JOURNAL OF CHROMATOGRAPHY A
·
2016
·
IF 3.926
Qingxiang Zhou,Man Lei,Jing Li,Kuifu Zhao,Yongli Liu
Magnetic Fe@MgAl-layered double hydroxides (MgAl-LDHs) composite was firstly synthesized by coating MgAl-layered double hydroxides on the surface of the dispersed nanoscale zero valent irons with co-precipitation method and characterized by transmission electron microscopy and X-ray diffraction techniques. The synthesized Fe@MgAl-LDHs nanoparticles were investigated for magnetic solid phase extraction (MSPE) of 1-naphthol and 2-naphthol from the water samples. The elutent containing 1-naphthol and 2-naphthol was analyzed by high performance liquid chromatography with variable wavelength detection (HPLC–UV). Under optimal conditions, there is good linear relationship between the concentration and the peak area in the range of 0.5–200 μg L −1 with the correlation coefficients ( r 2 ) above 0.998 for 1-naphthol and 2-naphthol. The limits of detection were 0.22 μg L −1 and 0.19 μg L −1 for 1-naphthol and 2-naphthol, respectively, and precisions were both below 2.5% ( n = 6). The real water analysis demonstrated that the spiked recoveries were in the range of 79.2–80.9% ( n = 3). All these results indicated that the developed MSPE–HPLC–UV method was proved to be an efficient tool for the analysis of naphthols.
研究领域:
环境科学
·
分析化学
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DOI
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2021
·Vol. 146
·期 6
·2445-2462
·
IF 4.626
Usman Muhammad,Yu Haojie,Wang Li,Titinchi Salam,Khan Amin,Naveed Kaleem-ur-Rehman,Nazir Ahsan,Elshaarani Tarig,Fahad Shah,Amin Bilal ul
Ferrocene (Fc)-based polymers have promising application in burning rate catalysts (BRCs) for solid composite propellants, and some of them have already been practically used. However, they have some drawbacks such as high migration during a long-time storage. Copolymers of poly(2-(methacryloyloxy) ethyl ferrocene carboxylate- co -glycidyl methacrylic acid)s (P(FHEMA -co- GMA)s) were synthesized to overcome the migration problem of Fc-based BRCs as well as to boost the burning rate (BR) of ammonium perchlorate (AP)-based propellants. The structures of the obtained P(FHEMA -co- GMA)s were confirmed by proton nuclear magnetic resonance ( 1 H NMR) and Fourier transform infrared (FT-IR) spectroscopy. Cyclic voltammetry (CV) method was used to study their electrochemical behavior, and the P(FHEMA -co- GMA)s showed redox behavior for the existence of the Fc units. Because of the formation of integrated network structures, the P(FHEMA -co- GMA)s have good anti-migration performances. The BR catalytic property of P(FHEMA -co- GMA)s were investigated by thermogravimetry (TG) and differential thermogravimetry (DTG). They showed competent catalytic effects on the thermal decomposition of AP.
研究领域:
材料科学
·
电化学
·
推进剂技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Chenxia Yang,Ying Meng,Xintong Wang,Xin Li,Tong Yu,Weiming Liao,Wenjun Xie,Qianchen Jiang,Han Wang,Cheng Shi,Wenxuan Jiao,Xiling Bian,Fang Hu,Xiaowei Wang,Yani Liu,Liangren Zhang,KeWei Wang,Qi Sun
Enhancing α7 nAChR function serves as a therapeutic strategy for cognitive disorders. Here, we report the synthesis and evaluation of 2-arylamino-thiazole-5-carboxylic acid amide derivatives 6–9 that as positive allosteric modulators (PAMs) activate human α7 nAChR current expressed in Xenopus ooctyes. Among the 4-amino derivatives, a representative atypical type I PAM 6p exhibits potent activation of α7 current with an EC50 of 1.3 μM and the maximum activation effect on the current over 48-fold in the presence of acetylcholine (100 μM). The structure–activity relationship (SAR) analysis reveals that the 4-amino group is crucial for the allosteric activation of α7 currents by compound 6p as the substitution of 4-methyl group results in its conversion to compound 7b (EC50 = 2.1 μM; max effect: 58-fold) characterized as a typical type I PAM. Furthermore, both 6p and 7b are able to rescue auditory gating deficits in mouse schizophrenia-like model of acoustic startle prepulse inhibition.
