Membranes
·
2022
·Vol. 12
·期 11
·1151
·
IF 4.562
Jiawen Wu,Zhiwen Li,Qingfeng Zhou,Mercy Chigwidi,Yang Jiao,Yanchao Xu,Hongjun Lin
The co-deposition between polyphenols and amines has been demonstrated in order to prepare positively charged nanofiltration (NF) membranes for multivalent cation rejection in recent years; however, the low reactivities of the involved polyphenols usually cause a long co-deposition time and unsatisfactory rejection. Herein, a novel plant polyphenol (PG) was co-deposited with tetraethylenepentamine (TEPA) in a much shorter time period to prepare positively charged NF with high multivalent cation rejection membranes. The performance of the co-deposition membranes can be easily controlled by adjusting the mass ratio of PG and TEPA, reaction time, and pH value of the buffer solution. The optimal membrane, prepared under a polyphenol and polyamine mass ratio of 1:1, coating time of 2 h, and pH value of 8.0, shows a decent pure water permeability of 8.43 L m−2h−1bar−1while maintaining a superior 96.24% MgCl2rejection. More importantly, the universality of this method was corroborated by employing other amines with different molecular weights in the co-deposition. This work provides new insights for the preparation of high-performance positively charged NF membranes.
研究领域:
材料科学
·
环境工程
·
化学工程
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DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 42
·6508-6514
·
IF 5.047
Hui Huang,Juan Bai,Jiao Li,Lulu Lei,Wenjing Zhang,Shujun Yan,Yongxin Li
In this work, a fluorometric and colorimetric analysis of alkaline phosphatase (ALP) activity was developed based on nanozymes. The nanozymes were composed of nucleotides (ATP, ADP and AMP) coordinated with copper ions. All three kinds of nanozymes (ATP-Cu, ADP-Cu and AMP-Cu) exhibited polyphenol oxidase (PPO)-mimic activity by catalyzing a chromogenic reaction of 2,4-dichlorophenol (2,4-DP) and 4-aminoantipyrine (4-AP). However, there were obvious differences in the PPO-like activity and the fluorescence of the three nanozymes produced from the same concentration of nucleotides (keeping the concentration of Cu2+ unchanged at 5 mM). The catalytic activities of produced ADP-Cu and AMP-Cu were obviously higher than that of ATP-Cu at a certain nucleotide concentration of 3 mM. In addition, when ATP was hydrolyzed into ADP and AMP by ALP, more nanozymes were produced and the catalytic activity of the system was enhanced, which resulted in an obvious increase of the colorimetric signal. The signal intensity was proportional to ALP concentration in the range of 0–30 U L−1, and the detection limit for ALP was 0.3 U L−1 from the colorimetric detection. Moreover, the fluorescence intensity of the produced nanozymes was also proportional to the ALP concentration in the range of 1–30 U L−1 and the detection limit was 0.45 U L−1 from the fluorescence detection. A fluorometric and colorimetric sensing ALP method was thus established. The method showed a high selectivity for ALP activity compared with proteins, amino acids and other interference components. Furthermore, the proposed method was also used to detect ALP activity in human serum samples, which showed great potential for diagnostic and practical purposes.
研究领域:
生物化学
·
医学诊断
·
分析化学
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DOI
PubMed
高影响因子
RENEWABLE ENERGY
·
2022
·
IF 8.634
Rulu Huang,Huai Liu,Junhua Zhang,Yuan Cheng,Liang He,Lincai Peng
Design catalytic materials with high Lewis acid/base sites for catalytic transfer hydrogenation (CTH) of levulinic acid (LvA) to γ-valerolactone (GVL) is highly demanded but challenging. Herein, we report a concept of metal ion-polymer hybridization to design a tea polyphenol (TP) and HfCl 4 co-doped polyacrylonitrile (PAN) nanofiber (Hf@PAN-TP) via electrospinning technique . Comprehensive characterization revealed the well coordination between hafnium ions and phenolic hydroxyl groups of TP on PAN fiber, which promoted the formation of Lewis acid and Lewis base sites. As expected, a satisfactory GVL yield of 99.1% with 100% of LvA conversion was obtained using isopropanol as a hydrogen donor at 170 °C in 5 h, and the catalytic activity remained unchanged for five cycles. The kinetic study revealed the lower activation energy for CTH of LvA to GVL (33.5 kJ/mol), demonstrating the outstanding GVL formation rate of 3383.9 μmol/g . h. Based on the systematical combine of catalyst characterization and catalytic behavior, the structure-function relationship and reaction mechanism were proposed. More gratifyingly, Hf@PAN-TP was applicable for catalytic reduction of various carbonyl compounds, demonstrating a great potential for upgrading biomass-derived aldehydes/ketones.
