JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2025
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IF 14.3
Mingyang Li,Yanen Wang,Qinghua Wei,Juan Zhang,Yalong An,Xiaohu Chen,Zhisheng Liu,Dezao Jiao
Polyvinyl alcohol (PVA)-based hydrogels are widely used in the fields of tissue engineering, biomedicine, and flexible sensors due to their low cost, excellent biocompatibility, and simple gelation methods. Repeated freeze-thaw cycles are essential for the preparation of such hydrogels. Although this process can enhance the mechanical properties of the hydrogels to a certain extent, it can also result in opacity and limited tensile performance, significantly restricting their application in wearable devices and electronic skin. This study introduced cellulose nanofibers into polyacrylamide (PAM)/PVA double interpenetrating network hydrogel system, achieving the preparation of a multifunctional composite hydrogel with a “triple-network interlock” structure. Under the synergistic effects of multiple networks, multiple hydrogen bonds, and nano-reinforcement, this composite hydrogel requires only a single freeze-thaw cycle to achieve a tensile strength exceeding 1 MPa, which is significantly higher than that of PVA hydrogels subjected to multiple freeze-thaw cycles. The PVA-based hydrogel prepared in this work balances tensile strength (1.41 MPa), elongation (1332%), transparency (89.8%), and toughness (6.73 MJ m − ³). Additionally, this composite hydrogel exhibits high sensitivity (GF = 8.74), rapid response (108 ms), fatigue resistance, and antibacterial properties, making it a reliable strain sensor over a wide strain range. When encapsulated on human joints, it can monitor body movements in real-time, such as movements of fingers, wrists, elbows, and knees, and can be integrated into peripheral circuits to achieve precise real-time control of robotic hands. This work presents a multifunctional composite hydrogel with great potential as a candidate material for tissue engineering, human-machine interaction, and high-performance wearable sensors.
研究领域:
材料科学
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生物医学工程
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柔性电子
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
·
IF 2.8
Fangya Zhang,Yifei Pei,Jie Hu,Qiyang Wang,Manqing Yan
Conductive hydrogels are promising for flexible wearable sensors due to their flexibility, conductivity, and sensing capabilities. Herein, a multifunctional polyvinyl alcohol/4-carboxyphenylboronic acid/carboxymethyl cellulose@polyaniline hydrogel is fabricated by embedding spherical carboxymethyl cellulose@polyaniline microspheres into a PVA/4-carboxyphenylboronic acid hydrogel. The synergistic effect of borate and hydrogen bonds forms a dynamic dual-crosslinking network, endowing the hydrogel with high tensile strength (0.31 MPa), excellent stretchability (1415%), fast self-healing ability, and good conductivity (3.57 S m −1 ). Notably, the engineered hydrogel is assembled as a dual-responsive sensor, exhibiting strain and temperature sensing for wearable electronics and healthcare monitoring applications. As a strain sensor, it showed good sensitivity (gauge factor: 1.88), fast response/recovery time (about 200 ms), and cyclic stability, allowing accurate detection of joint movements and facial expressions. As a temperature sensor, its temperature-sensing capability relies on the synergistic effect of the dynamic rearrangement of borate (B O C) bonds and hydrogen bonds, PANI's temperature-dependent conductivity, and ionic mobility. Thus, it exhibits a negative temperature coefficient of resistance (TCR = −1.52%/°C) in the temperature range of 20°C–60°C, enabling continuous body temperature monitoring and detection of febrile states. This work provides a general strategy for self-healing dual-responsive sensor hydrogels for wearable electronics in healthcare and human-robot interfaces.
研究领域:
材料科学
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柔性电子学
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可穿戴传感器
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生物医学工程
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智能材料
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高分子化学
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2025
·
IF 7.3
Qiuyan Tang,Wenbin Zhang,Hongzhen Cai,Keyan Yang,Jiankang Zhang,Yibo Zhang,Xiangsheng Han
Conductive hydrogels (CHs) are promising for flexible electronics in artificial intelligence and digital healthcare, but they still lack mechanical durability and long-term stability. Here, sustainable lignin-containing cellulose nanofibers (LCNFs) were used to strengthen the poly(vinyl alcohol) (PVA)/transition metal carbide and nitride (MXene) hydrogels through a simple “one-pot” procedure (abbreviated as P(LxMy)z). Owing to the rigid and polar phenolic hydroxyl groups on lignin, LCNFs formed dense hydrogen bonding with both PVA and MXene, dissipated the external stress, and endowed the composite hydrogels with superior mechanical properties (a tensile strength of ∼1.55 MPa and a toughness of ∼2.85 MJ m–3), conductivity (∼0.13 S m–1), stability, and biocompatibility. Combining all these features, the P(LxMy)z hydrogels demonstrated a sensitive (GF value of ∼2.3) and durable (more than 2400 cycles) response to deformation, which can be applied as an epidermal sensor to detect both drastic (e.g., joint movement) and subtle (e.g., swallow and frown) human motions and even to detect information on different speeches and handwritings. Thus, this work paves a new way to build tough, stable, and biocompatible CHs, demonstrating significant potential for durable and precise epidermal sensing applications.
