ENVIRONMENTAL TOXICOLOGY
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2021
·Vol. 37
·期 1
·101-119
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IF 4.119
Caixia Wang,Zhangyu Gu,Xueyan Gu,Xinyue Tan,Shuang Wang,Rui Zhang,Ruifen Li,Mingkun Sun,Chunyan Gui,Sheng Li,Yixing Ye,Jianhua Ma,Li Su,Changhao Liang
The aim of this study was to investigate the protective effects of Nano-Se against nickel (Ni)-induced hepatotoxicity and the potential mechanism. Hence, we constructed in vivo and in vitro models of Ni-induced hepatotoxicity. Sprague–Dawley (SD) rats were exposed to nickel sulfate (NiSO 4 , 5.0 mg/kg, i.p.) with or without Nano-Se (0.5, 1, and 2 mg/kg, oral gavage) co-administration for 14 days, and HepG2 cells were exposed to NiSO 4 (1500 μM) with or without Nano-Se (20 μM) for 24 h. Nano-Se obviously prevented Ni-induced hepatotoxicity indicated by ameliorating pathological change and decreasing Ni accumulation in rat livers. Ni induced a significant increase in hepatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GSH-Px), and malondialdehyde (MDA) level, decreased the glutathione (GSH) content while compared to those in the control group. Nano-Se administration improved the hepatic antioxidant capacity through increase hepatic GSH contents and GSH-Px activity, decrease the activities of SOD, CAT, and MDA level. Nano-Se improved the cell viability, decreased active oxygen (ROS) generation and ameliorated morphological changes of nuclear structures in Ni-treated HepG2 cells. In addition, Nano-Se inhibited the Ni-induced increases of cytochrome c, caspase-9, cleaved caspase-3, increased PI3K and AKT phosphorylation both in vivo and in vitro. Besides, the PI3K inhibitor Y294002 could inhibit the protective effects of Nano-Se on apoptosis. Thus, Nano-Se significantly activates PI3K/AKT signaling to ameliorate apoptosis in Ni-induced hepatotoxicity.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2021
·
IF 5.316
Ya-feng Deng,Yong Chen,Xiu-li Zhang,Qian Zhang,Zi-jian Wei,Dong Wang
An in-situ one-step hydrothermal method is used to prepare hybrid CuSe@NiSe nanosheets with vertical orientation and interpenetrating structure on the surface of copper foam (S-CuSe@NiSe). The S-CuSe@NiSe has excellent electrochemical performance and outstanding cycling performance. The specific capacitance of the S-CuSe@NiSe is 1478 F g -1 at a current density of 1 A g -1 and stabilizes at 990 F g -1 at 8 A g -1 . The specific capacitance retention of S-CuSe@NiSe is 81.7% after 10,000 cycles. The all-solid-state flexible capacitors prepared with S-CuSe@NiSe as electrode (S-CuSe@NiSe-SFCs) also exhibit excellent flexibility, superior electrochemical performance and cycle stability. Its capacitance reaches 333 F g -1 at a current density of 1 A g -1 . Capacitance retention of 79.3% has been obtained after 10,000 charge-discharge cycles at 2 A g -1 .
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Nanoscale
·
2021
·Vol. 13
·期 42
·17846-17853
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IF 7.79
Ting Li,Qing Zhang,Xiao Hu Wang,Juan Luo,Li Shen,Hong Chuan Fu,Fei Gu,Nian Bing Li,Hong Qun Luo
Electrochemical water splitting is widely studied in the hope of solving environmental deterioration and energy shortage. The design of inexpensive metal catalysts exhibiting desired catalytic performance and durable stability for efficient oxygen evolution is the pursuit of sustainable and clean energy fields. Herein, a three-dimensional (3D) flower-like NiSe2 primary structure, modified with highly dispersed CuSe2 nanoclusters as the secondary structure, is obtained by regulating the growth trend of the nanosheets. Benefiting from the metallicity of selenides and the formation of a heterogeneous interface, NiSe2@CuSe2/NF shows comparable performance toward the oxygen evolution reaction (OER) in an alkaline environment. Upon regulating the synthesis conditions, the catalyst exhibits its optimal performance with ultralow overpotential for the OER when the Ni/Cu molar ratio is 1 : 0.2 and the hydrothermal temperature and hydrothermal time are 200 °C and 6 h, respectively. It provides a current density of 10 mA cm−2 when a potential of 201 mV is applied without iR compensation. In this work, the hierarchical heterostructures of NiSe2 and CuSe2 are synthesized, which exhibit high electrocatalytic activity towards the oxygen evolution reaction and provides a new possibility for the extensive application of copper-based compounds in advanced energy fields.
