查找使用阿拉丁产品的科研文献

Near-Infrared Light-Triggered NO Nanogenerator for Gas-Enhanced Photodynamic Therapy and Low-Temperature Photothermal Therapy to Eliminate Biofilms

Junjuan Li,Yue Tian,Qi Qin,Zhaolei Ding,Xue Zhao,Wei Tan

Purpose: Owing to its noninvasive nature, broad-spectrum effectiveness, minimal bacterial resistance, and high efficiency, phototherapy has significant potential for antibiotic-free antibacterial interventions and combating antibacterial biofilms. However, finding effective strategies to mitigate the detrimental effects of excessive temperature and elevated concentrations of reactive oxygen species (ROS) remains a pressing issue that requires immediate attention.Methods: In this study, we designed a pH-responsive cationic polymer sodium nitroside dihydrate/branched polyethylenimine–indocyanine green@polyethylene glycol (SNP/PEI-ICG@PEG) nanoplatform using the electrostatic adsorption method and Schiff’s base reaction. Relevant testing techniques were applied to characterize and analyze SNP/PEI-ICG@PEG, proving the successful synthesis of the nanomaterials. In vivo and in vitro experiments were performed to evaluate the antimicrobial properties of SNP/PEI-ICG@PEG.Results: The morphology and particle size of SNP/PEI-ICG@PEG were observed via TEM. The zeta potential and UV-visible (UV‐vis) results indicated the synthesis of the nanomaterials. The negligible cytotoxicity of up to 1 mg/mL of SNP/PEI-ICG@PEG in the presence or absence of light demonstrated its biosafety. Systematic in vivo and in vitro antimicrobial assays confirmed that SNP/PEI-ICG@PEG had good water solubility and biosafety and could be activated by near-infrared (NIR) light and synergistically treated using four therapeutic modes, photodynamic therapy (PDT), gaseous therapy (GT), mild photothermal therapy (PTT, 46 °C), and cation. Ultimately, the development of Gram-positive (G+) Staphylococcus aureus (S. aureus) and Gram-negative (G−) Escherichia coli (E. coli) were both completely killed in the free state, and the biofilm that had formed was eliminated.Conclusion: SNP/PEI-ICG@PEG demonstrated remarkable efficacy in achieving controlled multimodal synergistic antibacterial activity and biofilm infection treatment. The nanoplatform thus holds promise for future clinical applications.

Investigation of Cu-doped MnCeOx in PTFE catalytic fiber for synergistic removal of CB and NO at low temperature

Shengyong Lu,Xuanhao Guo,Manting Chen,Guanjie Wang,Juan Qiu,Jiaming Ding,Minghui Tang,Zhengdong Han,Yaqi Peng,Jianhua Yan

The synergistic removal of multiple pollutants from flue gas has attracted growing interest in recent years. In this study, Cu-doped MnCeO x catalysts were synthesized via an impregnation method and integrated into PTFE fibers using a split-film process to enable the simultaneous removal of chlorobenzene (CB) and nitrogen oxide (NO). Among the catalysts tested, Mn 2 Ce 1 Cu 0.6 O x exhibited the highest performance, achieving 90 % CB degradation and 100 % NO conversion at 180 °C. The PTFE-based catalytic fibers also demonstrated excellent removal efficiency, reaching 83.7 % for dioxins at the same temperature. A possible reaction mechanism is proposed in which the NH 3 -SCR process facilitates CB oxidation by generating reactive intermediates. Cu doping was found to enhance the density of acid sites and promote the ring-opening of CB, thereby suppressing chlorine accumulation and improving catalyst stability. These findings provide valuable insights for the development and optimization of catalytic bag filters for the efficient, synergistic removal of multiple pollutants from industrial emissions.

Bridging acute-chronic myocardial infarction treatment: Dual-regulating of ROS/fibrosis via microenvironment-responsive release of NO and curcumin

Fang Zhang,Bingbing Zhao,Keqiang Lu,Xueping Zeng,Zikun Wang,Wei Chen,Yunyun Zhou,Juanjuan Peng,Lingzhi Zhao

Oxidative stress and fibrosis are core drivers of post-myocardial infarction dysfunction. Conventional therapies predominantly address either acute oxidative damage or chronic fibrosis, lacking strategies that concurrently target the two interconnected processes. Here, a microenvironment-responsive nanomedicine delivering nitric oxide (NO) and curcumin specifically to the infarcted heart is presented (named C@Si-NM). Constructed from glutathione-sensitive cyclic nitrate-trimethylene carbonate-polyethylene glycol block copolymer micelles crosslinked with silica, the system releases both NO and the encapsulated curcumin upon encountering elevated glutathione levels at the infarction site. In cardiomyocytes, NO suppresses the opening of mitochondrial permeability transition pore, inhibiting the release of reactive oxygen species, while curcumin directly acts as an antioxidant. In fibroblasts, NO inhibits the TGF-β/Smad pathway and curcumin downregulates the production of TGF-β, jointly suppressing fibrosis. The combined nanomedicine C@Si-NM significantly improved cardiac function in a rat model of MI after four weeks of treatment, resulting in an ejection fraction of 74 %. This value approached the normal range of 81 % and was superior to the outcomes observed with NO monotherapy at 62 % or curcumin monotherapy at 63 %. This strategy effectively mitigates both oxidative damage and fibrosis, bridging the gap between acute and chronic therapeutic interventions of myocardial infarction.

