic kinetics under physiological conditions. Here we report a multifunctional nanoplatform that integrates Fenton-like catalysis with spin-dependent electronic structure modulation, glutathione (GSH) depletion, and photothermal conversion. Compared with single-atom Co sites, Co nanoparticles exhibiting collective spin polarization display enhanced catalytic activity toward hydrogen peroxide (H 2 O 2 ), resulting in more efficient generation of hydroxyl radicals (·OH). Theoretical calculations indicate that collective spin polarization modulates the electronic structure of Co, facilitating the adsorption and activation of intermediates and accelerating the catalytic reaction kinetics. Additionally, Cu species are introduced to deplete intracellular GSH, thereby reducing the scavenging of ROS. Y6 loading enhances photothermal conversion efficiency, further potentiating tumor inhibition, while the resulting hyperthermia also promotes the catalytic process. Both in vitro and in vivo studies confirm the effective tumor suppression. These findings demonstrate that spin-dependent electronic structure engineering provides a promising strategy to enhance the therapeutic efficacy of CDT. Scale modulation from Co single-atom to Co nanoparticles induces collective spin polarization, transforming localized spins into collective spin-polarized state. This spin evolution promotes the adsorption and activation of H 2 O 2 and accelerates Fenton-like ·OH generation. The spin-enabled catalytic enhancement supports more efficient chemodynamic therapy for tumor therapy. Download: Download high-res image (113KB) Download: Download full-size image
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Nature Communications
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2026
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IF 18.1
Jin Yiqi,Wu Bo,Li Wenzheng,Wang Chunlei,Fan Li,Wen Lixian,Li Jiawei,Wang James,Lei Jinggui,Fan Jiantao,Li Hui
Cation degradation in ionomers critically limits the durability of pure-water-fed anion exchange membrane water electrolysis, particularly at the anode where high overpotentials and near-neutral pH induce harsh oxidative stress. However, prevailing cation design remains rooted in alkali-stability frameworks, which fall short under these oxidative conditions. Here, a multiscale approach combining molecular degradation and operando diagnostics identifies electrochemical oxidation as the dominant anodic cation degradation pathway in anion exchange membrane water electrolysis, prompting a shift toward oxidation-resistant cation design. Electrolyzers incorporating oxidation-tolerant trimethylammonium-functionalized ionomers achieve 360-hour stability at 1 A cm⁻ 2 , doubling the durability of alkali-stable N , N -dimethylpiperidinium-based ionomers. Mechanistic studies under simulated anode conditions reveal electrochemical oxidative degradation pathways of cations, establishing a molecular-level evaluation framework. Operando diagnostics with reference-integrated electrolyzers reveal that cation oxidation elevates ohmic and ionic transport resistances. This multiscale study directly traces device failure to cation oxidation, redefining cation design around oxidative stability to enhance durability in pure-water-fed anion exchange membrane water electrolysis.
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Small
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2026
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IF 11.8
Lingxin Kong,Hui Luo,Weiliang Xiong,Sihai Lv,Qifan Li,Yongzhi Cheng,Fu Chen,Xiangcheng Li
Magnetic porous carbon foams, with low density, strong attenuation, and improved impedance matching, have been introduced as effective microwave absorbers to combat electromagnetic interference. In this study, morphology regulation of CoMn-MOF derived composites anchored on carbon foam were prepared by in situ growth and high-temperature pyrolysis. The pyrolysis temperature significantly influences the structural and chemical properties of the magnetic carbon foams. At a matching thickness of 1.45 mm, the material yielded a wide absorption bandwidth of 4.46 GHz, along with a minimum reflection loss of −51.54 dB at 1.55 mm. The excellent microwave absorption properties were contributed to the conductive loss, dipole polarization, interfacial polarization, natural resonance, exchange resonance, and impedance matching. The prepared magnetic porous carbon foams also integrate thermal insulation property. This work established a promising design strategy for advanced microwave absorbers that combine low density with high absorption efficiency, broadband absorption capabilities, and thermal insulation properties.
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Small
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2026
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IF 11.8
Shengze Ban,Yueqi Shen,Jianyi Huang,Yuxiang Xu,Wanxin Chen,Yu Tong,Weihua Ning
0D metal halides are promising light emitters owing to strong quantum confinement and efficient self-trapped exciton (STE) emission, yet achieving both broadband tunability and near-unity PLQY in lead-free systems remains challenging. This study reports the synthesis and comprehensive characterization of Sb 3+ -doped 0D perovskite single crystals, (BYA) 4 InCl 7 : xSb 3+ . Structural analysis confirms the successful substitution of Sb 3+ into the isolated [InCl 6 ] 3− octahedra, which are spatially separated by bulky BYA + organic cations, thereby preserving the intrinsic 0D framework. Sb 3+ incorporation induces a substantial bandgap narrowing from 4.08 to 2.85 eV, accompanied by a pronounced enhancement of broadband STE emission. At an optimal doping level (x = 4.87%), the material achieves an ultrahigh PLQY of 97.53%. Temperature-dependent photoluminescence measurements, together with density functional theory calculations, reveal that the exceptional emission efficiency arises from strong electron phonon coupling and a low activation energy for thermal quenching. Furthermore, a prototype white light-emitting diode fabricated using the (BYA) 4 InCl 7 : Sb 3+ phosphor exhibits excellent color rendition (CRI = 89.3) and robust operational stability. This study elucidates the structure property interplay governing Sb 3+ -doped 0D indium halides and highlights their promise as high-performance emitters for advanced optoelectronic devices.
