EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY
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2017
·Vol. 119
·期 10
·1600105
·
IF 2.145
Qiaoxian Huang,Jian Chen,Chunjiang Liu,Cheng Wang,Chenghui Shen,Yiyi Chen,Qingyong Li
Adding antioxidant is one of the most effective ways to prevent oil systems from oxidation. Curcumin (Cur) and its derivatives have a significant antioxidant activity as potential antioxidants. In this work, the oxidative stability of fish oil treated with three different concentrations (0.1, 0.2 and 0.3 mg/g) of Cur, its two synthetic analogues (compounds 14 and 25 ) and α-tocopherol (positive control) are determined after 70 days at 4 and 25 °C. The antioxidants are evaluated by acid (AV), peroxide (PV), conjugated diene (CD) values, thiobarbituric acid-reactive substances (TBARS) as well as polyunsaturated fatty acid (PUFA) in fish oil. Results show that Cur and α-tocopherol could protect fish oil from oxidation more effectively than compound 14 and 25 at 4 °C, whereas compound 14 and 25 could protect fish oil from oxidation more effectively than Cur and α-tocopherol at 25 °C. Temperature is an important factor on lipid oxidation in the process of fish oil storage resulted from antioxidant activity of compounds determined by temperature. Curcumin shows the decreased ability to protect fish oil from oxidation with increasing temperature. Compounds 14 and 25 show increasing ability to protect fish oil from oxidation with increasing temperature. Practical applications: Compounds 14 and 25 are potential antioxidants to extend expiration date of the fish oil product. Temperature is a key variable for fish oil storage. Compounds 14 and 25 show higher biological stability than that of Curcumin. In long-term storage at 25 °C, compounds 14 and 25 perform better antioxidant activity in fish oil than Curcumin, and tocopherol.
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RSC Medicinal Chemistry
·
2025
·
IF 3.6
Kehan Chen,Hui Yang,Guo Xu,Yunhan Hu,Xue Tian,Song Qin,Tianyue Jiang
Topical delivery of therapeutics on the skin can effectively alleviate skin symptoms of psoriasis and reduce systemic toxicity. However, the low delivery efficiency caused by the stratum corneum barrier limits the therapeutic impact. Here, we reported an oligopeptide hydrogel that encapsulates cell-penetrating-peptide (CPP)-decorated curcumin-loaded nanoemulsions (Cur-CNEs) to enhance the skin penetration of curcumin for topical treatment of psoriasis. After being applied to the skin of psoriatic mice, the Cur-CNE embedded oligopeptide hydrogel (Cur-CNEs/Gel) provided a prolonged residue time of Cur-CNEs on the skin lesion. The fluidic and elastic properties of the nanoemulsions enabled them to effectively pass through the interstitial spaces of the stratum corneum, while the CPP decoration further enhanced skin penetration and cellular uptake of Cur-CNEs. The Cur-CNEs/Gel exhibits effective alleviation of the symptoms of psoriasis in mice and provides a promising strategy for topical treatment of psoriasis.
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Food Biophysics
·
2024
·
IF 2.8
Weng Shuni,Su Huanhuan,McClements David Julian,Wang Yuting,Li Teng,Fu Yuying
Curcumin (CUR) is found to exhibit a broad spectrum of potentially beneficial biological activities, which make it suitable as a nutraceutical ingredient in functional foods and supplements. But its application for this purpose is often limited by its low water-solubility, chemical stability, and bioavailability. In this study, acid-treated soybean protein isolate (SPI) and chitosan quaternary ammonium salt (CQAS) were used to assemble colloidal carriers for CUR to form soybean protein isolate-curcumin-chitosan quaternary ammonium salt nanoparticles (SPI-CUR-CQAS NPs). The nanoparticles formed were relatively small (< 400 nm), approximately spherical, and strongly positively charged (> 45 mV). Fluorescence spectroscopy demonstrated that the dominant interaction between CUR and SPI was hydrophobic attraction, while the dominant interaction between CQAS and SPI was electrostatic attraction. The encapsulation efficiency (95.4%) and loading capacity (14%) of the SPI-CUR-CQAS NPs (pH 1.5) were relatively high. The vitro digestion experiments showed that the CUR was progressively released from the nanoparticles under stomach, small intestine, and colon conditions. Moreover, the final bioavailability of the encapsulated CUR (63%) was much higher than for free CUR (18.5%). The SPI-CQAS NPs developed in this study can therefore be used as an effective delivery system for CUR in functional foods.
