JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Can Zhang,Pingping Zhang,Wenyuan Zhu,Shuo Li,Yue Gu,Jing Wu,Di Wen,Weili Hao,Ke Wang,Ling Ma,Kaoqi Lian
Herein, a magnetic cationic Schiff base polymeric material (Fe 3 O 4 @SiO 2 - Schiff -TAPB-DA) was fabricated simply and rapidly, which was explored as a magnetic adsorbent for magnetic solid-phase extraction (MSPE) for enriching seven avermectins insecticides in surface water and milk matrices combined with ultra-high performance liquid chromatography mass spectrometry (UPLC-MS/MS). Under the optimized pretreatment and instrumental parameters, the analytes showed good linearity in the range of 0.5–200.0 ng·mL −1 with a correlation coefficient (R 2 ) greater than 0.9990 and high precision. The limits of detection for the analytes were 0.004–0.047 μg· L −1 for surface water sample and 0.008–0.250 μg·kg −1 for milk samples. Satisfactory recoveries of spiked target compounds were in the range of 82.25- 100.87 % for surface water sample and 72.73- 119.62 % for milk samples. The results indicated powerfully Fe 3 O 4 @SiO 2 - Schiff -TAPB-DA was of significant potential as an MSPE adsorbent for the detection of avermectin insecticides in surface water and milk, which provides a quick and efficient idea for enriching avermectins insecticides in complicated matrices.
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ADVANCED FUNCTIONAL MATERIALS
·
2025
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IF 19
Hongwei Li,Xueliang Li,Dazhao Wang,Jianfeng Yan,Shichao Lv,Ang Qiao,Haitao Zhang,Qiang Yan,Jianrong Qiu,Shifeng Zhou
Metal-organic frameworks (MOFs) glass is a newly invented hybrid materials with the unique optical response and great potential for photonic applications. Unfortunately, limited by the high viscosity and instability issue of the ZIF-62 precursor, the controllable synthesis of homogeneous MOFs glass remains a significant challenge. In this manuscript, it is found that reducing the stoichiometric ratio between Zn ions and the ligand precursor can effectively suppress the growth of the ZIF-62 and enable to obtain tiny precursor particles. By using them, the homogenous MOFs glass free of bubbles can be fabricated by gentle heat-treatment. This hybrid MOFs glass exhibits interesting optical response, including intense luminescence, atmosphere sensitive optical response and high energy particle scintillating emission. The applications for active atmosphere sensing and neutron detection with extremely high signal-to-noise ratio of 27.1 dB are demonstrated. The results suggest that homogenous amorphization of MOFs may create a new type of photonic material with unprecedent optical response and significant sensing application.
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International Journal of Pharmaceutics-X
·
2025
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IF 6.4
Peipei Dou,Liang Chen,Yiyang Xie,Wenbei Xu,Xinran Zhang,Xiaomei Deng,Haiqing Xu,Jingran Li,Vincent Kawuribi,Shaohui Zheng,Kai Xu,Jing Zhang
Nanomaterials-based theranostic strategy have emerged as innovative techniques for gliomas treatment. However, the existence of blood-brain barrier (BBB) hinders efficient drug delivery to glioma, and the hypoxic condition of tumor microenvironment (TME) significantly reduces therapeutic efficacy. Thus, in this study, we developed a novel reactive oxygen species (ROS)-generating nanoplatform responsive to the TME. This platform utilized mesoporous PtNi nanoparticles (NPs) as carriers, loaded with chelated gadolinium porphyrin (Gd-HMME), to enable combined sonodynamic and chemodynamic therapy under magnetic resonance imaging (MRI) guidance. Employing a transferrin (Tf)-mediated trans-BBB strategy, Tf-PtNi@Gd-HMME-PEG (TPGP) precisely targeted and penetrated glioma tissues, facilitating T1-weighted enhanced imaging of tumor regions. The MRI enhancement signal achieved was 1.64-fold of the control group. Concurrently, the intrinsic acoustic sensitivity and enzyme-like catalytic activity of TPGP produce substantial ROS under ultrasound stimulation. These ROS interact with hydrogen peroxide in the TME to generate toxic free radicals, collectively acting on tumor cells to deliver a dual assault via sonodynamic and chemodynamic mechanisms to effectively inhibit tumor growth and ameliorate the tumor microenvironment. This study underscores the potential of TPGP as a multifunctional nanoplatform for targeted glioma therapy, combining diagnostic imaging with synergistic therapy to overcome the BBB and hypoxic TME.