研究领域:
材料科学
·
催化化学
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DOI
高影响因子
Frontiers in Nutrition
·
2026
·
IF 5.5
Hong Wang,Bingqi Huang,Wenhong Zhao,Gongliang Liu,Weidong Bai
Introduction Chinese olive ( Canarium album L.) is a rich source of phenolic compounds and has been suggested to exhibit distinct lipid-lowering bioactivities from those reported for Mediterranean olive polyphenols. Methods This study investigated the effects of polyphenol-rich Chinese olive extracts on sodium oleate-induced lipid accumulation in HepG2 cells. Results Treatment with extracts was associated with a significant reduction in intracellular total lipid and triglyceride levels in a concentration-dependent manner. RT-qPCR results revealed that extract treatment was accompanied by the downregulation of lipogenesis-related genes (SREBP-1c, ACC1, FASN, and DGAT2) and the upregulation of β -oxidation-associated genes (PGC-1α, PPARα, CPT-1A, and ACOX1). Western blot analysis showed that extract treatment was associated with AMPK phosphorylation, occurring concurrently with the observed lipid-associated changes. Furthermore, treatment with extracts was accompanied by decreased expression of miR-122 and miR-21, which correlated with the expression of their respective lipid-metabolism target genes. UPLC–MS/MS analysis identified 39 phenolic compounds in the extract, including methyl brevifolincarboxylate and ellagic acid derivatives, indicating a complex phenolic composition. Discussion These results demonstrate that attenuation of lipid accumulation by polyphenol-rich Chinese olive extracts in HepG2 cells is accompanied by AMPK phosphorylation and miRNA modulation. This finding supports the potential of Chinese olive extracts as a natural hepatoprotective ingredient for the development of functional foods and nutraceuticals.
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产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2026
·
IF 12.4
Jiaying Yan,Panpan Wang,Ying Cao,Jinlong Zhu,Xingyan Jin,Luwei Li,Chuandong Wu,Hao Zhang,Hui Xie,Jun Ma
Nanofiltration (NF) membrane technology is pivotal in water purification, yet commercial membranes degrade over time, reaching end-of-life (EOL) status and requiring costly replacement, which contributes to environmental waste. Herein, a novel strategy is proposed for regenerating EOL NF membranes by constructing a stable ternary crosslinked network incorporating the adhesion characteristics of tannic acid (TA)-polyvinyl alcohol (PVA) self-assembled sticky particles and their metal coordination effect with Fe 3+ . The sticky particle adhesion and Fe 3+ crosslinking processes were investigated by atomic force microscopy (AFM) and quartz crystal microbalance-dissipation (QCM-D) measurements, which revealed the formation process of TA-PVA-Fe ternary network. Compared to binary networks, the TA-PVA-Fe ternary network exhibited markedly reduced pore size (molecular weight cut-off (MWCO) = 399 Da, average diameter (d adv ) = 0.674 nm), resulting in enhanced monovalent/divalent salt separation performance (Cl - / SO 4 2 − separation factor of 54.5). The TA-PVA-Fe regenerated EOL NF membrane demonstrates robust Cl - / SO 4 2 − separation capability during extended-duration operation, maintaining Na 2 SO 4 rejection at 97.3 ± 0.7% and NaCl rejection at 29.6 ± 0.5%. Additionally, it exhibits superior antifouling properties, reducing flux decline by over 45% relative to TA-Fe membranes under organic foulant challenges. These findings underscore the potential of this eco-friendly approach for recycling EOL membranes and advancing sustainable water treatment technologies.