研究领域:
神经科学
·
药物化学
✓ 已验证
DOI
PubMed
高影响因子
Green Synthesis and Catalysis
·
2020
·
IF 0
Bingmei Su,Lian Xu,Xinqi Xu,Lichao Wang,Aipeng Li,Juan Lin,Lidan Ye,Hongwei Yu
As an important building block for the synthesis of angiotensin-converting enzyme inhibitors, ethyl ( R )-2-hydroxyl-4-phenylbutanoate [( R )-HPBE] has attracted increasing attention. The key to industrial biosynthesis of ( R )-HPBE is a biocatalyst that efficiently reduces ethyl 2-oxo-4-phenylbutanoate (OPBE) with high R -enantioselectivity. This paper proposed a strategy for identifying key residues involved in enantioselectivity control based on per-residue free energy decomposition and sequence conservatism analysis. Using this strategy, 4 nonconservative sites with high energy contribution to binding of OPBE were chosen as engineering targets, generating variant Mu27 with 99% conversion and 98% ( R ) ee value at substrate loading of up to 500 mmol/L. MD simulations suggested the higher stability and formation probability of Mu27-OPBE proR prereaction state as key reasons for the excellent R -enantioselectivity of Mu27 towards OPBE. The success in this study provides a viable approach for rational design of alcohol dehydrogenases with high enantioselectivity towards unnatural substrates.
研究领域:
生物化学
·
酶工程
·
计算生物学
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DOI
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2026
·
IF 2.4
Zhen Chang,Yaxuan Zhen,Chunying Zhu,Taotao Fu,Youguang Ma
The densities and dynamic viscosities of pure components, binary solutions and ternary solutions of 2-amino-2-methyl-1-propanol (AMP), 2-ethylaminoethanol (EAE) and water were systematically measured at (293.15–323.15) K. Based on experimental findings, calculations were made for the excess molar volume, thermal expansion coefficient, dynamic viscosity deviation, and solution viscous activation energy to assess intermolecular interactions. The negative excess molar volumes of binary and ternary aqueous solutions indicate significant hydrogen bonding interaction and a filling effect within the solutions. The negative excess molar volumes of binary and ternary aqueous solutions indicate significant hydrogen bonding interactions and a filling effect within the solutions. For the AMP–EAE system, the hydrogen bonding interaction and filling effect are weakened due to the similar volume and steric hindrance effect.
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产品关联
DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 52
·期 1
·547-558
·
IF 2.047
Zhou Jian,Ren Sili
The phosphor-converted white light-emitting diode (WLED) has received tremendous attention as a promising alternative to traditional light sources in lighting and displays. Herein, a novel broadband red emitter Ca 2 Sr(PO 4 ) 2 :Mn 2+ was successfully designed and synthesized based on the Sr-alloying and Mn-doping of Ca 3 (PO 4 ) 2 . The phase purity of the materials was verified by x-ray diffraction (XRD) analyses, while a scanning electron microscope (SEM) coupled with an energy-dispersive spectrometer (EDS) was employed to confirm the uniform dopant distribution. XRD Rietveld refinements were further performed to clarify the site occupation of alloying Sr and the Mn dopants. Effective site engineering confined the Mn dopants in a highly symmetric Ca5 site and excluded the immersion of Sr, leading to an extraordinarily long fluorescence lifetime. Density functional theory (DFT) simulations also revealed the good potential of the materials as host matrices for activators such as Mn 2+ . Finally, Ca 2 Sr(PO 4 ) 2 :Mn 2+ was used to fabricate a WLED prototype based on a near-ultraviolet (n-UV) commercial LED chip, which realized a warm white-light emission and high color rendering index (Ra) of 82.9. This WLED was able to survive the long-term stability test while maintaining high luminous efficacy of ~ 60 lm/W within 20 h, showing its great potential in practical applications.
