MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Jianwei Xin,Irfan Muhammad,Zihui Meng,Yuqi Zhang
O-Phthalaldehyde (OPA) is a novel chemical disinfectant that has seen widespread use in healthcare environments. To ensure the efficacy of OPA-based disinfection in clinical practice, precise and reliable determination of its operational concentration is essential. Current methods, such as indicator strips, offer only semi-quantitative results, with their accuracy being influenced by multiple factors. Thus, there is an urgent need for the development of novel, efficient, and straightforward quantitative detection methods for OPA. DVD-R discs can be regarded as one-dimensional photonic crystals, which inspired the design of one-dimensional photonic crystal hydrogel (1DPCH) using DVD-R discs as templates. A sensor responsive to OPA was constructed by functionalizing the 1DPCH with ethylenediamine, thereby introducing amino groups into the hydrogel. These amino groups interact with OPA, and as the OPA concentration increases, the hydrogel undergoes enhanced crosslinking, leading to volume shrinkage. This shrinkage results in a reduction in the groove spacing of the embedded photonic crystal, which in increase the first-order diffraction spacing. By measuring the variation of the first-order diffraction spacing, the change in groove spacing can be quantified through a mathematical relationship. The experimental results exhibited a strong linear correlation with the change in groove spacing over the concentration logarithm range of 10 1 –10 6 nmol/L. the limit of detection was 1.26 nmol/L. additionally, the sensor exhibited high recovery rates (96.09–103.35 %) and low relative standard deviation (1.68–3.95 %) when detecting OPA in diluted disinfectant solutions. These findings suggest that the developed 1DPCH sensor is highly effective for the detection of OPA in clinical applications
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产品关联
DOI
高影响因子
VACUUM
·
2025
·
IF 3.9
Zhuo Li,Huiling Du,Nan Kong,Na Cao,Kemeng Hu,Lan Yang,Xian Du
Carbon dioxide conversion represents a highly promising carbon reduction strategy, and photocatalytic conversion technology, characterized by greenness, non-toxicity, and sustainability, holds significant importance. However, enhancing CO 2 adsorption on photocatalysts and improving charge carrier separation efficiency remain substantial challenges. In this study, based on MIL-101, we designed a highly interconnected TiO 2 @MIL-101 bifunctional heterojunction by in-situ compositing TiO 2 on its surface through Ti-O-Cr bonding, aiming to achieve in-situ adsorption and conversion of carbon dioxide. This composite photocatalyst exhibits enhanced photocatalytic activity, with an average CO production rate of 35.39 μmol h −1 g −1 and a CH 4 production rate of 13.81 μmol h −1 g −1 . Compared to unmodified MIL-101 (Cr), these values are increased by 1.25-fold and 2.8-fold, respectively. Experimental results combined with DFT calculations demonstrate that the porous structure and high specific surface area of MIL-101 facilitate the diffusion of CO 2 on the photocatalyst surface and improve interfacial reaction kinetics. The synergistic effect between Ti-O-Cr bonds and the built-in electric field within the highly interconnected heterojunction accelerates the directional transfer of charge carriers at the heterointerfaces, effectively promoting the catalytic conversion of carbon dioxide.
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高影响因子
FEBS LETTERS
·
2016
·Vol. 590
·期 16
·2619-2628
·
IF 3.519
Yu-Ying Zhang,Rui-Xue Xu,Shuai Gao,Ai-Xia Cheng
Oroxylin A and hispidulin, compounds which are abundant in both Scutellaria and liverwort species, are important lead compounds for the treatment of ischemic cerebrovascular disease. Their enzymatic synthesis requires an O -methyltransferase able to interact with the related flavonoid's 6-OH group, but such an enzyme has yet to be identified in plants. Here, the gene encoding an O -methyltransferase (designated PaF6OMT) was isolated from the liverwort species Plagiochasma appendiculatum . A test of alternative substrates revealed that its strongest preferences were baicalein and scutellarein, which were converted into, respectively, oroxylin A and hispidulin. Allowed a sufficient reaction time, the conversion rate of these two substrates was, respectively, 90% and 100%. PaF6OMT offers an enzymatic route to the synthesis of oroxylin A and hispidulin.