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.6
Jianye Li,Ruigang Zhou,Jiali Huang,Jing Cheng,Haibo Liu,Fanghong Chen,Jianxin Ma,Junjie Huang
Gallic acid (GA), recognized for its antioxidant and anti-inflammatory bioactivities, has demonstrated efficacy in ameliorating experimental colitis. However, its clinical translation is impeded by poor water solubility. Deep eutectic solvents (DESs), as environmentally friendly green solvent systems, have emerged as promising candidates to address this limitation. Hydrogels are considered a viable strategy to enhance the anti-colitis efficacy of GA. The hydrogel (PC-CuGA) was fabricated using a one-step mixing method and cross-linked through non-covalent interactions by DES, polyvinyl alcohol (PVA), chitosan (CS), GA, and Cu 2 + . Additionally, DSS-evoked colitis was established and applied to clarify the regulatory efficacy of PC-CuGA on intestinal barrier impairment, inflammatory response, and redox imbalance. Results revealed that PC-CuGA exhibited a robust gel state with excellent temporal stability, superior storage modulus, enhanced structural integrity, and favorable biosafety. In the colitis model, PC-CuGA intervention effectively mitigated DSS-induced pathology, as evidenced by reduced weight loss, attenuated colon shortening, and lowered disease activity index (DAI) scores. Histopathological analysis further demonstrated that PC-CuGA preserved intestinal barrier integrity and protected tight junction proteins. Mechanistically, PC-CuGA significantly dampened the activation of the TLR4/MyD88/NF-κB axis and downregulated the expression of pro-inflammatory cytokine genes, while upregulating the expression of anti-inflammatory cytokines. Collectively, these findings elucidate that the protective effects of PC-CuGA against experimental colitis associated with reinforcing intestinal barriers, suppressing oxidative stress, and excessive inflammation. This work provides a novel therapeutic strategy for the prevention and management of colitis, highlighting the potential of DES-based hydrogels in enhancing the bioavailability and efficacy of bioactive compounds.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 18
·52084
·
IF 3.125
Tao Chen,Cheng Cai,Yan-ting Zhang,Zeng Zhao,Shu-yan Zhang,Chong-gang Wu,Xing-hou Gong,Jiang Hong,Tao Hu
The paradox of obtaining dielectric elastomers (DEs) with both low modulus and high-dielectric properties has long been puzzling researchers in this field. To solve this problem, a preliminary attempt is made here by solution compounding polyphenol nanoparticles modified multiwalled carbon nanotube (PNs@MWCNT) with polydimethylsiloxane (PDMS) to obtain PDMS based DEs with excellent electromechanical properties. The PNs layer can improve the interfacial interaction between MWCNT and PDMS probably through interfacial hydrogen bonding, thus improving the dispersion of PNs@MWCNT in PDMS. Compared with pure MWCNT filled PDMS nanocomposites, despite the hardening effect brought by the filler network, a softening effect (i.e., decreased cross-linking) by the finer filler-dispersion enhances in PNs@MWCNT/PDMS, resulting in lower moduli. Meanwhile, the as-prepared PNs@MWCNT/PDMS composites exhibit high permittivity, low-dielectric loss and high-breakdown strength. Finally, the PNs@MWCNT/PDMS nanocomposites show excellent electromechanical properties with a largest actuated strain of 7.4% at a breakdown strength of 13.1 kV/mm, which is 2.2 times that (3.3%@13.3 kV/mm) of MWCNT/PDMS and 3.9 times that (1.9%@18.8 kV/mm) of neat PDMS.
