ACS Nano
·
2020
·
IF 14.588
Yuan Liu,Gongxun Bai,Yongxin Lyu,Youjie Hua,Renguang Ye,Junjie Zhang,Liang Chen,Shiqing Xu,Jianhua Hao
Realizing multicolored luminescence in two-dimensional (2D) nanomaterials would afford potential for a range of next-generation nanoscale optoelectronic devices. Moreover, combining fine structured spectral line emission and detection may further enrich the studies and applications of functional nanomaterials. Herein, a lanthanide doping strategy has been utilized for the synthesis of 2D ZnSe:Er3+ nanosheets to achieve fine-structured, multicolor luminescence spectra. Simultaneous upconversion and downconversion emission is realized, which can cover an ultrabroadband optical range, from ultraviolet through visible to the near-infrared region. By investigating the low-temperature fine structure of emission spectra at 4 K, we have observed an abundance of sublevel electronic energy transitions, elucidating the electronic structure of Er3+ ions in the 2D ZnSe nanosheet. As the temperature is varied, these nanosheets exhibit tunable multicolored luminescence under 980 and 365 nm excitation. Utilizing the distinct sublevel transitions of Er3+ ions, the developed 2D ZnSe:Er3+ optical temperature sensor shows high absolute (15.23% K–1) and relative sensitivity (8.61% K–1), which is superior to conventional Er3+-activated upconversion luminescent nanothermometers. These findings imply that Er3+-doped ZnSe nanomaterials with direct and wide band gap have the potential for applications in future low-dimensional photonic and sensing devices at the 2D limit.
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高影响因子
JOURNAL OF CELLULAR PHYSIOLOGY
·
2020
·Vol. 236
·期 3
·1889-1902
·
IF 5.546
Wenhui Yao,Kai Wang,Xiniao Wang,Xinran Li,Jieyan Dong,Yusheng Zhang,Xuansheng Ding
Icariin (ICA), as a flavonoid glycoside, is associated with the improvement of vascular complications in diabetes. However, its protective mechanisms remain to be well-established. Here, we tested the hypothesis that ICA attenuates vascular endothelial dysfunction by inhibiting endoplasmic reticulum (ER) stress in type 1 diabetes. In streptozotocin-induced diabetic rats, ICA positively affected acetylcholine-induced vasodilation and phenylephrine-induced vasoconstriction in aortas. ICA treatment significantly attenuated ER stress in diabetic rats and high-glucose induced human umbilical vein endothelial cells. Incubation with ICA in vitro attenuated vascular reactivity in diabetic rats, which was blocked by the ER stress inducer, and peroxisome proliferator-activated receptor α (PPARα), sirtuin1 (Sirt1), or AMP-activated protein kinase-α (AMPKα) inhibitors. Western blot showed that ICA activated the PPARα/Sirt1/AMPKα pathway, which contributed to reducing ER stress and activating endothelial nitric oxide synthase in vivo and vitro. Our results implicate that ICA normalizes ER stress to attenuate endothelial dysfunction by the regulation of the PPARα/Sirt1/AMPKα pathway.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Jingxiao Liu,Zhichun Zou,Fei Shi,Xin Song,Haoyuan Zhang,Han Zhang,Xiaoying Song,Xinran Zhao,Zixuan Wang,Jiahong Kang
In order to further improve the luminescence of NaYF 4 :Yb,Er, we successfully constructed pitaya-like Cs 0 · 3 WO 3 @NaYF 4 :Yb, Er particles, in which Cs 0 · 3 WO 3 particles were encapsulated in NaYF 4 :Yb, Er particles. This structure enhanced the intensity of 407, 527, 542 and 657 nm emission peaks by 10.1, 5.9, 5.5 and 1.8 times, respectively. Through calculated, the Commission Internationale de l’Eclairage (CIE) chromaticity coordinates changed from (0.28, 0.71) to (0.25, 0.73), indicating that the emission colour was tuned from yellow to green. The construction mechanism of this structure and the mechanism of upconversion (UC) luminescence enhancement were discussed. By studying the different luminescence mechanisms of NaYF 4 :Yb, Er excited by 1550 and 980 nm laser, we found that the UC luminescence enhancement and colour tuning of NaYF 4 :Yb, Er were due to the localized surface plasmon resonance (LSPR) effect of Cs 0 · 3 WO 3 , which can absorb more excited photons and transfer them to the Er 3+ ion 4 I 11/2 level. Given that the transition process of green light emission is easier than red light emission, the redundant photons are more inclined to achieve emitting green light and show UC luminescence enhancement and emission colour tuning. Overall, the as-prepared novel pitaya-like Cs 0 · 3 WO 3 @NaYF 4 :Yb, Er particles exhibit strong UC luminescence enhancement and colour tuning, thus having great application prospect in the field of luminescent displays.