研究领域:
材料科学
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纳米技术
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柔性电子学
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可穿戴传感器
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生物医学工程
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2025
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IF 9
Jia Ding,Chao Fan,Yulong Li,Jian Zhang,Jiaxing Hu,Jianguo Wang
Citalopram is a widely employed antidepressant and commonly produced by intramolecular etherification of 5-cyanodiol with highly corrosive and toxic p -toluenesulfonyl chloride as co-reactant. In this work, citalopram was synthesized using a catalyst-membrane coupling reactor (CMCR) in the absence of p -toluenesulfonyl chloride. The CMCR comprised a solid acid resin catalyst (HND-2) and a polyvinyl alcohol (PVA) membrane supported on a polymeric hollow fiber to achieve in-situ water separation through vapor permeation. The results revealed that incorporating the PVA membrane increased the conversion of 5-cyanodiol hydrochloride and selectivity towards citalopram by approximately 9.2 % and 4.0 %, respectively. It was found that water adsorbed and confined on HND-2 catalyst created micro-environment for the dissociation of hydrogen ions and etherification reaction. The Karl Fischer titration revealed that vapor permeation by PVA membrane effectively and completely removed the generated water during the reaction, resulting in an improvement in catalytic performance. The PVA membrane also maintained its separation capacity in six reaction cycles, demonstrating a good reusability in CMCR for the etherification of 5-cyanodiol hydrochloride.
研究领域:
化学工程
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有机合成
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膜技术
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催化化学
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药物化学
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DOI
高影响因子
RSC Advances
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2025
·Vol. 15
·期 27
·21300-21310
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IF 4.6
Yu-Ling Qi,Hao-Yu Zhou,Guo-Zhi Han
Self-healing hydrogels have the ability to repair themselves at the incision after being damaged and can return to their original state of morphology and performance. However, constructing a hydrogel with superior mechanical strength and tensile properties after self-healing remains a challenge. In this work, using polyvinyl alcohol, borax, chitosan, and a type of SiO2@g-C3N4@TiO2 nanoparticles as raw materials, a novel photo-regulated self-healing hydrogel was developed using a freezing–thawing method, which could achieve a synchronous increase in Young's modulus and tensile strength under visible light irradiation during the self-healing process. In addition, the doping of the SiO2@g-C3N4@TiO2 nanoparticles improved the self-healing performance of the PVA-based hydrogels. With the addition of a trace amount of SiO2@g-C3N4@TiO2 nanoparticles, the self-healing efficiency of the hydrogel increased from 26.67% to 45.67% in darkness and from 41.33% to 65.67% under visible light irradiation.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Bohan Zhang,Jinglei Yang,Qiaojun Jiang,Ruping Zheng,Liting Qiu,Jingxin Chen,Ruiyun You,Zixing Yan,Yudong Lu
In clinical settings, there is a significant demand for the monitoring of therapeutic drugs. Surface-enhanced Raman spectroscopy (SERS) has shown considerable potential in the field of drug analysis. Designing SERS sensors with high sensitivity, strong stability, excellent reproducibility is a challenging and fascinating goal in the field of chemical measurement. In this study, a simple and portable AuNPs/C-CNF/PVA hydrogel SERS sensor was developed, composed of gold nanoparticles (AuNPs), carboxylated cellulose nanofibers (C-CNF) and polyvinyl alcohol (PVA). Due to the “screening” effect of the hydrogel network, it is capable of separating hydrophobic molecules from macromolecules and enabling the enrichment of hydrophilic small molecules. When used to analyze 6-thioguanine (6-TG) and methylene blue (MB) in plasma, the AuNPs/C-CNF/PVA hydrogel SERS sensor showed limit of detection (LOD) as low as 7.9 × 10 −8 M for 6-TG and 3.3 × 10 −9 M for MB. Based on this technology, in blood spiking experiments using clinical samples, the recovery rate for 6-TG ranged from 99.16 % to 103.51 %, while the recovery rate for MB ranged from 93.13 % to 101.70 %. Therefore, the AuNPs/C-CNF/PVA hydrogel SERS sensor enables ultra-sensitive, integrated detection of drugs in plasma through separation and enrichment, without the need for complex pretreatment steps. This approach holds great promise for application in clinical therapeutic drug monitoring.