研究领域:
材料科学
·
纳米技术
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DOI
高影响因子
Small
·
2025
·
IF 12.1
Guanxin Zhao,Han Yang,Yating Sun,Xinyi Li,Xiaofang Li,Min Liu,Dan Li,Jiulong Zhang,Xiuli Zhao
Rheumatoid arthritis (RA) is an auto-immune disease characterized by inflammatory episodes and joint degradation. Activated macrophages produce large amounts of reactive oxygen species (ROS) and pro-inflammatory cytokines, which damage chondrocytes and destroy the cartilage matrix. Therefore, a promising therapeutic strategy for the treatment of RA is to inhibit the secretion of pro-inflammatory cytokines and ROS to promote macrophage polarization and facilitate cartilage repair. In this paper, an active targeting nanomedicine based on metal-phenolic networks (MPNs) is constructed to re-polarize activated macrophages for RA therapy. Sr 2+ and Cu 2+ are first coordinated with tannic acid (TA) to prepare TSC, and TNF-α siRNA is loaded into TSC via simple ultrasonic treatment to obtain TSSC. Finally, TSSC is coated with M1 macrophage membrane (termed as TSSC@M1) to enhance its inflammatory targeting ability. TSSC@M1 can actively target macrophages by releasing TA, Cu 2+ , and TNF-α siRNA to synergistically scavenge ROS and inhibit the expression of TNF-α to induce macrophage polarization, while Sr 2+ can further protect cartilage. In the collagen-induced arthritis (CIA) mouse model, TSSC@M1 can accumulate at inflamed joints and alleviate RA symptoms by modulating macrophage phenotype and repairing cartilage. Overall, TSSC@M1 NPs offer a promising and safe approach to treat RA.
研究领域:
纳米医学
·
免疫治疗
·
风湿病学
·
药物递送
·
生物材料
·
炎症性疾病
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DOI
高影响因子
DESALINATION
·
2022
·
IF 11.211
Xueting Zhao,Tingyuan Wang,Ruoxi Wang,Youyou Lan,Yuanyuan Jiang,Jiefeng Pan
Solar-driven interfacial evaporation, as an emerging solar thermal utilization technology for water production, provides an opportunity for alleviate water-energy nexus. Superwetting membranes, as famous interface materials , combine hierarchical micro-nano architectures and open-porous structures that enable high-efficient solar-driven interfacial evaporation. Herein, the design and synthesis of photothermal membranes with polyphenol-mediated nanostructured coating by integrating the tannic acid (TA)-polyethyleneimine (PEI) complexation and the oxidation-mediated TA-Fe II complexation is reported. The assembled TA-PEI/Fe II/III coating features hierarchical raspberry-like architectures derived from the TA-PEI nanoconjugates and the oxidized metal-organic hybrid networks with black appearance, which enabled the broaden solar absorption, excellent photothermal conversion and fast water diffusion of the photothermal membranes. Driven by sunlight illumination, the photothermal membranes are capable to achieve evaporation rate of 2.01 kg·m −2 ·h −1 and solar-to-vapor conversion efficiency of 94.6 %, which competes well with other photothermal membranes. The superposition of TA-PEI/Fe II/III coating over open-porous membrane substrates synchronously promoted thermal localization and facilitated water-to-steam generation. The reliable durability and salt resistance of the photothermal membranes are also demonstrated. Furthermore, photothermal membranes enables clean water production from seawater and sewage, demonstrating >99.9 % salt and oil pollutant removal . The universality of the polyphenol-mediated coating strategy offers powerful opportunities to engineer photothermal membranes for water purification application.
