Probiotics and Antimicrobial Proteins
·
2024
·
IF 4.4
Zheng Xiumei,Zhang Zhe,Shan Tianhu,Zhao Maozhen,Lu Haiyan,Zhang Lanwei,Liang Xi
Atherosclerosis is a major cause of cardiovascular disease (CVD). The trimethylamine (TMA)-trimethylamine N-oxide (TMAO) pathway is a key crossover pathway highly associated with diet, gut microbiome, and atherosclerosis. The Bifidobacterium animalis subsp. lactis F1-3–2 ( Bif. animalis F1-3–2, No. CCTCCM2020832) was screened through in vitro and in vivo experiments in the early stage of this study with excellent lipid-lowering and anti-inflammatory function. By building an atherosclerosis model and focusing on TMAO, the specific mechanism of Bif. animalis F1-3–2 to improve atherosclerosis was explored. The study found that Bif. animalis F1-3–2 effectively improved the accumulation of aortic plaque in atherosclerotic mice. The strain improved lipid metabolism in serum and liver. It decreased the serum TMA and TMAO, regulated bile acid composition, participated in the farnesoid X receptor (FXR) pathway to improve lipid metabolism, and further reduced the aortic macrophage foam cell accumulation. In addition, the strain could improve the structure of the intestinal microbiome and reduce the proportion of Firmicutes and Bacteroidetes. The abundance of Turicibacter , Clostridium sensu stricto_1 , and Romboutsia was reduced at the genus level. The differential microbiota is highly correlated with bile acid metabolism, which is speculated to be involved in ameliorating atherosclerotic lipid metabolism disorders. Graphical abstract
研究领域:
微生物学
·
心血管疾病
·
营养学
·
代谢组学
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2023
·
IF 6
Zihao Dong,Yajuan Qu,Yuyang Jiao,Ke Xue,Wenguang Zhu,Hai Liu,Jianguang Qi,Yinglong Wang
A series of poly(1-vinyl-3-methylimidazole dimethyl phosphate- co -N-isopropylacrylamide) oligomers was synthesized by reversible addition-fragmentation chain transfer polymerization. The co-oligomers exhibited a pH-tunable lower critical solution temperature (LCST) phase transition in aqueous solutions. By changing the pH of the aqueous solution (HCI), the hydrogen bonding between the internal molecules of the co-oligomers and water molecules was weakened, which effectively reduced the cloud-point temperature. Poly(1-vinyl-3-methylimidazole dimethyl phosphate- co - N -isopropylacrylamide) oligomers exhibit an upper critical solution temperature (UCST) type of phase transition in an ester solution, which is associated with the formation and breaking of hydrogen bonds within the co-oligomers molecules. FT-IR analysis revealed the effect of temperature on hydrogen bonding between the functional groups. Energy decomposition, Electrostatic Potential (ESP), Atoms-in-Molecules (AIM), and Interaction region indicator (IRI) analyses demonstrated the presence of hydrogen bond donors N–H and imidazole ring C–H, and hydrogen bond acceptors C = O and P = O in the co-oligomers. The sites of hydrogen bonding between the co-oligomers and the solvent molecules as well as intermolecular forces were found to be the main factors contributing to the LCST/UCST-type phase transition.
