INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Shuang Cai,Linlin Wang,Xilong Cui,Xinshu Zou,Sidi Zheng,Fanhui Liu,Chun Shi,Yanhua Li,Zhiyun Zhang
The multi-drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) and complex wound microenvironment challenge the repair of MRSA infected wound. Herein, in this study, α-tocopherol modified glycol chitosan (TG) nanoparticles encapsulated with phytochemical rhein (Rhein@TG NPs) were prepared for comprehensive anti-infection and promotion of MRSA infected wound healing. Rhein@TG NPs could not only specifically release rhein in the infection site in response to low pH and lipase of infectious microenvironment, but also up-regulated M1 macrophage polarization in the infection stage, thus achieving synergistically bacterial elimination with low possibility of developing resistance. Additionally, the NPs reduced the levels of pro-inflammatory factors in the post-infection stage, scavenged the ROS, promoted cell migration and angiogenesis, which significantly improved the microenvironment of infected wound healing. Therefore, this antibiotic-free NPs enabling anti-infection and promotion of wound healing provides a new and long-term strategy for the treatment of MRSA infected wound.
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JOURNAL OF CHROMATOGRAPHY A
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2024
·
IF 3.8
Huifeng Deng,Yanqun Yang,Jianbin Ju,Yu Jiang,Xiaowen Huang,Zhenyu Li,Rui Shi,Guihua Ruan,Yipeng Huang
In this study, 4-vinylphenylboronic acid, ionic liquid, and dipentaerythritolhexakis(3-mercaptopropionate) were used as functional monomers to prepare monolithic column in fused-silica capillaries by thermally induced sulfhydryl-alkenyl click polymerization. Based on the properties of 4-vinylphenylboronic acid and ionic liquid, the monolithic capillary column (VPBA-SH-IL) exhibited excellent permeability and chemical stability with the ability to efficiently enrich trace amounts of cytokinins from complex substrates via B←N coordination, π-π interactions, cation-π interactions, S-π interactions and hydrophobic interactions. Under the optimal adsorption conditions, the adsorption efficiency of VPBA-SH-IL for six cytokinins could reach more than 95 %, and the adsorption capacities ranged from 0.18 to 0.99 mg·m −1 . A reliable and sensitive method for the determination of six cytokinins in organs of tomato (root, stem, leaf and fruit) was established by using the monolithic capillary column as in-tube solid-phase microextraction coupled with UHPLC-MS/MS. The developed method showed a wide linear range (0.010–10.0 μg·L −1 ) and low limits of detection (1.6–3.3 ng·L −1 ). The recoveries of the six cytokinins in spiked samples ranged from 80.6 % to 108 % with the relative standard deviations of 2.4–8.7 % ( n = 5). The VPBA-SH-IL shows good potential for extraction and analysis of trace cytokinins in complex matrices such as plants, which is of great significance in exploring the mechanism of plant growth and development.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Fengxian Ju,Lingyu Hua,Jing Xu,Tianduo Li,Tao Wei,Aijie Lv,Huan Yang
Rigid and fragile nature of collagen-based materials cross-linked with biocompatible aldehyde-functionalized polysaccharides remains a challenge. Drawing inspiration from the pangolins' protective barrier, we introduce a novel cross-linker with a flexible chain to impart a “rigid-flexible coupled structure” to the collagen-based matrix. Successful integration of dibenzaldehyde-terminated-PEG (DF-PEG) into collagen molecules was confirmed by XRD and FTIR analyses. CD measurements demonstrated that the intact triple-helical structure was preserved in all samples. Distinct effects of DF-PEG with varying molecular weights on the aggregation behavior of collagen molecules were evaluated using multiple quantitative analysis techniques. Specifically, when the molecular weight of DF-PEG was below 20,000, multipoint hydrogen bonds and Schiff-base linkages were produced as the molecular weight of DF-PEG increased, which synergistically enhanced the aggregation behavior of collagen molecules. While the aggregation behavior of collagen molecules was slightly diminished upon the molecular weight of DF-PEG reached 20,000. This reduction can be attributed to the limited accessibility of the molecular reactive sites in the extended DF-PEG chains. Finally, a computational test of the binding interactions between collagen molecules and DF-PEG was conducted to validate the experimental results. Our biomimetic design strategy offers a new approach for the preparation of collagen-based materials with exceptional physicochemical properties.
