JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
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2023
·Vol. 112
·期 1
·e35316
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IF 3.4
Qinwei Yang,Jiadong Zhu,Jing Chen,Peizhi Zhu,Chunxia Gao
As potential alternatives for calcium phosphate bone cements, magnesium phosphate bone cements (MPC) have attracted considerable attention in recent years. However, their several defects, such as rapid setting times, highly hydration temperature and alkaline pH due to the part of the unreacted phosphate, restricted their applications in human body. With aim to overcome these defects, a novel polypeptite poly(γ-glutamic acid) (γ-PGA) modified MPC were developed. Effect of γ-PGA content on the injectability, anti-washout ability, setting times, hydration temperature, mechanical compressive strength, in vitro bioactivity and degradation were investigated. Moreover, in vitro cyto-compatibility was evaluated using MC3T3-E1 cells by CCK-8 and Live/Dead staining. All these results indicated that the 10%PGA-MPC with an improved handling performances, low hydration temperature, high mechanical compressive strength, and good cyto-compatibility hold a great potential for bone repair and regeneration.
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Journal of Materials Chemistry B
·
2023
·
IF 7
Chuang Hu,Haoran Ji,Yan Gong,Xuhui Yang,Yunxuan Jia,Yuanhao Liu,Guangyu Ji,Xiansong Wang,Mingsong Wang
Following the global COVID-19 pandemic, the incidence of tracheal epithelial injury is increasing. However, the repair of tracheal epithelial injury remains a challenge due to the slow renewal rate of tracheal epithelial cells (TECs). In traditional nebulized inhalation treatments, drugs are enriched in the lungs or absorbed into the blood, reducing drug concentration at the tracheal injury site. In this study, we prepared an epidermal growth factor (EGF)-loaded gamma-polyglutamic acid (γ-PGA)/epsilon-poly-L-lysine (ε-PLL) (PP) hydrogel (EGF@PP) to promote the repair of tracheal epithelial injury. Epidermal growth factor promotes the proliferation of TECs and enhances vascularization, thereby accelerating injury repair. The PP hydrogel exhibits outstanding wet adhesion, slow drug release, and antibacterial and anti-inflammatory properties, making it suitable for application in the airways and creating an environment conducive to epithelial repair. Here, we established a rabbit model of tracheal injury using a laser to destroy the tracheal epithelium and delivered EGF@PP powder to the injury site under fiberoptic bronchoscopy guidance. Our findings revealed that this was an effective therapeutic strategy for accelerating the repair of tracheal epithelial injury.
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CHEMISTRY-A EUROPEAN JOURNAL
·
2023
·Vol. 29
·期 52
·e202300950
·
IF 4.3
Fukun Li,Ronghe Yang,Zheng Tian,Ziting Du,Jinhang Dai,Xingmin Wang,Ning Li,Jie Zhang
Graphical Microwave-assisted one pot cascade transformation of furfural to γ-valerolactone catalyzed by Sc(OTf) 3 . γ-Valerolactone (GVL) is considered as a star biochemical which can be used as a green solvent, fuel additive and versatile organic intermediate. In this study, metal triflate (M(OTf) n ) was utilized as the catalyst for one-pot transformation of furfural (FF) to GVL in alcohol media under microwave irradiation. Alcohol plays multiple functions including solvent, hydrogen donor and alcoholysis reagent in this cascade reaction process. And process efficiency of GVL production from FF upgrading is strongly related to the effective charge density of selected catalyst and the reduction potential of selected alcohol. Complex (OTf) n -M−O(H)R, presenting both Brønsted acid and Lewis acid, is the real catalytic active species in this cascade reaction process. Among various catalysts, Sc(OTf) 3 exhibited the best catalytic activity for GVL production. Various reaction parameters including the Sc(OTf) 3 amount, reaction temperature and time were optimized by the response surface methodology with the central composite design (RSM-CCD). Up to 81.2 % GVL yield and 100 % FF conversion were achieved at 143.9 °C after 8.1 h in the presence of 0.16 mmol catalyst. This catalyst exhibits high reusability and can be regenerated by oxidative degradation of humins. In addition, a plausible cascade reaction network was proposed based on the distribution of product.