研究领域:
高分子化学
·
物理化学
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DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2021
·Vol. 18
·期 11
·e2100301
·
IF 2.408
Zhuojin Yang,Yi Zheng,Nafisa Tursumamat,Mingyan Zhu
Isorhamnetin is a natural flavonoid which shows a variety of biological activities such as antioxidant, anti-inflammatory and antitumor. In order to identify the cellular binding protein of isorhamnetin as potential anti-cancer target, we first synthesized 3′- O -substituted quercetin as isorhamnetin homologues and evaluated the growth inhibitory activity of these derivatives on breast, colon and prostate cancer cell lines. The preliminary results showed that the 3′- O modification did not affect the cytotoxic activity of the scaffold. Analysis of the co-crystal structure and the docking pose of isorhamnetin with reported binding protein of isorhamnetin or quercetin indicated the 3′- O -substitution groups located outside of the binding pocket, which is in accordance with activity of 3′- O derivatives. Then a biotin conjugate of isorhamnetin with a tetraethylene glycol (PEG) 4 linker at the 3′ position was synthesized and the resulting probe retained the anti-proliferative activity on cancer cell lines, while the cellular fluorescence analysis showed the distribution of probe inside the cells which indicated the probe had limited cell permeability. Finally, pull down assay both in situ inside cells and in the cell lysates indicated the isorhamnetin biotin probe was capable of protein labeling in cell lysates. These findings provide the isorhamnetin 3′- O -biotin probe as a tool to reveal the target proteins of isorhamnetin. Graphical
研究领域:
药理学
·
癌症研究
·
化学
·
分子生物学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Xiao Wang,Ying Zheng,Lan Xu
An electrochemical strategy for adenine detection was described. In order to generate a 3D net-work composite film, gold nanoparticles (Au NPs) capped with 3-thiophene acetic acid (3-TAA) were used to couple with molecular imprinting technique (MIT). In the presence of the 3-TAA capping Au NPs (Au NPs-T), the electrode-surface-tethered 3-TAAs were polymerized to form a homogeneous conductive material immobilized into the electrode. Through this sensor fabrication, Au NPs-T associating with the Au electrode resulted in enhanced sensitivity and MIT contributed to the specificity.
研究领域:
电化学
·
生物传感器
·
纳米技术
·
分析化学
·
分子印迹
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DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2012
·
IF 0.901
Xiaoming PENG,Yufeng HU,Chuanwei JIN,Zhixin WANG,Chao MIAO,Zheyu LI
Viscosities were measured for the ternary systems Y(NO 3 ) 3 +La(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +Ce(NO 3 ) 3 +H 2 O, and La(NO 3 ) 3 +Nd(NO 3 ) 3 + H 2 O and their binary subsystems Y(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +H 2 O, Ce(NO 3 ) 3 +H 2 O, and Nd(NO 3 ) 3 +H 2 O at 293.15, 298.15 and 308.15 K. The results were used to test the applicability of simple equations for the viscosity of the mixed solutions. The predictions agreed well with measured values, implying that the viscosities of the examined electrolyte solutions could be related to those of their constituent binary solutions using these simple equations.
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Xiao-Fan Wu,Qingmei Ge,Nan Jiang,Mao Liu,Hang Cong,Zhu Tao
Utilizing a novel concept of chiral amplification induced by host-guest interactions, a new macrocyclic compound , benzo[3]uril (BU[3]), was formed in a chiral microenvironment via the encapsulation of L -cysteine∙H + (L-Cys∙H), and the electrochemiluminescence properties of BU[3] were sensibilized with the formation of a supramolecular complex . Based on this principle, an ultra-sensitive chiral electrochemiluminescence sensor was constructed to recognize the enantiomer of penicillamine (PA). This sensor exhibited high selectivity and sensitivity for L -PA compared to other reported values, with a detection limit of 10 -12 mol·L -1 within a linear range of 10 -5 –10 -10 mol·L -1 , and no obvious electrochemiluminescence response to D -PA. The sensor presents high stability, good reproducibility, strong anti-interference ability, and acceptable recovery, which suggests an ability to quantitatively detect L -PA in an aqueous environment.
