DALTON TRANSACTIONS
·
2024
·Vol. 53
·期 8
·3722-3730
·
IF 3.5
Shiquan Cao,Yujia Kang,Huiping Tang,Zhi Chen
The extraction of lead-212 (212Pb) from radioactive thorium (Th) waste is immensely important, as it serves to mitigate environmental risks associated with radioactive waste and provides a vital source for medical isotopes. To economically extract 212Pb from thorium, we synthesized a novel extractant known as 2,13-disulfonyldiethylamine dibenzo-18-crown-6 (DSADB18C6). We assessed its performance in isolating Pb(II) by employing stable lead and optimizing the parameters of the extraction system. The results showcased an exceptional ability to extract Pb(II) efficiently. Within 10 minutes, using 20 mmol of DSADB18C6 and under conditions of 10 mg L−1 lead concentration (HNO3 = 0.5 mol L−1), the extraction efficiency reached up to 96.1%. Even after four rounds of stripping with 0.4 mol L−1 ammonium citrate, the efficiency remained at 90.2%. Moreover, the extraction stoichiometry and thermodynamics revealed that DSADB18C6 exhibited superior extraction performance compared to the commercial extractant 4′,4′′,(5′′)-di-(tert-butyldicyclohexano)-18-crown-6 (DtBuDC18C6), in line with the density functional theory (DFT) calculation result. Furthermore, we successfully separated 212Pb from the thorium nitrate solution, maintaining radioactive equilibrium with its progeny. Gamma-spectroscopy confirmed a recovery yield of extraction exceeding 85.7%. This study presents a viable approach, underscoring the potential of DSADB18C6 as a promising extractant for the effective separation of 212Pb from radioactive thorium sources.
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PubMed
高影响因子
Cancers
·
2024
·Vol. 16
·期 9
·1614
·
IF 4.5
Tiantian Song,Zheming Yu,Qitao Shen,Yu Xu,Haihong Hu,Junqing Liu,Kui Zeng,Jinxiu Lei,Lushan Yu
Simple SummaryAcute T-lymphoblastic leukemia is a disease with a very low survival rate after relapse, and the search for new therapeutic agents is important for the clinical benefit of patients with acute T-lymphoblastic leukemia. Our study developed YLS010, a small molecule that is more sensitive to acute T-lymphoblastic leukemia cells, based on the structure of the invented small molecule YLS004. This novel small molecule demonstrated good antitumor activity in vivo and in vitro with acceptable toxicity. These findings provide a new avenue for the development of clinical drugs for patients with acute T-lymphoblastic leukemia.Abstract(1) Background: The research group has developed a new small molecule, 6-Isopropyldithio-2′-deoxyguanosine analogs-YLS004, which has been shown to be the most sensitive in acute T-lymphoblastic leukemia cells. Moreover, it was found that the structure of Nelarabine, a drug used to treat acute T-lymphoblastic leukemia, is highly similar to that of YLS004. Consequently, the structure of YLS004 was altered to produce a new small molecule inhibitor for this study, named YLS010. (2) Results: YLS010 has exhibited potent anti-tumor effects by inducing cell apoptosis and ferroptosis. A dose gradient was designed for in vivo experiments based on tentative estimates of the toxicity dose using acute toxicity in mice and long-term toxicity in rats. The study found that YLS010 at a dose of 8 mg/kg prolonged the survival of late-stage acute T-lymphoblastic leukemia mice in the mouse model study. (3) Conclusions: YLS010 has demonstrated specific killing effects against acute T-lymphoblastic leukemia both in vivo and in vitro. Preclinical studies of YLS010 offer a new opportunity for the treatment of patients with acute T-lymphoblastic leukemia in clinical settings.
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高影响因子
POLYMER DEGRADATION AND STABILITY
·
2025
·
IF 7.4
Wen-Jie Jin,Bao-Ping Dong,Xian-Wei Cheng,Jin-Ping Guan,Shu-Sheng Xiong
A highly efficient and reactive flame retardant (FR) agent was developed and in situ self-polymerized on polyamide 6 (PA6) fabrics, yielding a durable and multifunctional textile. The FR agent, designated DOPO-pCA, was synthesized using bio-based p-coumaric acid and DOPO. The treated PA6 exhibited outstanding flame retardancy and anti-dripping performance, with a limiting oxygen index of 31.0% and a reduced damaged length of 12.3 cm. Cone calorimetry confirmed significant fire-safety improvements, with the peak heat release rate and total heat release reduced by 30.7% and 23.8%, respectively. The superior fire resistance should be attributed to the enhanced quenching effect of phenoxy and phosphoroxy radicals. Owing to its self-polymerization and reactivity, DOPO-pCA imparted durable FR functionality, with only slight deterioration observed after 30 laundering cycles. Moreover, the treated PA6 fabrics exhibited excellent resistance to UV resistance and antibacterial activity against S. aureus . The PA6 fabrics treated with 40 g/L DOPO-pCA achieved a high UV protection factor (UPF) of 52.4 and an antibacterial rate of 92.3%. Here, this work proposes a cleaner and novel strategy for developing durable and multifunctional PA6 fabrics.
