JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2022
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IF 3.119
Yanjuan Peng,Ziteng Wang,Wenhao Jiao,Xinxin Cheng,Jingjing Yang,Yonghong Hu,Li Mi
This article deals with the saturated solubility and solvation behavior of 2-bromo-9-fluorenone in 10 industrial common solvents and three binary mixed solvents by means of experimental and mathematical correlations. Solubility experiments were investigated using the static equilibrium method combined with high-performance liquid chromatography (HPLC) from 278.15 to 323.15 K at atmospheric pressure. The results showed that the maximum and minimum solubility of 2-bromo-9-fluorenone was 0.0526 (mole fraction) in 1,4-dioxane at 323.15 K and 0.0002 (mole fraction) in methanol at 278.15 K, respectively, and the solubility increased with the increase in temperature in all solvents. Furthermore, the solubility data of 2-bromo-9-fluorenone was analyzed using the Apelblat model, the Buchowski–Ksiazaczak λh model in pure solvents, CNIBS/R-K model, and the Jouyban–Acree model in binary solvent mixtures. By error comparison, the Apelblat model and the CNIBS/R-K model can better predict the solubility of 2-bromo-9-fluorenone. In addition, the solvation behavior was illustrated by the KAT-LSER model in pure solvents, and the result shows that the cohesive energy density in the solution is the main factor affecting 2-bromo-9-fluorenone. Therefore, the solubility data is very important for optimizing the extraction process and recrystallizing 2-bromo-9-fluorenone to obtain a higher yield in industry production.
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Journal of Environmental Chemical Engineering
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2022
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IF 7.968
Han Lin,Liangzhao Huang,Zhihan Gao,Wenting Lin,Yuan Ren
To reduce the occurrence of PPCPs in the environment, its removal in wastewater treatment plants (WWTPs) has attracted much attention. This study reported the removal characteristics of 10 typical PPCPs in two biological treatment processes: blast aeration and UNITANK. The results demonstrated that caffeine (CAF), bezafibrate (BZB), gemfibrozil (GFB), metoprolol (MET), sulfamethoxazole (SMX), and sulfamerazine (SMZ) were mainly removed through biodegradation. Among them, the removal efficiency of CAF was the largest (>85%), and MET was the lowest (<30%). Sulfadiazine (SDZ), naproxen (NPX), sulpiride (SUL), and ofloxacin (OFX) were removed through the combined effect of biodegradation and sludge adsorption. During biotransformation of sulfonamides (SAs), MET, and SUL, some of the conjugates were decomposed into their parent forms again. The results revealed that the adsorption of drugs was correlated with octanol-water partition coefficient (K ow ) and electrostatic interaction. The biodegradation efficiency was affected by oxygen supply conditions. The facultative environment, longer sludge retention time (SRT) and hydraulic retention time (HRT) were positively correlated with the removal of most drugs (CAF, SUL, GFB, MET, NPX, OFX, SDZ, SMX). This paper summarized the similarities and differences of drugs’ removal characteristics under different processes and wish to provide useful suggestion for the removal technology of PPCPs in WWTP.
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Advanced Energy Materials
·
2020
·Vol. 10
·期 25
·2000892
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IF 25.245
Yongchao Tang,Xuejin Li,Haiming Lv,Dong Xie,Wenlong Wang,Chunyi Zhi,Hongfei Li
In aqueous alkaline Zn batteries (AZBs), the Co 3+ /Co 4+ redox pair offers a higher voltage plateau than its Co 2+ /Co 3+ counterpart. However, related studies are scarce, due to two challenges: the Co 3+ /Co 4+ redox pair is more difficult to activate than Co 2+ /Co 3+ ; once activated, the Co 3+ /Co 4+ redox pair is unstable, owing to the rapid reduction of surplus Co 3+ to Co 2+ . Herein, CoSe 2− x is employed as a cathode material in AZBs. Electrochemical analysis recognizes the principal contributions of the Co 3+ /Co 4+ redox pair to the capacity and voltage plateau. Mechanistic studies reveal that CoSe 2− x initially undergoes a phase transformation to derived Co x O y Se z , which has not been observed in other Zn//cobalt oxide batteries. The Se doping effect is conducive to sustaining abundant and stable Co 3+ species in Co x O y Se z . As a result, the battery achieves a 10 000-cycle ultralong lifespan with 0.02% cycle −1 capacity decay, a 1.9-V voltage plateau, and an immense areal specific capacity compared to its low-valence oxide counterparts. When used in a quasi-solid-state electrolyte, as-assembled AZB delivers 4200 cycles and excellent tailorability, a promising result for wearable applications. The presented effective strategy for obtaining long-cyclability cathodes via a phase transformation-induced heteroatom doping effect may promote high-valence metal species mediation toward highly stable electrodes.