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RSC Advances
·
2025
·Vol. 15
·期 51
·43676-43682
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IF 4.6
Hua Zeng,Xiaoyi Sun,Qian Li,Sheng Song
Thermotropic liquid crystalline polymers (TLCPs) have been widely studied since the 1970s, and producing TLCPs in a more efficient way for both cost saving and performance enhancement has always intrigued us. One of the most effective ways is further increasing the degree of acetylation of monomers. Herein, we report a strategy of introducing a second acetylating agent, acetylates of polyphenols, which works at high temperatures when the first acetylating agent, acetic anhydride, is removed from the system. A model reaction proved that benzene-1,3,5-triyl triacetate (PGAc) could efficiently acetylate phenol to form phenyl acetate at 200 °C in a short time (1 h), which was evidenced by 1H NMR. Adding the second acetylating agent, PGAc, in the polycondensation of HBA and HNA without modifying the process flow accelerated the propagation stage even in the absence of catalyst as shown by the data of distillate with time and the evacuation time of the melt polycondensation. Furthermore, other acetylates of polyphenols were also found to be acetylating agents to accelerate the polymerization and form a series of new TLCPs, inserting a small amount of which didn’t affect the chemical structures and thermodynamic properties much. The strategy of introducing a second acetylating agent shows great potential in both theoretical research and practical application.
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Materials Today Energy
·
2025
·
IF 8.6
Hongliang Fu,Qiaowei Wang,Yue Lian,Yongfeng Hu,Jing Zhao,Huaihao Zhang
It is crucial to rationally design catalysts with high activity and strong stability for electrolytic water oxygen evolution reaction (OER). Here, Ni-FeNbO 4 @NC microspheres were successfully synthesized as OER catalysts by interface optimization and Ni-doping. To address FeNbO 4 problems such as easy agglomeration, low catalytic activity and poor electrical conductivity, the catalyst was incorporated in N p-orbital of imidazole and metals (Ni and Fe) empty d-orbitals to form coordination compound, thus avoiding oxides direct contact and effectively improving dispersion. Moreover, Ni-doping provides additional catalytic active sites, good current impact resistance and large intrinsic conductivity for Ni-FeNbO 4 @NC. Besides, under high-temperature carbonization, the Ni-FeNbO 4 surface imidazole evolves into N-containing carbon layer, which enhances overall electrical conductivity to reduces ohmic overpotential. According to density functional theory calculations (DFT), Ni-doping lowers Gibbs free energy of OER decisive rate step, and enlarges reaction kinetics. From in-situ Fourier Transform infrared spectroscopy (FTIR) and in-situ differential electrochemical mass spectrometry (DEMS), Ni-FeNbO 4 @NC displays multiple types of catalytic active sites (Ni∗, and C-N∗) and efficient oxygen production efficiency. Under the synergistic effect of interface optimization and Ni-doping, Ni-FeNbO 4 @NC exhibits good catalytic activity in OER (low overpotential: 286 mV@10 mA cm −2 , small Tafel slope: 56.7 mV dec −1 , 50 h long stability).
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POLYMER ENGINEERING AND SCIENCE
·
2025
·
IF 3.2
Xinru Yan,Yan Wang,Yaoming Zhang,Qihua Wang,Zhancheng Zhang,Mingchao Shao,Xianqiang Pei
To address the demand for lightweight, wear-resistant PEEK friction materials in humanoid robotics, this study employed liquid-assisted mechanochemical synthesis to create ZIF-62 crystals. These crystals were then incorporated as functional fillers into PEEK to fabricate ZIF-62/PEEK composites using fused deposition modeling (FDM) technology. The analysis explored how the material's properties related to mechanics and wear are affected by the amount of ZIF-62 (1–3 wt.%), utilizing pin-on-ring friction tests with GCr15 steel rings as the counterface. The tribological mechanisms of the composites were explored by analyzing the morphology of the composites' surfaces after wear, along with the morphology and chemical composition of the transfer films developed on the matching surface. Particular emphasis was placed on the impact of interfacial tribochemical reactions and transfer film establishment on the composite's tribological performance. Research indicates that the integration of ZIF-62 boosts the composite's strength and ability to withstand wear. Specifically, at a ZIF-62 concentration of 3 wt.%, the composites reach 3.7 × 10 −6 mm 3 /Nm, representing a 71.5% decline compared to pure PEEK, showcasing outstanding anti-wear capabilities. Findings of the study provide a unique solution for the tribological modification of PEEK, which is instructive for the design and preparation of PEEK tribo-materials used in humanoid robots.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zhipeng Wang,Junkai Wang,Runchang Su,Gang Zhou,Yuhang Liu,Mei Zhang,Min Guo