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TALANTA
·
2025
·
IF 6.1
Hao Zhang,Wanyi Li,Ying Zhong,Meng Zhang,Kaile He,Yihan Yuan,Jinyi Wang
Surface-enhanced Raman scattering (SERS) based on noble metal nanoparticles has garnered significant attention in analytical chemistry due to its simplicity and rapidity for low-concentration detection. Although widely applied in fields like environmental monitoring, food safety, and biomedical diagnostics, the impact of silver nanoparticle shape on SERS performance remains insufficiently studied. Furthermore, traditional stationary solid and liquid SERS approaches are limited by inconsistent reproducibility and temporal variations in uniformity, respectively. To overcome these limitations, we introduce a simple continuous and online Ag SERS platform that employs spherical silver colloids within a capillary-Teflon tube system for dynamic, real-time analyte detection. Continuous fluid flow reduces variations in colloids, ensuring uniformity, while the enclosed system limits dynamic behaviors of colloids, enhancing stability. This platform demonstrates outstanding stability, with relative standard deviations of 2.30%. Its versatility is showcased through the quantitative detection of melamine in milk, 6-thioguanine in serum, and histamine in beer, demonstrating its capability for accurate, real-time detection in complex food matrices. This continuous and online Ag SERS platform represents a significant advancement in reliable, high-performance analyte detection, offering promising prospects for real-time analytical applications and providing a cost-effective, scalable solution for widespread use.
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Bo He,Jianuo Ma,Luobing Xiang,Han Wang,Xi Wang,Chunwang Yi
As a representative of dope-dye, the color masterbatch method has been widely applied in modern dyeing processes, while it has difficulties in solving the dispersibility of inorganic pigments color master batch in the polymer matrix. In this work, attapulgite (ATP) was used as the adsorption carrier of inorganic pigments to prepare color-dyed attapulgite (CD-ATP). The selected environmentally friendly inorganic pigments were well adsorbed by ATP in KOH aqueous solution, and could stably be monodispersed in KOH aqueous solution for more than 168 h. Moreover, the KOH aqueous solution could be reused repeatedly, thereby, a sustainable method to prepare novel CD-ATP was realized. By blending the as-prepared CD-ATP with polyamide-6 (PA6), a series of dope-dyed colorful PA6 composites was prepared. Scanning electron microscope (SEM) results indicated that the CD-ATP was still monodispersed in the PA6 matrix, and endowed PA6 with a vivid color. Further studies show that the adding of CD-ATP had little influence on the properties of PA6, but significantly reduced the water adsorption. This novel color-dyed ATP has potential implications in making paper-making blankets and is highly expected to have more extensive applications in many fields of life.
研究领域:
材料科学
·
染色技术
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COMPOSITES SCIENCE AND TECHNOLOGY
·
2025
·
IF 9.8
Yining Wang,Yuxi Pan,Mingguang Zhang,Yu Deng,Zhimin Wang,Xigao Jian,Yousi Chen
Grounded in the principle of “like dissolves like”, the development of water-soluble sizing agents characterized by matrix-like structures has emerged as a focal point of research within the interface domain. Nevertheless, the reliance exclusively on the entanglement forces between the sizing agent and the matrix is deemed inadequate. In this study, a novel water-soluble dual-component sizing agent tailored for the nylon 6 (PA6) resin matrix has been developed. By leveraging the self-emulsifying and water-soluble properties of sodium lignosulfonate (SL) and polyamic acid (PAA), these components are concurrently introduced onto the fiber surface. Following treatment, a distinct interfacial region is established on the fiber surface as a result of their interactions. Exploiting their intrinsic differences at processing temperatures facilitates differential wetting of the matrix resin on the fiber surface, consequently resulting in the formation of a “mechanical interlocking” structure between the fiber and the matrix. The findings reveal that the flexural strength and interlaminar shear strength of the modified CF/PA6 composites achieved values of 977.8 MPa and 74.1 MPa, corresponding to enhancements of 27.4 % and 28.8 %, respectively, when compared to their unmodified counterparts. This innovative sizing agent not only significantly enhances interfacial adhesion but also confers high added-value potential to lignin-derived materials, a factor that is essential for future sustainable development.