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ADVANCED MATERIALS
·
2024
·
IF 27.4
Yibo Xu,Shirong Wang,Hongli Liu,Xianggao Li
Organic metal halide perovskite solar cells (PSCs) bearing both high efficiency and durability are predominantly challenged by inadequate crystallinity of perovskite. Herein, a polymer microencapsulation-expansion-contraction strategy is proposed for the first time to optimize the crystallization behavior of perovskite, typically by adeptly harnessing the swelling and deswelling characteristics of poly(4-acryloylmorpholine) (poly(4-AcM)) network on PbI 2 surface. It can effectively retard the crystallization rate of perovskite, permitting meliorative crystallinity featured by increased grain size from 0.74 to 1.32 µm and reduced trap density from 1.12 × 10 16 to 2.56 × 10 15 cm −3 . Moreover, profiting from the protection of poly(4-AcM) microencapsulation layer, the degradation of the perovskite is markedly suppressed. Resultant PSCs gain a robust power conversion efficiency (PCE) of 24.04%. Typically, they maintain 91% of their initial PCE for 13 008 h in a desiccated ambient environment and retain 92% PCE after storage for 4000 h with a relative humidity of 50 ± 10%, which is the state-of-the-art long-term stability among the reported contributions.
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THERAPEUTIC DRUG MONITORING
·
2024
·
IF 2.8
Fan Xudong,Guo Suhang,Zhang Ruoying,Cai Qingshan,Lang Yazhen,Huang Jinpeng,Chen Yuanyuan,Zhang Ying,Xu Yingying,Chen Meng,Yang Gaoyi,Cai Xinjun
Introduction: Linezolid, moxifloxacin, rifapentine, rifabutin, cycloserine, clofazimine, bedaquiline, levofloxacin, prothionamide, and ethionamide are commonly used second-line antituberculosis (anti-TB) drugs. To support therapeutic drug monitoring in regular clinical practice, the authors sought to develop a method based on ultra–high-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) that would allow for the simultaneous quantification of multiple second-line anti-TB drugs in human serum. Methods: Analytes were extracted from human serum by protein precipitation. UHPLC-MS/MS was performed using a gradient at a flow rate of 0.3 mL/min, and each sample was taken for 7.5 minutes. The mass spectrometry scanning mode used was electrospray ionization with multiple reaction monitoring in the positive mode. Results: Validation showed that endogenous substances in the sample did not interfere with the assay, and the relationship between X and Y was highly linear, with a coefficient of determination (R 2 ) >0.9954 for each curve. The accuracy (85.0%–114.7%) and precision (intraday: 0.27%–9.32%; interday: 0.20%–7.66%) were less than 15.0%, and the internal standard-normalized matrix effects were consistent (coefficient of variation ≤4.40%). The analytes were stable in the final extract and human serum under various storage conditions (recovery: 87.0%–115.0%). The clinical applicability of the method was demonstrated by quantitative determination of analytes in serum samples obtained from patients with TB. Reproducibility of the drug concentrations measured in clinical samples was confirmed by incurred sample reanalysis. Conclusions: A simple and reliable analytical method was developed and validated for the simultaneous determination of 10 anti-TB drugs in human serum using UHPLC-MS/MS. Quantitation of anti-TB drugs in clinical samples confirmed that the assay is suitable for therapeutic drug monitoring in regular clinical practice.
