Nanoscale
·
2014
·Vol. 6
·期 8
·4361-4370
·
IF 6.739
Xijian Liu,Qian Wang,Chun Li,Rujia Zou,Bo Li,Guosheng Song,Kaibing Xu,Yun Zheng,Junqing Hu
A low-toxic difunctional nanoplatform integrating both photothermal therapy and chemotherapy for killing cancer cells using Cu2−xSe@mSiO2–PEG core–shell nanoparticles is reported. Silica coating and further PEG modification improve the hydrophilicity and biocompatibility of copper selenide nanoparticles. As-prepared Cu2−xSe@mSiO2–PEG nanoparticles not only display strong near infrared (NIR) region absorption and good photothermal effect, but also exhibit excellent biocompatibility. The mesoporous silica shell is provided as the carrier for loading the anticancer drug, doxorubicin (DOX). Moreover, the release of DOX from Cu2−xSe@mSiO2–PEG core–shell nanoparticles can be triggered by pH and NIR light, resulting in a synergistic effect for killing cancer cells. Importantly, the combination of photothermal therapy and chemotherapy driven by NIR radiation with safe power density significantly improves the therapeutic efficacy, and demonstrates better therapeutic effects for cancer treatment than individual therapy.
研究领域:
纳米医学
·
肿瘤学
·
生物材料科学
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DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Xinglin Wen,Yonglu Yang,Yong Pan,Jitao Hu,Xiaoyue Wan,Yanhui Yang,Sébastien Leveneur,Juncheng Jiang
The hydrogenation of 2,4-dinitrotoluene (2,4-DNT) into 1-methyl-2,4-cyclohexanediamine (2,4-MCHD), a significant yet underutilized raw material for the synthesis of methylcyclohexane diisocyanate (HTDI) with exceptional properties, represents one of the most promising reactions for the development of diisocyanate chemical processes. In this study, we developed a highly efficient and stable heterogeneous catalytic system for the direct hydrogenation of 2,4-DNT to 2,4-MCHD using Li-modified γ-Al 2 O 3 supported Ru nanoclusters (Li-modified-Ru/γ-Al 2 O 3 ). Under mild reaction conditions, we successfully inhibited side reactions, such as deamination, achieving a selectivity exceeding 95% for 2,4-MCHD, while the conversion of 2,4-DNT surpassed 99%. Kinetic studies revealed that the hydrogenation of 2,4-DNT in this system occurs as a tandem reaction, with the hydrogenation of the benzene ring identified as the rate-determining step. Investigations into the structure–activity relationship indicated that the valence state of the Ru nanocluster, the acid-base properties of the catalyst, the modification by Li, and the synergistic effects of various elements within the catalyst are critical factors contributing to the high activity and stability of the Li-modified-Ru/γ-Al 2 O 3 catalyst for the hydrogenation of 2,4-DNT to produce 2,4-MCHD. This work represents the first example of the direct hydrogenation of dinitroaromatic compounds to yield diamino aliphatic compounds and provides a solid foundation for understanding such reaction systems.
研究领域:
化学工程
·
催化材料科学
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产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2022
·
IF 9.463
Hafezeh Nabipour,Shuilai Qiu,Xin Wang,Lei Song,Yuan Hu
In this study, adenine was used as an efficient adsorbent for in situ removal of zinc ions, resulting in the formation of a bio-based metal–organic framework (bioMOF). The as-prepared bioMOF was further used as flame retardant additives to prepare fire-safe polymers. TGA results indicated that the bioMOF can improve the char yield in the EP composites. The EP composite with 8.0 wt% bioMOF displayed a high limiting oxygen index (LOI) of 31.0% as well as a UL-94 V-0 rating. Additionally, the peak heat release rate, total heat release, and smoke production rate of the EP composite with 8.0 wt% bioMOF declined by 56.3%, 50.5%, and 72.0%, respectively. Furthermore, the EP composite with 8.0 wt% bioMOF also displayed higher glass transition temperature and better tensile strength than the pristine EP. This work provides a novel approach to preparing fire-safe polymers through recycling waste from adsorbent materials of water decontamination.
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产品关联
DOI
高影响因子
International Journal of Refrigeration
·
2025
·
IF 3.8
Shiya Lin,Yiqi Xie,Xianyang Chen,Pengcheng Lin,Ying Chen
Advanced cold chain systems are essential for maintaining nutritional integrity and reducing spoilage in perishable fruits. However, conventional mechanical refrigeration incurs considerable energy consumption and operational costs. This study introduces a green, safe, and cost-effective alternative—Brine Phase Change Cold Storage Gels (BPCCSGs). With a low phase change temperature (−11.29 °C), high latent heat (242.14 J·g⁻¹), and elevated thermal conductivity (0.835 W·m⁻¹·K⁻¹), BPCCSGs are well-suited for cold chain applications involving subtropical fruits. Additionally, the risk of cold storage material leakage and its consequent detriment to fruit safety could be significantly reduced by using our state-of-the-art gel packaging technique. Gel-based encapsulation effectively minimized leakage risk and prevented potential contamination. Pre-charging BPCCSGs during off-peak hours significantly improved energy and cost efficiency (3.82 × 10⁻⁵ $·J⁻¹), while reducing environmental burden. Moreover, the improvement in thermal conductivity and the optimization of the spatial layout facilitated temperature uniformity of BPCCSGs at cold storage scenarios. Finally, the integration of a 5G-enabled sensor system enabled real-time monitoring of temperatures and locations. The system was successfully deployed in waxberry logistics, ensuring real-time traceability and maintaining fruit quality, highlighting its potential for next-generation cold chain systems.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Baocheng Ji,Wenhao Zhao,Xu Xu,Yu Han,Mingsha Jie,Gaigai Xu,Yanhong Bai
The purpose of this study was to develop a modified QuEChERS method based on melamine sponge for rapid determination of multi-class veterinary drugs in milks by UPLC-MS/MS. Through simple infiltration and extrusion, fast and convenient matrix purification could be achieved within several seconds, and there was no need of extra phase separation operations. Good linearity with correlation coefficient (R 2 ) ≥0.999 was obtained for all drugs in the range of 2~500 µg·kg −1 . The obtained matrix effects were within ±20% for all monitored drugs. The recoveries of all monitored drugs ranged from 60.7% to 116.0% at three spiked levels (50, 100, and 200 µg·kg −1 ), with relative standard deviations less than 7.4%. Comparatively low LODs and LOQs were obtained in the ranges of 0.1~3.8 µg·kg −1 and 0.2~6.3 µg·kg −1 , respectively. Compared with conventional purification adsorbents, melamine sponge yielded an equal or higher purification performance with matrix removal rate as high as 52.5% and acceptable recoveries in range of 60%-120% for all monitored drugs. The satisfactory results have demonstrated the good potential of melamine sponge in matrix purification for rapid determination of multiclass residues in food safety.