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PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2025
·
IF 2.5
Jie Wang,Xuemei Gu,Xia Gao,Jing Chen,Zhiyang Lv,Siyu Zhang,Siyu Ni,Fei Shi,Xialin Chen,Liang Cao,Zhenzhong Wang,Wei Xiao
In order to enhance the therapeutic value of curcumin in liver cancer treatment, glycyrrhetinic acid-modified pH-sensitive curcumin liposomes (GA-pH-Lip@Cur) was developed.GA-pH-Lip@Cur was prepared using a thin film dispersion ultrasonication method, and the optimal formulation process was selected through single-factor experiments and a Box-Behnken design-response surface methodology. The liposomes were evaluated for their morphological appearance, particle size, in vitro release at different pH levels, and biocompatibility. The anti-tumor effect of GA-pH-Lip@Cur was assessed using cell viability assays (CCK-8). The in vivo hepatic targeting and anti-liver tumor efficacy of GA-pH-Lip@Cur were evaluated through pharmacokinetic and pharmacological experiments.The results indicated that optimized GA-pH-Lip@Cur exhibited uniform particle size distribution, good stability, pH-sensitive in vitro release with sustained behavior. Compared to conventional liposomes, GA-pH-Lip@Cur showed prolonged average retention time in vivo and significantly increased curcumin distribution in liver tissues, indicating excellent liver targeting. Both in vitro and in vivo evaluations demonstrated the effectiveness of GA-pH-Lip@Cur in inhibiting liver cancer cell proliferation and suppressing liver tumor growth in tumor-bearing mice. In conclusion, GA-pH-Lip@Cur, by leveraging the acidic tumor microenvironment and overexpression of glycyrrhetinic acid receptors in liver cells, encapsulates curcumin to improve its bioavailability, and target its delivery to the liver tumor sites.
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JOURNAL OF PHYSICAL CHEMISTRY B
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2025
·
IF 2.9
Zhuoni Liu,Xianshuo Zhang,Xiaoyong Wang,Tianxiang Yin
Eutectic solvents (ESs) have shown great efficiency on increasing the solubility, stability, and bioactivity of active pharmaceutical ingredients (APIs) in recent research studies. Curcumin is an important API driven from natural plants, which displayed a series of biofunctions like antibacterials, anti-inflammatory, and anticancer activities etc. However, its poor water solubility and stability hindered its further clinic application. Herein, a series of novel ESs based on matrine and fatty acids (i.e., octanoic acid, decanoic acid, and lauric acid) were developed. The phase behavior and cytotoxicity of these ESs were investigated. Moreover, the prepared ESs displayed excellent ability on enhancing the solubility of curcumin with the highest solubility being 28 mg/mL at 298 K, which was nearly 50000-fold than that in water. The curcumin showed high stability in ESs, where only 10% of curcumin decomposed under light irradiation for 6 h. Furthermore, biofilms based on these ES solutions of curcumin have been prepared and displayed high antioxidant and antibacterial activities. To summarize, the prepared eutectic systems provide a new strategy for further application of curcumin.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Siyi Liu,Yuxi Wang,Yue Huang,Mengtao Hu,Xiangxiang Lv,Yuhao Zhang,Hongjie Dai
In this study, the curcumin was firstly encapsulated in gelatin (GLT) and/or cellulose nanocrystals (CNC) stabilized emulsions, then further mixed with sodium alginate (SA) to form emulsion-filled hydrogel beads loaded with curcumin (Cur). The Cur-loaded emulsions showed a droplet size of 20.3–24.4 μm with a uniform distribution. Introducing CNC and/or SA increased the viscosity of emulsions accompanied by viscoelastic transition, while the modulus was reduced due to destruction of GLT gel. Cur was doubly immobilized in the hydrogel beads with >90 % of encapsulation efficiency. The results of simulated gastrointestinal tract experiments revealed that the beads possessed a good pH sensitivity and controlled release behavior to prolong the retention of Cur in the gastrointestinal tract. After 6 h of UV irradiation, the Cur-loaded emulsion-filled hydrogel beads showed a higher antioxidant activity than that of pure Cur, effectively delaying the photodegradation of Cur. In addition, the beads had better stability in aqueous and acidic environments, which was favorable for prolonging the release of Cur. These results suggest that the emulsion-filled hydrogel beads have great potential for the delivery of lipophilic bioactive molecules.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Yue Cao,Yanchen Wang,Xin Zhang,Bo Ren,Bo Wang,Xiaodong Yang