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BIOCHEMICAL PHARMACOLOGY
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2022
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IF 6.1
Yin-Peng Bai,Cheng-Jie Yang,Nan Deng,Mi Zhang,Zhi-Jun Zhang,Lei Li,Yong Zhou,Xiong-Fei Luo,Chuan-Rui Xu,Bao-Qi Zhang,Yue Ma,Ying-Qian Liu
A series of new 7-ethyl-10-fluoro-20-O-(cinnamic acid ester)-camptothecin derivatives were synthesized and evaluated for cytotoxicity against four human tumor cell lines including HepG2 (hepatocellular carcinoma), SW480 (colorectal cancer), A2780 (ovarian cancer), and Hucct1 (intrahepatic cholangiocarcinoma). The results of cytotoxic activities in vitro showed that most of the camptothecin derivatives harbor promising cytotoxic activity against tested tumor cell lines. Among them, compound XJS-11 exhibited broad-spectrum inhibitory activities against HepG2, SW480, A2780, and Hucct1 cell lines with IC 50 values of 0.03, 0.09, 0.22, and 0.32 μM, respectively. Further investigation demonstrated that compound XJS-11 exhibited more effective growth inhibition against a variety of human hepatoma cells (Sk-hep-1, Hep3B and Huh7) and lower cytotoxicity against immortalized normal human liver cell line L02 than the positive control topotecan . Especially, XJS-11 showed higher selective toxicity in two kinds of human hepatoma cells and immortalized normal human liver cell line (IC 50(L-02) /IC 50(HepG2) = 113.20; IC 50(L-02) /IC 50(Hep3B) = 85.60) than topotecan (IC 50(L-02) /IC 50(HepG2) = 9.45; IC 50(L-02) /IC 50(Hep3B) = 8.52). Mechanistically, XJS-11 induced cell cycle arrest and cell apoptosis in HepG2 and Hep3B cells by inhibiting Top I activity in a manner similar to that of topotecan. Meanwhile, XJS-11 could attenuate the tumor growth in both xenograft and primary HCC mouse models. In addition, the acute toxicity assay showed that XJS-11 did not cause lethality or significant body weight loss with a single intraperitoneal dose at 100 mg/kg or with an intraperitoneal dose at 25 mg/kg for 7 days. Moreover, unlike topotecan, XJS-11 had no apparent toxicity to the mouse liver, kidney, and hemopoietic system of the C57BL/6 mice. Taken together, XJS-11 merits further development as a new generation of the camptothecin-derived drug candidate.
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LANGMUIR
·
2013
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IF 4.187
Yumin Leng,Yonglong,Li,An Gong,Zheyu Shen,Liang Chen,Aiguo Wu
A new kind of analytical reagent, hexadecyl trimethyl ammonium bromide (CTAB), and dithizone product-modified gold nanoparticle dispersion, is developed for colorimetric response to 10 types of heavy metal ions (Mn+), including Cr(VI), Cr3+, Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, and Pb2+. The color change of the modified gold nanoparticle dispersion is instantaneous and distinct for Mn2+, Co2+, Ni2+, Cu2+, Zn2+, Cd2+, Hg2+, and Pb2+. The color change results from the multiple reasons, such as electronic transitions, cation−π interactions, formation of coordination bonds, and Mn+-induced aggregation of gold nanoparticles (AuNPs). The different combining capacity of heavy metal ions to modifiers results in the different broadening and red-shifting of the plasmon peak of modified AuNPs. In addition, Cr(VI), Cu2+, Co2+, Ni2+, and Mn2+ cause the new UV–vis absorption peaks in the region of 360–460 nm. The interactions between the modifiers and AuNPs, and between the modifiers and Mn+, are investigated by using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The results confirm that AuNPs are modified by CTAB and dithizone products through electrostatic interactions and Au–S bonds, respectively, and the Mn+–N bonds form between Mn+ and dithizone products. Furthermore, the experimental and density functional theory calculated IR spectra prove that dithizone reacts with NaOH to produce C6H5O– and [SCH2N4]2-. The validation of this method is carried out by analysis of heavy metal ions in tap water.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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2017