The power conversion efficiency (PCE) of perovskite solar cells (PSCs) based on SnO 2 electron transport layer (ETL) has exceeded 26.1 %. However, defects located at interfaces of ETL/perovskite films and perovskite/hole transport layer (HTL) remain a key factor in reducing performance of PSCs, especially in the air environment. The effect of single defect passivation of SnO 2 ETL/perovskite or perovskite films/HTL on performance of PSCs is limited. In addition, the green and stable characteristics of passivation agents are important factors that must be considered for the sustainable development of perovskite solar cells. To address this, natural amphiphilic betaine molecules and green hydrogen bond system composed of imidazole and salicylic acid (ImA-SA HBS) are introduced, which simultaneously passivate SnO 2 ETL/perovskite and perovskite/HTL defects. The addition of betaine not only improves the charge extraction at the SnO 2 /perovskite interface, but also suppresses the recombination of photogenerated carriers. Furthermore, due to introduction of ImA-SA HBS, the charge transport between perovskite grains and energy level matching of perovskite/HTL interface are improved, which increase the PCE of PSCs prepared in air from 20.67 % to 22.20 %. Furthermore, the PSCs passivated with betaine and HBS show no decrease in PCE after being stored in air for 66 days. This paper provides theoretical basis and technical support for defect passivation strategy and performance optimization of PSCs prepared in air environment.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Xin Wang,Shuangjie Qin,Caiwen Wu,Hongbo Li,Hongjuan Li,Jinghua Yu
Milk fat globule membrane materials possess diverse biological activities and excellent emulsifying properties, but their application in the dairy industry remains limited. In this study, high-fat emulsions were prepared by replacing anhydrous milk fat with high-fat cream at different ratios, and their physicochemical properties were characterized. The interfacial composition, microstructure, and mechanical properties were analyzed using sodium dodecyl sulfate polyacrylamide gel electrophoresis, nuclear magnetic resonance, laser confocal microscopy, and atomic force microscopy. The results revealed that samples with added membrane materials exhibited superior stability during storage and under simulated gastrointestinal conditions. Membrane proteins and phospholipids adsorbed heterogeneously on the milk fat globule (MFG) interface and exhibited stronger fluorescence. The addition of membrane materials reduced the Young's modulus of the interfacial membrane (646.17 ± 5.24 kPa). The emulsion prepared via this method was enriched with membrane components, altering interfacial molecular distribution and mechanical properties, enhancing MFG stability.
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高影响因子
Talanta Open
·
2025
·
IF 3.7
Qiao Chen,Xiaoran Zhang,Xinyue Zhou,Peng Huang,Daming Feng,Xu Xu,Chunhua Ge
We report a metal-free perylene-based polyimide framework (PDI-PB) as an efficient electrocatalyst for oxygen reduction reaction (ORR)-enhanced cathodic electrochemiluminescence (ECL). PDI-PB enhances reactive oxygen species (ROS) generation via oxygen reduction that significantly amplify the luminol–dissolved oxygen ECL signal. The resulting biosensor enables ultrasensitive detection of dopamine (DA) over a wide linear range (5 × 10 -5 to 100 μM) with a record-low detection limit of 9.76 pM (S/N = 3). The sensor exhibits excellent selectivity, stability, and reproducibility, and was successfully applied to detect DA in human sweat, serum, and urine, yielding recoveries of 97.0–101.1%. Density functional theory (DFT) calculations reveal that PDI-PB’s superior electronic structure facilitates efficient charge transfer and oxygen activation. This work presents a new strategy for metal-free organic electrocatalyst design, combining mechanistic insight with high-performance ECL biosensing for non-invasive health monitoring and clinical diagnostics.