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Yuehan Cao,Ruiyang Zhang,Tianli Zhou,Shengming Jin,Jindi Huang,Liqun Ye,Zeai Huang,Fang Wang,Ying Zhou
Limited by the chemical inertness of CO2 and the high dissociation energy of the C═O bond, photocatalytic CO2 conversion is highly challenging. Herein, we prepare ultrathin oxygen-modified h-BN (O/BN) nanosheets containing B–O bonds. On the O/BN surface, CO2 can be chemically captured and is bonded with the B–O bond, leading to the formation of an O–B–O bond. This new chemical bond acting as an electron-delivery channel strengthens the interaction between CO2 and the surface. Thus, the reactants can continuously obtain electrons from the surface through this channel. Therefore, the majority of gaseous CO2 directly converts into carbon active species that are detected by in situ DRIFTS over O/BN. Moreover, the activated energies of CO2 conversion are significantly reduced with the introduction of the B–O bond evidenced by DFT calculations. As a result, O/BN nanosheets present an enhanced photocatalytic CO2 conversion performance with the H2 and CO generation rates of 3.3 and 12.5 μmol g–1 h–1, respectively. This work could help in realizing the effects of nonmetal chemical bonds in the CO2 photoreduction reaction for designing efficient photocatalysts.
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DOI
PubMed
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 49
·30725-30733
·
IF 3.361
Sen-Ju Ma,Hai-Bo Li,Ting Li,Zhen-Zhen Su,Zhen-Zhong Wang,Xin-Sheng Yao,Wei Xiao,Yang Yu
Phytochemical investigations on the dry leaves of Illicium dunnianum have led to the isolation of 24 lignans. Illiciumlignans G–K (1–5) were five undescribed benzofuran lignans, illiciumlignan L (6) was one undescribed ditetrahydrofuran lignan, illiciumlignans M–O (7–9) were three new sesquilignans, and compounds 10, 12, 13, 15, and 18–21 were firstly isolated from the genus Illicium. Their structures were elucidated by detailed spectroscopic analyses (UV, IR, HR-ESI-MS, and NMR) and CD experiments. All isolates were evaluated by measuring their inhibitory effects on PGE2, and NO production in LPS-stimulated RAW 264.7 macrophages.
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PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2022
·
IF 5.307
Yuan Kong,Yong-Jia Yi,Xiao-Qing Liu,Pan Yu,Lin-Guo Zhao,Dong-Dong Li
Berberine is a quaternary isoquinoline alkaloid that exhibits potent hypoglycemic and hypolipidemic activity. Many medicinal chemists are currently working on structural modifications around the parent scaffold of berberine, expecting to further enhance its hypolipidemic activity and reducing its cytotoxicity. In this study, a focused berberine-like compound library containing 12,600 molecules was built via the introduction of various “drug-like” fragments at the C8 and C9 positions of berberine. Sixteen comopounds were hit by using the in-house QSAR models previously reported by our group. Considering synthesis feasibility and the cost of building-blocks, only four berberine analogs (library ID: 2028 , 3847 , 6033 , and 12456 ) were selected and synthesized for investigating their lipid-lowering activities. Preliminary lipid-lowering study showed that compound 12456 with the phenylsulfonyl group at the C9 position had potent cholesterol inhibitory activity in HepG2 cells, superior to that of the parent compound berberine. Subsequently, a total of twenty-five 9- O -phenylsulfonyl-berberines ( 1a - 1y ) and twenty-four 9- O -phenylsulfonyl-tetrahydroberberine ( 2a - 2x ) were designed, synthesized, and evaluated by lipid-lowering experiments. The results displayed that most compounds exhibited more lipid-lowering activities than berberine. Among them, compound 1m inhibited cholesterol production close to 50% in both cell models when compared with the blank control; the inhibition of triglycerides exceeded 70%. Moreover, 1m also had significant pharmacological effects on the inhibition of LDLC and promotion of HDLC production, especially in the HepG2 cell model, in which the inhibitory rate against LDLC was close to 70% and the increase rate of HDLC was more than 75%. The hypolipidemic experiment of SD rats demonstrated that after 40 days of administration ( 1m , 15 mg/kg/d), blood cholesterol was reduced by 19.6%, triglycerides reduced by 34.52%, and LDLC reduced by 41.49%, when compared with the high-fat diet model (HFD). In addition, after 80 days of administration, the three indexes of 1m were still better than that of berberine. Oil Red O staining and H&E staining results showed that 1m exhibited potent lipid scavenging activity. All in all, 1m was discovered and identified as a potent lipid-lowering agent and a new berberine-like candidate, being evaluated by subsequent studies.