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DYES AND PIGMENTS
·
2024
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IF 4.1
Zelin Zhang,Fengshan Liu,Yang Xu,Huanrong Li
The growing demands for multiple-level optical information encryption require the development of novel room temperature phosphorescence (RTP) materials with long afterglow performance and multi-color phosphorescence. Carbon dots (CDs), as a new generation of carbon-based luminescent nanomaterials , have received widespread attention. Here, a series of sulfur-doped carbon dots (S-CDs) with different sulfur doping regulation are proposed as emitters to fabricate RTP materials by embedding boric acid (BA) matrix. With different sulfur doping amount, S-CDs exhibit green, yellow-green and orange RTP, respectively. The RTP spectrum can be split into three emission centers with different intensities. Thus, the multi-color RTP emission is ascribed to varied surface state of S-CDs involving the phosphorescence center intensity changes, which results from sulfur doping. The RTP lifetimes of these S-CDs are calculated to be 579.28, 540.87, and 288.89 ms, which is measured for S-CDs-G@BA, S-CDs-Y@BA and S-CDs-O@BA, respectively. In addition, the phosphorescence quantum yield (PQY) is 27.93 %, 10.62 % and 13.58 %, respectively. The encryption test is performed utilizing these multi-color RTP S-CDs, demonstrating that these S-CDs have good RTP performance and are suitable for anti-counterfeiting and information encryption.
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POLYMERS FOR ADVANCED TECHNOLOGIES
·
2025
·Vol. 36
·期 8
·e70303
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IF 3.4
Shenghua Xu,Weihong Guo
This study develops a sequential surface functionalization strategy for strontium-substituted hydroxyapatite-graft-poly(γ-benzyl-L-glutamate) (Sr10-HA- g -PBLG) porous microspheres to enable in situ scaffold assembly. Hydrazine hydrate-mediated aminolysis and alkaline hydrolysis introduced surface amino (2.87 × 10 −2 mol/g) and carboxyl (1.76 × 10 −2 mol/g) groups, respectively, while preserving structural integrity (verified by FT-IR/XRD/SEM). Subsequent EDC/NHS-activated grafting of 3-amino-1,2-propanediol (AP) achieved 90% efficiency, followed by NaIO 4 oxidation to generate aldehyde functionalities (2.65 × 10 −3 mol/g). Through dynamic imine crosslinking between aldehyde- and amino-functionalized microspheres, 3D scaffolds were formed in situ. The scaffolds exhibited hierarchical porosity (pore size: 40–60 μm, porosity: 85.4% ± 2.3%), exceptional hydration capacity (613.6% ± 24.1% water retention), and enhanced mechanical properties (storage modulus > 13,000 Pa, compressive strength: 0.53 ± 0.02 MPa, tensile strength: 0.068 ± 0.02 MPa). Controlled degradation in PBS (pH = 7.4) showed 46.24% mass loss over 31 weeks. This interfacial engineering approach provides a versatile platform for designing polymer-ceramic hybrids with tailorable surface reactivity and structural adaptability. Adipose-derived stem cells were cultured in vitro, and the dual-fluorescence tracking strategy revealed spatially coordinated cellular colonization patterns, demonstrating porous microsphere scaffold's potential for precision-controlled 3D cell delivery in tissue engineering applications.
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EUROPEAN POLYMER JOURNAL
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2024
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IF 5.8
Zhixia Gong,Tiaozhen Yu,Zhi Cai,Ying Yi,Jingli Zhang,Weiquan Cai,Yihua Yin,Guanghua He,Yaqi Xiao,Peiyu Xu,Huiyi Wu,Sihui Lin
Photoactivated pesticides with high activity, environmental friendliness, and no drug resistance represent the direction of pesticide development. However, poor photostability and lack of targeting ability greatly restrict their practical application. Herein, a novel amphiphilic photoactivated polymeric propesticide was synthesized by conjugation of mPEG with the photo/enzyme-labile o-nitrobenzyl ester group followed by grafting protoporphyrin IX (PpIX), which could self-assemble into photo/esterase responsive polymer micelles in aqueous solutions for a controlled release of PpIX. The fluorescence quenching caused by the aggregation of PpIX into hydrophobic core could enhance its photostability. UV/esterase stimulation could trigger the release of PpIX and restore its photodynamic activity. Compared to a single stimulus, dual stimulation could trigger more PpIX release and resulting in higher photodynamic activity and antibacterial effect. In addition, light exposure also showed little influence on the photodynamic activity and antibacterial effect of the system due to enhanced photostability. Compared with PpIX, the nanosystem exhibited higher wettability and retention ability on plant leaves and could resist rainwater washout. Weed control experiment also demonstrated that the system’s control effect on barnyard grass. Therefore, this study provides new ideas for promoting the application of photoactivated pesticides in the field of plant protection.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Yi He,Xiaoyu Yang,Shunbi Xie,Runzi Zhang,Yao Liu,Mengjun Wang
