SYNTHESIS-STUTTGART
·
2014
·Vol. 46
·期 05
·621-628
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IF 2.443
Shengrong Liao,Chun Qin,Peifen Yao,Jinsheng Li,Xuefeng Zhou,Junfeng Wang,Zhishu Huang,Yonghong Liu
A facile and efficient synthesis of novel seven-membered heterocyclic derivatives containing 3-aminoazepan-2-one backbone is described using 1,4-protected piperazine-2,5-diones and alkynes as starting materials. The reaction may undergo Michael addition, unusual nucleophilic attack to an amide group, and keto–enol tautomerization. The reaction showed different reactivity when using substrates with different protecting groups: it had higher efficiency when using either alkanoyl-protecting group with cesium carbonate as the base, or benzoyl-protecting group with triethylamine as the base, but no reaction when using benzyl or allyl protecting groups with a variety of bases (Et3N, DBU, K2CO3, Cs2CO3, KHCO3, CsHCO3, and KOt-Bu).
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SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Wangyao Zhang,Yang Yang,Fenfen Li,Guosheng Song,Yong Shao,Ruizhuo Ouyang,Lina Xu,Weiwei Li,Yuqing Miao
A simple one-step method was successfully developed to prepare stable nanosized Ni(OH) 2 @Cr(OH) 3 hybrid particles by just adding NaOH to a mix solution containing Ni(NO 3 ) 2 and Cr(NO 3 ) 3 at room temperature. In contrast, under the exact same conditions, flocculent Ni(OH) 2 or Cr(OH) 3 precipitate was obtained after the addition of equivalent NaOH in a solution containing same amount of Ni(NO 3 ) 2 or Cr(NO 3 ) 3 as in the mix solution. The interaction between Ni(II) and Cr(III) ions was believed to make major contribution to the formation of stable Ni(OH) 2 @Cr(OH) 3 nanohybrid without aggregation to large-size particles. The prepared Ni(OH) 2 @Cr(OH) 3 hybrid nanoparticles were well characterized by the scanning electron microscopy (SEM), the transmission electron microscopy (TEM), X-ray diffraction (XRD), and electrochemical measurements with results showing uniform size, smooth surface, good monodispersibility, fast electron transfer rate as well as promising electrocatalytic properties toward glucose (Glu) and cysteine (Cys) oxidation. The presence of a small amount of Cr(OH) 3 in the composite not only improved the stability and monodispersibility of the Ni(OH) 2 @Cr(OH) 3 hybrid particles, decreased their size to nanoscale, but also exerted positive effect to the electrochemical properties of the obtained Ni(OH) 2 based nanomaterials like the electron transfer rate and the electrocatalytic activity. Satisfactory electrocatalytic performances of the Ni(OH) 2 @Cr(OH) 3 nanohybrid toward Glu and Cys oxidations were achieved, respectively, in certain concentration ranges with acceptable detection limits and correlation coefficients, suggesting the potential facilitation of electrocatalysis toward other small molecules by the newly prepared Ni(OH) 2 @Cr(OH) 3 nanohybrid.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 130
·期 6
·3862-3868
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IF 1.395
Ronghui Guo,Yani Li,Jianwu Lan,Shouxiang Jiang,Ting Liu,Wanqi Yan
In this study, silver nanoparticles were synthesized on cotton fabric modified with 3-aminopropyltrimethoxysilane (APTMS) using sodium citrate as a reducing/stabilizing agent by microwave-assisted process. The presence of a highly oriented amino-terminated self-assembled monolayer and formation of APTMS was demonstrated by an X-ray photoelectron spectroscopy (XPS) analysis. The silver-coated cotton fabrics were examined by scanning electron microscopy (SEM) and energy dispersive X-ray (EDX). UV protection, antistatic, and hydrophobic properties were also evaluated. The results show that silver-coated fabric modified with APTMS possesses excellent antistatic, UV protection with ultraviolet protection factor (UPF) of 396.5 and superhydrophobic properties with contact angle of 153.2°. APTMS pretreatment improves the adhesive strength between silver coatings and cotton fabric. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 3862–3868, 2013
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NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 39
·期 11
·8999-9005
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IF 3.086
Yingda Du,Ming Xing,Zhiman Li,Wei Guo
Along with the rapid development of modern medicine, the creation and evaluation of nanoparticulate contrast agents have attracted considerable attention of scientists worldwide. Herein, we designed and synthesized a metabolizable nano-sized contrast agent based on rod-like PEGylated gadolinium hydroxide (defined as PEG-Gd(OH)3) via a facile and economic route. Due to the high amount of gadolinium in these nanorods, these well-prepared PEG-Gd(OH)3 could provide more enhanced contrast than clinical iodine-based agents under the usual voltages in computed tomography (CT) imaging. Different from other small molecule-based contrast agents, our PEG-Gd(OH)3 exhibited an obvious liver-targeted property based on our in vivo experiments, indicating their expected usage in the detection of hepatic metastases. Long-term toxicity and possible metabolic pathway demonstrated that these nanorods exhibit overall safety and could not cause gadolinium-associated nephrogenic systemic fibrosis (NSF). With its high biocompatibility and superior contrast efficacy, PEG-Gd(OH)3 could bring more opportunities to a new generation of nanoparticulate CT contrast agents in biomedicine.
