Molecular Catalysis
·
2021
·
IF 5.062
Yuchen Zhu,Hao Wu,Zheng Fang,Xiaobing Yang,Kai Guo,Wei He
Cobalt (II)-meso-tetra(4-carboxyphenyl) porphyrin supported by deprotected lignin was synthesized through the covalent linkage between carboxy groups in the porphyrin and hydroxyl groups in the lignin. The resulting supporting catalysts were applied in the selective oxidation of 5-hydroxymethylfurfural. Through solvent optimization, 5-hydroxymethyl-2-furancarboxylic acid and 2,5-furandicarboxylic acid could be selectively obtained. Steric effect of lignin prevented unwanted aggregation-caused quenching, avoiding catalyst deactivation. Thus, supported catalysts displayed better catalytic efficiency compared free metal porphyrin catalyst. Unlike the excessive use of sodium hydroxide in the oxidation of HMF catalyzed by metal catalysts, an equivalent amount of sodium hydroxide was used in this oxidation process. Meanwhile, lower activation energy was detected when metal porphyrin supported by deprotected lignin was used. By adjusting the pH in the reaction, supported catalysts could be reused. The catalytic activity remained stable during the recycling experiments.
研究领域:
化学
·
催化材料科学
✓ 已验证
DOI
高影响因子
Communications Biology
·
2025
·Vol. 8
·期 1
·1-14
·
IF 5.1
Xu Tianqi,Fang Dan,Li Fulei,Wang Zhiqiang,Liu Yuan
Antimicrobial resistance poses a severe threat to human health, with colistin serving as a critical medication in clinical trials against multidrug-resistant Gram-negative bacteria. However, the efficacy of colistin is increasingly compromised due to the rise of MCR-positive bacteria worldwide. Here, we reveal a notable metabolic disparity between mcr -positive and -negative bacteria through transcriptome and metabolomics analysis. Specifically, pyridoxal 5’-phosphate (PLP), the active form of vitamin B6, was significantly diminished in mcr -positive bacteria. Conversely, supplementing with PLP could reverse the metabolic profile of drug-resistant bacteria and effectively restore colistin’s bactericidal properties. Mechanistically, PLP was found to augment bacterial proton motive force by inhibiting the Kdp transport system, a bacterial K + transport ATPase, thereby facilitating the binding of the positively charged colistin to the negatively charged bacterial membrane components. Furthermore, PLP supplementation triggers ferroptosis-like death by accumulating ferrous ions and inducing lipid peroxidation. These two modes of action collectively resensitize mcr -harboring Gram-negative bacteria to colistin therapy. Altogether, our study provides a novel metabolic-driven antibiotic sensitization strategy to tackle antibiotic resistance and identifies a potentially safe antibiotic synergist.
研究领域:
微生物学
·
药理学
·
代谢组学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2021
·Vol. 26
·期 23
·7307
·
IF 4.412
Dong Zhang,Mojiao Zhao,Yumei Li,Dafang Zhang,Yong Yang,Lijing Li
Xanthine oxidase (XOD) inhibition has long been considered an effective anti-hyperuricemia strategy. To identify effective natural XOD inhibitors with little side effects, we performed a XOD inhibitory assay-coupled isolation of compounds fromSmilacis Glabrae Rhizoma(SGR), a traditional Chinese medicine frequently prescribed as anti-hyperuricemia agent for centuries. Through the in vitro XOD inhibitory assay, we obtained a novel XOD inhibitor, 5-O-caffeoylshikimic acid (#1, 5OCSA) with IC50of 13.96 μM, as well as two known XOD inhibitors, quercetin (#3) and astilbin (#6). Meanwhile, we performed in silico molecular docking and found 5OCSA could interact with the active sites of XOD (PDB ID: 3NVY) with a binding energy of −8.6 kcal/mol, suggesting 5OCSA inhibits XOD by binding with its active site. To evaluate the in vivo effects on XOD, we generated a hyperuricemia mice model by intraperitoneal injection of potassium oxonate (300 mg/kg) and oral gavage of hypoxanthine (500 mg/kg) for 7 days. 5OCSA could inhibit both hepatic and serum XOD in vivo, together with an improvement of histological and multiple serological parameters in kidney injury and HUA. Collectively, our results suggested that 5OCSA may be developed into a safe and effective XOD inhibitor based on in vitro, in silico and in vivo evidence.Keywords:Smilacis Glabrae Rhizoma;5-O-caffeoylshikimic acid;potassium oxonate;hyperuricemia;XOD inhibitor
研究领域:
药理学
·
药物化学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2016