研究领域:
分析化学
·
材料科学
·
电化学
·
手性和超分子化学
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DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2021
·
IF 9.127
Yingmin Jin,Xin Zong,Xuebai Zhang,Chaojun Liu,Dong Li,Zhenggang Jia,Gen Li,Xuanguang Zhou,Junhua Wei,Yueping Xiong
Composite solid electrolyte (CSE) consisting of Li + conductive fillers and polymer matrix has become attractive for high energy-density lithium batteries . Current researches focus on the “ceramic in polymer”-type CSE due to the severe agglomeration of ceramic particles. Consequently, the destroyed percolation network impedes the further improvement in ionic conductivity . In this work, we report a novel structural design of ceramic-enriched CSE consisting of three-dimensional (3D) interconnected Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP), polyvinylidene fluoride (PVDF) and LiN(SO 2 ) 2 (CF 3 ) 2 (LiTFSI). The 3D LATP network is constructed through the surface functionalization of LATP particles by polymethyl methacrylate (PMMA). Owing to the intermolecular interaction between PMMA and PVDF, the incorporation of PMMA-coated LATP (denoted as LATP@PMMA) enables the uniform distribution of ceramic phase and generates interconnected LATP network. Noticeably, such an electrolyte maximizes the utilization of inorganic fillers through the facile treatment of zero-dimensional materials, which is comparable to those 3D template-derived fillers. Furthermore, continuous Li + conduction pathways through LATP framework and LATP/PVDF interphase are guaranteed by the enhanced affinity of LATP towards PVDF matrix and the intrinsic Li + complexation capability of PMMA. Remarkable cycling performances of the LiNi 0.5 Co 0.2 Mn 0.3 O 2 /LATP@PMMA-PVDF/Li batteries confirm the feasibility of 3D ceramic-enriched composite electrolyte in the application of solid-state lithium batteries.
研究领域:
材料科学
·
电化学
·
电池技术
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DOI
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Liling Cao,Shengzi Zhang,Dan Zhao,Bingxuan Li,Tao Yan,Guangsai Yang,Zheshuai Lin,Min Luo,Ning Ye
A new d10 transition-metal iodate fluoride, namely, Cd3(IO3)(IO4)F2·0.1CdO, was successfully designed and synthesized via the mid-infrared hydrothermal method. It crystallizes in the polar space group R3m and features the coexistence of the [IO3]− and [IO4]3– groups. Cd3(IO3)(IO4)F2·0.1CdO has a strong second-harmonic-generation response of about 3.0 times that of KDP(KH2PO4), large birefringence (0.133 at 546.1 nm), and a wide energy band gap (4.00 eV). In addition, the power laser damage threshold (LDT) measurement indicated that it possesses a high LDT of 84.29 MW/cm2, which is about 30 times that of AgGaS2. These superior properties showed that Cd3(IO3)(IO4)F2·0.1CdO may be an excellent nonlinear-optical crystal for visible and mid-infrared application.
研究领域:
材料科学
·
光学
·
晶体学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2011
·
IF 2.089
Yu-Feng Hu,Xiao-Ming Peng,Shan Ling,Jin-Zhu Zhang,Chuan-Wei Jin
Conductivities were measured for the ternary systems Y(NO3)3 + Ce(NO3)3 + H2O, Y(NO3)3 + Nd(NO3)3 + H2O, and Ce(NO3)3 + Nd(NO3)3 + H2O and their binary subsystems Y(NO3)3 + H2O, Ce(NO3)3 + H2O, and Nd(NO3)3 + H2O at (293.15, 298.15, and 308.15) K. The measured conductivities were used to test the generalized Young’s rule and the semi-ideal solution theory. The comparison results show that the generalized Young’s rule and the semi-ideal solution theory can yield good predictions for the conductivities of the ternary electrolyte solutions, implying that the conductivities of aqueous solutions of (1:3 + 1:3) electrolyte mixtures can be well predicted from those of their constituent binary solutions by the simple equations.
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产品关联
DOI
高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2011
·Vol. 40
·期 8
·1447-1457
·
IF 1.335
Hu Yu-Feng,Jin Chuan-Wei,Zhang Jin-Zhu,Ling Shan
Electrical conductivities were measured for the ternary systems Y(NO 3 ) 3 +La(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +Ce(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +Nd(NO 3 ) 3 +H 2 O, and their binary subsystems Y(NO 3 ) 3 +H 2 O, La(NO 3 ) 3 +H 2 O, Ce(NO 3 ) 3 +H 2 O, and Nd(NO 3 ) 3 +H 2 O at (293.15, 298.15 and 308.15) K. The measured conductivities were used to test the generalized Young’s rule and the semi-ideal solution theory. The comparison results show that the generalized Young’s rule and the semi-ideal solution theory can yield good predictions for the conductivities of the ternary electrolyte solutions, implying that the conductivities of aqueous solutions of (1:3 + 1:3) electrolyte mixtures can be well predicted from those of their constituent binary solutions by the simple equations.
