POLYMER
·
2016
·
IF 3.586
Gang Li,Guoping Zhang,Rong Sun,Ching-Ping Wong
Via the radical polymerization of 2-(dimthylamino) ethyl methacrylate in the polyacrylic acid solution, we obtain the dually pH-reponsive polyelectrolytes complex hydrogel, which could be triggered to be swollen either in acid and basic environments. The results show that the responsive behavior of these PEC hydrogels is insensitive to monomer concentration in the prepolymerization, but can be tuned by changing the charge ratio or introducing chemical crosslinker. Moreover, other amazing propertise of the prepared PEC hydrogel are presented, which are including the ionic strength-responsiveness, the modest mechanical property (a tensile stress of 0.2 MPa and a tensile strain of 1500%) and the self-healing ability (a self-healing efficiency of ca. 70%). In brief, we report a multi-functional hydrogel which might serve as a new platform for responsive materials.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Xuegang Li,Pengqi Gong,Qiming Zhao,Xue Zhou,Yanan Zhang,Yong Zhao
A novel DNA hybridization optical fiber sensor with temperature and pH compensation for detecting a common lung cancer gene of epidermal growth factor receptor (EGFR) gene was demonstrated in this paper. The paper proposes the first research to achieve dual surface plasmon resonance (SPR) in an Fiber Bragg grating (FBG) and implement a three-parameter detection of DNA sequence , temperature and pH using a single fiber. Probe DNA sequences (pDNA) and PAA/CS, a pH-sensitive material, are immobilized on the sensor surface for EGFR gene exon-20 detection and temperature and pH monitoring simultaneously. The effectiveness of this functionalized method has been proved by using an atomic force microscope (AFM) and scanning electron microscope (SEM). The limit of detection (LOD) of EGFR gene was experimentally verified to 13.5 nM. The advantages of fast response, high sensitivity, label free, plug in, low LOD and three-parameter detection demonstrated by this sensor in the experiment are important for the field of DNA hybridization research and solving the problems of biosensor susceptibility to temperature and pH.
研究领域:
生物医学工程
·
分子生物学
·
光学传感
✓ 已验证
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 1
·399
·
IF 4.6
Chen Zhang,Qiong Yuan,Ziqi Zhang,Yanli Tang
Stimuli-responsive drug release and photodynamic therapy (PDT) have aroused extensive attention for their enormous potential in antitumor treatment. pH-responsive drug delivery systems (PFE-DOX-1 and PFE-DOX-2) based on water-soluble conjugated polymers were constructed in this work for high-performance synergistic chemo-/PDT therapy, in which the anticancer drug doxorubicin (DOX) is covalently attached to the side chains of the conjugated polymers via acid-labile imine and acylhydrazone bonds. Concurrently, the intense fluorescence of poly(fluorene-co-ethynylene) (PFE) is effectively quenched due to the energy/electron transfer (ET) between the PFE-conjugated backbone and DOX. Effective pH-responsive drug release from PFE-DOX-2 is achieved by the cleavage of acylhydrazone linkages in the acidic tumor intracellular microenvironment. Additionally, the drug release process can be monitored by the recovered fluorescence of conjugated polymers. Furthermore, the conjugated polymers can produce reactive oxygen species (ROS) under light irradiation after drug release in an acidic environment, which prevents possible phototoxicity to normal tissues. It is noted that PFE-DOX-2 demonstrates remarkable antitumor cell performance, which is attributed to its efficient cell uptake and powerful synergistic chemo-/PDT therapeutic effectiveness. This report thus provides a promising strategy for in vivo anticancer treatment with the construction of a stimuli-responsive multifunctional drug delivery system.Keywords:conjugated polymer;drug release;photodynamic therapy;chemotherapy;antitumor treatment;synergistic therapy
研究领域:
材料科学
·
生物医学工程
·
肿瘤学
·
聚合物化学
✓ 已验证
DOI