·
IF 8.328
Jing Guo,Shanhui Zhu,Youliang Cen,Zhangfeng Qin,Jianguo Wang,Weibin Fan
A series of ordered mesoporous Nb x W (8 − x) oxides with tunable Nb/W ratio were successfully synthesized by evaporation-induced self-assembly method. The mesoporous structure, morphologies, surface chemical state, and acidic properties of these catalysts were fully characterized by low-temperature sorption of N 2 , small-angle and wide-angle XRD, TEM, Raman, XPS, and Py-IR. It was shown that the Nb x W (8 − x) oxides created large amounts of Lewis as well as Brønsted acid sites, which promoted the isomerization of glucose to fructose followed its dehydration to 5-hydroxymethylfurfural (HMF). Mannose was also formed via the epimerization of glucose. Of them, the mesoporous Nb 4 W 4 exhibited the best catalytic activity with a comparatively low E a about 90.2 kJ/mol and good stability in aqueous medium. The kinetic behavior revealed that Lewis acid sites facilitated to glucose-to-fructose isomerization while Brønsted acid sites promoted the dehydration of fructose to form HMF.
研究领域:
催化化学
·
生物质转化
·
绿色化学
·
多相催化
·
材料化学
·
碳水化合物化学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yixuan Wang,Shijia Fu,Yao Zeng,Siwen Jiao,Guihong Chai,Yuehong Xu
5-aminolevulinic acid photodynamic therapy (ALA-PDT) is an emerging therapeutic strategy for skin cancer due to its noninvasiveness and high spatiotemporal selectivity. However, poor skin penetration, poor intratumoral delivery, the instability of aqueous ALA, and the tumor’s inherent hypoxia microenvironment are major hurdles hindering the efficacy of ALA-PDT. Herein, we aim to address these challenges by using microneedles (MNs) to assist in delivering nanoparticles based on natural polymeric tea polyphenols (TP NPs) to self-assemble and load ALA (ALA@TP NPs). The TP NPs specifically increase cellular uptake of ALA by A375 and A431 cells and reduce mitochondrial membrane potential. Subsequently, the photosensitizer protoporphyrin IX derived from ALA accumulates in the tumor cells in a dose-dependent manner with TP NPs, generating reactive oxygen species to promote apoptosis and necrosis of A375 and A431 cells. Interestingly, TP NPs can ameliorate the tumor’s inherent hypoxia microenvironment and rapid oxygen consumption during PDT by inhibiting hypoxia inducible factor-1α, thereby boosting reactive oxygen species (ROS) generation and enhancing ALA-PDT efficacy through a positive feedback loop. After ALA@TP NPs are loaded into MNs to fabricate ALA@TP NPs@MNs, the MNs enhance skin penetration and storage stability of ALA. Importantly, they exhibit remarkable antitumor efficacy in A375-induced melanoma and A431-induced squamous cell carcinoma with a reduced dose of ALA and reverse hypoxia in vivo . This study provides a facile and novel strategy that integrates MNs and green NPs of TP for addressing the bottlenecks of ALA-PDT and enhancing the ALA-PDT efficacy against skin cancers for future clinical translation.
研究领域:
癌症治疗
·
纳米技术
·
药学
·
生物医学工程
·
皮肤病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2025
·
IF 7.5
Hucheng Ge,Yufei Gu,Feifei Liu,Yanmei Huang,Yuke Liu,Silin Wu,Yunshuang Hu,Zhixia Li,Hongfei Lin
The core–shell structured MCM-22/ZSM-5 zeolite (MZCS50) was synthesized through a combination of hydrothermal crystallization (to form the MCM-22 core) and steam-assisted crystallization (to form the ZSM-5 shell). The MCM-22 core exhibited lamellar cake-like shape with a diameter of 3 ∼ 4 µm, while the ZSM-5 shell consisted of aggregated nanoparticles. MZCS50 possessed a high specific surface area, a micropore-mesopore coexisting structure, and was Brønsted acid-dominant material. MZCS50 was used as a catalyst for the cracking of low-density polyethylene (LDPE) to produce BTEX (benzene, toluene, ethylbenzene and xylenes). The results showed that 550 °C was the optimal temperature for LDPE cracking. The maximum liquid yield achieved was 23.4 %, with selectivities to BTEX, xylenes and p -xylene of 79.8 %, 43.2 %, and 21.3 %, respectively. Repeated cracking experiments demonstrated that MZCS50 exhibited good stability and superior catalytic performance in converting toluene to xylenes and further transforming xylene isomers into p -xylene. These results indicate that the core–shell structured MZCS50 is a promising catalyst for converting plastic wastes into valuable p -xylene.