研究领域:
材料科学
·
环境科学
·
能源科学
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DOI
高影响因子
Food Bioscience
·
2022
·
IF 5.318
Gui-Li Huang,Tian-Tian Liu,Jia-Jia Ma,Ling-Xiang Sun,Si-Yao Sui,Xin-Yao Quan,Yu-Ning Wang
The harvested loquat fruits are prone to browning, leading to a decline in fruit quality. Inhibiting activity of polyphenol oxidase (PPO) is an important way to prevent browning. In this study, we evaluated the inhibitory impact of oligomeric procyanidins (OPC) on hydroxylation of monophenol and oxidation of o-diphenol catalyzed by PPO and effect of OPC on loquat fruits storage . The obtained results revealed that OPC could attenuate the activity of monophenolase and diphenolase. For monophenolase activity, the inhibition rate was observed to be dose-dependent with an IC 50 of 11.6 ± 3.4 μg/mL for the steady-state rate. For diphenolase activity, OPC inhibited PPO activity ( IC 50 = 15.75 ± 2.1 μg/mL) with a reversible and competitive mechanism and quenched fluorescence of PPO by forming OPC-PPO complex with one binding site in a static procedure. In addition, the data obtained from storage assays revealed that OPC could enhance the quality of harvested loquat fruits by attenuating the PPO activity, augmenting the content of total phenolics and flavonoids , and simultaneously delaying the browning of loquats. In this research, we identified a potent PPO inhibitor and expanded its potential as a food preservative.
研究领域:
食品科学
·
植物生理学
·
采后技术
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DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8
Yongxing Li,Haiyu Ji,Shuang Yang,Wenhao Cao,Jiarong Zou,Zhangliang Zhu,Jinfang Zhang,Mei Li
Interactions between polyphenols and starch are critical for modulating starch functionality through structural reorganization. This study systematically compared the interaction of young apple polyphenols (YAP) with A-type (corn starch, CS), B-type (potato starch, POS), and C-type (pea starch, PES) under autoclaving. Multi-technique analysis confirmed the formation of starch-YAP complexes and structural reorganization into A+V- and B+V-type crystalline polymorphs. Distinct differences in complex properties were observed among the crystal types. CS-based complexes (CSY_4) demonstrated the highest loading capacity (785.61 ± 0.37 mg/g) and long-range crystallinity (9.35%), yet exhibited the lowest short-range order (0.885 ± 0.044); PES-based complexes (PESY_4) showed the highest encapsulation efficiency (97.40 ± 0.02%) alongside the lowest swelling power (1.63 ± 0.01 g/g) and solubility (0.36 ± 0.01 g/g); whereas POS-based complexes (POSY_4) presented the lowest amylose content (13.71 ± 0.17%). These structural modifications led to markedly suppressed digestibility, with resistant starch content increasing to 52.02 ± 2.41% (CSY_4), 56.55 ± 0.43% (POSY_4), and 57.19 ± 1.80% (PESY_4), and POS demonstrated the greatest efficacy in lowering the estimated glycemic index (eGI) (ΔeGI = 14.83). The study elucidates a crystal-type-dependent strategy for designing slow-digesting starch-based functional foods through polyphenol-mediated structural engineering.
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产品关联
DOI
PubMed
高影响因子
COMPOSITES COMMUNICATIONS
·
2026
·
IF 7.7
Shan Cheng,Ning Wang,Qingfeng Sun,Jingyao Feng,Qingguang Bao,Zhenghui Liu,Xigao Jian,Nan Li
This study provides a novel strategy for improving the interfacial properties of advanced thermoplastic composites. Metal-organic framework (MOF) materials exhibit significant potential in enhancing the interfacial properties of composite materials due to their special structure and extremely high specific surface area. However, existing introduction methods relying on pre-acidification treatments can impair the mechanical properties of carbon fibers (CFs) and lead to issues such as uneven growth of MOFs. This paper utilizes resveratrol (RES) in reaction with hexachlorocyclotriphosphazene (HCCP) and bisphenol S (BPS) to construct a polyphenol cross-linked coating on the surface of CFs. The coating provides excellent heterogeneous nucleation sites for ZIF-67 without the need for pre-acidification, successfully enabling the loading of MOF on the fiber surface. Compared to unmodified composites, the interlaminar shear strength (ILSS) and flexural strength of CF@ZIF-67/ polyphthalazine ether sulfone ketone (PPESK) increased by 32.44% and 29.62%, respectively. The storage modulus reached 42 GPa, and the glass transition temperature rose to 298°C. Fracture morphology analysis further revealed that the failure mode shifted from interface debonding to resin cohesive failure, demonstrating a substantial enhancement in interfacial bonding.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）