Uniform Zn2+-Doped BiOI Microspheres Assembled by Ultrathin Nanosheets with Tunable Oxygen Vacancies for Super-Stable Removal of NO

Fei Rao,Gangqiang Zhu,Mirabbos Hojamberdiev,Weibin Zhang,Shiping Li,Jianzhi Gao,Fuchun Zhang,Yuhong Huang,Yu Huang

Highly exposed active facets and surface oxygen vacancies (OVs) are beneficial for the photocatalytic removal of various harmful organic compounds. In this study, uniform Zn2+-doped BiOI microspheres, assembled by ultrathin nanosheets with highly exposed {001} facets, with OVs were successfully synthesized for NO removal under visible light irradiation. The phase structure and chemical states are analyzed by means of X-ray diffraction and X-ray photoelectron spectroscopy, respectively. The transmission electron microscopy observations reveal that replacing Bi3+ with Zn2+ can lead to the increased exposure of the {001} facets. X-ray photoelectron and electron paramagnetic resonance spectroscopy results confirm that low-state Zn2+ increases the number of OVs, indicating that an increased number of OVs and a reduced thickness of the nanosheets can enhance the photocatalytic activity for the removal of NO. The photo-oxidative removal efficiency of NO over 3%Zn-BiOI reaches 53.6% and remains highly stable (52.9%) for up to 210 min under visible light irradiation. The calculation of interface adsorption confirms that OVs and Zn2+ can not only offer a donor energy level to extend the solar response range but also act as adsorption sites for low concentration of NO and O2 to optimize the transmission capacity of surface charge carriers. Moreover, this work systematically explains the function of OVs and Zn2+ in the adsorption process of NO. The in situ Fourier transform infrared spectroscopy supports understanding of the photo-oxidative removal mechanisms of NO over Zn-BiOI: (i) the byproducts were bidentate nitrites (bi-NO2–), chelate nitrites (ch-NO2–), and bridging nitrites (br-NO3–) in the dark condition and (ii) the final products were bridging nitrites and bidentate nitrites (bi-NO3–) under visible light irradiation. OVs are found to play an important role both in the dark adsorption and photo-oxidative removal of NO by the 3%Zn-BiOI sample.

The promotion effect of Fe on CeZr2O x catalyst for the low-temperature SCR of NO x by NH3

Sun Xiao,Guo Rui-tang,Li Ming-yuan,Sun Peng,Pan Wei-guo,Liu Shu-ming,Liu Jian,Liu Shuai-wei

Fe was used as the modifier to improve the performance of CeZr 2 O x catalyst for the selective catalytic reduction (SCR) reaction with ammonia. Experimental results revealed that proper Fe species (Fe/Ce molar ratio = 2) could effectively improve the SCR activity of CeZr 2 O x , along with the elevated resistance to SO 2 and H 2 O. The characterization results including BET, XRD, H 2 -TPR and NH 3 -TPD confirmed that Fe species in Fe 2 CeZr 2 O x catalyst could inhibit the formation of ZrO 2 crystals and lead to higher reducibility and surface acidity. In addition, more Ce 3+ and surface active oxygen species could be detected on Fe 2 CeZr 2 O x compared with CeZr 2 O x . By means of in situ DRIFT technique, it could be deduced that the SCR reaction process over Fe 2 CeZr 2 O x was accelerated mainly through theL–H pathway due to the advanced adsorption of NH 3 and NO x species, along with the promoted NO conversion to NO 2 . Therefore, the modification of CeZrO x catalyst by Fe had a significant stimulation effect on its low-temperature SCR performance.

The Cu(I)- and HNO3-catalyzed oxidation of substituted toluenes to the benzoic acid based on NO x recycling

Wei Mengyi,Qian Chao,Chen Xinzhi

Based on the recycling of NO x , the Cu(I)- and HNO 3 -catalyzed oxidation of 2-chloro-4-(methylsulfonyl)toluene to 2-chloro-4-(methylsulfonyl)benzoic acid has been developed with an excellent yield of 84.2% and a purity of 99.7%. The optimized reaction conditions (160 °C, oxygen pressure 1.5 MPa, HNO 3 concentration 25 wt%, HNO 3 : substrate 0.5:1) use 1.0 mol% CuI as catalyst. The dosage of HNO 3 in the new process is only 25% of the stoichiometric amount and 12.5% of the amount of the traditional process. The NO x emission is 5% amount of the traditional process. The oxidation of several additional toluene derivatives with comparable yields demonstrates the generality to these reaction conditions.