研究领域:
材料科学
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光电技术
·
照明技术
·
固体物理
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DOI
高影响因子
XENOBIOTICA
·
2022
·
IF 1.997
Kunna Li,Ying Zou,Yang Wang,Mengyue Zhou,Jing Li,Rong Tan,Shiyu Zhang,Weiwei Li,Jiang Zheng
2-Methylnaphthalene (2-MN) is an environmental pollutant. Studies have shown that 2-MN is teratogenic, carcinogenic, and cytotoxic. However, the mechanisms of 2-MN induced toxicities remain unclear.This study aimed to characterise reactive metabolites of 2-MN, to define the metabolic pathway, and to determine the enzymes participating in the metabolic activation.A hydroxylation metabolite of 2-MN, 2-naphthalenemethanol (2-NM), was observed in 2-MN-containing mouse liver microsomes.A glutathione (GSH) conjugate was detected in mouse S9 incubations fortified with 2-MN and GSH. A GSH conjugate and an NAC conjugate were found in mouse liver and urine, respectively, in animals given 2-MN. Hepatic protein covalent binding derived from 2-NM was observed in animals administered 2-MN.Cytochrome P450 enzymes and sulfotransferases participated in the metabolic activation of 2-MN.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Research
·
2023
·
IF 11
Guangchun Song,Jia Xu,Hong Zhong,Qi Zhang,Xin Wang,Yitong Lin,Scott P. Beckman,Yunbo Luo,Xiaoyun He,Jin-Cheng Li,Kunlun Huang,Nan Cheng
The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment. However, research on alleviating metabolic diseases, such as hyperglycemia, has not been reported. Herein, we found that the single-atom Ce-N4-C-(OH)2 (SACe-N4-C-(OH)2) nanozyme promoted glucose absorption in lysosomes, resulting in increased reactive oxygen species production in HepG2 cells. Furthermore, the SACe-N4-C-(OH)2 nanozyme initiated a cascade reaction involving superoxide dismutase-, oxidase-, catalase-, and peroxidase-like activity to overcome the limitations associated with the substrate and produce •OH, thus improving glucose intolerance and insulin resistance by increasing the phosphorylation of protein kinase B and glycogen synthase kinase 3β, and the expression of glycogen synthase, promoting glycogen synthesis to improve glucose intolerance and insulin resistance in high-fat diet-induced hyperglycemic mice. Altogether, these results demonstrated that the novel nanozyme SACe-N4-C-(OH)2 alleviated the effects of hyperglycemia without evident toxicity, demonstrating its excellent clinical application potential.