·Vol. 106
·期 5
·1236-1246
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IF 3.076
Miusi Shi,Can Wang,Yulan Wang,Cuizhu Tang,Richard J. Miron,Yufeng Zhang
Bone grafts are widely used in bone regeneration to increase the speed and quality of new bone formation. While they are routinely characterized based on their biocompatible and bioactive properties, they also exert a profound impact on host immune responses, which in turn can display a significant effect on the healing and repair process. In this study, we investigated the role of macrophage behavior on deproteinized bovine bone matrix (DBBM, BioOss) to investigate their impact on creating either a pro- or anti-inflammatory microenvironment for tissue integration. RT-PCR and immunofluorescence staining results demonstrated the ability for RAW 264.7 cells to polarize toward M2 wound-healing macrophages in response to DBBM and positive control (IL-4). Interestingly, significantly higher expression of interleukin-10 and higher number of multinucleated giant cells (MNGCs) was observed in the DBBM group. Thereafter, conditioned media (CM) from macrophages cultured with DBBM seeded with MC3T3-E1 cells demonstrated a marked increase in osteoblast differentiation. Noteworthy, this effect was reversed by blocking IL10 with addition of IL10 antibody to CM from the DBBM macrophages. Furthermore, the use of dendritic cell specific transmembrane protein (DC-STAMP)-knockout to inhibit MNGC formation in the DBBM group resulted in a significant reduction in osteoblast differentiation, indication a pivotal role for MNGCs in biomaterials-induced osteogenesis. The results from this study indicate convincingly that the immune response of macrophages towards DBBM has a potent effect on osteoblast differentiation. Furthermore, DBBM promoted macrophage fusion and polarization towards an M2 wound-healing phenotype, further created a microenvironment favoring biomaterial-induced osteogenesis. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1236–1246, 2018.
研究领域:
生物材料
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免疫学
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组织工程
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骨科
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JOURNAL OF MICROBIOLOGY
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2024
·Vol. 62
·期 1
·49-62
·
IF 3.3
Xu Tao,Wang Chutong,Li Minying,Wei Jing,He Zixuan,Qian Zhongqing,Wang Xiaojing,Wang Hongtao
Tuberculosis (TB), a bacterial infectious disease caused by Mycobacterium tuberculosis (M. tuberculosis ), is a significant global public health problem. Mycobacterium tuberculosis expresses a unique family of PE_PGRS proteins that have been implicated in pathogenesis. Despite numerous studies, the functions of most PE_PGRS proteins in the pathogenesis of mycobacterium infections remain unclear. PE_PGRS45 (Rv2615c) is only found in pathogenic mycobacteria. In this study, we successfully constructed a recombinant Mycobacterium smegmatis ( M. smegmatis ) strain which heterologously expresses the PE_PGRS45 protein. We found that overexpression of this cell wall-associated protein enhanced bacterial viability under stress in vitro and cell survival in macrophages. MS_PE_PGRS45 decreased the secretion of pro-inflammatory cytokines such as IL-1β, IL-6, IL-12p40, and TNF-α. We also found that MS_PE_PGRS45 increased the expression of the anti-inflammatory cytokine IL-10 and altered macrophage-mediated immune responses. Furthermore, PE_PGRS45 enhanced the survival rate of M. smegmatis in macrophages by inhibiting cell apoptosis. Collectively, our findings show that PE_PGRS45 is a virulent factor actively involved in the interaction with the host macrophage.