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JOURNAL OF MAGNETIC RESONANCE IMAGING
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2023
·
IF 4.4
Xue Yang,Ying Liu,Cai-xia Fu,Ying-Hua Chu,Qun Chen,He Wang,Da-Xiu Wei,Ye-Feng Yao
Background Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in human brains, playing a role in the pathogenesis of various psychiatric disorders. Current methods have some non-neglectable shortcomings and noninvasive and accurate detection of GABA in human brains is long-term challenge. Purpose To develop a pulse sequence capable of selectively detecting and quantifying the 1 H signal of GABA in human brains based on optimal controlled spin singlet order. Study Type Prospective. Subjects/Phantom A phantom of GABA (pH = 7.3 ± 0.1) and 11 healthy subjects (5 females and 6 males, body mass index: 21 ± 3 kg/m 2 , age: 25 ± 4 years). Field Strength/Sequence 7 Tesla, 3 Tesla, GABA-targeted magnetic resonance spectroscopy (GABA-MRS-7 T, GABA-MRS-3 T), magnetization prepared two rapid acquisition gradient echoes sequence. Assessment By using the developed pulse sequences applied on the phantom and healthy subjects, the signals of GABA were successfully selectively probed. Quantification of the signals yields the concentration of GABA in the dorsal anterior cingulate cortex (dACC) in human brains. Statistical Tests Frequency. Results The 1 H signals of GABA in the phantom and in the human brains of healthy subjects were successfully detected. The concentration of GABA in the dACC of human brains was 3.3 ± 1.5 mM. Data Conclusion The developed pulse sequences can be used to selectively probe the 1 H MR signals of GABA in human brains in vivo. Evidence Level 1 Technical Efficacy Stage 1
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Crystals
·
2023
·Vol. 13
·期 5
·810
·
IF 2.7
Ruonan Tian,Huai Tan,Gang Chen,Hongtao Guan,Chengjun Dong,Zongyou Yin
Although individual γ-Fe2O3and α-Fe2O3have been widely fabricated for gas sensors, their mixed phase of α/γ-Fe2O3might deliver excellent sensing properties. In this study, a facile solvothermal method was used to fabricate Fe-alkoxide. After thermal treatment, it was converted into γ-Fe2O3, α-Fe2O3and their mixed-phase α/γ-Fe2O3with a nanosheets-assembled flower-like structure. We studied the influence of calcination temperature on the phase and sensing properties on acetone detection. The α/γ-Fe2O3which annealed at 400 °C included 18% α-Fe2O3and it exhibited excellent sensing performance towards acetone compared to that of γ-Fe2O3and α-Fe2O3. It showed a response of 353 to acetone with a concentration of 200 ppm, and a low limit of detection of 0.5 ppm at 160 °C. In addition, the change in responses with acetone concentration from 50 to 200 ppm shows a good linear relationship. Moreover, this material has good reproducibility and selectivity as well as a fast response time of 22 s and recovery time of 14 s to 200 ppm. Therefore, our mixed phase of α/γ-Fe2O3possesses great prospects for acetone detection.Keywords:Fe2O3;phase;gas sensor;acetone;sensing performance
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CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Fuming Miao,Shuai Zhang,Xueliang Sun,Yamin Li,Ruize Shang,Wenli Wu,Weizhou Jiao,Youzhi Liu
In this study, Mn-CoO X / γ -Al 2 O 3 (MCA) was prepared by impregnation for catalytic ozonation of phenol in a rotating packed bed (RPB), and the effects of high gravity factor ( β ), liquid flow rate ( Q L ), initial solution pH and gaseous ozone concentration ( C O 3 ) on the mineralization of phenol were explored. The results show that the degradation rate of phenol ( η phenol ) reaches 100% at 9 min and the mineralization rate ( η TOC ) reaches 95.01% at 45 min under conditions of β = 104, C O 3 = 80 mg L -1 , Q L = 80 L/h, and pH = 6. Compared with the bubbling reactor (BR)/MCA/O 3 and O 3 /RPB systems, the η TOC of the MCA/O 3 /RPB system is increased by 25.81% and 40.85%, respectively. The electron paramagnetic resonance (EPR) results reveal that hydroxyl radical (·OH) plays a critical role in the degradation of phenol by MCA catalyzed ozonation. The quenching experiment using tertiary butyl alcohol (TBA) as a scavenger of ·OH reveals that the ratio of direct and indirect degradation of phenol is 16:9. The intermediates generated during the degradation of phenol were detected by gas chromatography-mass spectrometry (GC–MS), and possible degradation pathways were proposed. In conclusion, MCA-catalyzed ozonation and RPB have a synergistic effect on ·OH initiation and improve the degradation and mineralization of phenol. This study provides a new perspective for the degradation of phenol.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xiaoyang Chen,Jian Chen,Yijie Liu,Yang Liu,Yun Gao,Siwei Fan,Xiangxi He,Xiaohao Liu,Chao Shen,Yong Jiang,Li Li,Yun Qiao,Shulei Chou