研究领域:
分析化学
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生物医学工程
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药物分析
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Jiawei Zhang,Kaili Zhang,Chen Tian,Gaoyue Zhang,Xiao Jiang,Kui Wang,Kang Sun,Jianchun Jiang
Kraft lignin (KL), a major by-product of the pulp and paper industry, has garnered significant research attention due to its abundant availability and distinctive chemical structure, making it a promising candidate for applications such as biofuels, carbon materials, and polymer composites. Despite these advantages, its utilization in fine chemical industries, including nanomaterials, is constrained by its inherent dark color and broad molecular weight distribution. Addressing these limitations has become a central focus in ongoing research efforts aimed at enhancing the functionality and commercial viability of KL. In this study, we fractionated KL from a paper-making enterprise using pH fractionation, and obtained four kinds of lignin with different molecular weights. Following that, lignin microspheres (LMPs) were formed by self-assembly from four sizes of KL. Analyzing the KL and LMP properties, the low molecular weight lignin, such as KL-2, exhibited good antioxidant properties (84.27 %, 5 mg/mL), high brightness (ISO% = 7.6), high L ⁎ value (L ⁎ = 86.2) and low polydispersity index (PDI = 1.19). The LMP showed a narrow size distribution (1.0–1.4 μm). When the LMP content is 5 %, the 5 % LMP/PVA film maintains high transparency and exhibits excellent UV protection, achieving a UV shielding rate of up to 94.6 %. Therefore, this study offered an effective way for the comprehensive utilization of pulping waste KL.
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
ACS Applied Polymer Materials
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2026
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IF 4.7
Yuling Lv,Yanyou Huang,Liangdong Ye,Ruibing Shen,Ziwei Li,Shanrong Li,Zuocai Zhang,Shaorong Lu
Under low-carbon policies, green biodegradable materials such as okra polysaccharide (OP) and poly(vinyl alcohol) (PVA) have gained prominence. In this study, flexible PVA/OP/CA/CB (POAB) composite films are prepared via a simple one-pot method using citric acid (CA) as a cross-linker and carbon black (CB) as a filler. At a safe voltage of 6 V, the surface saturation temperature of the POAB composite films reaches 50 °C, making it a viable option for flexible electric heating devices to help patients alleviate joint pain and stiffness. At a light power density of 1.1 W/cm2, the POAB composite films exhibit a surface saturation temperature as high as 140 °C, demonstrating outstanding photothermal conversion performance. As a wearable strain sensor, POAB composite films feature a wide response range (125%) and excellent cyclic stability (700 s), enabling the monitoring of the range of motion across different joint areas. This assists physicians and rehabilitation therapists in evaluating patients’ recovery progress. Furthermore, after 28 days of biodegradation in soil, it retains its structural integrity with outstanding stability. In summary, POAB composite films enable simultaneous management of the Joule heating effect, photothermal conversion, and wearable strain sensing, contributing to sustainable energy development.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.5
Wenzhen Du,Manli Yang,Xiaoxue Han,Wenjing Yin,Longyu Guo,Chen Liang,Hai Peng,Yongchao Ma
The severe pollution, high cost and the limited functionality constrain the agricultural mulch film extensive development. To address these issues, a low-cost, eco-friendly, and multifunctional biodegradable polyvinyl alcohol-based mulch film (PUCH) was designed with acid-hydrolyzed and hydrothermally pretreated corncob (CC) lignocellulose as reinforcing fillers, crosslinked by glutaraldehyde, urea as fertilizer, and glycerol as plasticizer. Compared with the control sample of PU-0, PUCH-20 exhibited the highest toughness, tensile strength and elongation, which increased by 92.82%, 80.54% and 51.37%, respectively. On the other hand, the PUCH mulch film also demonstrated the improved water resistance, thermal insulation performance, thermal stability and biodegradability. Furthermore, the PUCH-40 mulch film presented outstanding UV-shielding of UVC (92.1%), UVB (95.6%) and UVA (96.9%), and the thermal insulation performance was promoted by nearly 10 °C compared to the blank sample without covering film. Additionally, the PUCH mulch films showed better growth pattern compared with the commercial polyethylene mulch film. The degradation rate of PUCH-40 reached 40.10% after 100th days. These results indicate this work develops an innovative, green and efficient strategy to design high-performance degradable mulch film to promote crop growth in the field of sustainable agriculture.