研究领域:
微生物学
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免疫学
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传染病学
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International Journal of Nanomedicine
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2023
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IF 8
Yuping Zhao,Yanna Zhao,Qisan Ma,Bin Sun,Qingpeng Wang,Zhuang Ding,Huaizhen Zhang,Xiuling Chu,Min Liu,Zhengping Wang,Jun Han
Background The combination of chemo-photodynamic therapy based on nano-technology has emerged as a preferable and promising measure for synergetic antitumor therapy.Purpose The aim of this study was expected to overcome most of the safety concerns from nano-carriers and improve the chemo-photodynamic synergistic antitumor efficacy.Methods Herein, we reported a facile and effective approach based on the self-assembly of chemotherapeutic agent 10-hydroxycamptothecin (HCPT) and photosensitizer chlorin e6 (Ce6) for preparing stably dual-functional nanorods (NRs).Results The chemical thermodynamic parameters obtained from isothermal titration calorimeter (ITC) and the microcosmic configuration snapshots acquired by molecular dynamics (MD) simulations verified that HCPT and Ce6 molecules tended to assemble with each other through various intermolecular forces. The as-prepared HCPT/Ce6 NRs possessed a relatively uniform size of around 165 nm and zeta potential of about −29 mV, together with good stability in aqueous solution and freeze-dried state. In addition, both the extra- and intracellular reactive oxygen species (ROS) generation capacity of the NRs under laser irradiation was significantly enhanced compared with Ce6 injections. Moreover, the dual-functional HCPT/Ce6 NRs exhibited a substantial in vitro/in vivo synergistic antitumor efficacy under laser irradiation due to the integration of the two therapeutic modalities into one drug delivery system. Besides, no obvious hepatic or renal toxicity was observed in the NRs treatment groups.Conclusion Taken together, HCPT/Ce6 NRs demonstrated a powerful efficacy in chemo-photodynamic therapy for breast cancer. Therefore, the carrier-free dual-functional NRs prepared in a facile and effective strategy might give inspiration for the development of combined antitumor therapy.
研究领域:
纳米技术
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药学
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肿瘤学
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材料科学
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INORGANIC CHEMISTRY
·
2023
·
IF 4.6
Enming Ping,Xiaoxiao Chen,Yunshan Zhou,Lijuan Zhang,Lingyun Kong,Nan Chen
In this work, CAU-10-H@γ-AlOOH is prepared, and then UTSA-16 is loaded on CAU-10-H@γ-AlOOH to obtain UTSA-16@CAU-10-H@γ-AlOOH. Using the as-prepared composites as stationary materials by cryogenic gas chromatography at 77 K, while CAU-10-H@γ-AlOOH achieves the complete separation of ortho-H2 (o-H2) and D2 with a resolution R of 1.66 and a separation time t of 9.52 min, UTSA-16@CAU-10-H@γ-AlOOH achieves higher efficiency separation of hydrogen isotopes in a shorter separation time (4.56 min) with R = 1.7. Molecular simulation results show that CAU-10-H has both chemical affinity quantum sieving and kinetic sieving effects for H2/D2 at 77 K, and UTSA-16 can only exert the kinetic sieving effect. UTSA-16’s load on CAU-10-H@γ-AlOOH weakens the adsorption of hydrogen isotopes, and the presence of Co2+ in UTSA-16 promotes the conversion of para-H2 to ortho-H2. In gas chromatography, H2 was preferentially desorbed from the system due to strong D2 adsorption caused by the chemical affinity quantum sieving effect and faster H2 diffusion caused by the kinetic sieving effect. These additive effects achieved efficient hydrogen isotope separation at 77 K.
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Na Li,Junren Xu,Yiqiao Zhao,Mengmeng Zhao,Zhonghua Liu,Kunbo Wang,Jianan Huang,Mingzhi Zhu
Tea polyphenols transform under processing methods, but a systematic study on their changes in the same large-leaf tea cultivar is lacking. Here, Camellia sinensis var. assamica cv. Yunkang-10 leaves underwent six processing methods and were assessed using optimized nontargeted (UHPLC-Q-Exactive Orbitrap-MS) and targeted (UHPLC-QqQ-MS) polyphenomics, along with molecular networking analysis. 903 and 52 polyphenolic compounds (catechins, flavones and flavonols, and phenolic acids) were respectively relatively and absolutely quantified for the first time. Dark and black teas, with the lowest polyphenol content, differed from the other four tea types, although variations existed among these four teas. However, some flavonol and flavone aglycones (e.g. kaempferol, apigenin), as well as some phenolic acids (e.g. ellagic acid, gallic acid), exhibited higher levels in dark and black teas. Correlations between polyphenolic composition and electronic sensory characteristics were observed using E-tongue and E-eye. This study enriches understanding of polyphenol profiles in Chinese teas post diverse processing.
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