Due to the heterogeneity of the tumor, it is difficult to achieve complete ablation of the tumor by single photothermal treatment. Moreover, their broader use is constrained by the intrinsic high uptake in the reticuloendothelial system (RES) organs, resulting in slow elimination from the body and potential toxicity. In this study, we report a single-step synthetic approach to fabricate versatile FeCP-NPs, leveraging the coordination bonds formed between bioactive polyphenolic compounds (curcumin), Fe III ions, and polyvinyl pyrrolidone (PVP). The FeCP-NPs possess the following favorable characteristics: (1) The components of FeCP-NPs originate from natural products, an endogenous element, and an FDA-approved polymer, guaranteeing good biosafety. (2) FeCP-NPs exhibit excellent photothermal properties. (3) After the photothermal treatment is completed, the dynamic disassembly strategy triggered by deferoxamine mesylate (DFO) can induce the dissociation of nanoparticles and achieve rapid clearance in vivo. (4) Curcumin released during the disassembly of FeCP-NPs can be combined with photothermal therapy to achieve complete tumor ablation. A comprehensive analysis of the safety, biodistribution, and clearance patterns of FeCP-NPs is conducted in vitro or in vivo. This work provides a nanoparticle with great clinical translational potential and provides a new solution for inhibiting tumor growth.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Yuejiao Wu,Jian Yang,Ke Shen,Liyan Liu,Jing Cao,Zhaomei Wang
Curcumin (Cur) is a bioactive nutraceutical with great potential in biological, nutritional, and medical applications. However, these applications are limited by various factors such as insufficient ingestion, low aqueous solubility, and relatively high toxicity to normal cells. To tackle these obstacles, we synthesized a novel Cur-modified-rhamnogalacturonan (RG-C) nano-micelle carrier to target-deliver Cur to hepatocellular carcinoma HepG2 cells via specific recognition of RG-I by the overexpressed surface galactin-3 receptor. Fourier transfer infrared, UV–vis, and 1 H NMR analyses confirmed the conjugation between RG and Cur RG-C loaded with Cur (RG-CC) was formed via self-assembly in an aqueous solution with a drug loading efficiency of 12.2%. RG-CC micelle was ellipsoidal or cubic with a size ranging between 100 and 200 nm by scanning electron microscopy observation. Cur release from RG-CC exhibited a controlled and pH-dependent manner with 50% at pH 5.0 in contrast to 5% at pH 7.4 after 24 h exposure. RG-CC possessed more potent anti-proliferative activity against HepG2 cells than normal embryonic kidney 293T cells. Compared to free Cur, both the anti-proliferative effect and uptake of RG-CC were significantly higher in HepG2 cells as revealed from laser confocal microscopy and flow cytometry analyses. RG-CC was a promising anticancer candidate and deserves further preclinical and clinical investigations.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Long Jiao,Yuwei Li,Mingyu Tian,Shuyi Zhao,Xiaoye Zhang,Soottawat Benjakul,Bin Zhang
A novel class of halogenated curcumin, X-Cur (X = F, Cl, or Br), was synthesized, and its photosensitivity was evaluated. The results showed that Br-Cur with the highest singlet oxygen (1O2) generation capacity exhibited a better photodynamic inactivation (PDI) effect on the small yellow croaker (Larimichthys polyactis) than curcumin. This was attributed to the heavy atom effect of Br, which resulted in Br-Cur having the smallest singlet–triplet energy difference ΔEst(S1-T3) (0.140 eV) and the largest spin–orbit coupling value (0.642262 cm–1). When L. polyactis was treated with 0.025 wt % Br-Cur and exposed to blue LED irradiation (450 nm, 20 mW/cm2) for 20 min, the increase in the total volatile basic nitrogen content (28.23 ± 2.38 mg/100 g on day 6), pH, and total viable count (6.13 ± 0.06 log CFU/g on day 6) could be effectively controlled. Accordingly, Br-Cur is a promising photosensitizer for PDI preservation.