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RSC Advances
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2014
·Vol. 4
·期 107
·62096-62104
·
IF 3.708
Junjie Li,Lei Wang,Xiaole Jia,Xiongzhi Xiang,Cheuk-Lam Ho,Wai-Yeung Wong,Hua Li
Polymer–inorganic composites show great potential for use as thermoelectric (TE) materials. However, the TE performance of these materials needs to be improved. One way to improve the TE performance would be to synthesize novel conductive polymers with high Seebeck coefficients to prepare polymer–inorganic TE composites. In this study, acidized and ammoniated forms of poly[(3-methylthiophene-2,5-diyl)(diphenylaminobenzylidene)(3-methylthiophene quinodimethane-2,5-diyl)] (PMTDPABQ) were successfully synthesized with high Seebeck coefficients. These polymers were used to prepare a series of PMTDPABQ/graphite (G) bulk composites by mechanical ball milling and cold pressing. The morphology, thermal stability, and TE performance of these composites were evaluated. The G was uniformly dispersed in the polymer matrix, and the composite materials exhibited good thermal stability at temperatures up to 200 °C. The acidized PMTDPABQ/G composites exhibited better TE performance than the ammoniated PMTDPABQ/G composites. The highest TE figure of merit, ZT = 5.32 × 10−3, was obtained using acidized PMTDPABQ/G and was approximately 3 times greater than that of polythiophene (PTh)/G (1.37 × 10−3).
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NUTRITION RESEARCH
·
2015
·
IF 2.472
Qian Wang,Shuang-ting Wang,Xin Yang,Pan-pan You,Wen Zhang
Myricetin (MyR), a naturally occurring flavonol widely distributed in fruits, vegetables, and medicinal plants , has anticancer, anti-inflammatory, antihyperlipidaemic , and antiobesity activities. In the present study, we hypothesized that the antiobesity property of MyR is mediated via suppression of differentiation of preadipocytes into adipocytes and promotion of lipolysis of mature adipocytes, which effectively decrease the intracellular triglyceride concentration of adipocytes. Accordingly, the aim of this work was to investigate the effects of MyR on adipocyte differentiation and lipolysis in differentiated 3 T3-L1 adipocytes. Our results showed that MyR inhibited differentiation of 3 T3-L1 preadipocytes in a concentration-dependent manner. Myricetin downregulated the mRNA and protein levels of CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptor γ , both of which are major adipogenic transcription factors. Furthermore, the mRNA levels of other adipogenesis-related transcription factors, namely, CCAAT/enhancer-binding protein β , sterin regulatory element binding protein 1-c, peroxisome proliferator-activated receptor γ coactivator–1, adipocyte protein 2 , lipoprotein lipase and glucose transporter 4 , were also reduced by MyR treatment. Moreover, MyR significantly inhibited the phosphorylation of extracellular signal–regulated kinase, Jun N-terminal kinase, and p38 during the differentiation process. On the other hand, MyR induced a dose-dependent increase in glycerol release in fully differentiated adipocytes, indicating its stimulatory effect on adipocyte lipolysis. Furthermore, MyR downregulated mRNA level of perilipin A and enhanced the phosphorylation level of extracellular signal–regulated kinase, Jun N-terminal kinase, and p38 during lipolysis. Taken together, these findings indicate that MyR exerts antiobesity activity in adipocytes.
