SENSORS AND ACTUATORS B-CHEMICAL
·
2022
·
IF 9.221
Yi-Min Shan,Kang-Kang Yu,Nan Wang,Fan-Yuan Yu,Kun Li,Yan-Hong Liu,Xiao-Qi Yu
More evidence supports that endoplasmic reticulums stress (ER stress) has close relationship with many disease, including Alzheimer’s disease, and such diseases are often closely related to senescence. Both ER stress and senescence involve disorder of redox regulation and may further cause ClO - accumulation. It is of great importance to develop a tool to visualize ralated organelles to investigate the role of ClO - during ER stress or senescence. In this work, a novel dual-targetable ClO - probe RT-ER was designed, and the probe could image endoplasmic reticulums and lysosome by sequence under stimulation of ClO - . RT-ER worked in a ratiometric manner and was extremely sensitive to ClO - ( ~ 484 folds enchancement within 10 s after the stimulation of ClO - ). RT-ER showed great biocompatibility and was further applied in living cells imaging. We demonstrated that RT-ER enables both exogenous and endogenous ClO - imaging. Compared with the commercial dye Lysosome-Tracker Deep Red, RT-ER showed better photobleaching resistance. We successfully used RT-ER to track the interaction between endoplasmic reticulum and lysosome after ClO - accumulation. More importantly, with the help of RT-ER, we further revealed the level of ClO - change during ER stress and senescence, which will facilitate the functional study of ClO - −disease contacts.
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JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2023
·
IF 5.7
Lijuan Huang,Rui Xiong,Jiaxing Xie,Qi Liu,Yu Zhang,Qing Yang,Chunlin Zhao,Xiao Wu,Tengfei Lin,Cong Lin,Min Gao,Baisheng Sa
Tunable photoluminescence (PL) has wide applications in optical waveguides and communication. Since the PL intensity is strongly dependent on the crystal field symmetry, curvature-dependent strain-induced PL modulation is expected in flexible antiferroelectric (AFE) thin film materials. Here, flexible Er-doped Pb 0.98 La 0.02 Zr 0.95 Ti 0.05 O 3 (PLZT) AFE thin films were prepared via the sol-gel method. A giant and reversible PL intensity modulation (482%) was achieved during the bending process. Based on density functional theory (DFT) calculations and Raman spectra measurements, the relationship amongst the curvature-dependent strains, crystal structure, and PL modulation was discussed. The induced strain leads to lattice distortion and even a phase transition, both of which contribute to the reduction in crystal symmetry and thus significantly enhance the PL intensity.
研究领域:
材料科学
·
光学
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Wenbin Zhang,Gongxun Bai,Jiawen Wang,Ruyue Zhang,Wensong Jiang,Yang Zhang,Shiqing Xu,Liang Chen
Rare earth-doped nanomaterials can achieve diverse upconversion luminescence by changing doping ions, presenting them as promising candidates for rapid temperature measurement. However, most upconversion luminescent phosphors have a thermal quenching effect, which greatly weakens the luminous intensity of the material and impairs thermometry performances. Here, we studied the synthesis of Bi 4 Ti 3 O 12 nanosheets tridoped with Er 3+ , Yb 3+ , and Nd 3+ ions using molten salt method. Notably, this luminescent material demonstrates both thermal quenching and thermal enhancement effects. The unusual phenomenon results in a high sensitivity of the optical temperature sensor based on the inter-ion energy level between Er 3+ and Nd 3+ . At 523 K, this sensitivity reaches 5.94×10 −2 K −1 , surpassing that of sensors relying on the thermal coupling of only Er 3+ ions by nearly ninefold. Our findings suggest a promising strategy to augment the temperature sensing sensitivity of luminescent materials, paving the way for potential applications in precise temperature monitoring.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 4.7