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Translational Oncology
·
2020
·
IF 3.558
Jie Cui,Jiatao Liu,Lulu Fan,Yue Zhu,Bei Zhou,Yu Wang,Wei Hua,Wei Wei,Guoping Sun
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Endoplasmic reticulum stress (ERS) is generally activated in HCC and is important for the sensitivity of HCC to anticancer drugs. ERS-dependent autophagy is a crucial mechanism affecting the sensitivity of HCC to anticancer drugs, but the mechanism by which ERS regulates autophagy is not well understood. Zinc finger protein 263 (ZNF263) is a transcription factor member of the zinc finger family. However, its functional role in HCC remains to be studied. In the current study, we investigated the role of ZNF263 in regulating ERS-induced chemoresistance in HCC and its possible mechanism. We found that ZNF263 was the most significant ERS-specific super-enhancer bounding transcriptional factor and was up-regulated in HCC patients and cell lines. Further, ZNF263 expression correlated with ERS, clinical stage and shorter survival in HCC patients. ZNF263 knockdown by RNA interference results in decreased proliferation, apoptosis resistance, and chemoresistance. Further study showed that ZNF263 increased chemoresistance by activating ERS-related autophagy. In conclusion, our study highlights ZNF263 as a functional ERS-related tumor activator and indicates it as a potential target for HCC therapy.
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JOURNAL OF PROTEOME RESEARCH
·
2021
·
IF 4.466
Peng Ma,Zijing Wang,Yisa Wang,Biyu Hou,Jialin Sun,He Tian,Bowen Li,Guanghou Shui,Xiuying Yang,Xinyu Yang,Guifen Qiang,Chong Wee Liew,Guanhua Du
Once protein synthesis is excessive or misfolded protein becomes aggregated, which eventually overwhelms the capacity of the endoplasmic reticulum (ER), a state named ER stress would be reached. ER stress could affect many tissues, especially the liver, in which nonalcoholic fatty liver disease, liver steatosis, etc. have been reported relative. However, there is still a lack of systematic insight into ER stress in the liver, which can be obtained by integrating metabolomics and transcriptomics of the tissue. Here, tunicamycin was utilized to induce ER stress in C57BL/6N mice. Microarray and untargeted metabolomics were performed to identify the genes and metabolites significantly altered in liver tissues. Surprisingly, apart from the predictable unfolded protein response, liver lipid, arginine, and proline metabolisms were affirmed to be related to ER stress. Also, the ketone body metabolism changed most prominently in response to ER stress, with few studies backing. What is more, succinate receptor 1 (Sucnr1) may be a novel marker and therapeutical target of liver ER stress. In this study, the combination of the metabolome and transcriptome provided reliable information about liver pathological processes, including key relative pathways, potential markers, and targets involved in ER stress of the liver.