研究领域:
化学工程
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Xuege He,Jiayu Shi,Chang Gao,Wenrong Che,Xianhai Zeng,Miao Zuo
This study presents a novel method for synthesizing biochar catalysts with multiple oxygen-containing functional groups, enabling the high-yield production of the biomass-derived platform compound 5-hydroxymethylfurfural (HMF) under mild conditions. Using an aqueous–methyl isobutyl ketone (MIBK) biphasic system, fructose conversion at 100°C for 4 h achieved an HMF yield of 92%. Furthermore, the roles of various functional groups on sulfonated biochar in substrate conversion were elucidated through molecular binding energy calculations, intermolecular weak interaction analysis, and frontier orbital theory. Detailed density functional theory (DFT) calculations further explored the catalytic mechanism, reaction energy barriers, and solvent effects in aqueous-phase fructose-to-HMF conversion. The results revealed that, compared to sulfate and sulfonic groups, hydroxyl and carboxyl groups on sulfonated biochar exhibited higher binding energies with fructose but lower energy gaps, facilitating electron exchange with reaction substrates and promoting nucleophilic side reactions. This study provides a solid theoretical foundation and valuable insights for the efficient and green synthesis of HMF using biochar catalysts in aqueous solvents.
研究领域:
生物质化学
·
催化反应机制
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMISTRY
·
2017
·Vol. 36
·期 3
·187-193
·
IF 1.852
Qing-Ning Zhao,Qing-Wen Song,Ping Liu,Qian-Xia Zhang,Jun-Hua Gao,Kan Zhang
The production of fine chemicals using CO 2 as C 1 building block through inexpensive heterogeneous catalysts with high efficiency under low pressure is challenging. Herein we propose for the first time the utilization of a multifunctional heterogeneous zinc-modified HZSM-5 (ZnHZSM-5) catalyst for upgrading CO 2 by incorporation into cyclic carbonates from CO 2 and epoxides. Owing to the nice surface properties such as abundant Lewis acid, Brønsted acid and Lewis base sites, large surface area, and plenty of micropores, CO 2 could be concentrated and well activated in ZnHZSM-5 verified by CO 2 -TPD, TG-MS, etc . Meanwhile, the epoxides were also activated through metal center and hydrogen bond. Therefore, the reaction can easily assemble at the catalyst interface and show exceptional performance, affording the aimed products with high yield of up to 99% in the presence of commercial tetra- n -propylammonium bromide (90% in kilogram scale with 0.004 mol% ZnHZSM-5 and 0.015 mol% n Pr 4 NBr).
研究领域:
催化化学
·
环境化学
·
绿色化学
·
材料化学
·
有机合成
·
能源化学
·
工业化学
✓ 已验证
DOI
高影响因子
AICHE JOURNAL
·
2023
·Vol. 69
·期 6
·e18054
·
IF 3.7
Feng Xiong,Chen Ji,Shengzhi Gan,Peng Liang,Yi Huang,Jin Shang,Baoyu Liu,Jinxiang Dong
Mesoscopically structured ZSM-5 nanosheets were prepared as highly active catalysts for the alkylation between toluene with methanol. The results showed that the Brønsted acid sites of ZSM-5 nanosheets were mainly distributed on the external surface in aluminum-rich zeolites owing to the charge-balance between positive quaternary ammonium cation (N + ) in C ph-10-6-6 , Na + ions and negative aluminosilicate species. In addition, it revealed that high alkalinity was easier to depolymerize the Si O Si species in Aluminum-rich synthesis gel, and the high alkalinity was required for silica-rich systems to dissolve silica species in order to finish the self-assemble process, leading to ZSM-5 nanosheets with high alkalinity presenting enhanced catalytic performance. Moreover, the optimized ZSM-5-50-2.5 was effective for the alkylation between toluene and methanol with toluene conversion of up to 50%, and it was stably operated for 48 h under the harsh conditions of WHSV = 32.5 h −1 with a desired stability.