PubMed
高影响因子
Polymer Chemistry
·
2014
·Vol. 6
·期 7
·1127-1136
·
IF 5.368
Shangfeng Wang,Bin Wu,Feng Liu,Yun Gao,Weian Zhang
We herein report a new strategy to fabricate novel well-defined alternating copolymers of poly(VBCDEG-alt-SaAEMI)s which were synthesized via alternating RAFT copolymerization of para-methoxydiethylene glycol-substituted styrenes (VBCDEG) and N-(2-salicylaldehyde-aminoethyl)maleimides (SaAEMI). 1H NMR, 13C NMR, FTIR and GPC results indicate that poly(VBCDEG-alt-SaAEMI) copolymers have well-defined alternating structures and narrow polydispersity (Mw/Mn < 1.35). It is interesting that poly(VBCDEG-alt-SaAEMI) alternating copolymers exhibit an excellent selective fluorescence “OFF–ON” response to Zn2+ by inhibiting the photoinduced electron transfer (PET) effect through copolymerization, while the monomer SaAEMI almost has no fluorescence response to Zn2+ due to the PET process. The sensors based on poly(VBCDEG-alt-SaAEMI) alternating copolymers have very fast response (30 s) to Zn2+, 62-fold fluorescence enhancement in aqueous solution and a detection limit of about 0.25 μM. Additionally, the poly(VBCDEG-alt-SaAEMI) alternating copolymers also show a remarkable green fluorescence “OFF–ON” switch (230∼fold) when the pH turns from 11 to 12, thus these copolymers have potential application in dual-color detection.
研究领域:
材料化学
·
分析化学
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Zejun Liu,Jinquan Wan,Yongwen Ma,Yan Wang
The traditional Electro-Fenton (EF) is an efficient technology for wastewater treatment but suffers from the acidic condition requirement and external catalyst addition. To overcome these challenges, a GF@MoS 2 @FeOCl cathode was fabricated using a facile method. The as-prepared GF@MoS 2 @FeOCl cathode showed excellent performance for ciprofloxacin (CIP) degradation in EF process with RuO 2 /Ti electrode as the anode. H 2 O 2 was electro-generated and activated on-site at the cathode at mild pH without adding Fe 2+ . CIP was 100% removed with 74.4% of mineralization in 90 min at pH 6. The GF@MoS 2 @FeOCl cathode exhibited good reusability after consecutive runs of degradation. The degradation intermediates were investigated, and the possible mechanism was proposed. This work demonstrated that the prepared GF@MoS 2 @FeOCl cathode is a promising candidate for contaminants treatment in an EF system.
研究领域:
环境科学
·
材料科学
·
污水处理
✓ 已验证
DOI
PubMed
高影响因子
ACS Nano
·
2021
·
IF 15.881
Zhijie Zhang,Xiao Xiao,Yihao Zhou,Linjun Huang,Yanxin Wang,Qinglin Rong,Zhenyang Han,Huaijiao Qu,Zhijun Zhu,Shumao Xu,Jianguo Tang,Jun Chen
Tunable gating graphene oxide (GO) membranes with high water permeance and precise molecular separation remain highly desired in smart nanofiltration devices. Herein, bioinspired by the filtration function of the renal glomerulus, we report a smart and high-performance graphene oxide membrane constructed via introducing positively charged polyethylenimine-grafted GO (GO-PEI) to negatively charged GO nanosheets. It was found that the additional GO-PEI component changed the surface charge, improved the hydrophilicity, and enlarged the nanochannels. The glomerulus-inspired graphene oxide membrane (G-GOM) shows a water permeance up to 88.57 L m–2 h–1 bar–1, corresponding to a 4 times enhancement compared with that of a conventional GO membrane due to the enlarged confined nanochannels. Meanwhile, owing to the electrostatic interaction, it can selectively remove positively charged methylene blue at pH 12 and negatively charged methyl orange at pH 2, with a removal rate of over 96%. The high and cyclic water permeance and highly selective organic removal performance can be attributed to the synergic effect of controlled nanochannel size and tunable electrostatic interaction in responding to the environmental pH. This strategy provides insight into designing pH-responsive gating membranes with tunable selectivity, representing a great advancement in smart nanofiltration with a wide range of applications.