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Nature Communications
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2026
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IF 18.1
Guo Pan,Dai Yunkun,Zhang Yunlong,Liu Bing,Ma Miao,Liu Bo,Zhang Ziyu,Zhao Zigang,Chen Aibing,Shen Lixiao,Zhao Lei,Wang Zhenbo
Atomically dispersed catalysts based on 3 d metals have been extensively explored in the catalytic field, but stabilizing 4 d and 5 d metals like Ru, Pd, and Pt as single atoms remains a challenge due to their high cohesive energies. Herein, we develop a hydrogen-embrittlement-inspired strategy that leverages H 2 permeation to weaken metal-metal cohesion in 4 d /5 d metal clusters during high-temperature synthesis. Hydrogen diffuses into the clusters, driving their dissociation into individual atoms, which are subsequently stabilized by nitrogen dopants in carbon supports, resulting in the formation of stable M-N 4 single-atom sites. Taking Ru as a model system, ex-situ microscopy and spectroscopy offer definitive evidence that hydrogen permeation disrupts Ru-Ru bonding interactions, facilitating the conversion of Ru clusters into isolated RuN 4 sites during the H 2 -assisted thermal activation process. Consequently, the prepared NC-Ru-950 catalyst achieves satisfactory activity and stability for acidic oxygen reduction and proton exchange membrane fuel cells. This work introduces a robust and universal strategy for stabilizing 4 d and 5 d transition metals as single-atom catalysts, offering a promising route to develop high-performance electrocatalysts.
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Journal of Water Process Engineering
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2026
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IF 6.6
Li Zeng,Hanbin Wu,Yiyang Xu,J. Paul Chen,Yiqiao Xie,Yang Yu
The efficient treatment of dye-containing wastewater remains a critical environmental issue, primarily due to its biological toxicity to aquatic microorganisms and high chromaticity. In this work, two types of Co₃O₄-functionalized ceramic hollow fiber membranes were designed to activate peroxymonosulfate (PMS) for the efficient removal of dyes from water. Compared to the static-deposited membrane (SCHFM), the dynamic-deposited membrane (DCHFM) demonstrated a higher loading capacity and more uniform distribution of Co 3 O 4 on both the surface and internal pores, leading to a significant enhancement in catalytic performance. Under optimal operating parameters, the DCHFM achieved over 98% removal of rhodamine B (RhB) during the filtration. Radical quenching and electron paramagnetic resonance (EPR) confirmed the involvement of multiple reactive oxygen species, including singlet oxygen ( 1 O 2 ), hydroxyl radical (HO•), sulfate radical (SO 4 •− ) and superoxide radical (•O 2 − ), with 1 O₂ identified as the predominant reactive species. Furthermore, the functionalized membrane exhibited outstanding operational stability and reusability with negligible cobalt leaching. The findings of this study provide a high-performance catalytic membrane system for the advanced purification of industrial wastewater.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Qiuqiu Mu,Xiaobin Yang,Lin Lin,Lizhi Wang,Zhixiang Mu,Jingjing Liu
Chronic hyperglycemia-associated wounds pose major therapeutic challenges because microbial colonization, sustained inflammation, and severe oxidative injury act in concert to impede timely tissue regeneration. Targeting these combined challenges, the present work created an advanced multifunctional wound dressing, designated ADZ1, designed for the combined therapy of diabetic wounds. This system was assembled through Schiff base conjugation of aminated alginate and oxidized pullulan, followed by integration of copper-doped ZIF-8 nanostructures loaded with quercetin (ZIF-8@QC). The resulting architecture demonstrates an intelligent, self-mending, injectable porous matrix. Within an infected wound’s acidic milieu, degradation of the hydrogel occurs responsively, liberating ZIF-8@QC nanocargos. These nanoparticles catalyze available H 2 O 2 to produce considerable reactive oxygen species, enabling powerful initial antimicrobial action. Afterwards, prolonged quercetin release delivers sustained antioxidative and anti-inflammatory benefits. In vivo assessment employing a type‑1 diabetic rat model bearing Staphylococcus aureus -infected wounds revealed that ADZ1 markedly hastened wound closure (exhibiting merely 23.1% remaining wound area at day 14). In summary, by intelligently orchestrating staged bacteria-suppressing, antioxidative, inflammation-mitigating, and pro‑angiogenic activities, the ADZ1 platform demonstrates significant potential for a holistic therapeutic regimen addressing diabetic wounds.