Metal–CO2 batteries, especially Li–CO2 and Na–CO2 batteries, are regarded as ideal new-generation energy storage systems owing to their high energy density and extraordinary CO2 capture capability. However, the advancement of metal–CO2 batteries is still at an early stage. The problems caused by accumulation of carbonates during charge–discharge cycles, such as large polarization and poor reversibility, restrict their practical application. Therefore, designing efficient catalysts is crucial for promoting the decomposition of carbonate to improve the electrochemical performance of metal–CO2 batteries. Herein, we first adopted sea urchin-like γ-MnO2 as the cathode material for Li/Na–CO2 batteries. Benefiting from the unique structure and excellent catalytic activity of γ-MnO2, the as-prepared Li–CO2 and Na–CO2 batteries can achieve low overpotentials of 1.28 and 1.36 V, respectively, at a current density of 100 mA g–1 with a cutoff capacity of 1000 mA h g–1. The overpotentials are lower than those of most of the state-of-the-art catalysts in previous reports. After 100 and 50 cycles of Li–CO2 and Na–CO2 batteries, respectively, their charging termination voltages remain at around 4.1 and 3.9 V, respectively; such a low charging platform indicates the excellent catalytic activity of the γ-MnO2 cathode on the discharge products. Our findings offer a promising guideline to design efficient electrocatalysts for high-performance metal–CO2 batteries.
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APPLIED CATALYSIS A-GENERAL
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2018
·
IF 4.521
Liqin Wang,Heqin Guo,Qilong Xie,Jungang Wang,Bo Hou,Litao Jia,Jinglei Cui,Debao Li
Furfural is one of the most valuable biomass platform compounds which is typically prepared from hemicellulose. Conversion of cellulose and its derived hexoses, which are the most abundant resource in nature, to furfural, is a big challenge. The amount of the reactive form (fructofuranose) which was beneficial to the formation of furfural and HMF, was increased when the solvent transformed from water to γ-butyrolactone (GBL)-water. The GBL promoted the adsorption of fructose on HY. The transfer of fructose from the solution to the channels of HY was enhanced with the introducing of GBL in solvent. The HY zeolite with apertures of 7.4 Å was found to promote the formation of acyclic fructose from cyclic fructose (8.6 Å) in the synergy with GBL. The Brønsted acid sites in the channels of HY favored the selective cleavage of the C C bond in acyclic fructose to xylose, and promoted the following dehydration of xylose to furfural, simultaneously. The furfural yield was increased while the 5-hydroxymethylfurfural (HMF) yield was decreased with the decrease of the Brønsted acid sites density. The maximum furfural yield was 37.8% over HY-3, while the maximum HMF yield was 69.2% over HY-1 in the conversion of fructose in GBL-water solvent. In addition, the etherification of HMF was the main factor for the low HMF yield and carbon balance in fructose conversion in GBL-water solvent.
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Russian Journal of Physical Chemistry A
·
2019
·Vol. 93
·期 7
·1343-1348
·
IF 0.581
Liang An,Zhao Xiaolian,Xu Chengkang,Yan Zhaoxiong,Yang Zhihua,Xu Zhihua
Abstract In this work, magnetically separable and recyclable γ-Fe 2 O 3 /HAp/Ag 3 PO 4 composite microsheets were prepared by hydrothermal and in-situ ion-exchange methods, in which photoactive Ag 3 PO 4 nanoparticles and magnetic γ-Fe 2 O 3 nanoparticles are distributed on the hydroxyapatite (HAp) microsheets. Characterization of the samples was performed by XRD, FE-SEM, EDS, FT-IR, and VSM. The photocatalytic performance of the samples was checked by investigating the degradation process of four different organic dyes under visible-light irradiation. Photocatalytic experiments reveal that all γ-Fe 2 O 3 /HAp/Ag 3 PO 4 samples show certain photocatalytic activities for the degradation of OII, and the degradation rate is different when diverse γ-Fe 2 O 3 /HAp/Ag 3 PO 4 samples are added into the OII solution. FHA-4 exhibits the highest degradation rate, and it could degrade different organic dyes, which means it has the potential to be applied into the treatment of complex wastewater containing different organic dyes. In addition, FHA-4 exhibits ferromagnetic feature, and can be easily separated from water by an external magnetic field.