Wenying Fu,Ying Yan,Chongchong Shu,Chenxin Xu,Yinghua Chen,Yiqun Xia,Jundixia Chen,Yunzhi Chen,Ri Cui,Peng Zou,Daoyong Ni
6-Methoxydihydrosanguinarine is a natural alkaloid derived from medicinal plants that exhibits significant antitumor activity, making it a promising candidate for cancer therapy. However, the exact molecular mechanisms underlying its effects require further investigation. In this study, we investigated the cytotoxicity and underlying mechanisms of 6-Methoxydihydrosanguinarine in human non-small cell lung cancer (NSCLC) cells. Our findings reveal that reactive oxygen species (ROS) accumulation is the key driver of its antitumor activity. Mechanistically, 6-Methoxydihydrosanguinarine activates the JNK signaling pathway and induces endoplasmic reticulum (ER) stress, both of which can be reversed by the ROS scavenger N-acetylcysteine (NAC). Interestingly, 6-Methoxydihydrosanguinarine also activates autophagy, and inhibition of autophagy reverses the JNK and ER stress pathway activation induced by 6-Methoxydihydrosanguinarine. Notably, 6-Methoxydihydrosanguinarine synergistically enhances cisplatin-induced NSCLC cell death, and this synergistic effect is abolished by NAC, highlighting the critical role of ROS accumulation in their combined efficacy. This study systematically elucidates the molecular mechanisms of 6-Methoxydihydrosanguinarine against NSCLC, revealing that, in addition to the JNK and autophagy pathways, ER stress also mediates its antitumor effects. Moreover, our data establish a rationale for exploring 6-Methoxydihydrosanguinarine in NSCLC therapy and highlight its combination with cisplatin as a potentially effective strategy.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Miao Dazhuang,Suo Xiaopeng,Geng Xinqian,Yang Ying,Wang Gaoming,Zhou Yang,Jia Yunhe,Yang Shuofei,Li Heping,Li Gaohua
Diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, and delayed tissue regeneration, yet effective strategies to regulate the pathological immune microenvironment remain limited. Here, integrated single-cell transcriptomics and multi-omics analyses revealed significant enrichment of endoplasmic reticulum stress (ERS)-related signaling in pro-inflammatory macrophages within diabetic wounds, suggesting a potential mechanism driving chronic inflammation. To target this process, we developed an injectable dynamic hydrogel (GPOK-2@EVs) incorporating Artemisia argyi-derived extracellular vesicles (EVs) for localized immunomodulatory therapy. The hydrogel was formed through dual dynamic crosslinking between phenylboronic acid-modified gelatin and oxidized konjac glucomannan, providing self-healing capability, injectability, tissue adhesion, and pH/ROS-responsive degradation for sustained EV release. In vitro experiments demonstrated that GPOK-2@EVs exhibited excellent biocompatibility and effectively reprogrammed macrophages toward an anti-inflammatory phenotype, accompanied by reduced inflammatory cytokine secretion, alleviated ERS activation, decreased ROS accumulation, and improved mitochondrial integrity. GPOK-2@EVs significantly enhanced endothelial angiogenic activities, including cytoskeletal remodeling, tube formation, and migration. In a diabetic mouse wound model, GPOK-2@EVs accelerated wound closure, promoted granulation tissue formation and collagen deposition, enhanced vascularization, and suppressed inflammatory and ERS responses. These findings demonstrate that EV-loaded dynamic hydrogels can modulate the inflammatory microenvironment and promote diabetic wound regeneration, providing a promising biomaterial strategy for chronic wound therapy. Graphical GPOK-2@EVs hydrogel promotes wound healing through ROS-responsive EV release, macrophage modulation, inflammatory cytokine reduction, and enhanced angiogenesis.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xiaolei Zhang,Nan Gao,Zong Tan,Dongjun Lv,Zhongmin Liu,Qi Tang,Fei Yang,Xiaoli Wang,Hui Zhao,Xueting Liu,Jinyang Li,Jiahao Wang