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ACTA MATERIALIA
·
2021
·
IF 8.203
Jie Chen,Qiang Sun,Deyu Bao,Bang-Zhou Tian,Zegao Wang,Jun Tang,Dali Zhou,Lei Yang,Zhi-Gang Chen
Thermoelectric materials strengthened by defect engineering can also suffer from the compromise of plasticity, and in turn results in negative effect on the processability, reliability and durability of thermoelectric devices. Here, we introduce nano-twinned CuAgSe secondary phase to achieve simultaneously increased compressive strength and plasticity of the β-Ag 2 Se pellets without obviously sacrificing the thermoelectric performance, as evidenced by our thermoelectric measurements. Our pellet shows a maximum compressive strength of 96 MPa, which is ∼104% higher than that of pristine Ag 2 Se, ascribed to the impeded crack propagation by the CuAgSe secondary phase. An extraordinary deformation value of ∼19% is observed at the maximum compressive strength, which is attributed to the intrinsically large plastic deformation of the Ag 2 Se matrix, the deformable nano-twinned CuAgSe secondary as well as the interaction between the Ag 2 Se matrix and the CuAgSe secondary phase. This work indicates that introducing nano-twinned secondary phase in thermoelectric materials is a promising strategy for developing high-performance thermoelectric materials with high strength and plasticity.
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NANOTECHNOLOGY
·
2021
·Vol. 32
·期 34
·345706
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IF 3.874
Leqiu He,Yan Wang,Yajie Guo,Guobing Li,Xubin Zhang,Wangfeng Cai
Novel core−shell nanostructure electrodes benefit from the excellent properties of their constituent materials, as well as the synergy between them. However, it is challenging to fabricate such structures efficiently. In this study, NiSe nanorods were fabricated using Ni foam as the conductive substrate and reactant via a one-step hydrothermal process, and Ni(OH)2 nanosheets were coated on the surface of the nanorods via one-step electrodeposition. The effect of the structure and morphology on the properties of the material was explored using scanning electron microscopy, x-ray diffraction, and electrochemical technology. The obtained core−shell NiSe/Ni(OH)2 exhibited an areal capacity of 1.89 mAh cm−2 at a current density of 5 mA cm−2. The assembled NiSe/Ni(OH)2//AC hybrid supercapacitor exhibited excellent energy and power densities, indicating that NiSe/Ni(OH)2 has great potential for use as a battery-type electrode in energy storage systems.
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Journal of Energy Storage
·
2021
·
IF 6.583
Xiaobo Chen,Jiangyue Zhu,Jianghao Cai,Yang Zhang,Xiaohua Wang
Herein, we report a composite structure by incorporating MoSe 2 nanosheets in organ-like Ti 3 C 2 T x MXene (MXene/MoSe 2 ) as new nanohybrid anode materials for high-performance asymmetric supercapacitors. Benefits of the positive advantages including unique heterostructure, enhanced active area for redox reactions, and beneficial synergetic interaction, the specific capacitance of the MXene/MoSe 2 composite electrode was high up to 1358.5 F g −1 at 1 A g −1 , much higher than that of the pure Ti 3 C 2 T x MXene and MoSe 2 electrodes. In addition, when applied the synthesized Ti 3 C 2 T x MXene/MoSe 2 nanohybrid as positive electrode in asymmetric supercapacitor (ASC), excellent performance is observed. For instance, a high specific energy of 55.6 Wh kg −1 , high specific power of 800.3 W kg −1 with the capacitance retention of 94.1% even after 10,000 cycles at a high current density of 5 A g −1 are obtained. These results indicate that the MXene/MoSe 2 composite will be a high promising candidate for supercapacitors.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Hua Yan,Jiangtao Dong,Xuan Huang,Xuezhong Du