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PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Shumeng Wu,Caixia Feng,Bingbing Fan,Yonghong Li,He Wang,Yanmei Zhou
Heteroatoms-doped hierarchical porous carbons have attracted considerable interest owing to their efficient utility in supercapacitors . However, the increase of defects tends to sacrifice the electrical conductivity of carbon materials. Therefore, it is of great significance to build a good conductive network by increasing the graphitization degree of porous carbons . Here, this study reports the use of serine phosphate protic salt ([Seri][H 2 PO 4 ]), Pluronic F127 and cobalt nitrate to engineer the N/O/P co-doped hierarchical porous graphitic carbon materials. The Co 2+ catalyzes the graphitization of porous carbons under high temperature. A large number of mesopores, highly doped heteroatoms (O: 4.2 wt%, N: 4.07 wt%, P: 0.81 wt%) and conductive carbon skeleton boost the ultrafast transport of electrons and ions, resulting in high specific capacitance, wide operating voltage and outstanding rate performance. The symmetric supercapacitor assembled in KOH electrolyte shows good frequency response with the scan rate up to 1.5 V s −1 on the working voltage of 0–1.3 V. At the same time, when the power density reaches up to 21.3 kW kg −1 , its energy density remains 8.74 W h kg −1 . Furthermore, the symmetric supercapacitor delivers a high energy density of 81.42 W h kg −1 at the power density of 875 W kg −1 with an ultrahigh working voltage of 3.5 V in 1-ethyl-3-methylimidazolium tetrafluoroborate (EMIMBF 4 ) electrolyte. More promisingly, all-solid device based on the optimized sample exhibits outstanding flexibility, which greatly broadens its practicability. This work marks the importance of the balance between porous structure, heteroatom doping and high conductivity for advanced supercapacitors .
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高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Hanqing Wu,Linlu Zheng,Liangbin Lin,Hongyu Guo,Fafu Yang
Fluorescent sensors had been extensively applied on sensing various biomolecules effectively, but no fluorescent sensor for oleanolic acid was presented up to now. In this work, the first fluorescent sensor for oleanolic acid was designed and synthesized based on o-phenyl-bridged bis-tetraphenylimidazole ( PTPI ). PTPI was prepared by bridging two tetraphenylimidazole units and o-phenylenediamine via Schiff-base condensation in yield of 86%. PTPI showed high sensing selectivity for oleanolic acid among 26 biomolecules and ions. The blue fluorescence at 482 nm was enhanced by 4.5 times after sensing oleanolic acid in aqueous media. The fluorescence sensing ability of PTPI for oleanolic acid maintained stable in pH = 5–9. The detecting limitation was as low as 0.032 μM. The detecting mechanism was clarified as 1:1 binding stoichiometry by fluorescence Job’s plot, mass spectrometry, 1 H nuclear magnetic resonance and fourier transform infrared spectroscopy. The detecting ability of PTPI for oleanolic acid was successfully used for paper test and real samples of grapes and Kuding tea with recoveries in the range of 96.0%-106.0%, indicating the good application potential for on-site detecting oleanolic acid in real samples of fruits and food.