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POLYMER ENGINEERING AND SCIENCE
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2026
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IF 3.6
Qiyu Bian,Luyao Zhou,Yi Wang,Hongjie Luo,Xiao Huang
Introducing inorganic thermal fillers into organic polymers is the major solution to increase thermal conductivity (TC), but typically at the expense of optical transparency. Fabrication of transparent thermally conductive polymers remains a great challenge today. In this work, negatively charged and highly crystalline cellulose nanocrystals (CNCs) are introduced into polyvinyl alcohol (PVA). Owing to their closely matched refractive indices, the prepared CNC/PVA composites exhibit enhanced TC and reduced loss of optical transparency. The CNC/PVA composite with 75 wt% CNC loading shows cross-plane TC of 0.33 W m −1 K −1 (1.74 times that of pristine PVA) while retaining 77% of the original transparency of PVA at 600 nm. Addition of cetyltrimethylammonium bromide (CTAB) further improves the thermal and optical properties of CNC/PVA composites. With 0.5 wt% CTAB, the composite has a significantly enhanced cross-plane TC of 0.92 W m −1 K −1 (4.84 times that of pristine PVA), while preserving 96% of original PVA transparency at 600 nm. Comparative studies using neutral and anionic surfactants suggest that the improvement in TC by CTAB is probably due to the promoted CNC network formation by cations. Highlights CNC/PVA composite with cross-plane TC of 0.92 W m −1 K −1 and 85% transmittance is prepared. Matched RI between CNC and PVA is the key for transparency of the composite. CTAB can further increase the TC due to cationic-promoted network formation.
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ENZYME AND MICROBIAL TECHNOLOGY
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2022
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IF 3.705
Yun-Tao Zhao,Kun Zhang,Jian Zeng,Haowen Yin,Wenjing Zheng,Rui Li,Anzi Ding,Shaohong Chen,You Liu,Wenjin Wu,Zhanxin Jing
Enzyme immobilization technology has a key role in improving the stability of enzyme reaction systems and biocatalyst utilization rates. In this study, polyvinyl alcohol/sodium alginate@Fe 3 O 4 (PVA/SA@Fe 3 O 4 ) magnetic immobilized-enzyme hydrogel beads were prepared. Their structure and morphology were characterized by scanning electron microscopy, surface area and porosity analyses, Fourier transform infrared spectroscopy , X-ray photoelectron spectroscopy and a vibrating sample magnetometer. The capability of PVA/SA@Fe 3 O 4 to adsorb neutral protease was investigated with variations in composition, temperature, pH, stirring speed, enzyme concentration, and crosslinking concentration. The optimal parameters of the immobilization process were determined by response surface methodology (3% neutral protease, 4% crosslinking at 200 rpm, 45 °C and pH 7.2), under which an immobilization rate of 41.98 mg/g was obtained. The thermal stability , acid-base stability, and reusability of the immobilized enzyme were improved significantly. After seven cycles, the immobilized enzyme activity remained at 30.8% that of the initial enzyme activity . The results indicate that the immobilization of NP onto magnetic PVA/SA@Fe 3 O 4 hydrogel beads improves enzyme efficiency, giving this process potential industrial applications.
研究领域:
生物化学
·
酶工程
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DOI
PubMed
高影响因子
Food Packaging and Shelf Life
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2026
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IF 10.8
Jie Yao,Mengran Zhang,Guohua Zhao,Damao Wang
A bioactive and biodegradable packaging film was fabricated via a solvent-casting method using poly(vinyl alcohol) (PVA) reinforced with alkaline–peroxide treated brewers’ spent grain (BSG-M) and zinc oxide nanoparticles (ZnO-NPs). Alkaline–peroxide treatment was applied to BSG, which is reported to disrupt lignin–carbohydrate associations and promote microfibrillation, yielding a modified lignocellulosic filler containing residual proteins that dispersed uniformly within the PVA matrix, thereby enhancing the tensile performance and soil degradability of the composite films. The incorporation of an optimal ZnO loading (2–3 wt%) facilitated the formation of dense hydrogen-bond networks and increased the tortuosity of the diffusion path. Consequently, the composite films exhibited a UV-B blocking efficiency exceeding 96%, antibacterial inhibition rates up to ∼100% (depending on ZnO loading) against Escherichia coli and Staphylococcus aureus , and a moderate DPPH-radical scavenging activity (approximately 20%). Specifically, the PBZ-3 film (containing 3 wt% ZnO) significantly enhanced the preservation of strawberries during 8 days of storage at 4 °C. Compared with commercial polyethylene (PE) packaging, the PBZ-3 film minimized weight loss to 12.84% and provided superior vitamin C retention and improved visual quality, while maintaining the critical advantage of biodegradability. Furthermore, soil burial tests demonstrated a 54% mass loss within 30 days, confirming a favorable balance between functional performance and biodegradability. These results indicate that the PVA/BSG/ZnO ternary composite film is a promising biodegradable active packaging material with moisture-barrier, UV-shielding, antibacterial, and extract-based antioxidant functions for fresh produce.
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