Roxithromycin (ROX) is an effective antibiotic, but its prolonged administration may lead to hepatotoxicity and other side effects. To address this concern, the present study introduced a novel strategy that integrated a CHA-mediated dual-end DNA walker with hydrogen-bonded organic frameworks (HOFs) combined with Au nanoparticles (NPs) as efficient SERS substrates, enabling highly sensitive detection of ROX in food. Notably, HOF possessed a large specific surface area and strong adsorption properties that making it excellent platforms for the in-situ synthesis of abundant Au NPs and contributed to robust and uniform SERS signals. When ROX was present, it can trigger the activation of CHA and resulting the formation of a dual-end DNAzyme structure. Meanwhile, under the catalytic action of Mg 2+ , DNAzyme initiated the DNA walker mechanism and generated a substantial amount of Output DNA. Moreover, the Au@4-NTP@Ag core-shell structure generated numerous SERS “hot spots” and combined with the signal-amplifying capability of HOF@Au, leading to a remarkable improvement in SERS sensitivity. Based on this mechanism, the developed sensor employs a “signal-on” strategy for ultra-sensitive detection of ROX, achieving a detection range from 1.0 × 10 −6 to 1.0 × 10 −13 mol/L with a detection limit of 3.72 × 10 −14 mol/L. Furthermore, the method had been successfully applied to the detection of ROX in real food samples, including milk and honey, offering a promising and innovative framework for the development of next-generation SERS biosensors. This approach demonstrated significant potential for highly selective and sensitive antibiotic monitoring in food safety applications.
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Asia-Pacific Journal of Chemical Engineering
·
2025
·
IF 1.6
Zhiwei Shi,Xinyu Jia,Hao Chen,Yagang Zhang,Xinfu He,Anning Zhou,Mingyi Wang
Aromatics and hydrogenated aromatics constitute the primary constituents of the recycled solvent utilized in coal liquefaction. However, the presence of hydrogenated aromatics complicates the assessment of the effects of aromatic compounds during the coal liquefaction process. To eliminate the effect of hydrogenated aromatics, solvent-free experiments and experiments with specific polycyclic aromatic compounds (pyrene, fluoranthene, phenanthrene, and naphthalene) were conducted, along with utilizing density functional theory calculations. Results show that the shuttle role of naphthalene is influenced by catalyst activity. In the presence of a low-active catalyst, naphthalene acts as a shuttle agent facilitating indirect hydrogen transfer. However, with a high-active catalyst, direct transfer of hydrogen from H 2 to pyrolysis radicals occurs without involving naphthalene as an intermediary. Polycyclic aromatic compounds exhibit higher hydrogen shuttle ability (pyrene > fluoranthene > phenanthrene > naphthalene). The high hydrogen shuttle ability can be attributed to the higher reactivity in hydrogenation and lower energy barriers for hydrogen transfer. A nonradical hydrogen transfer pathway has been proposed, promoting cleavage of strong covalent bonds and enhancing the yield of asphaltene and preasphaltene. Additionally, π–π inter actions between polycyclic aromatic compounds and pyrolysis radicals have been evaluated. The interactions contribute positively to radical stability. Substances characterized by a greater number of aromatic rings display a more pronounced stabilizing effect on free radicals.
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SCIENCE
·
2025
·Vol. 389
·期 6761
·
IF 45.8
Minju Kim,Mingyue Zhang,You-Liang Zhu,Yan Yan,Xin Pu,Woosung Choi,Sein Chung,Kilwon Cho,Jeongwon Kim,Vladimir Tsukruk,Zhenzhong Yang,Nicholas A. Kotov,Zhong-Yuan Lu,Dong Ha Kim,Zhiqun Lin
Supramolecular assemblies hold great promise for advanced chiral materials because of their structural diversity and dynamic features, but their low chiroptical activity limits practical applications. We report hierarchical supramolecular assemblies with giant chiroptical activity and mechanical attributes achieved through coassembly of achiral amphiphilic unimolecular micelles and chiral additives. Chiral fibrillar assemblies emerge from the nanostructured environment imposed by the micelles, driven by progressive chirality transfer through multiple hydrogen bonds between components. Integrating multifarious achiral luminescent molecules and nanocrystals into these assemblies leads to full-color circularly polarized luminescence–active materials with dissymmetry factors of ~10 −1 . A concentration-dependent chirality inversion is accessed through tailoring the coassembly kinetics. This strategy enables efficient red CPL, crucial for quantum and optical technologies.