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Nanoscale Research Letters
·
2019
·Vol. 14
·期 1
·1-10
·
IF 3.159
Yuan Maohui,Wang Rui,Zhang Chaofan,Yang Zining,Yang Xu,Han Kai,Ye Jingfeng,Wang Hongyan,Xu Xiaojun
The presence of manganese ions (Mn 2+ ) in Yb/Er-co-doped nanomaterials results in suppressing green (545 nm) and enhancing red (650 nm) upconversion (UC) emission, which can achieve single-red-band emission to enable applications in bioimaging and drug delivery. Here, we revisit the tunable multicolor UC emission in a single Mn 2+ -doped β-NaYF 4 :Yb/Er microcrystal which is synthesized by a simple one-pot hydrothermal method. Excited by a 980 nm continuous wave (CW) laser, the color of the single β-NaYF 4 :Yb/Er/Mn microrod can be tuned from green to red as the doping Mn 2+ ions increase from 0 to 30 mol%. Notably, under a relatively high excitation intensity, a newly emerged emission band at 560 nm ( 2 H 9/2 → 4 I 13/2 ) becomes significant and further exceeds the traditional green (545 nm) emission. Therefore, the red-to-green (R/G) emission intensity ratio is subdivided into traditional (650 to 545 nm) and new (650 to 560 nm) R/G ones. As the doped Mn 2+ ions increase, these two R/G ratios are in lockstep with the same tunable trends at low excitation intensity, but the tunable regions become different at high excitation intensity. Moreover, we demonstrate that the energy transfer (ET) between Mn 2+ and Er 3+ contributes to the adjustment of R/G ratio and leads to tunable multicolor of the single microrod. The spectroscopic properties and tunable color from the single microrod can be potentially utilized in color display and micro-optoelectronic devices.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2019
·Vol. 19
·期 11
·7169-7177
·
IF 1.093
Qin Zhuozhuo,Liu Wenxia,Chen Huabin,Chen Jun,Li Zhenzhen
Developing full-spectrum photocatalysts that harvests solar light from ultraviolet to near-infrared light has aroused great interest in photodegradation of organic pollutants, due to the imminent energy crisis and growing pollution issues. Herein, we report an excellent full-spectrum
photocatalyst derived from calcination of an Mg/Zn/Al/Er-hydrotalcite-like compound. The photocatalyst is a stable multi-phase oxide consisting of various syntrophic Er3+-doped metal oxides with different particle sizes and morphology. Its ultraviolet (UV) photocatalytic activity
is maximized by increasing the fraction of Zn2+ and sustaining the pure hydrotalcite-like phase with an appropriate fraction of Mg2+ in preparing the Mg/Zn/Al/Er-hydrotalcite-like precursor. The visible and NIR photocatalytic activities are triggered by an indirect excitation
involving an up-conversion process. The major active species of the photocatalyst in the photodegradation of methyl orange are superoxide anions and photogenerated holes. Nevertheless, hydroxyl radicals also play a moderate role in the photodegradation process. This work finds a new way to
prepare full-spectrum photocatalysts with tunable chemical compositions via an environmentally friendly hydrotalcite-like precursor.
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高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 31
·15348-15358
·
IF 9.931
Ziqiu Ren,Jinde Wu,Na Wang,Xin Li
Current perovskite solar cells (PSCs) often use high-purity single-crystal metal oxides prepared by complex growth processes as electron transport layers (ETLs). In particular, TiO2, as an ETL, can deteriorate the stability of PSCs under illumination. Here, we report a passivation strategy using Er-doped TiO2 synthesized with a one-step hydrothermal method as an ETL. Notably, the oxygen-induced defects in TiO2 have decreased to an acceptable level for PSCs due to the introduction of Er3+ ions. More interestingly, we find that a phase junction can be formed in the mixed crystalline rutile/anatase phase of TiO2, and this TiO2 phase junction can achieve efficient charge separation and accelerate internal electron transfer of the ETL. Taking advantage of these facts, we obtain TiO2-based PSCs through a two-step sequential deposition method in ambient air, whose best efficiency increases by 45.8%. Moreover, the Er-doped device exhibits remarkable ultraviolet resistance ability, whose efficiency is maintained over 90% even after 500 hour ultraviolet irradiation. We believe that this demonstrated strategy provides an effective way for preparing efficient and ultraviolet resistant PSCs in air.
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Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 26
·6512-6520
·
IF 5.256
Mengxiao Li,Weijing Yao,Jun Liu,Qingyong Tian,Li Liu,Jin Ding,Qingwen Xue,Qiang Lu,Wei Wu
Rare-earth ion (RE3+) doped up-conversion (UC) fluorescent materials and novel fluorescent carbon quantum dots (CDs) have been widely used as traditional anti-counterfeiting materials owing to their excellent optical properties. The drawbacks of these materials are being exposed gradually with the widespread occurrence of counterfeit products in the market because of their single fluorescence mode and easy replication. In this work, we propose a novel strategy to combine both luminescent materials with different modes via a facile solvothermal method. Interesting, the composite materials show unalterable down-conversion (DC) blue light under a 365 nm ultraviolet (UV) analyzer, except for adjustable UC luminescence properties. The UC and DC optical properties are measured and the probable mechanism is proposed, indicating that the dual-mode fluorescence processes are separate and do not interference with each other. Moreover, we use a mixture containing a small number of UCMPs/CDs and poly(acrylic acid) (PAA) aqueous solution as a colorless anti-counterfeiting ink, and successfully print a variety of dual-mode fluorescence patterns through the screen printing technique, including QR codes, the logo of Wuhan University, and clover patterns. The composite materials show good dispersion and outstanding dual-mode fluorescence properties, suggesting that they are promising luminescent materials in the anti-counterfeiting field.