ER-Fc-MOF@CF monolith integrates PE capture and Fenton-like oxidation. • Carbonization tunes conductivity, defects, and MOF anchoring on CF. • CF-900 achieves 91.14% PE removal under flow-through conditions. • Captured PE undergoes localized ROS-mediated surface oxidation. • Monolithic design reduces powder catalyst loss and secondary release. Microplastic remediation requires efficient particle capture and interfacial oxidation because dispersed polymers have limited contact with short-lived reactive oxygen species (ROS) in bulk solution. Here, an electroresponsive ferrocene metal–organic framework (ER-Fc-MOF) was grown in situ on thermally engineered foam carbon (CF) to construct ER-Fc-MOF@CF monoliths for polyethylene microplastic capture and subsequent electro-Fenton-like treatment. Carbonization temperature regulated the scaffold architecture, surface chemistry, defect structure, electrical resistivity, and ER-Fc-MOF coverage. Among the investigated samples, CF-900 retained accessible hierarchical porosity while exhibiting the lowest resistivity and densest ER-Fc-MOF coverage. The optimized ER-Fc-MOF@CF-900 achieved 91.14% flow-through removal from a 100 mg·L −1 polyethylene (PE) suspension. Zeta-potential, FTIR, and XPS analyses suggested pH-dependent electrostatic attraction and localized polar interactions involving oxygen-containing groups, while the interconnected monolith facilitated particle interception and retention. The low-resistance CF-900 scaffold supported electron transport and H 2 O 2 activation at ER-Fc-MOF domains. SEM, EDS, FTIR, and XPS showed progressive PE surface oxidation, including roughening, oxygen enrichment, and increased C O, C O, and O–C=O signals, while EPR identified ·OH, ·O 2 − , and 1 O 2 . After 36 h, dissolved organic carbon (DOC) reached 67.21 mg·L −1 in the PE-containing system versus 8.80 mg·L −1 in the PE-free control, supporting PE-associated dissolved organic carbon release. This work establishes a self-supporting MOF–carbon platform coupling PE capture, flow-through interception, and interfacial oxidative transformation. Download: Download high-res image (205KB) Download: Download full-size image
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RSC Advances
·
2013
·Vol. 3
·期 48
·26367-26375
·
IF 2.562
Lining Sun,Yannan Qiu,Tao Liu,Hongshang Peng,Wei Deng,Zhijuan Wang,Liyi Shi
The homogeneously transparent hybrid gels (Ln–N–P-gel, Ln = Sm, Yb, Nd, Er, Pr, Ho, Tm) containing lanthanide complexes (by using dinaphthoylmethane (dnm) as the primary ligand and 1,10-phenanthroline (phen) as the synergic ligand) via the in situ approach have been prepared. The dnm ligand was synthesized and adopted with the aim to sensitize the lanthanide ions with visible light. The properties of Ln–N–P-gels were investigated by Fourier-transform infrared (FT-IR), diffuse reflectance (DR), scanning electron micrographs (SEM), fluorescence spectra and thermogravimetric analyses. The results reveal that the lanthanide complexes are successfully in situ synthesized in the corresponding Ln–N–P-gels. Under the excitation of visible-light, the Ln–N–P-gels showed the respective visible (Sm3+) and near-infrared (Sm3+, Yb3+, Nd3+, Er3+, Pr3+, Ho3+, Tm3+) luminescence. The near-infrared (NIR) luminescence of Sm3+, Pr3+, Ho3+, and Tm3+ complexes sensitized by visible-light had been rarely reported previously, which is highly desired for biomedical and photonics applications. Based on the relevant energy levels, a model was proposed to explain the visible-NIR luminescence of the Ln–N–P-gels based on the visible-light excitation.