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PubMed
高影响因子
FOOD CHEMISTRY
·
2017
·
IF 4.529
Lei Zhou,Zhiqiang Xiong,Wei Liu,Liqiang Zou
Gentisic acid and cyanidin-3-O-glucoside are important bioactive polyphenols which are widely distributed in many fruits and cereals. In this work, kinetic study, spectral analysis and computational simulation were used to compare the inhibitory effects and inhibition mechanisms of gentisic acid and cyanidin-3-O-glucoside on mushroom polyphenoloxidase (PPO). The inhibitory effect of cyanidin-3-O-glucoside on PPO was much stronger than that of gentisic acid. Gentisic acid inhibited PPO in a reversible mixed-type manner while cyanidin-3-O-glucoside was an irreversible inhibitor. Gentisic acid and cyanidin-3-O-glucoside made the thermal inactivation of PPO easier, and induced apparent conformational changes of PPO. Compared with gentisic acid, cyanidin-3-O-glucoside had stronger effects on the thermal inactivation and conformation of PPO. Molecular docking results revealed gentisic acid bound to the active site of PPO by hydrogen bonding, π–π stacking and van der Waals forces. However, cyanidin-3-O-glucoside might irreversibly interact with the Met or Cys in PPO by covalent bonds.
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Surfaces and Interfaces
·
2024
·
IF 5.7
Fangfang Shang,Hengdao Quan,Xiaoxun Ma
In this study, 3-trifluoromethylpyrazole (TMPZ) was developed as a multifunctional electrolyte additive to enhance wettability between separator and electrolyte, CEI formation and remove HF to improve the performance of Li/NCM622 batteries by experiment and theoretical calculation. After 200 cycles at 30 °C, the discharge capacity retention of batteries at 1 C with 0.5 wt% TMPZ additive is remarkably enhanced from 68.3 % to 83.2 %. The enhanced electrochemical performance of the batteries by adding TMPZ additive is evaluated by the spectroscopic characterization and theoretical calculation. It is demonstrated that TMPZ can generate uniform and dense CEI film via ring-opening electrochemical polymerization of TMPZ on the NCM622 electrode surface. The CEI film helps to suppress the breakdown of LiPF 6 electrolyte and the leaching of transition metals, effectively avoiding harmful side reactions between the NCM622 electrode and the electrolyte. Furthermore, introducing TMPZ can enhance the wettability between separator and electrolyte, therefore providing more channels of Li + to accelerate reaction kinetics of batteries.
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SOLID STATE IONICS
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2024
·
IF 3
Ke Huang,Mingyang Duan,Xiaojuan Lu,Feng Zhang
As a new type of clean and efficient energy storage device, lithium-ion batteries have been widely used in electronic products, electric vehicles, and other fields, and the accompanying safety issues are of increasing concern. Therefore, solid-state lithium-ion conductors have become a current research hotspot. This paper used graphene oxide material to design and prepare Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 solid electrolytes by the co-precipitation method and performed some relevant characterizations. The results showed that the addition of graphene oxide optimized the electrolyte structure improved the density of the powder, promoted grain growth, improved the transport path of lithium ions, and thus increased the total ionic conductivity . The optimal doping ratio was 0.5 wt%, and the total ionic conductivity reached the maximum of 2.42 × 10 −4 S/cm. Compared to pure Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 , the ionic conductivity increased by 154% after using the graphene oxide . It is believed that larger grains, fewer grain boundaries, and denser microstructure resulted in a less distorted migration pathway for lithium ions. Under the influence of graphene oxide , Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 exhibited better air stability than pure Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 electrolyte. The electrolyte prepared in this study showed great application potential in all-solid-state batteries.