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Analytical Methods
·
2017
·Vol. 9
·期 5
·835-840
·
IF 1.9
Zhongling Gao,Lei Wang,Lun Wang,Hongqi Chen
Long wavelength luminescent NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles that were synthesized and modified with poly(acrylic acid) (PAA) were used to detect sulfide ions. The NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles were synthesized to give an emission peak in the red-light region. When the carboxyl-functionalized NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles and cupric ions (Cu2+) were mixed, the luminescence was quenched because of coordination between the carboxyl of PAA and Cu2+. However, when sulfide ions were added into the system, due to the competitive binding between S2− and Cu2+, the luminescence of the NaYF4:Yb,Er/NaGdF4 core–shell upconversion nanoparticles was recovered. Based on the recovery of the luminescence intensity, a turn-on system for the detection of sulfide ions was designed. Under optimal conditions, the linear range for the detection of sulfide ions ranged from 2.63 × 10−2 to 2.25 × 102 μM (R = 0.99) with a limit of detection for sulfide ions as low as 2.20 × 10−2 μM. The method was successfully applied to sulfide ion sensing in different environments.
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JOURNAL OF ELECTRONIC MATERIALS
·
2024
·
IF 2.2
Li Yunkai,Wang Lige,Yang Ruizhi,Liang Li,Luan Qingdong,Liu Jing
Copper selenide (Cu 2 Se) has attracted extensive research interest in the field of thermoelectricity due to its large abundance of constituent elements, environmental friendliness, and excellent thermoelectric properties. In this study, a facile and low-cost hydrothermal synthesis method combined with vacuum sintering was used for Cu 2 Se-based sample preparation, and the possibility of improving the thermoelectric properties of Cu 2 Se by doping with rare earth elements (Tm, Er, Lu) was explored using experimental tests and density functional theory calculations. The electronic structure calculations show that the electrical conductivity is increased due to the increased electron density after rare earth element doping. At the same time, the sharp increase in the density of states at the Fermi level after rare earth element doping enhances the Seebeck coefficient of the Cu 2 Se matrix. The experimental results show that the thermoelectric properties of all the samples doped with rare earth elements (Tm, Er, Lu) were improved compared to the Cu 2 Se matrix. The doping of rare earth elements led to an increase in point defects and the formation of pores in the samples, which play an important role in reducing the thermal conductivity. Among them, the Tm-doped Cu 1.995 Tm 0.005 Se sample reached a maximum ZT value of 0.80 at 773 K, which is a nearly 43% increase compared to the Cu 2 Se matrix (ZT max = 0.56).
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2017
·Vol. 101
·期 3
·1266-1278
·
IF 2.841
Lin Chen,YeHua Jiang,XiaoYu Chong,Jing Feng
Thermal barrier coatings (TBCs) are one of the most important materials in gas turbine to protect the high temperature components. RETa 3 O 9 compounds have a defect-perovskite structure, indicating that they have low thermal conductivity, which is the critical property of TBCs. Herein, dense RETa 3 O 9 bulk ceramics were fabricated via solid-state reaction. The crystal structure was characterized by X-ray diffraction (XRD) and Raman Spectroscope. Scanning electron microscope (SEM) was used to observe the microstructure. The thermophysical properties of RETa 3 O 9 were studied systematically, including specific heat, thermal diffusivity, thermal conductivity, thermal expansion coefficients, and high-temperature phase stability. The thermal conductivities of RETa 3 O 9 are very low (1.33-2.37 W/m·K, 373-1073 K), which are much lower than YSZ and La 2 Zr 2 O 7 ; and the thermal expansion coefficients range from 4.0 × 10 −6 K −1 to 10.2×10 −6 K −1 (1273 K), which is close to La 2 Zr 2 O 7 and YSZ. According to the differential scanning calorimetry (DSC) curve there is not phase transition at the test temperature. Due to the high melting point and excellent high-temperature phase stability with these oxides, RETa 3 O 9 ceramics were promising candidate materials for TBCs.
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