研究领域:
材料科学
·
纳米技术
·
环境工程
·
化学工程
✓ 已验证
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Yiqian Lv,Bo Wang,Jingmao Zhao,Haiqing Liu,Ziji Li,Fangze Zi,Yuhao Guo
To overcome the critical limitation of conventional epoxy coatings in providing long-term barrier effect against corrosion species and on-demand corrosion inhibition at damaged sites, this study develops a self-protective CeO 2 @ZrP/EP composites coating via in-situ hydrothermal growth of pH-responsive CeO 2 nanoparticles on lamellar α-ZrP nanosheets. The hydroxyl-rich CeO 2 nanoparticles not only enhance interfacial compatibility by filling voids and creating mechanical interlocking between α-ZrP nanosheets and the epoxy matrix, but also enable pH-triggered Ce 3+/4+ release under acidic condition. After 60 days immersion, the composite coating achieved a low-frequency impedance modulus (|Z| 0.01Hz ) of 3.5 × 10 9 Ω·cm 2 , which is four orders of magnitude higher than pure EP coating (3.7 × 10 5 Ω·cm 2 ). Crucially, elemental mapping confirmed 2.0 wt% cerium enrichment at artificial scratches, demonstrating autonomous active inhibition. This dual-action strategy synergistically integrates durable barrier protection with intelligent corrosion inhibition, providing long-term steel protection in marine environments.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2019
·
IF 2.606
Haoyuan Cai,Peng Wang,Dun Zhang
Application of the polymer capsules as vehicles for antibacterial surface against bacterial infections is restricted by spontaneous leakage and specifically responsive release of antibacterial agents. Herein, we present the integration of pH-responsive nanocapsules as delivery tools for hydrophobic biocide within layer-by-layer (LbL) films utilizing alternating imine linkages as the driving force for assembly, thus enabling the introduction of drug and controlled release. The novel capsules are fabricated by means of electrostatic LbL assembly, namely, tannin acid/chitosan nanocapsules embedded with triclosan@cetyltrimethylammonium bromide micelles (TCS@CTAB/TA/CH). The nanocapsules achieve an excellent pH-responsive activity that the release efficiency of antibacterial agent triclosan (TCS) increases by nearly 61.8% from pH 8 to 4. Subsequently, the smart nanocapsules are alternatively incorporated via imine linkage into the dextran aldehyde (DA) polyelectrolyte multilayers in LbL deposition (denoted as (DA-TCS@CTAB/TA/CH) n films). The as-prepared samples are characterized by FTIR, FESEM, TEM, DLS and AFM . Noticeably, the (DA-TCS @CTAB/TA/CH) 20.5 film exhibites optimal pH-responsive activity with release concentration of TCS up to 4.01 mg/L at pH 6. The bacteriostatic percentages of (DA-TCS@CTAB/TA/CH) 20.5 against E . coli and P . aeruginosa are respectively 99.62% and 97.35% after 24-h incubation at pH 6. Besides, the multilayers are capable of supplying a long-term (30 days) antibacterial property. The self-polishing mechanism of (DA-TCS@CTAB/TA/CH) n films is proposed to illuminate the enhanced antibacterial and antiadhesive performances. It seems that the films present a promising way to incorporate biocide to resist bacterial infections and prolong the antimicrobial activity of antibacterial surface.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2014
·Vol. 161
·期 4
·H249
·
IF 2.859
Yong Kong,Yan Sha,Shengkai Xue,Yong Wei
A novel conducting polymer, poly(aniline-co-p-aminobenzoic acid) (PAABA), was successfully synthesized via electrochemical copolymerization of aniline and p-aminobenzoic acid (p-ABA) in 2 M H2SO4 solution. The results of FTIR and SEM revealed the differences between the obtained copolymer and its two corresponding homopolymers. Compared to polyaniline which has a rather limited useful pH range, PAABA presents excellent redox activity from pH < 1.0 to pH 10.0. The ion exchange properties of the copolymer were also investigated by using electrochemical quartz crystal microbalance (EQCM) and cyclic voltammetry, demonstrating a special anion exchange behavior different from polypyrrole. In other words, the spatial structure of anions instead of the radius of anions studied plays a key role in the anion exchange affinity sequence.
