INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Bo Chen,Fengling Yu,Sha Wang,Yang Liu,Dehong Li,Yuning Chen,Guohua Dao,Zhixiang Xu,Xuejun Pan
Aerogel was selected as one of IUPAC Top Ten Emerging Technologies in Chemistry in 2022, and has attracted tremendous concerns of scientists in removal of emerging contaminants. In this work a novel Fe 3+ cross-linked alginate aerogel (SA/DA-Fe 3+ ) with multiple sorption sites were facilely fabricated and applied for highly efficient removal of tetracycline (TC) from water. Results showed that Fe 3+ and DA cooperatively improve adsorption of TC and TC was efficiently removed over a broad pH range of 4–8. The kinetics process can be better described by a chemisorption controlled pseudo-second-order kinetics model and Langmuir isotherm equation with characteristics of monolayer coverage. The fitted q max value of TC at ambient temperature was 804.6 mg g −1 higher than those of other reported adsorbents. Multiple interactions including π-π EDA, complexation, hydrogen bonding, electrostatic attraction, etc. were involved in adsorption process. Moreover, SA/DA-Fe 3+ aerogel exhibited satisfactory stability, reusability, and recyclability for consecutive applications. Most importantly, after consecutively running for >1000 h with dynamic sorption capacity over 500 mg g −1 , the packed-column was still not saturated, manifesting its great potentials for treating actual wastewaters. Thus, above superiorities make SA/DA-Fe 3+ a promising candidate adsorbent for treating TC-containing wastewater.
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Materials Today Bio
·
2023
·
IF 8.2
Fangguo Liang,Yusheng Yang,Yuyong Chen,Jiajun Xie,Shencai Liu,Zilin Tan,Liangjie Tian,Zhiqiang Yu,Zhanjun Shi,Peigen Xie,Hong Ding,Qinfeng Yang
In recent years, electroconductive hydrogels (ECHs) have shown great potential in promoting nerve regeneration and motor function recovery following diabetic peripheral nerve injury (PNI), attributed to their similar electrical and mechanical characteristics to innate nervous tissue. It is well-established that PNI causes motor deficits and pain, especially in diabetics. Current evidence suggests that ropivacaine (ROP) encapsulated in poly lactic-co-glycolic acid (PLGA) microspheres (MSs) yield a sustained analgesic effect. In this study, an ECH electroconductive network loaded with MS/ROP (ECH-MS/ROP) was designed as a promising therapeutic approach for diabetic PNI to exert lasting analgesia and functional recovery. This dual delivery system allowed ROP's slow and sequential release, achieving sustained analgesia as demonstrated by our in vivo experiments. Meanwhile, this system was designed like a lamellar dressing, with desirable adhesive and self-curling properties, convenient for treating injured nerve tissues via automatically wrapping tube-like structures, facilitating the process of implantation. Our in vitro assays verified that ECH-MS/ROP was able to enhance the adhesion and motility of Schwann cells. Besides, both in vitro and in vivo studies substantiated that ECH-MS/ROP stimulated myelinated axon regeneration through the MEK/ERK signaling pathway, thereby improving muscular denervation atrophy and facilitating functional recovery. Therefore, this study suggests that the ECH-MS/ROP dressing provides a promising strategy for treating diabetic PNI to facilitate nerve regeneration, functional recovery and pain relief.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2023
·Vol. 27
·期 3
·753-761
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IF 2.5
Chu Youqun,Zhang Huixuan,Zhou Huihui,Xu Tengfei,Yan Hui,Huang Zhangkao,Zhao Fengming