研究领域:
纳米技术
·
生物化学
·
代谢疾病
·
药理学
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Lemeng Wang,Chi Fang,Xiaoqian Du,Kun Fu,Xiangfeng Tian,Pan Zhang,Dong Fu
The surface tensions ( γ ) and viscosities ( η ) of 1-dimethylamino-2-propanol (DMA2P) − 1-(2-aminoethyl)piperazine (AEP) and DMA2P − 1,5-diamino-2-methylpentane (DAMP) were measured and correlated. According to the CO 2 capture temperature from the thermal power plant flue gas (around 313 K), the experimental temperatures were selected to be 303.2 K, 313.2 K and 323.2 K. The mass fractions of DMA2P ranged from 0.300 to 0.500, and those for activators (AEP and DAMP) ranged from 0.050 to 0.150. Temperature and composition dependences of γ and η were demonstrated on the basis of experiments and calculations. The activation energy ( E a) was estimated from the temperature dependence of viscosity. Analytical formulations of surface entropy ( S S ) and surface enthalpy ( H S ) were deduced from the analytical equation of γ . S S and H S were calculated and their variations with respect to mass fraction were analyzed.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2013
·
IF 2.004
Chao Guo,Shaoyun Chen,Yongchun Zhang
Solubility measurements of carbon dioxide (CO2) in aqueous 2-(2-aminoethylamino)ethanol (AEEA, 15 wt %), AEEA + N-methyldiethanolamine (MDEA, 5, 10 wt %), and AEEA + 2-amino-2-methyl-1-propanol (AMP, 5, 10 wt %) solutions as CO2 absorbents were performed at CO2 partial pressure from (0.8 to 800) kPa and temperatures of (303, 313, and 323) K. With increasing the MDEA/AMP amount to AEEA, CO2 loading of the absorbents decreased, while the absorption rate increased. At low CO2 partial pressure (< 30 kPa), the loading of AEEA + AMP was higher than that of AEEA + MDEA, while at high CO2 partial pressure (> 100 kPa), the loading of AEEA + AMP was lower than that of AEEA + MDEA at the same concentration. Furthermore, the absorption rate was in the order AEEA + AMP > AEEA + MDEA > AEEA.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Advanced Ceramics
·
2022
·Vol. 11
·期 3
·392-402
·
IF 11.534
Feng Chao,Zhou Xu,Tao Bingjing,Wu Haitao,Huang Shifeng
Dense microwave dielectric ceramics of Ce 2 [Zr 1 − x (Al 1/2 Ta 1/2 ) x ] 3 (MoO 4 ) 9 (CZMAT) ( x = 0.02–0.10) were prepared by the conventional solid-state route. The effects of (Al 1/2 Ta 1/2 ) 4+ on their microstructures, sintering behaviors, and microwave dielectric properties were systematically investigated. On the basis of the X-ray diffraction (XRD) results, all the samples were matched well with Pr 2 Zr 3 (MoO 4 ) 9 structures, which belonged to the space group \(R\bar 3c\) . The lattice parameters were obtained using the Rietveld refinement method. The correlations between the chemical bond parameters and microwave dielectric properties were calculated and analyzed by using the Phillips—Van Vechten—Levine (P—V—L) theory. Excellent dielectric properties of Ce 2 [Zr 0.94 (Al 1/2 Ta 1/2 ) 0.06 ] 3 (MoO 4 ) 9 with a relative permittivity ( ε r ) of 10.46, quality factor ( Q × f ) of 83,796 GHz, and temperature coefficient of resonant frequency ( τ f ) of −11.50 ppm/°C were achieved at 850 °C.
研究领域:
材料科学
·
陶瓷
·
微波介电材料
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2014
·Vol. 5
·期 20
·5967-5977
·
IF 5.368
Bo Zhang,Hui Tang,Peiyi Wu
Dynamic thermal phase transition behavior of a well-defined poly(N-isopropylacrylamide)–poly(2-hydroxyethyl methacrylate) (PNIPAM–PHEMA) interpenetrating polymer network (IPN) microgel in D2O synthesized by two-step precipitation polymerization was studied by means of IR spectroscopy in combination with the perturbation correlation moving window (PCMW) technique and two-dimensional correlation spectroscopy (2Dcos) analysis. Due to the hydrophobic and non-thermo-responsive properties of PHEMA and the special IPN structure, the IPN microgel exhibited an unusual thermally induced collapse process. The introduction of PHEMA would lower the volume phase transition temperature (VPTT) and the volume phase transition degree. 2Dcos was finally employed to discern the sequence order of all the group motion during heating and cooling processes. PHEMA plays different roles in different stages during the volume phase transition. Additionally, as PHEMA exhibits only a slight response to temperature, it would provide the PNIPAM–PHEMA IPN microgel with good reversibility.
研究领域:
高分子科学
·
生物材料
·
药物递送
·
智能响应材料
·
热敏性水凝胶
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）