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Yuxin Jiang,Ting Li,Senbin Chen,Jintao Zhu
Employing hydrogen-bonded (H-bonded) bottlebrush architecture to realize intelligent therapeutics is particularly advantageous but rare. Herein, we target the construction of H-bond-mediated supramolecular bottlebrush copolymer micelles, FU-IR780@P1, for synergistic cancer chemo/photothermal therapies (CT/PTT). To do so, we first design an H-bonding amphiphilic bottlebrush random copolymer carrier, P(NBDAP-co-NBPEO) (i.e., P1, poly(norbornene-terminated diaminopyridine-co-norbornene-terminated poly(ethylene oxide)), featuring randomly dispersed dual functionalities: H-bonding DAP (diaminopyridine) motifs and hydrophilic PEO (poly(ethylene oxide)) content. On the other hand, by tethering the chemotherapeutic 5-fluorouracil (FU) onto the photothermal agent IR780, “two-in-one” multifunctional prodrug, FU-IR780, is fabricated, integrating an H-bonding site, chemodrug, photothermal, and fluorescence imaging in single formulation. Thanks to the H-bonding DAP/FU association-mediated self-assembly, supramolecular FU-IR780@P1 nanomedicine is thus created, where FU-IR780 can be released on demand via pH/thermal-responsive rupture of the DAP/FU H-bonding interaction, thus enabling intelligent and synergistic CT/PTT. Such H-bonded bottlebrush polymers contribute a fine toolbox that is conducive to attain biomedical requirements for intelligent antitumor treatments.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Na Zhang,Lei-qiang Liu,Yao Zhang,Jun Shen,Yu-gao Wang,Gang Liu,Yan-xia Niu
Coal tar pitch (CTP) is a carbon material with abundant yield in China, but the toxic polycyclic aromatic hydrocarbons (PAHs) contained in it have restricted its broader applications. In order to reduce the PAHs content, an alkylation method was developed in this study to modify CTP (MCTP) by using 1-dodecene as the alkylating reagent, and the optimal reaction conditions (temperature 170 °C, time 4 h, solvent dosage 60 times that of CTP, and alkylating reagent dosage 4 times that of CTP) for synthesizing the MCTP were determined by alkylation modification with model compounds. Compared with CTP, the content of PAHs in MCTP was reduced by 97.35 %. The mechanism of the reaction was explained by analyzing the types of alkylation products and combining structural analyses of CTP and MCTP. PAHs emissions from fumes and the toxic equivalent quantity (TEQ) among different environmental standards were greatly reduced, while MCTP demonstrated low cytotoxicity and ecotoxicity. The method can also be applied to the toxicity assessment of road materials such as alkylation by-products.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Han Gao,Shang Gao,Lei Wang,Zhen Song,Xiaolei Qu,Minli Wang,Tao Long,Jinzhong Wan
Thermal treatment is a commonly applied soil remediation technique that can also change the properties of soil. However, few studies looked into the transformation and mechanism of soil organic matter (SOM) at the molecular level when contaminated soil undergoes thermal remediation. Herein, FT-ICR MS, pyrolysis gas chromatography mass spectrometry (Py-GC–MS), and size exclusion chromatography-diode array detector-fluorescence detector-organic carbon detector (SEC-DAD-FLD-OCD) were used to unveil the molecular transformation mechanism of SOM under 100 °C and 400 °C treatments. The macromolecules transformed to humic and fulvic components after 400 °C treatment, while few transformations occurred after 100 °C treatment. The molecules decreased with the increase in temperature. After 400 °C treatment, over 99 % of the molecules were newly produced, which were mainly aromatic (66 %) and lignin-like (19 %) components. After 100 °C treatment, most of the molecules (73.6 %) were reserved. The unsaturation and aromatic structures of SOM increased significantly after the 400 °C treatment, while the changes were relatively minor after the 100 °C treatment. The fracture of the carbon skeleton, cyclization, and H abstraction reactions were the main mechanisms for the molecular transformation of SOM during 400 °C treatment, while volatilization was the main transformation scheme during 100 °C. Statistical results of pyrolysates show the increase of aromatic components, and the molecular markers reflected the increase of condensed organic carbon and the decrease of phenols, alkene components during 400 °C treatment. The sorption of PAHs for soil decreased after treatment, owing to the loss and transformation of SOM. This study advances the mechanistic understanding of transformation in SOM molecular signatures during thermal treatment.
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危险品化学品经营许可证（带存储）