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CHEMICAL ENGINEERING JOURNAL
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2019
·
IF 8.355
Hai-Bin Qiu,Yi Hu,Han-Juan Chong,Li Yuan,Guo-Ping Sheng
Ionic liquids (ILs) have been widely applied in chemical industry due to their unique properties. There is mounting evidence that they are toxic to various living organisms. Thus, it is crucial to develop methods to efficiently degrade and mineralize ILs to reduce their potential risks to the environment. In this work, the degradation of 1-butyl-3-methylimidazolium bromide ([C 4 MIM]Br), an imidazolium-based IL, was investigated in aqueous solution via 60 Co γ-ray irradiation. Results show that [C 4 MIM]Br could be effectively degraded by γ-ray irradiation. The irradiation-induced degradation of [C 4 MIM]Br fitted well to the pseudo-first-order kinetics model. The kinetic constant ( k ) increased linearly with the increase of irradiation dose rate (R 2 = 0.942) and solution pH value (R 2 = 0.974), and decreased with the increase of [C 4 MIM]Br concentration. Fourteen intermediates were detected using a liquid chromatography-mass spectrometry analysis. Based on these intermediate products, the degradation pathways and mechanisms of [C 4 MIM]Br were proposed. The free radicals (e.g., aqueous electron (e aq – ), hydroxyl radical ( OH), and hydrogen atom (H )) generated by γ-ray irradiation showed synergistic effects in the degradation and mineralization of [C 4 MIM]Br. Moreover, the toxicity assessment using C. elegans and Chlorella pyrenoidosa as model organisms demonstrates that sufficient γ-ray irradiation could effectively reduce the potential risks of [C 4 MIM]Br and its intermediates to the environment. These findings of this study may offer an efficient and environmentally friendly approach for effectively removing ILs and other persistent organic pollutants.
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FUEL
·
2018
·
IF 4.908
Hui-Chao Hu,Shaokai Zhang,Tong Zeng,Yiying Lin,Liulian Huang,Lihui Chen,Yonghao Ni
In this paper, a robust method based on solvent-volume controlled full evaporation headspace gas chromatography technique (FE HS-GC) was developed to high throughput quantify γ-valerolactone (GVL) concentration in sample solution. The results showed that the full evaporation of GVL can be achieved by the equilibration process in headspace sampler at 150 °C for 5 min. For eliminating the matrix effect and pressure effect on GVL quantification, the sample volume added in headspace vial should be controlled within 15 μL. The present method was proved that has a very high precision (error < 1.11%), high precision (recoveries from 95.6% to 102.1%), and an excellent limit of quantification (153 mg/L). The present method was applied in valuation of GVL yield in a heterogeneous catalytic system and its recovery in a GVL-based biomass pretreatment process, and has given some valuable information. The present method is simple, rapid, efficient, and can be an excellent tool for screening reaction medium and catalysts in GVL synthesis and its related biorefinery processes.
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RADIATION PHYSICS AND CHEMISTRY
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2018
·
IF 1.435
Pei Dai,Anren Cheng,Xuena Zhao,Yang Jiao,Yongjun Lu,Liancai Wang,Xinmiao Zeng
This article focused on the effect of radiation vulcanization on the mechanical properties and the aging resistance performance in hot oil of the hydrogenated nitrile butadiene rubber (HNBR). The effect of absorbed dose on micromorphology, mechanical properties and thermal stability of radiation vulcanized HNBR (RV-HNBR) was investigated. The fractured surface of the HNBR systems was inspected in scanning electron microscope (SEM). SEM investigation showed that the cross-linked structure was more complete by the γ-ray radiation than heat vulcanization. A study of the compression permanent set property and tensile property of γ-ray radiation vulcanized HNBR was presented. Compared with heat vulcanized HNBR (HV-HNBR), RV-HNBR exhibited outstanding compression recovery performance after immersed in IRM 903 oil at 150 °C for 24 h. The compression-resilience property and the dimensional stability were improved with the absorbed dose increasing. When the absorbed dose was 250 kGy, the compression permanent was 40.1%. The good resistance to hot oil bring radiation vulcanized HNBR to meet many of the most stringent sealing application requirements.
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