研究领域:
催化
·
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Jun Xiao,Mengmeng Wang,Yaru Wang,Xunxun Li,Jiaqin He,Yunchong Liu,Qingfeng Xu,Hua Li,Najun Li,Dongyun Chen,Jianmei Lu
Catalytic oxidation is one of the most promising methods to remove toluene; manganese-cerium catalysts have high activity in the catalytic oxidation of toluene. Herein, nano-sized ZSM-5 was synthesized using a simple hydrothermal method, and catalysts with different Mn and Ce contents were prepared via alcohol-induced redox precipitation at room temperature. In addition, zeolite provides sufficient surface area for the dispersion of manganese cerium catalysts and plays a role in concentration and enrichment in the catalytic conversion of toluene. Based on the experimental characterization results, the 20Ce/M1Z1 catalyst exhibited the best catalytic activity, achieving 90% toluene conversion at 215 °C. Moreover, the catalyst still has excellent catalytic activity in humid environments. This work provides a new strategy to expose more active sites and enhance toluene adsorption, which provides a reference for the development of more efficient catalysts in the future.
研究领域:
环境科学
·
催化材料
✓ 已验证
DOI
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2025
·
IF 3.3
Gahlot Himanshi,Kang Sun Chul
Synergistic therapy is unwaveringly developing as a potential approach to enhance the effectiveness of anticancer medications in chemotherapy. Incorporating adjuvants alongside conventional anticancer medications has demonstrated selective cytotoxicity toward cancer cells while mitigating adverse effects such as DNA damage and systemic toxicity in normal cells. The extended use of 5-FU, a synthetic medicine used in chemotherapy, has many adverse effects, which limit its long-term use in clinical settings. Numerous investigations have demonstrated that luteolin exhibits anticancer effects and alleviates inflammation in mammalian cells. In this study, we provide the first experimental evidence of the synergistic interaction between luteolin and 5-FU in murine melanoma (B16F10) cells, compared to monotherapies (luteolin and 5-FU alone). Using MTT assay for cell viability, flow cytometry for cell cycle analysis, and Western blotting for apoptosis markers, we demonstrate that simultaneous exposure to luteolin and 5-FU speeds up oxidative stress and enhances the production of endogenous ROS. The combination therapy induced the G1-phase cell cycle arrest (65.39%) and decreased the cell viability of B16F10 cells to 34.6%. This, in turn, activates the DNA damage response and initiates the apoptotic pathway by suppressing autophagy and the DNA repair system. Further, the co-treatment of luteolin and 5-FU significantly decreases the mitochondrial membrane potential and reduces ATP production. The results indicate that the combination of luteolin and 5-FU may improve treatment efficacy while potentially decreasing the necessary dosage of 5-FU, therefore reducing its toxicity in clinical settings.
研究领域:
肿瘤学
·
药理学
·
生物化学
·
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2014
·Vol. 25
·期 4
·755-762
·
IF 1.077
Wu Kai-Fei,Jiang Fen,Xiao Han,Bai Xian-Li,Mo Shao-Yin,Feng Yu
Three new metal–organic complexes [Fe(pyip)(H 2 O) 2 ] n ( 1 ), [Co(pyip)(H 2 O) 2 ] n ( 2 ) and [Ni(pyip)(H 2 O) 2 ] n ( 3 ) have been synthesized and characterized based on the carboxylic acid with N donor ligand (H 2 pyip=5-(Pyridin-3-yl)isophthalic acid). X-ray structure analysis reveals that complexes 1 – 3 showed identical 3-D supramolecular architecture that adopt different metal center. They all crystallize in hexagonal space group P 6(5) and exhibited exclusive coordination mode. One of the H 2 pyip adopt bidentate chelate coordination mode and the other coordination carboxylate oxygen atom adopts the single dentate bridging mode. Moreover, the two novel complexes were characterized by IR spectrum, elemental analysis, fluorescent properties, thermogravimetric analysis and powder X-ray diffraction.
研究领域:
无机化学
·
材料科学
·
配位化学
·
晶体工程
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）