Two novel stimuli-responsive drug delivery systems (DDSs) were successfully created from bovine serum albumin- or myoglobin-gated upconversion nanoparticle-embedded mesoporous silica nanovehicles (UCNP@mSiO2) via diselenide (Se–Se)-containing linkages. More importantly, multiple roles of each scaffold of the nanovehicles were achieved. The controlled release of the encapsulated drug doxorubicin (DOX) within the mesopores was activated by triple stimuli (acidic pH, glutathione, or H2O2) of tumor microenvironments, owing to the conformation/surface charge changes in proteins or the reductive/oxidative cleavages of the Se–Se bonds. Upon release of DOX, the Förster resonance energy transfer between the UCNP cores and encapsulated DOX was eliminated, resulting in an increase in ratiometric upconversion luminescence for DOX release tracking in real time. The two protein-gated DDSs showed some differences in the drug release performances, relevant to structures and properties of the protein nanogates. The introduction of the Se–Se linkages not only increased the versatility of reductive/oxidative cleavages but also showed less cytotoxicity to all cell lines. The DOX-loaded protein-gated nanovehicles showed the inhibitory effect on tumor growth in tumor-bearing mice and negligible damage/toxicity to the normal tissues. The constructed nanovehicles in a spatiotemporally controlled manner have fascinating prospects in targeted drug delivery for cancer chemotherapy.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
·
IF 8.128
Jinxin Wei,Zhe Hu,Wenjie Zhou,Yi Qiu,Hanqing Dai,Yuanyuan Chen,Zhongjie Cui,Siyu Liu,Haiyang He,Wanlu Zhang,Fengxian Xie,Ruiqian Guo
With the blooming development of zero-dimensional nanomaterials , I-III-VI alloying quantum dots (QDs) with outstanding photoelectrical properties have emerged to attract much attention as promising environmentally-friendly substitutions for conventional binary Cd-based QDs. In this work, a facile one-pot method was introduced to synthesize unreported quaternary Ag-Cu-Ga-Se/ZnSe (ACGSe/ZnSe) QDs. A relatively high photoluminescence quantum yield (PL QY) of 71.9% and a tunable emission from 510 to 620 nm were successfully achieved. We explored the roles of alloying compositions in ACGSe/ZnSe QDs, inferring that increased Ag proportion would not only lower the V defect level which leads to the blue shift of emission, but also slow the ZnSe shelling process owing to the larger lattice distortion. At last, the white light-emitting diodes (WLEDs) were fabricated with ACGSe/ZnSe QDs as the conversion layer, indicating that the as-prepared QDs are a promising candidate for further applications.
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APPLIED PHYSICS LETTERS
·
2021
·Vol. 118
·期 18
·
IF 3.791
Yin Feng,Yan Kelan,Shen Liming,Bao Ningzhong
Random metamaterial with negative electric permittivity ( ε < 0) and negative magnetic permeability ( μ < 0) is a group of attractive alternatives to ordered double negative metamaterials (DNMs) with periodic unit cells; however, the preparation of random DNMs with a relatively convenient preparation process and their electromagnetic property adjustment are of challenge. Here, we report the preparation of metallic ferromagnetic selenospinel composites, x CdCr 2 Se 4 ·(1− x )CuCr 2 Se 4 , from metallic powders by using a simple solid-state reaction process, and double negative ε and μ have been observed in the frequency range of 120–650 MHz for 0.2CdCr 2 Se 4 ·0.8CuCr 2 Se 4 and 73–520 MHz for 0.4CdCr 2 Se 4 ·0.6CuCr 2 Se 4 . The negative ε is owing to the plasmonic state of delocalized carriers in the metallic ferromagnetic CuCr 2 Se 4 , which can be described with the Drude model. The suppression of the magnetic resonance induced by the eddy current has been alleviated by the proper addition of the paramagnetic semiconductor CdCr 2 Se 4 . A theoretical model deduced from Maxwell's equation has been constructed based on the skin effect to elucidate the magnetic resonance-dependent negative permeability. Our work introduces the metallic ferromagnetic chalcospinels into the field of random DNMs and sheds light on the theoretical understanding and tuning mechanism on the double negative properties.