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
·
IF 2.843
Zhen Sun,Yueer Yan,Gang Li,Yahong Zhang,Yi Tang
A facile and fast microwave-assisted approach without any other pre/post-treatment has been proposed to hydrothermally synthesize six kinds of MFI-type heteroatom (Mn, Ga, Ti, Sn, Cr, Zr) zeolites. By comparing with oven heating mode, it is found that microwave field displays a positive effect on the introduction of partial heteroatoms in the zeolite framework. Moreover, differing from the conventional heating, microwave irradiation displays different influences on the different heteroatom zeolites because different heteroatoms cause different polarities and wave-absorption abilities of M–O bonds under microwave irradiation. Furthermore, this positive effect of microwave is embodied not only on heteroatom zeolite synthesis and heteroatom state in zeolite framework but also the resultant catalytic performance. This finding provides an easy route for the synthesis of novel heteroatom zeolite being difficult to prepare by conventional mode, along with a new direction for the exploration of microwave effect.
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高影响因子
Science China-Materials
·
2022
·Vol. 66
·期 3
·1062-1070
·
IF 8.64
Wang Yang,Chen Sai,Sun Jiachen,Xie Yufei,Zhao Zhi-Jian,Pei Chunlei,Gong Jinlong
Supported vanadium oxides (VO x ) are alternative candidates for non-oxidative propane dehydrogenation (PDH) owing to their competitive performance. This paper describes the roles of V−O sites on PDH over monomeric VO x species supported on ZrO 2 , Al 2 O 3 and SiO 2 . With the control of pre-reduction, stable structures of V−O sites are obtained for PDH, including V−O-support (V−O−S), V−OH and V=O sites. By tuning the V densities over individual support, the propylene formation rate shows a linear correlation with the number of the V−O−S site, which indicates the V−O−S site plays a decisive role in PDH rather than V−OH and V=O sites. Moreover, the specific activity per V−O−S site over ZrO 2 (8.2 × 10 −3 s −1 ) is higher than those over Al 2 O 3 (6.7 × 10 −3 s −1 ) and SiO 2 (2.8 × 10 −3 s −1 ), due to the discrepant Lewis acidity of various V−O−S sites. This research provides a fundamental insight into the intrinsic nature of V−O sites for non-oxidative propane dehydrogenation.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 41
·19712-19721
·
IF 3.925
Wenxian Wang,Yufei Zhou,Dan Yang,Xianfen Zhang,Lijiao Guan,Yuding Zhang,Saipeng Huang
Selenite (SeO32−), as the most toxic form of selenium in water, is a great threat to water quality and human health, which also has been closely associated with various physiological and pathological processes. The sensitive detection and quantification of SeO32− are imperative for the early diagnosis and prevention of selenite-associated disease. Herein, we constructed novel o-phenylenediamine functionalized carbon quantum dots (OPD-CQDs) by a one-step hydrothermal method. The OPD-CQDs exhibited good water solubility, high quantum yield, strong photostability, excellent biocompatibility and cell imaging capabilities, and also displayed high selectivity and sensitivity to SeO32− with an excellent linear relationship and a low limit of detection (86 nM). Moreover, the OPD-CQDs were successfully employed for the quantitative determination of SeO32− in tap water and human serum with high accuracy and recovery rate. In particular, the designed OPD-CQDs were successfully applied for intracellular SeO32− detection with excellent biocompatibility and cellular imaging capability. The present research demonstrated that OPD-CQDs provided a novel approach for imaging and detecting SeO32− in live cells and in vivo. Based on these excellent properties and comprehensive applications, OPD-CQDs illustrated great potential to offer a scientific and effective method for SeO32− detection in complex environments and clinical early diagnosis of SeO32− related diseases.
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高影响因子
ORGANOMETALLICS
·
2020
·
IF 3.804
Liangwei Zhang,Long Liu,Tianzeng Huang,Qizhi Dong,Tieqiao Chen
A palladium-catalyzed cyclobutanation of aryl sulfonates with strained alkenes has been developed. The methodology is featured to achieve the cleavage of both C–O and C–H bonds of phenol derivatives in one pot. Under the reaction conditions, in addition to reactive triflates, the relatively inactive tosylates and mesylates can also be transformed into the corresponding benzocyclobutanes in high yields. This reaction can be carried out in gram-scale experiments with a low loading of the palladium catalyst and is applicable to the cyclobutanative modification of bioactive molecules, highlighting its synthetic value in organic synthesis.
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高影响因子
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