研究领域:
材料科学
·
光学
·
生物医学工程
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高影响因子
ACS Applied Electronic Materials
·
2022
·
IF 4.494
Linghui Shen,Tong Wei,Yongchao Shi,Xiangyu Wang,Liwei Wu,Jiao Cui,Tianyang Zhang,Hongzhi Yu,Zepeng Li
Upconversion (UC) luminescence materials with dynamically adjustable activity under external stimuli are of great interest owing to their potential applications in optical storage and high-sensitivity optical switches. Recently, photochromic (PC) effect was considered as an alternate way to regulate the UC luminescence of inorganic materials; however, external-field-induced bleaching was routinely completed by single stimulation, which limited its practical application. In this work, one kind of smart phosphor, Er-activated Bi7Ti4NbO21 intergrowth bismuth layer-structured ceramics that exhibited both intense UC green emission and prominent PC reaction, was synthesized. The UC luminescence, PC effect, and their coupling properties were researched. Interestingly, light–heat and light–light dual-controlled UC luminescence and PC processes were realized. Accompanying the PC effect, the UC luminescence can be reversibly modified by alternating 405 and 532 nm light stimulation (or thermal stimulation). Under 405 nm irradiation, the UC luminescence quenching ratio can reach up to 80.8%. Meanwhile, the UC luminescence raise ratio can respectively reach up to 426.9 and 118.1% under 250 °C thermal treatment and 532 nm light bleaching. The UC luminescence modulation was exposed to be tightly related to the irradiation coloration and thermal/light decoloration processes. Good fatigue resistance of the UC luminescence switching was also achieved. The mechanisms related to the UC luminescence modulation and PC process were discussed. These results indicated that Er-activated Bi7Ti4NbO21 samples can be adopted as a kind of optical data memory materials.
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高影响因子
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
·
2022
·
IF 4.52
Long Zhu,Mingrong Wang,Shuo Fu,Kaiqi Li,Jialin Liu,Zaizhao Wang
Bisphenol A (BPA) is a widely used endocrine disruptor , which has attracted much attention due to its harmful effects on male reproduction. To investigate the interference of BPA on steroid synthesis in males, male rare minnows ( Gobiocypris rarus ) were exposed to 15 μg L −1 BPA for 7, 14 and 21 d. Meanwhile, a positive control group was performed with 25 ng L −1 17α-ethynyl estradiol (EE2). Results showed that BPA exposure induced lower testosterone (T) levels, while affecting the transcripts of steroidogenic gene StAR . Moreover, BPA induced abnormal germ cells proliferation in the testis in rare minnow. Transcriptome analysis showed that 354 transcripts significantly differentially expressed after BPA exposure for 14 d, several of them were enriched in the signaling pathways of cell cycle process, PPAR signaling pathway, the steroid synthesis pathway and estrogen signaling pathway. BPA significantly increased estrogen receptor (ER) levels and induced abnormal protein levels of PPARγ. BPA disrupted the StAR expression by interfering ER enrichments within StAR 5′ flanking region . Additionally, our study also revealed that BPA and EE2 might have different mechanisms for interfering with steroid hormone levels and germ cells proliferation in the testis.