The nano-Ag–TiO 2 hollow microsphere precursors were prepared by the one-pot solvothermal method using L-tyrosine as the template agent and reducing agent. Subsequently, the nano-Ag–TiN hollow microsphere composites were formed by reducing nitride in an ammonia-filled atmosphere. The esterification of ethanol solvent and L-tyrosine microdroplet template generates traces of water in situ for the hydrolysis of alkane titanium. As the L-tyrosine microdroplet templates are sacrificed and incorporated into the titanium dioxide matrix, a hybridized hollow structure is formed. With the help of L-tyrosine, the surface of Ag–TiO 2 hollow microsphere precursors appeared folded rough surface, and the nanosilver was mostly distributed in the TiO 2 spherical shell. The constructed Ag–TiO 2 hollow microsphere demonstrated a good linear relationship between the current response value and the concentration in the range of 0.2–220 μM of H 2 O 2 , with the lowest detection limit of 0.04 μM. In the same concentration range, whereas the lowest detection limit of Ag–TiN hollow microsphere was 0.02 μM. The detection results of H 2 O 2 revealed that the Ag–TiN/HMS electrode has outstanding interference resistance, stability, and repeatability.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2018
·Vol. 18
·期 12
·8269-8275
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IF 1.354
Wang Manchao,Peng Lin,Wang Jiahui,Li Changqing,Guan Lihao,Lin Yuqing
In this study, hierarchical ternary nanocomposites, i.e., Cu–TiO2-mesoporous silica microspheres (Cu–TiO2-MSM), were synthesized as ternary photocatalyst system to improve the visible light photocatalytic degradation of the environmental pollutant model
dye methylene blue (MB). The innovation of this method is in situ depositing TiO2 and Cu2O nanoparticles sequentially onto the surface of mesoporous silica microspheres to form highly active heterostructure. The improved activity for the degradation of MB is attributed
to: (1) the high adsorption capacity of the porous and interconnected-channel-structure MSM to MB; (2) the valence band electrons of TiO2 released from the conduction band generating abundant highly active free radicals, which directly reacted with adsorbed MB. The photocatalytic
degradation efficiency to MB was found to be 98% in 5 min, and almost 100% in 20 min. This study paves a way for the development of a ternary-doped catalyst for visible light photocatalytic degradation and may exhibit widely application in industry.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Jianwei Wang,Xiaoqiang Pei,Ge Liu,Jianfeng Bai,Yajie Ding,Jianqiang Wang,Fu Liu
Silver loaded nanofibrous membrane with high catalytic performance for 4-nitrophenol under continuous gravity-driven filtration was developed in this study. A polydopamine (PDA) microsphere and nanofiber coordinated composite structure was fabricated through an in situ PDA synthesis to achieve a high catalyst loading and controllable residence time of 4-nitrophenol. The incorporated PDA microspheres played an important role for the enhancement of catalytic performance due to the increased surface area (23% increase compared with PAN and PAN-PDAs-Ag) and reduced membrane porosity. Silver loading amount and the residence time of 4-nitrophenol was increased by more than 108% (from 1.2 wt% to 2.5 wt%) and 45% (from 0.79 s to 1.15 s) when comparing with PAN-PDAc-Ag and PAN-PDAs-Ag nanofibrous membrane. The conversion rate of 4-nitrophenol in a gravity-driven filtration process was as high as 97% when PAN-PDAs-Ag nanofibrous membrane was used, which was much higher than the PAN-PDAc-Ag membrane (80%). In addition, the PAN-PDAs-Ag nanofibrous membrane exhibited excellent recycle performance, the conversion rate was maintained as high as 93% after five times of reuse. The microsphere and nanofiber coordinated structure with enhanced surface area and controllable residence time of contaminants proposed in this study might advance the real applications of electrospun nanofibrous membrane for catalytic removal of contaminants.