研究领域:
材料科学
·
化学工程
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2019
·
IF 4.833
Wen-Jing Zhu,Ben-Wen Cui,Hui Min Wang,Ji-Xing Nan,Hu-Ri Piao,Li-Hua Lian,Cheng Hua Jin
Six series of 4-(benzo[ c ][1,2,5]thiadiazol-5-yl)-3(5)-(6-methylpyridin-2-yl)- pyrazoles 18a – d , 19a – d , 22a – d and 3(5)-(6-methylpyridin-2-yl)-4-(thieno[3,2,- c ]- pyridin-2-yl)pyrazoles 20a – d , 21a – d , 23c , 23d have been synthesized and evaluated for their activin receptor-like kinase 5 (ALK5) and p38α mitogen activated protein (MAP) kinase inhibitory activities in enzymatic assays. Among these compounds, the most active compound, 22c , inhibited ALK5 phosphorylation with an IC 50 value of 0.030 μM in the enzymatic assay. Compound 22c showed four-fold more potent activity against ALK5 kinase than the clinical candidate, compound LY-2157299 . The selectivity index of 22c against p38α MAP kinase is 235, which is much higher than that of LY-2157299 (4) and equally selective to that of EW-7197 (218). Compound 22c effectively suppressed protein and mRNA expression of collagen I and α-SMA in TGF-β-induced LX-2 human hepatic stellate cell (HSC), this result shows that compound 22c has the ability to inhibit the activation of HSC. Compound 22c is expected to be a preclinical candidate for the treatment of hepatic fibrosis .
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Sikai Wu,Jing Shi,Jixiang Chen,Deyu Hu,Liansheng Zang,Baoan Song
A series of novel 6-sulfonyl-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives were designed and synthesized. CoMFA models were established to analyze the quantitative structure–activity relationships on the basis of the EC50 values of the compounds. The models were used to design and synthesize compounds 32 and 33 with higher activities. The EC50 values of compound 33 against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas oryzae pv. oryzicola (Xoc) were 0.59 and 1.63 mg/L, respectively, which were higher than those of thiodiazole copper (90.43 and 97.93 mg/L) and bismerthiazol (68.37 and 75.59 mg/L). Moreover, protective activities of compound 33 against bacterial leaf streak (BLS) and bacterial leaf blight (BLB) were 49.65% and 49.42%, respectively, which were superior to those of thiodiazole copper (44.28% and 41.51%) and bismerthiazol (38.89% and 40.09%). Protective activity of compound 33 against BLS was closely related to the improvement of defense-related enzyme activities, chlorophyll content, and photosynthesis activation. This is consistent with the upregulated expression of defense responses and photosynthesis-related proteins.
研究领域:
药物化学
·
植物病理学
·
分子生物学
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高影响因子
Biomed Research International
·
2020
·
IF 2.276
Lei Xiao,Xia Zhang,Zhiyi Chen,Jianhua Li,Bing Li,Lin Li
Hair loss is a common disease in dermatology, while the approved drugs may have unpredictable side effects. In this study, the effect of timosaponin BII extracted from Anemarrhena asphodeloides on hair growth of C57BL/6 mice was investigated by measuring the hair follicle morphology, hair growth length and area in C57BL/6 male mice, and the immunohistochemical analysis of β-catenin, Wnt3a, and Wnt10b in the dorsal skins of mice after topical application with minoxidil and timosaponin BII for 15 days. The decrease in skin brightness, the increase in the regrowing area of hair and hair follicles numbers, and the improvement of hair follicle morphology in the group applied with 0.5% timosaponin BII indicated an induction of the anagen phase in telogenic mice skin, which were comparative to the 2% minoxidil treatment. The immunohistochemical analysis detected an increase in the expression of β-catenin and Wnt10b, supporting the theory of the activation of the β-catenin/Wnt pathway was one of the pathways that are related to anagen phase induction. Anemarrhena asphodeloides is a herb commonly used for metabolic disorders in China. The present study is the first to show that the timosaponin BII, which is present at a high concentration in A. asphodeloides, promotes hair growth in C57BL/6 male mice. The results indicate that timosaponin BII may be a potential promoting agent for hair growth.