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产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 12
·2023
·
IF 3.164
Haoguo Yue,Lingqian Kong,Bo Wang,Qing Yuan,Yan Zhang,Hongmei Du,Yunyun Dong,Jinsheng Zhao
Three soluble conjugated polymers, named BEDPP, FLDPP, and CADPP, were prepared through the Suzuki polymerized reaction, and employed benzene (BE), fluorene (FL), and carbazole (CA) as the donor units, respectively. The electron-deficient molecule 2,5-bis-(2-octyldodecyl)-3,6-bis-(5-bromo-thiophene)-pyrrole[3-c]pyrrole-1,4-diketone(DPP) was introduced and used as the acceptor unit. The properties of these three copolymers were studied by a series of detailed characterization analysis, including X-ray photoelectron spectroscopy (XPS), colorimetry, electrochemical measurements, spectroelectrochemistry, kinetics, quantitative calculation, and thermogravimetric (TG) analysis, etc. The results revealed that BEDPP displayed a blue color in the neutral state and a light brown color in the oxidized state, FLDPP exhibited a cyan color in the neutral state and a gray color in the oxidized state, while CADPP displayed pure blue color in the neutral state and a light gray color in the oxidized state. All these polymers possess narrow optical band gaps lower than 1.80 eV and satisfactory thermal stability. The kinetic characterization showed that the optical contrasts (ΔT%) in the near-infrared region were superior to the visible region. The optical contrasts of BEDPP, FLDPP, and CADPP are 41.32%, 42.39%, and 45.95% in the near-infrared region, respectively, which made them a good application prospect in the near-infrared region. Amid the three polymers, CADPP has the highest coloration efficiency (around about 288 cm2·C−1) and fast switching times (0.77 s in the coloring process and 0.52 s in the bleaching process) in the visible region, and the comprehensive performance of CADPP can be comparable to that of the reported D-A (Donor-Acceptor) type blue color polymers. In general, based on the good performances and the stable neutral blue color, the three polymers had profound theoretical significance for the development of electrochromic material and the completion of the RGB (Red, Green, Blue) color space.Keywords:electrochromic;pyrrole[3-c]pyrrole-1,4-diketone;donor-acceptor;neutral blue color;conjugated polymer
研究领域:
材料科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 7
·2325-2331
·
IF 4.58
Huang Xinan,Jiang Hong,Li Yongxin,Sang Lijia,Zhou Huipeng,Shahzad Sohail Anjum,Ibupoto Zafar Hussain,Yu Cong
A sensitive and selective luminescent nanoprobe (referred to as DEPN) is designed for the determination of Cu(II) ions. DEPN shows two emission peaks, one at 602 nm and caused by [Ru(bpy) 3 ] 2+ , the other (peaking at 500 nm) caused by silver nanoclusters (AgNCs). The luminescence of the ruthenium complex is inert and acts as the internal reference signal, while that of the AgNCs is quenched by Cu(II) ions. Under 350 nm photoexcitation, a linear relationship is found between the ratio of emission intensity (I 500 /I 602 ) and the concentration of Cu(II) ions in the 0.1–16 μM range. The detection limit of Cu(II) ions is estimated to be 50 nM. The DEPN was applied to the determination of Cu(II) ions in (spiked) water samples, and to intracellular imaging of Cu(II) in HeLa cells using confocal fluorescence microscopy.
Schematic presentation of a dual-emission photoluminescence nanoprobe for selective Cu 2+ sensing. The emission of the Ag nanoclusters (at 500 nm) is quenched by Cu 2+ , while that of the Ru(bpy) 3
2+ -doped silica nanoparticles (at 602 nm) remains unchanged and serves as a reference.
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DOI
高影响因子
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