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COLLOID AND POLYMER SCIENCE
·
2018
·Vol. 296
·期 7
·1267-1271
·
IF 1.967
Li Siqi,Xu Dandan,Pan Ting,Wu Quanzhou,He Jianfeng
Three-dimensionally ordered macroporous microspheres (3DOMMs) with copolymer skeletons have been successfully fabricated using a colloidal crystal templating method. The spherical SiO 2 colloidal crystal was firstly self-assembled as template via the evaporation-induced self-assembly process in a water/oil suspension system. The 3DOMMs were obtained by sealing the silica colloidal crystal template with polyethylene glycol 1500 (PEG 1500) after the infiltration of the precursor into the interstice of the template. The compositions of the precursor had an important effect on the structural order and integrity of the 3DOMMs. The structural strength of the microspheres was obviously improved by adding 2-hydroxyethyl methacrylate (HEMA) and 3-(trimethoxysilyl)propyl methacrylate (KH570) into the precursor. The chromatographic column packed with the 3DOMMs showed higher permeability and lower backpressure compared with the column packed with the traditional bulk materials and was suitable for the fast chromatographic separation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2018
·
IF 2.829
Xuechen Tang,Hongbin Yang,Yongbo Gao,Zeeshan Ali Lashari,Changxiao Cao,Wanli Kang
A kind of silica-reinforced polymer microspheres was proposed and prepared by inverse suspension polymerization, in which the nano-silica modified by 3-(methacrylyloxy) propyl trimethoxysilane (MPS) was used as reinforcing material. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and dynamic light scattering (DLS) were utilized to analyze their structural properties. The effects of SiO 2 on swelling capability, mechanical shear resistance, stability and viscoelastic property were studied. Plugging behavior was examined by sand pack model experiments. The results show that SiO 2 can effectively adjust swelling behavior, and greatly improve mechanical shear resistance of polymer microspheres. Compared with conventional polyacrylamide microspheres, these silica-reinforced polymer microspheres displayed better dispersion stability and viscoelastic property. In addition, these microspheres exhibited an improved thermal stability, where the maximum degradation temperature was 11 °C higher than that of conventional ones. The plugging rate can be 83.87% and was promoted by 11.54% in sand pack model. This work can provide a viable candidate material for the deep conformance control in oilfields, and supply theoretical support for its application.
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TALANTA
·
2018
·
IF 4.244
Xiao Sun,Jing Li,Li Xu
In the present study, the narrow-dispersed penetrable poly(methacrylic acid- co -ethylene glycol dimethacrylate) (poly(MAA- co -EDMA)) microspheres were successfully synthesized based on the sacrificial support method. The poly(MAA- co -EDMA) microspheres mirrored the porous structure of the sacrificial support, i.e. penetrable silica, characteristic of copious mesopores and throughpores. In addition, they possessed large surface area, adjustable hydrophobicity and the cation-exchange ability. Owing to their multi functionalities, they were applied as chromatographic stationary phase to separate proteins in different separation modes, including reversed phase, hydrophobic interaction and weak cation exchange. Moreover, thanks to their throughpores, fast separation at low column backpressure could be achieved in these three modes. Both protein recovery and column stability were satisfactory. The penetrable poly(MAA- co -EDMA) microspheres were potential stationary phase matrix for fast protein separation.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2022
·
IF 5.895
Qiushuang Sheng,Xiaoning Hou,Yang Wang,Nan Wang,Xuming Deng,Zhongmei Wen,Dan Li,Li Li,Yonglin Zhou,Jianfeng Wang
The efficacy of colistin, the last option against multidrug-resistant (MDR) Gram-negative bacteria, is severely threatened by the prevalence of plasmid- or chromosome-mediated colistin resistance genes. Herein, naringenin has dramatically restored colistin sensitivity against colistin-resistant Klebsiella pneumoniae infection without affecting bacterial viability, inducing resistance and causing obvious cell toxicity. Mechanism analysis reveals that naringenin potentiates colistin activity by multiple strategies including inhibition of mobilized colistin resistance gene activity, repression of two-component system regulation, and acceleration of reactive oxygen species-mediated oxidative damage. A lung-targeted delivery system of naringenin microspheres has been designed to facilitate naringenin bioavailability, accompanied by an effective potentiation of colistin for Klebsiella pneumoniae infection. Consequently, a new recognition of naringenin microspheres has been elucidated to restore colistin efficacy against colistin-resistant Gram-negative pathogens, which may be an effective strategy of developing potential candidates for MDR Gram-negative bacteria infection.