研究领域:
材料科学
·
电化学
·
高分子化学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2020
·Vol. 11
·期 12
·2098-2109
·
IF 5.342
Jian Zhang,Xiaomin Zhu,Cheng Miao,Yanzhe He,Youliang Zhao
Despite tremendous progress in macromolecular self-assembly, the influence of topology and hydrolysis on hierarchical self-assembly has been scarcely revealed. This study aims at the design of toothbrush-like copolymers with linear and cyclic backbones to reveal multi-tunable properties, and the introduction of pH/oxidation-responsive and hydrolyzable Y junctions endows the copolymers with unique hydrolysis-induced topological and morphological transformations. The cyclization of the polymer backbone can lead to distinct bulk and solution properties such as chain relaxation, solution viscosity and self-assembly, revealing the crucial role of cyclic architecture. Upon pH and oxidation stimuli, at least eight kinds of distinct nanostructures involving spheres, vesicles, disks and sea urchins are achieved by self-assembly. Hydrolysis-induced (co)assembly dependent on topology, pH and hydrolysis time offers programmable formation of a diversity of nanostructures. Both toothbrushes can self-assemble into unilamellar vesicles, while the vesicles bearing cyclic toothbrushes are readily converted into double-lamellar vesicles upon heating, sonication and short-time pH stimulus. Our research can provide new insight into topology-related formation and transition processes of polymer nanoparticles. The success of this study paves the way for macromolecular engineering towards promising shape-dependent properties and applications.
研究领域:
高分子化学
·
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2021
·
IF 4.749
Dan Zheng,Jingyang Zhao,Yucheng Li,Liyu Zhu,Mengchen Jin,Luying Wang,Jing Liu,Jiandu Lei,Zhonglong Li
In tumor therapy, polymer nanoparticles are ideal drug delivery materials because they can mask the disadvantages of anti-tumor drugs such as poor solubility in water, high toxicity, and side effects. However, most polymer-based nanoparticles do not themselves have anti-tumor properties. Herein, a novel pH-sensitive nanoparticle drug delivery system based on Ganoderma lucidum polysaccharides (GLPs), which have demonstrated anti-tumor activities, was designed to enable the delivery of methotrexate (MTX) and 10-hydroxycamptothecin (HCPT) to tumor cells, where they could exert synergistic anti-tumor effects. The prepared nanoparticles were irregularly spherical in shape with a uniform particle size of ∼190 nm, and they exhibited a high drug-loading capacity (MTX 21.5% and HCPT 22.6%) and excellent biocompatibility. Moreover, the loaded MTX and HCPT units were rapidly released under acidic conditions within the tumor cells while remaining stable under normal physiological conditions. Meanwhile, compared to free MTX and HCPT, the GLP–APBA–MTX/HCPT nanoparticles presented exhibited better tumor suppressive effects and fewer side effects in vivo, which indicates that they may be an effective anti-tumor treatment strategy.
研究领域:
药学
·
肿瘤学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
BIOMATERIALS
·
2013
·
IF 7.604
Shuai Xu,Jing Liu,Dian Li,Liming Wang,Jia Guo,Changchun Wang,Chunying Chen
We propose a modular synthetic strategy to constitute metallosalphen prodrugs in the form of coordination polymer nanoparticles , comprising magnetite nanocrystal colloidal cluster as core and salphen-In III coordination polymer as shell. These composite nanoparticles are not only equipped with intense photoluminescence , sensitive magnetic responsiveness and pH-dependent degradability, but also serve as prodrugs to accomplish intercellular conversion from non-toxic nanoparticles (Fe 3 O 4 @Salphen-In III ) to pharmacologically active complexes (Fe–salphen), allowing to specifically inhibit the proliferation of A549 cancer cells via caspase activation.
研究领域:
材料科学
·
生物医学工程
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）