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International Journal of Nanomedicine
·
2021
·
IF 6.4
Wanzhen Li,Ping Song,Ying Xin,Zhao Kuang,Qin Liu,Fei Ge,Longbao Zhu,Xuguang Zhang,Yugui Tao,weiwei zhang
Background With the development of bacterial resistance, the range of effective antibiotics is increasingly becoming more limited. The effective use of nanoscale antimicrobial peptides (AP) in therapeutic and diagnostic methods is a strategy for new antibiotics.Methods Combining both AP and cadmium selenide (CdSe) into a composite material may result in a reagent with novel properties, such as enhanced antibacterial activity, fluorescence and favorable stability in aqueous solution.Results AP-loaded CdSe NPs (AP-CdSe NPs) showed strong antibacterial activity against multidrug-resistant (MDR) Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) in vitro and in vivo. Colony-forming unit (CFU) and minimum inhibitory concentration (MIC) assays showed that AP-CdSe NPs have highly effective antibacterial activity. The quantitative analysis of apoptosis by flow cytometry analysis further confirmed that MDR E. coli and S. aureus treated with AP-CdSe NPs had death rates of 98.76% and 99.13%, respectively. Also, AP-CdSe NPs was found to inhibit bacterial activity in an in vivo bacteremia model in mice infected with S. aureus. In addition, the antibacterial mechanism of AP-CdSe NPs was determined by RNA sequencing analysis. Gene ontology (GO) analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis revealed the molecular mechanism of the antibacterial effect of AP-CdSe NPs. Importantly, histopathology analysis, and hematological toxicity analysis indicated that AP-CdSe NPs had few side effects.Conclusion These results demonstrate that AP loaded on CdSe NPs had a higher water solubility, bioavailability and antibacterial effect compared with raw AP. This study reports findings that are helpful for the design and development of antibacterial treatment strategies based on AP.
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Nanoscale Advances
·
2021
·Vol. 3
·期 8
·2334-2342
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IF 4.553
Senlin Qu,Xin Yuan,Yu Li,Xingyang Li,Xiujuan Zhou,Xiaogang Xue,Kexiang Zhang,Juan Xu,Changlai Yuan
The composition and defect tolerance of CuInSe2 (CISe) quantum dots (QDs) provide a scaffold to design defects via tailoring the elemental ratio or distributions for boosting photocatalytic H2 evolution (PHE). Herein, a ligand-assisted two-step aqueous method was developed to prepare defect CISe quantum dots for the first time. UV-vis, XPS, HRTEM, and HADDF investigations confirmed the typical double-absorption edges of copper vacancy defects and indium substituted at copper site defects in the structure constructed through initial synthesis tuned by Cu/In ratio and the ensued coarsening. The steady-transient PL suggested that the D–A recombination with prolonged PL lifetime dominated the emission of composition-optimized CuInSe2 with the Cu/In ratio of 1/4 (CISe-1/4). Further transient photocurrent and electrochemical impedance spectroscopy investigations demonstrated that surface defects in the structure favor the carriers' separation/transportation. The CISe-1/4 exhibited a superior PHE rate of 722 μmol g−1 h−1, about 23 times higher than that of the initially synthesized CISe-1/4 nucleus (31 μmol g−1 h−1), with a maximum apparent quantum efficiency (AQE) of 1.3%. The analysis of energy levels and the coulombic interaction energy of electron–hole (Je/h) based on Raman, extending UV-vis spectra investigations suggested that surface defects resulted in decreased Je/h of CISe-1/4, favoring the enhanced PHE of this structure. This work is expected to provide a reference for designing effective non-noble metal I–III–VI photocatalysts.
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BIOMATERIALS
·
2021
·
IF 12.479
Jichun Yang,Shuojiong Pan,Shiqian Gao,Tianyu Li,Huaping Xu
Carbon monoxide (CO) therapy and antiangiogenesis therapy (AAT) are regarded as promising approaches for cancer treatment. However, the poor tumor targeting ability and inevitable side effects prevent their clinical application. In this study, we developed H 2 O 2 -responsive diselenide-containing micelles that combined CO therapy with chemosensitization therapy and AAT in a single system. Under the interaction of intratumoral H 2 O 2 , CO and gemcitabine (GEM) were released in situ from the micelles to reduce side effects, and CO significantly sensitized the chemotherapeutic effect of GEM by elevating the level of reactive oxygen species (ROS) in human gastric cancer AGS cells. Furthermore, diselenide bonds in the micelles were oxidized to seleninic acid in organic form, which suppressed the expressions of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) to realize AAT. This study provides an integrated solution to combine CO therapy with chemosensitization therapy and AAT together with good biocompatibility .
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