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Food Bioscience
·
2024
·
IF 4.8
Lei Zhong,Jiangrong Tian,Qiuhui Hu,Liyan Zhao,Qiping Zhan,Mingwen Zhao
Curcumin is a hydrophobic dietary supplement and can mitigate oxidative damage. However, the low bioavailability of curcumin impedes its application in functional foods. Protein-coated nanoparticles are susceptible to environmental stress and have limited ability to reach mitochondria, where reactive oxygen species are generated. To overcome this limitation, we prepared mitochondria-targeted nanoparticles by modifying glycosylated oat protein isolate with triphenylphosphonium bromide for the efficient delivery of curcumin. In this study, the curcumin was incorporated into the spherical nanoparticles with high entrapment efficiency and loading capacity. The nanoparticles increased the stability of curcumin during heat treatment and light irradiation. The bioavailability of curcumin was improved in the nanoparticles due to their strong resistance against in vitro gastric digestion and good permeability across the Caco-2 cell monolayer. The nanoparticles realized lysosomal escape and exhibited specific accumulation in mitochondria upon internalization by Caco-2 cells. The mitochondria-targeted nanoparticles with no cytotoxicity further enhanced the antioxidant activity of curcumin by preserving mitochondrial membrane potential, increasing antioxidant enzyme activities, decreasing the concentrations of intracellular reactive oxygen species and malondialdehyde. This study highlights the potential application of glycosylated proteins in developing nanocarriers for precise delivery of hydrophobic nutrients.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Shaoyi Cao,Jingpeng Wang,Wenye Sun,Bang An,Mingcong Xu,Sha Luo,Chunhui Ma,Haipeng Yu,Zhijun Chen,Jian Li,Wei Li,Shouxin Liu
Cellulose nanocrystal (CNC) -based circularly polarized luminescent (CPL) materials, which are responsive to external stimuli, have attracted increasing attention in developing smart chiral photonic materials. In this study, chiral nematic bio-composite CNC films with right-handed (R-) CPL emission and tunable dissymmetry factors (g lum ) were prepared by encapsulating curcumin in chiral nematic CNC films via an evaporation-induced self-assembly strategy. The CPL active bio-composite CNC films exhibit multiple responsiveness to relative humidity (RH) and pH. It is noted that the pH response of the composite films is visualized, which is reflected in the variation of film colors, fluorescence, and CPL emission wavelengths. Additionally, with a hydrophobic treatment, the bio-composite CNC films exhibit enhanced water resistance and pH-responsive CPL in acid/base aqueous solutions. Based on the responsive circular polarization information, the bio-composite CNC films were developed as optical labels for multiple anti-counterfeiting applications. The reported environmentally friendly bio-composite CNC films provide a new reference for utilizing natural polysaccharides to build multi-mode responsive CPL materials.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Yunmei Li,Huilin Ma,Huan Shi,Biaobiao Wang,Desheng Li,He Tian,Xifan Mei,Chao Wu
Ulcerative colitis is an inflammatory disease that primarily involves intestinal inflammation and epithelial damage. The nano-targeted drug delivery system delivers drugs to the disease site, exerting effects such as inhibiting inflammatory response and reducing reactive oxygen species expression, thereby promoting recovery from ulcerative colitis. In this experiment, dextran sulfate-coated curcumin nanocrystals (NBD) were prepared for the oral treatment of ulcerative colitis (UC). NBD not only significantly enhances the water solubility and stability of curcumin but also possesses the ability of sustained release and targeting inflammatory macrophages. The sustained release effect of NBD was demonstrated by in vitro release experiments. In simulated gastric fluid, the cumulative release amount of NBD at 2 h was 21.99 ± 1.93 %, while in simulated colonic fluid, the cumulative release amount of NBD at 12 h was 84.98 ± 2.02 %. The ability of NBD to target inflammatory macrophages was verified through the transwell system, rat one-way intestinal perfusion experiment and in vivo imaging system. The in vitro and in vivo (mice) anti-inflammatory and antioxidant capacities of NBD were validated using immunofluorescence experiment, ELISA kits and reactive oxygen species-related detection kits. The results indicated that NBD could reduce inflammatory responses, promote macrophage polarization and inhibit oxidative stress. In addition, the therapeutic effect of NBD was further confirmed in this experiment by the clostridium perfringens-induced necrotizing enteritis model in chickens. In conclusion, NBD might be a potential pharmaceutical preparation for the treatment of UC.
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