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PubMed
高影响因子
Chemistry-An Asian Journal
·
2022
·Vol. 17
·期 14
·e202200161
·
IF 4.839
Bo Ling,Yaguang Wang,Ruo Mi,Di Wang,Hongqi Chen,Xiaohu Li,Ye Zhang,Lun Wang
Graphical NaGdF 4 ,Yb,Er@NaGdF 4 ,Yb,Tm@NaYF 4 core@shell@shell three-layer structure of upconversion nanoparticles coated with Fe−TCPP metal-organic frameworks nanocomposite was designed and constructed for multimodal imaging and synergetic chemodynamic therapy/photodynamic therapy of tumors. Here, NaGdF 4 ,Yb,Er@NaGdF 4 ,Yb,Tm@NaYF 4 core@shell@shell three-layer structure of upconversion nanoparticles (UCNPs) coated with Fe−Tetrakis (4-carboxyphenyl) porphine (TCPP) metal-organic frameworks (Fe-MOFs) nanocomposite (UCNPs@MOFs) was designed and constructed for multimodal imaging and synergetic chemodynamic therapy (CDT)/photodynamic therapy (PDT) of tumors. The UCNPs@MOFs were successfully applied for tumor cells imaging in vitro and in vivo in near-infrared (NIR) region. The doped Gd was used as contrast agent for the magnetic resonance imaging (MRI) of mouse tumors. The luminescence in the UV-vis region was absorbed by the Fe-MOFs to produce singlet oxygen ( 1 O 2 ) for PDT. The Fe 3+ doped in the MOFs can catalyze H 2 O 2 to produce oxygen and hydroxyl radical (⋅OH). Hydroxyl radical is used in CDT and cooperates with the 1 O 2 of PDT. Based on the CDT/PDT synergistic effects, the UCNPs@MOFs nanocomposite had obviously enhanced tumor inhibitory efficiency in vivo. These results described that the asprared UCNPs@MOFs nanocomposite have great potential in the effective multimodal imaging and treatment of tumors.
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高影响因子
CRYSTENGCOMM
·
2021
·Vol. 23
·期 21
·3892-3900
·
IF 3.545
Dandan Ju,Xiaoli Gao,Shouchao Zhang,Yang Li,Wenjing Cui,Yinhui Yang,Mingyan Luo,Shujing Liu
Temperature is one of the physical parameters that affects the emission luminescence properties of upconversion (UC) materials. Temperature-dependent emission color tuning and good temperature sensitivity in multifunctional β-NaYF4:Yb/Er@β-NaYF4:Yb/Tm microcrystals were achieved under 980 nm excitation. Based on the different emission bands (blue, green and red bands) and spectral sensitivities of the core–shell structured microcrystals to temperature, intense white-light emission was obtained at room temperature and a real-time naked-eye recognizable emission color change from white to the purplish-pink region was realized with the temperature increasing from 300 to 500 K. Furthermore, optical temperature sensing properties of the sample with good sensitivity (from 0.0034 to 0.0044 K−1) were investigated by using a fluorescence intensity ratio between 521 nm (2H11/2 → 4I15/2 transition) and 540 nm (4S3/2 → 4I15/2 transition) in the temperature range from 300 to 500 K. The results indicate that the sample has high sensitivity in a relatively wide range of temperature intervals, especially in the low temperature region. We believe that the multifunctional core–shell structured microcrystals exhibit promising applications in white-light emitting diodes, the anti-counterfeiting field, and temperature sensing.
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Scientific Reports
·
2021
·Vol. 11
·期 1
·1-13
·
IF 4.38
Wang Zijing,Ma Peng,Wang Yisa,Hou Biyu,Zhou Can,Tian He,Li Bowen,Shui Guanghou,Yang Xiuying,Qiang Guifen,Yin Chengqian,Du Guanhua
Endoplasmic reticulum (ER) stress is a cellular state that results from the overload of unfolded/misfolded protein in the ER that, if not resolved properly, can lead to cell death. Both acute lung infections and chronic lung diseases have been found related to ER stress. Yet no study has been presented integrating metabolomic and transcriptomic data from total lung in interpreting the pathogenic state of ER stress. Total mouse lungs were used to perform LC–MS and RNA sequencing in relevance to ER stress. Untargeted metabolomics revealed 16 metabolites of aberrant levels with statistical significance while transcriptomics revealed 1593 genes abnormally expressed. Enrichment results demonstrated the injury ER stress inflicted upon lung through the alteration of multiple critical pathways involving energy expenditure, signal transduction, and redox homeostasis. Ultimately, we have presented p-cresol sulfate (PCS) and trimethylamine N-oxide (TMAO) as two potential ER stress biomarkers. Glutathione metabolism stood out in both omics as a notably altered pathway that believed to take important roles in maintaining the redox homeostasis in the cells critical for the development and relief of ER stress, in consistence with the existing reports.
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高影响因子
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