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FREE RADICAL BIOLOGY AND MEDICINE
·
2025
·
IF 8.2
Jiansong Liu,Shuo Wang,Changyu Tao,Haoyun Liu,Yutong Mao,Xinhui Zhao,Kaiqi Cheng,Guanqun Mu,Meng Wang,Weibin Wang,Ence Yang,Jiadong Wang,Yang Yang
Peroxisomes are essential organelles that maintain cellular redox homeostasis. Although alternatively spliced variants of certain peroxisome-related genes have been identified, the regulatory mechanisms governing alternative splicing (AS) and its functional impact on peroxisomal redox homeostasis remain poorly understood. Here, we demonstrate that glucose starvation (GS) induces crotonylation of DEAD-box helicase 1 (DDX1), which is regulated by the crotonyltransferase general control non-repressed protein 5 (GCN5) and the decrotonylase histone deacetylase 1 (HDAC1). DDX1 crotonylation at the lysine 490 residue enhances its interaction with heterogeneous nuclear ribonucleoprotein K (HNRNPK), which mediates mutually exclusive AS of acyl-CoA oxidase 1 (ACOX1). The AS of ACOX1, driven by DDX1 crotonylation and HNRNPK, promotes the generation of peroxisomal ROS, thereby enhancing oxidative damage and ultimately suppressing colorectal cancer (CRC) cell proliferation. Our findings uncover a novel mechanism by which DDX1 crotonylation regulates the AS of peroxisome-related genes and mediates peroxisomal redox homeostasis. This discovery bridges a critical gap in our understanding of how posttranslational modifications (PTMs) of DEAD/DEXD box RNA helicases modulate gene AS and identifies a potential therapeutic target for colorectal cancer.
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BIOCATALYSIS AND BIOTRANSFORMATION
·
2025
·
IF 1.9
Yanho Hu,Yakun Shan,Yue Yang,Yudi Song,Yiming Li,Xi Wang,Ruining Zhang,Jun Zhao
Rare ginsenoside F1, a bioactive component of ginseng, possesses notable anti-tumour, anti-aging, and antioxidant properties; however, its low natural abundance and the difficulty of large-scale preparation limit its practical application. In this study, ginsenoside Rg1 was converted into rare ginsenoside F1 using a recombinant β-glucosidase (BgpA), BaBgl1A, and the products were analysed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). The results demonstrated that BaBgl1A selectively hydrolysed the glucose moiety at the C-6 position of Rg1. The biotransformation conditions were optimised to pH 5.0, 45 °C, a substrate concentration of 2 mg/mL, and an enzyme loading of 2.0 U/mg. Under these conditions, the biotransformation was completed within 12 h with a biotransformation conversion of 98%, and the product structure was confirmed by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF-MS). Molecular docking analysis revealed that hydrogen bonding was the dominant interaction between Rg1 and BaBgl1A, with an optimal binding energy of −7.9 kcal/mol. Rg1 bound to the active site of BaBgl1A through three key amino acid residues (ALA-178, SER-43, and SER-354), which facilitated the hydrolysis of the outer Glc residue at the C-6 position. These findings provide a novel strategy for the efficient large-scale preparation of rare ginsenoside F1.
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LANGMUIR
·
2025
·
IF 3.9
Ruiyv Bai,Weian Huang,Zengbao Wang,Yunfeng Liu,Lin Jiang
A novel Mannich base quaternary ammonium salt (MIB) was synthesized via a two-step method using imidazole, acrylamide, and benzyl bromide as primary raw materials. Its corrosion inhibition performance for N80 carbon steel in 20% HCl solution was investigated through weight loss and electrochemical experiments, and the synergistic effects between MIB and different additives were evaluated. MIB demonstrated potential as a temperature-resistant inhibitor, exhibiting a corrosion rate of 6.04 g·m–2 ·h–1 and an inhibition efficiency (IE) of 99.3% at 363 K with the addition of 1% MIB. A notable synergistic effect was observed when MIB was used in conjunction with KI. Under more severe conditions (433 K, 3 MPa, 20% HCl), the system maintained a corrosion rate of 59.12 g·m–2·h–1 while still achieving a high IE of 95%. Adsorption kinetics and thermodynamics studies revealed that the adsorption of MIB on the N80 steel surface followed the Langmuir adsorption model, increasing the energy barrier of the corrosion reaction and thereby making the process more difficult to occur. Theoretical calculations and surface analysis indicated that both neutral and protonated forms of MIB possess electron-donating and electron-accepting capabilities, which facilitate their adsorption onto the metal surface. Under high-temperature conditions, iodide ions (I–) not only adsorb onto the metal surface, filling the gaps between MIB molecules, but also form a negatively charged layer. This negative layer subsequently attracts the positively charged quaternary ammonium cations of MIB, thereby enhancing the adsorption capability of MIB on the metal surface in high-temperature environments.
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危险品化学品经营许可证（带存储）