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NANOTECHNOLOGY
·
2024
·Vol. 35
·期 50
·505502
·
IF 2.9
Zhihua Zhao,Hepeng Zhang,Pu Chen,Guixin Jin,Lan Wu
Two-dimensional material (2D material) MXene has great application potential in gas sensors because of its excellent controllable performance and vast specific surface area. In this study, we used a straightforward in-situ electrostatic self-assembly technique to create Fe(OH)3/Ti3C2Tx nanocomposites, which were then used to fabricate gas sensors for ammonia detection at room temperature (25 °C). Several characterization methods were performed aimed at determining the surface appearance and construction of the nanocomposites, and the sensing characteristics and mechanism were also systematically examined. The findings demonstrate the effective incorporation of amorphous Fe(OH)3 nanoparticles on the surface of Ti3C2Tx. Additionally the nanocomposites of Fe(OH)3/Ti3C2Tx have considerably higher specific surface area than pure Ti3C2Tx, hence offering more active NH3 adsorption sites. The response of the sensor to 100 ppm NH3 was 48.6% at room temperature, which was 9.3 times more higher than that of pure Ti3C2Tx. The sensors also have the advantages of long-term stability (33 d), low NH3 detection limit (500 ppb), and rapid recovery time (85 s) and response times (78 s). It is anticipated that this work will be helpful for developing the new generation of wearable ammonia sensors at room temperature.
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Frontiers in Pharmacology
·
2024
·
IF 4.4
Jiemei Shi,Min Liu,Jiajie Zhao,Ye Tan,Chunhui Jiang
Introduction: Mitochondrial dysfunction and oxidative stress play important roles in diabetic retinal vascular injuries. Honokiol (HKL) is a small-molecule polyphenol that exhibits antioxidant effects and has a beneficial effect in diabetes. This study aimed to explore the potential ability of HKL to ameliorate vascular injury in diabetic retinopathy (DR) and its possible mechanisms of action.Methods: The effect of HKL was evaluated in vascular injury in an in vivo type 2 diabetic (db/db) mouse model. In vitro, retinal microvascular endothelial cells were treated with high glucose (HG) to simulate the pathological diabetic environment. Cell viability, expression of apoptosis-related proteins, cellular reactive oxygen species, mitochondrial membrane potential, and morphological changes in the mitochondria were examined.Results: The diabetic mice exhibited severe retinal vascular damage, including vascular leakage in vivo and capillary endothelial cell apoptosis in vitro. HKL reversed the retinal vascular leakage in the diabetic mice. In vitro, HKL improved retinal capillary endothelial cell viability, decreased apoptosis, and reversed the HG-induced increased cellular oxidative stress and mitochondrial fragmentation. The sirtuin 3 (SIRT3) inhibitor 3-TYP blocked all the in vivo and in vitro protective effects of HKL against diabetic retinal vascular leakage and capillary endothelium and eliminated the decrease in oxidative stress levels and reduction of mitochondrial fragmentation.Discussion: In conclusion, these findings suggest that HKL inhibits vascular injury in DR, which was likely achieved through SIRT3-mediated mitochondrial fusion. This study provides a potential new strategy for the treatment of DR.
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JOURNAL OF BIOSCIENCE AND BIOENGINEERING
·
2024
·
IF 2.3
Mengyao Gui
Humic acid (HA), a common natural organic matter , could affect conventional anoxic denitrification. Aim of this study was to investigate effect of HA on the process of aerobic denitrification in Achromobacter sp. GAD-3, an aerobic denitrifying strain. The findings demonstrated that an increase in HA concentrations (≥5 mg L −1 ) promoted the aerobic denitrification process (excluding N 2 O reduction), manifesting as higher rates of nitrate removal (6.67–11.1 mg L −1 h −1 ) and lower levels of nitrite accumulation (30.2–20.7 mg L −1 ). This was attributed to the increased electron transfer activities and denitrifying reductase activities (including NAR, NIR and NOR) facilitated by HA. Accordingly, the expression of denitrification genes such as napA , cnorB , and nirS was enhanced by HA. Nonetheless, the nosZ gene and N 2 OR activity underwent suppression by HA, which was accountable for N 2 O emission. It is crucial to understand the HA mechanism towards aerobic denitrifiers for wastewater treatment plants to enhance nitrogen removal.
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