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POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Yuanmeng Lou,Yanyue Su,Yiheng Ma,Yunhong Jiao,Jianzhong Xu,Haiyun Ma
Bioactive glass (BG) has been a focus of research for biomedical applications due to its unique biological properties. Owning to its special composition (SiO 2 –CaO–P 2 O 5 ) and structure, BG becomes a potential flame retardant. In this paper, a novel type of BGs was synthesized and employed as a flame retardant for epoxy resin (EP). To further improve its flame retardancy properties, firstly, the chemical compositions of BGs were modified by doping Cu, Zn, Sr ions into the SiO 2 network by a sol-gel method combined with a template method and hydrothermal method; secondly, the microstructure of BGs was designed as a microsphere with a hollow mesoporous structure. Moreover, the obtained BGs were further functionalized with a polyphosphazene derivative (PZS) to integrate the excellent flame retardancy and mechanical properties. The results showed that Cu/Zn/Sr ions entered the SiO 2 network, while PZS was successfully deposited on the surface of mesoporous BGs. An improved comprehensive performance including flame retardancy, smoke suppression and mechanical strength enhancement was achieved by the presence of multiple flame-retardant atoms (Cu, Zn, Sr, Si, P, S, N, Cl) in the mesoporous BG microspheres. This study successfully applied BGs with high biocompatibility as flame retardant, broadening the types and categories of flame retardants.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Wantong Zhao,Lin Ma,Song Guo,Jia Yan Liu,Jingshu Piao,Mingguan Piao
Domperidone (DMP) is an effective peripheral D2 dopamine receptor antagonist . It is commonly used in the treatment of nausea and vomiting caused by Parkinson's disease . An oral preparation, which is rapidly absorbed after administration, and reaches a peak plasma concentration within 15–30 min, is commonly used. However, owing to the “first-pass effect” of liver metabolism and intestinal wall metabolism, the oral bioavailability of domperidone is low, and the action period is long. Therefore, in the present study, spray drying and emulsion solvent evaporation were combined to prepare a coated microsphere preparation with sustained release effect, and a gel matrix was selected to prepare a sustained-release coated microsphere gel for transdermal drug delivery. The pharmacokinetic results showed that the transdermal sustained-release coated microsphere gel effectively increased the Tmax, Cmax, T 1/2 , and AUC compared with those of an oral DMP group ( P < 0.05), and the relative bioavailability was 3.2 times that of the oral DMP group. This indicates that the preparation was able to ameliorate the problems associated with a traditional oral DMP formulation. Therefore, the present study may provide a theoretical basis for the transdermal delivery of DMP sustained-release microspheres.
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Particuology
·
2022
·
IF 3.251
Shenglong Zhang,Kai Wang,Guangsheng Luo
To prepare uniform polystyrene particles with ten microns of diameter, a parallel scaling-up strategy for the capillary-assembled stepwise microchannel was developed, which created uniform droplets with high-throughput and formed a large amount of emulsion templates for the polymerization of styrene and cross-linker. The microchannel droplet generator was robust for the flow rate deviation of the continuous phase in the jetting flow, and droplet generation frequency up to 2.8 × 10 4 Hz was achieved with only four parallel droplet generators, which were much more efficient than the parallelly scaled microfluidic devices working in dripping flow. 32–52 μm average diameter droplets with 4.5%–8.4% diameter variation coefficients were successfully prepared from the microchannel device fabricated by low-cost 3D-print method, and the droplets were subsequently turned to solid particles via a two-step polymerization in the platform. The polystyrene particles were further reduced to 16.9–23.5 μm with 5.0%–8.6% diameter variation coefficients due to the accompanying emulsion polymerization, and the working capacity of the platform reached hundred milligrams of particles per hour.
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