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Food Chemistry-X
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2026
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IF 9.2
Wenjie Yu,Qiuning Wang,Qifang Sun,Qiming Zhu,Tao Liu,Shengxiang Yi,Gaowei Zhang,Jie Zhu,Jingze Cao,Jinwang Li,Yan Li,Xiaoqing Fan,Xiali Guo,Yanling Song,Liping Luo
Fat content shapes rice eating and nutritional quality, yet its climate response remains unclear. In this study, we combined six years of multisite field observations across nine provinces in southern China with an interpretable random forest model to identify drivers of rice fat. The model showed that the minimum nighttime temperature during grain filling (TMIN) was identified as the primary factor. Fat content increased with TMIN, whereas the unsaturated fatty acid index (IUFA) exhibited three distinct accumulation patterns and generally declined at higher TMIN. This pattern indicates a physiological tradeoff potentially linked to changes in energy metabolism and membrane stability of rice. Patterns were independently validated in 2024 field trials at 11 sites. Furthermore, projections indicate higher fat under warming but declining IUFA, especially in early- and mid-season rice. These results support climate-resilient cultivation, sustainability, and quality management of rice.
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Journal of Environmental Chemical Engineering
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2026
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IF 7.5
Wanzi Li,Jie Yang,Yulong Yan,Hang Chen,Rui Zuo
The co-contamination of V(Ⅴ) and Cr(Ⅵ) in wastewater poses significant risks to aquatic ecosystems and human health. However, it remains challenging to both develop efficient adsorbents for their simultaneous removal and elucidate their interactions. In this study, a novel metal-organic framework (MOFs) adsorbent, UiO-66-NH₂, was synthesized in an open system at atmospheric pressure for the treatment of combined pollution of V(Ⅴ) and Cr(Ⅵ) in solution. Adsorption experiments demonstrated that UiO-66-NH 2 exhibits strong adsorption capacity toward V(V) and Cr(VI), primarily governed by chemisorption. The maximum adsorption capacities for V(V) and Cr(VI) in single system adsorption were 543.40 mg/g and 335.28 mg/g, respectively. In the binary system, V(V) and Cr(VI) adsorption capacities reached 712 mg/g and 501 mg/g, respectively, which were 1.92 and 3.32 times those in their respective single systems. This confirms synergistic effects. However, localized uptake fluctuations, such as a 4.4% decrease in Cr uptake with increasing V concentration, indicate competitive interactions. The material also showed selective adsorption toward V(V). Combined with material characterization and molecular dynamics (MD) simulations, the chemical composition and structural stability of the material were analyzed, and the adsorption mechanism at the micro level was revealed. The adsorption mechanism of UiO-66-NH 2 for V(V) and Cr(VI) involves electrostatic interactions, chemical reduction, hydrogen bonding, and coordination. These findings provide theoretical insights for the application of UiO-66-NH 2 in treating V(V) and Cr(VI) contaminants in wastewater and for the design of related adsorbents.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Lijuan Chang,Xianli Wang,Chengbin Liu,Hang Wen,Zhijie Zhang,Chunxia Yao
Perfluorooctanoic acid (PFOA) has attracted growing attention due to its widespread occurrence and harmful effects on humans. Owing to the strong C F bonds that confer inherent stability on PFOA, achieving efficient degradation via traditional photocatalysts is highly challenging. In this study, a UiO-66-NH 2 photocatalytic-persulfate (UiO-66-NH 2 /PS) integrated system was constructed to achieve high-efficiency PFOA removal, and its underlying mechanism was systematically revealed. A zirconium-based metal–organic framework, UiO-66-NH 2 , with readily tunable porosity was successfully synthesized via a solvothermal route, and its crystal structure, microstructure, and optical absorption behavior were confirmed through comprehensive characterizations. After optimization of the reaction parameters, the UiO-66-NH₂/PS system exhibited excellent PFOA degradation performance, with a markedly enhanced removal efficiency relative to the single UiO-66-NH 2 or persulfate system. The degradation efficiency of UiO-66-NH 2 /PS system in degrading PFOA was affected by ubiquitous anions and humic acid in water. Investigation of degradation pathways revealed that the cooperative action of photogenerated holes and SO₄• − /•OH radicals progressively cleaved the recalcitrant C F bonds, with short-chain perfluorocarboxylic acids (PFCAs) including perfluoroheptanoic acid (PFHpA, C 6 F 13 COOH), perfluorohexanoic acid (PFHxA, C 5 F 11 COOH), perfluoropentanoic acid (PFPeA, C 4 F 9 COOH), and perfluorobutyric acid (PFBA, C 3 F 7 COOH) identified as the main degradation intermediates. This study proposed a high-efficiency, economical and eco-friendly approach for the mineralization of PFOA, and meanwhile shed new light on the mechanism underlying the efficient degradation of PFOA by UiO-66-based photocatalysis combined with persulfate activation.
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