Potassium Titanate Nanobelts: A Unique Support for Au and AuRh Nanoparticles in the Catalytic Reduction of NO with CO

Xianwei Wang,Nobutaka Maeda,Daniel M. Meier,Alfons Baiker

Graphical Potassium titanate (K 2 Ti 8 O 17 ) nanobelts (KTN) are a unique support for Au and bimetallic AuRh nanoparticles showing strong enhancement of the catalytic reduction of NO with CO to N 2 .The KTN support facilitates the formation of surface nitrate, carbonate and isocyanide species, resulting in superior catalytic activity compared to corresponding TiO 2 -supported catalysts. The catalytic reduction of NO with CO was examined over monometallic Au and bimetallic AuRh nanoparticles supported on potassium titanate (K 2 Ti 8 O 17 ) nanobelts (KTN) and TiO 2 . The highly crystalline KTN, prepared from TiO 2 by a hydrothermal process using KOH, were several μm long and ca. 8 nm wide. Both Au and bimetallic AuRh catalysts showed a striking enhancement of the catalytic performance with KTN as support, compared to corresponding TiO 2 -supported catalysts. The reasons for this behavior could be traced back using in situ diffuse reflectance infrared Fourier transform spectroscopy in tandem with modulation excitation spectroscopy, which proved that the KTN support promotes the formation of surface nitrate (−NO 3 − ), carbonate (−CO 3 2− ), and isocyanide (−NCO) species. In particular, the combination of KTN with bimetallic AuRh nanoparticles results in the facile formation of isocyanide, which is a pivotal intermediate for producing dinitrogen molecules via the reaction with NO; NCO (a) +NO (a) →N 2 +CO 2 .

Investigation on the removal of NO from marine exhaust gas using the Na2S2O8-urea redox system in seawater carrier

Xing Xiangwen,Jiang Jingxuan,Liu Jing,Zhao Pei,Cui Lin,Dong Yong

The sodium persulfate (Na 2 S 2 O 8 )-urea system has been proven to be an excellent scrubbing solution for the wet removal of NO. Commonly, seawater is used as a wet carrier in marine applications. To further explore the feasibility of marine denitrification using Na 2 S 2 O 8 -urea system, this study proposed the Na 2 S 2 O 8 -urea-seawater composite redox system for NO removal from the marine exhaust gas. The effects of seawater carrier, reaction temperature, Na 2 S 2 O 8 concentration, urea concentration, pH value, and NO concentration on NO removal were investigated. Additionally, the NO 3 − concentration in the solution was measured. Results showed that the lowest normalized NO concentration was 0.099, with the corresponding mass of NO absorbed per unit volume of solution reaching 0.108 g·L −1 . The addition of seawater carrier and incremental reaction temperature, Na 2 S 2 O 8 , and urea concentration promoted the NO removal performance. When the pH value increased within the range of 4–7, the NO removal performance decreased. The NO removal performance increased as the pH value further increased to 8, but decreased again when the pH value increased to 11. An increase in NO concentration was detrimental to NO removal. The Cl − , HCO 3 − , and CO 3 2− in seawater could augment the total concentration of active free radicals to improve denitrification performance.

NO-Responsive Oleanolic Acid Self-Assembled Micelles Co-Loaded with BAY 11-7082 for Synergistic Chondroprotection and Anti-Osteoarthritis Therapy

Dandan Zhang,Zhigang Zhang,Dingxing Huang,Zhuoran Sun,Jiamin Huang,Chi Zhang,Qingyang Zeng,Qiling Liu,Wenzhuo Chen