研究领域:
药理学
·
皮肤病学
·
分子生物学
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Science China-Life Sciences
·
2025
·
IF 9.5
Liu Yaqi,Wang Yalei,Zhang Ni,Xiong Haijuan,Zhao Lipan,Qi Ying,Xie Jiping,Duan Xiaofeng,Yue Dongsheng,Qie Shuo
The hyperactivation of cyclin D1-CDK4/6 signaling is correlated with tumour metastasis and poor prognosis in patients with non-small cell lung cancer (NSCLC), suggesting the therapeutic potential of targeting CDK4/6 to treat NSCLC. Our preliminary data indicate CDK4/6 inhibitors are sequestered in lysosomes in NSCLC cells, a phenomenon that is termed lysosomal trapping and is associated with intrinsic drug resistance. It is promising to search for new compounds that could be co-administered with CDK4/6 inhibitors to reduce lysosomal trapping, thereby enhancing the sensitivity of NSCLC cells. Here, we find that metformin reduces the activity of the lysosomal pathway through genome-wide analyses; consistently, metformin reduces lysosomal trapping of CDK4/6 inhibitors in NSCLC cells. Biologically, metformin enhances the suppressive effects of CDK4/6 inhibitors on cell cycle progression, cell proliferation, and colony formation. Mechanistically, metformin suppresses lysosomal trapping by: (i) reducing translocation of TFEB into nuclei that leads to decreased lysosome biogenesis and (ii) disrupting lysosomal acidic environment through reduced V-ATPase activity and decreased interaction between LAMP1/LAMP2 and TMEM175. Clinically, combined treatment with metformin and CDK4/6 inhibitors decreased the growth of mouse xenografts and tumour cell organoids. In conclusion, our study provides a new mechanism for utilizing metformin to treat NSCLC by reducing lysosomal trapping, thereby increasing cellular sensitivity to CDK4/6 inhibitors.
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高影响因子
JOURNAL OF SOLUTION CHEMISTRY
·
2026
·
IF 1.3
Zhuo Chen,He Zhu,Junlei Shi,Chengxin Shen,Shun Yan,Huanxin Li,Xueguo Liu
The dissolution behavior of 6-methylcoumarin in eleven mono-solvents, namely methanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, isobutanol, 2-methyl-2-butanol, methyl acetate, ethyl acetate, n-propyl acetate and isopropyl acetate, was investigated with the static equilibrium method. The studied temperature ranged from 278.15 to 318.15 K at p = 100 kPa. The results demonstrated that the solubility of 6-methylcoumarin increased with the temperature increasing. Among the selected solvents, methyl acetate exhibited the highest solubility for 6-methylcoumarin, whereas 2-propanol had the lowest. At the same time, the experimental solubility data were fitted with van’t Hoff, λh , Wilson, and NRTL models, with the NRTL model providing the most accurate predicted results. Additionally, the mixing thermodynamics were calculated by using the NRTL model, which revealed that the mixing process is spontaneous, endothermic and entropy-driven. Finally, the dissolution mechanism of 6-methylcoumarin in the selected solvents was preliminarily analyzed from the perspectives of the molecular structural characteristics of the solute, the solute–solvent intermolecular interactions, and the physicochemical properties of the solvent.
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高影响因子
POLYMER
·
2026
·
IF 5.1
Qian WU,Wen-Jun PENG,Guo-Hua HU,Xian-Ming ZHANG,Wen-Xing CHEN
The performance of polyamide 6/polycarbonate (PA6/PC) blends is fundamentally limited by their thermodynamic immiscibility and weak interfacial interactions. Nanoparticle-based compatibilization offers a promising solution, yet achieving reliable interfacial localization remains a critical challenge. Here, we demonstrate that precise control over the molecular weight of polystyrene grafts on silica nanoparticles (SiO 2 -g-PS) enables selective interfacial localization and effective compatibilization in immiscible PA6/PC blends. Nanoparticles bearing short PS grafts tend to aggregate, whereas excessively long PS grafts preferentially disperse in the PC phase. In contrast, an optimized graft molecular weight (Mn ≈ 1.1 × 105 g/mol) favors localization at the PA6/PC interface, driven by stacking interactions as supported by density functional theory (DFT) calculations. This interfacial localization markedly refines the blend morphology, reducing the average diameter of the dispersed PC phase from 2.64 μm to 0.67 μm, and simultaneously enhances tensile strength and ductility. This work provides molecular-level guidance for the rational design of nanoparticle compatibilizers in immiscible polymer blends.
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危险品化学品经营许可证（带存储）