研究领域:
分析化学
·
食品安全
·
兽医学
✓ 已验证
DOI
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2018
·Vol. 41
·期 24
·4515-4524
·
IF 2.415
Xiaokang An,Jun Xu,Fengshou Dong,Xingang Liu,Xiaohu Wu,Ran Wang,Yongquan Zheng
An efficient and sensitive analytical method for simultaneous determination of trace amounts of a new insecticide broflanilide and its metabolites (S(PFH-OH)-8007 and DM-8007) residues in five typical Chinese soils (red soil, black soil, fluvo-aquic soil, cinnamon soil and paddy soil) was developed. The samples were prepared by a modified quick, easy, cheap, effective, rugged, and safe method. The determination of broflanilide and its metabolites was conducted by ultra high performance liquid chromatography with tandem mass spectrometry with an electrospray ionization source in the positive ion mode. This is the first report for the determination of broflanilide and its metabolites in different soils. Broflanilide and its metabolites were extracted from all soils with acetonitrile and purified by a mixture of primary secondary amine and graphitized carbon black. The average recoveries of the three compounds in five types of soil ranged from 85.3 to 111.8% and the relative standard deviations were less than 13.6%. The limit of quantification was 0.1 μg/kg for all three compounds. This method was successfully used to determine broflanilide and its metabolites in five types of soil. The method was validated to be simple and effective for the determination of trace residual broflanilide and its metabolites in five types of soil.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2016
·Vol. 39
·期 6
·1090-1098
·
IF 2.741
Yao Li,Xingang Liu,Xiaohu Wu,Fengshou Dong,Jun Xu,Yongquan Zheng
An effective analytical method for the simultaneous determination of a novel insecticide flupyradifurone and its two metabolites was developed using ultra high performance liquid chromatography with tandem mass spectrometry coupled with a quick, easy, cheap, effective, rugged, and safe procedure. The three target compounds were extracted with acetonitrile and cleaned up with octadecylsilane, and were separated successfully between 1.9 and 3.1 min using an HSS T3 chromatographic column connected to an electrospray ionization source. All the matrix-matched samples at three fortified levels (0.01, 0.05, and 0.5 mg/kg) provided satisfactory recoveries in the range of 70.3–116.5% with relative standard deviations below 18.6%. The limits of quantitation were 10 μg/kg for flupyradifurone and difluoroethylamino-furanone and 100 μg/kg for 6-chloronicotinic acid. The limit of quantification of flupyradifurone was far below the maximum residue limit in the USA. The method is of great significance for establishing maximum residue limits in China.
研究领域:
分析化学
·
食品安全
·
环境科学
·
农药残留分析
✓ 已验证
DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Xiang Xiong,Dan Li,Zhifeng Du,Chaomei Xiong,Hongliang Jiang
In this study, conventional Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) method was modified by magnetic solid-phase extraction (MSPE) for purification/pre-concentration of eleven estrogens and estrogen mimics from the extracts of pork and chicken muscles, prior to dansyl chloride (DNS-Cl) derivatization coupled with ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) assay. Dual octadecyl- and 2-aminoethyl-3-aminopropyl- groups functionalized mesoporous silica core-shell magnetic nanoparticles (C 18 /NH 2 -Fe 3 O 4 @mSiO 2 MNPs) were synthesized and employed as MSPE sorbent with remarkable aqueous compatibility in comparison with conventional C 18 functionalized sorbent. The proposed MSPE is easier to handle than the traditional SPE purification process in QuEChERS method. The lab-prepared MNPs were characterized by transmission electron microscope (TEM), brunner-emmet-teller (BET), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), thermo-gravimetric analysis (TGA) and vibrating sample magnetometer (VSM). Pre-column derivatization was conducted to significantly enhance the sensitivity of the analytes in MS/MS via analyzing their derivatives in positive ion mode instead of analyzing their original forms in negative ion mode. Under the optimal sample pretreatment and instrumental analysis conditions, the approach showed low limits of detection (LODs, 0.02‒3.00 µg kg –1 ), appropriate recoveries (81.1‒115.4%) and acceptable precisions (0.48‒15.1%, n = 6), with good feasibility and future prospect of trace compounds analysis in complex food samples.
研究领域:
分析化学
·
食品安全
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）