Osteoarthritis is an irreversible degenerative joint disease driven by sustained NF-κB-mediated inflammatory responses, and conventional intra-articular hyaluronic acid or small-molecule NF-κB inhibitors cannot achieve targeted on-demand treatment due to poor solubility, rapid clearance and lack of lesion microenvironment responsiveness. OA with inherent anti-chondrolytic activity can self-assemble into nanocarriers in water, yet it lacks stimuli-responsive capacity. Herein, we rationally designed and synthesized an OA-Der by covalently conjugating o-phenylenediamine fragments to the OA backbone.1H NMR and HRESI-MS spectra fully verified the accurate chemical structures of intermediate and final OA-Der. Blank OA-Der micelles exhibited uniform spherical core–shell nanostructures (50–150 nm) under TEM and AFM, while pathological high NO triggered complete disassembly of micellar assemblies. We further co-assembled OA-Der with NF-κB inhibitor BAY 11-7082 to construct NO-responsive BAY@OA-Der supramolecular micelles. In vitro experiments using human C28/I2 chondrocytes with LPS-induced inflammatory injury demonstrated that BAY@OA-Der significantly improved cell viability and reduced apoptotic chondrocyte proportion. At mRNA and protein levels, the supramolecular micelle formulation remarkably suppressed NF-κB p65 phosphorylation, downregulated cartilage-degrading ADAMTS5, and upregulated ACAN compared with free BAY or blank OA-Der. Collectively, this natural bioactive self-assembled NO-responsive delivery platform achieves synergistic anti-inflammatory and matrix-protective effects by precisely releasing drugs at NO-overexpressed osteoarthritis inflammatory sites and offers an in vitro design strategy for osteoarthritis responsive delivery systems.

The heterojunction regulated by Au nanoparticles efficient removal of NO through the synergistic effects of SPR and the electron bridge

Youzhou He,Zhiqiang Guo,Yue Li,Xingyan Liu,Kaili Wu,Yuyu Fang,Rong Peng,Min Fu,Bowen Lei

The elimination of low-concentration (ppb) nitrogen oxides (NO x ) in city and indoor environments, particularly the selective removal of NO while preventing toxic NO 2 formation is a significant challenge. Photocatalytic technology offers a promising solution, but its effectiveness is limited by high carrier recombination rates and insufficient active sites. This study introduces a photocatalyst (Au@NM/ZIF) that forms a Z-type heterojunction structure by precisely positioning gold nanoparticles within the NM/ZIF framework. The catalyst consists of amino-functionalized NH 2 -MIL-125 and ZIF-8, with gold nanoparticles serving dual roles: UV-Vis analysis shows that their surface plasmon resonance (SPR) enhances visible light absorption, promoting the generation of charge carriers that drive the oxidation of NO to NO 3 − . Additionally, X-ray photoelectron spectroscopy (XPS) and work function analysis indicate that gold nanoparticles function as an electronic bridge, optimizing charge transfer between NM and ZIF-8, improving electron-hole separation and increasing active site utilization, thereby significantly enhancing NO conversion efficiency. In situ Fourier-transform infrared spectroscopy (FT-IR), electron spin resonance (ESR), and radical capture experiments further clarify the formation pathways of preliminary products and completed outputs, emphasizing the important roles of active radicals (such as •OH and •O 2 − ) in the deep oxidation of NO. This research offers a valuable solution for effectively removing low-concentration NO x .

Synergistic Interface Nanoarchitectonics in InP-NBOC/Mo-CN Ternary Composites for Efficient Photocatalytic NO Oxidation with Ultralow NO2 Byproduct Generation

Wu Jundao,Huang Zeai,Zhang Fan,Liu Jiayi,He Yi,Hu Wei,Tang Xiao,Zairov Rustem,Sinyashin Oleg G.

The substantial presence of nitrogen oxides (NO and NO 2 ) in outdoor environments detrimentally impacts natural ecosystems and exerts significant influence on urban climates. Conventional NO x treatment methods frequently suffer from challenges such as harsh reaction conditions and high energy consumption. Consequently, the development of advanced photocatalytic systems to efficiently degrade NO x while minimizing the formation of toxic byproducts represents a critical challenge in environmental catalysis. In this study, a novel ternary composite material (5% Mo-CN/InP-NBOC) was constructed via hydrothermal synthesis and surface modification strategies, achieving 42% NO oxidation efficiency under visible light irradiation with a mere 0.9% NO 2 generation rate. This performance demonstrates efficient photocatalytic NO oxidation while effectively suppressing NO 2 production. Systematic characterization techniques, including XRD, TEM, and XPS, confirmed the successful integration of InP quantum dots (5–10 nm) and amorphous Mo-CN onto NBOC nanosheets, forming an intimate heterojunction structure. PL and ESR analyses revealed that Mo-CN enhances charge carrier separation and governs the NO oxidation process through the activation of dual free radical pathways (⋅O 2 − and ⋅OH). This work establishes a “quantum dot-primary catalyst-cocatalyst” ternary collaborative design paradigm, providing experimental evidence and theoretical models to address the challenges of synergistic optimization among activity, selectivity, and stability in photocatalytic NO x treatment.

Synergistic charge redistribution at SrTiO3@NH2-MIL-125 S-scheme heterostructure: steering photogenerated reactive species for efficient NO-to-nitrate conversion

Wenrui Dai,Chenxiang Wang,Jiajia Gao,Haotong Ma,Yingchun Miao,Shuo Wang,Zhanshuo Tao,Shuning Xiao