MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Wenfang Huang,Shulong Wang,Min Wu,Xinping Huang,Qifei Mo,Jiayao Xu,Rong Wang,Qingmin Wei
Hydrogen peroxide (H 2 O 2 ) plays a crucial role as a signaling molecule within cells. The concentration of H 2 O 2 differs in inflammation, cancer, cardiovascular and cerebrovascular diseases and neurodegenerative diseases compared to normal tissue. Therefore, the accurate determination of H 2 O 2 is important for the diagnosis and understanding of pathogenesis of disease. However, to accurately determine H 2 O 2 levels in vivo, highly sensitive biosensors and deep tissue penetrating imaging techniques are required. To address this challenge, we developed a biocatalytic porous structure composed of metal–organic frameworks (MOFs) that encapsulates horseradish peroxidase (HRP) and 3, 3′, 5, 5′-Tetramethylbenzidine (TMB) in situ, enabling biomineralization while maintaining the catalytic activity and stability of natural enzymes. This leads to the formation of a hypersensitive biological probe BSA@HRP@TMB@ZIF-8 (BHTZ). BHTZ is an activatable near-infrared probe and its absorption signal in the second near-infrared window (1030 nm) is activated in the presence of H 2 O 2 . The findings indicate that the BHTZ probe has high sensitivity, low toxicity and high stability, and can be utilized to detect H 2 O 2 levels in mice with drug-induced liver injury, such as that caused by lipopolysaccharide (LPS) in vivo. These results not only provide a highly sensitive and deep imaging method for monitoring physiological changes in H 2 O 2 levels in vivo, but also broaden the potential applications of MOFs in biomedical research and diagnostics.
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Laser & Photonics Reviews
·
2026
·
IF 9.7
Gaixin Zhang,Kejie Li,Jiaqi Zhao,Zhiying Wang,Zuoling Fu
Luminescent materials relying on Yb 3+ or Nd 3+ sensitization often suffer from severe thermal quenching at elevated temperatures, which limits their performance in high-precision ratiometric thermometry and optical encryption. Herein, we report a phonon-tuning strategy in lead-free Cs 2 NaTmCl 6 double perovskite nanocrystals that enables thermal enhancement of Tm 3 + -sensitized luminescence across the visible (450–680 nm) and near-infrared (NIR, 860–1600 nm) regions under 808 nm excitation.Tm 3+ acts as an efficient multi-path sensitizer, facilitating emissions from various lanthanide activators (Nd 3+ , Ho 3+ , Dy 3+ , Yb 3+ , and Er 3+ ). Notably, Tm 3+ -sensitized upconversion emissions of Ho 3+ (∼660 nm) and Nd 3+ (∼600 and 614 nm) exhibit substantial thermal enhancement from 313 to 533 K, with intensity increases of 7.6- and 1.6-fold, respectively, arising from optimized cross-relaxation pathways. In contrast, Tm 3+ -sensitized downshifting NIR emissions from Dy 3+ (∼1320 nm), Yb 3+ (∼980 nm) and Er 3+ (∼1550 nm) are dominated by energy transfer from the Tm 3+ 3 H 4 and 3 H 5 excited states. By exploiting the interplay between activator thermal quenching and Tm 3+ thermal enhancement, highly sensitive NIR-II ratiometric thermometry is achieved, delivering a maximum relative sensitivity of 1.59% K–1 based on the emission bands of Yb 3+ ( 2 F 5/2 → 2 F 7/2 ) and Tm 3+ ( 3 H 5 → 3 H 6 ). This phonon-tuning strategy further provides a broadband temperature-responsive platform for multimodal optical sensing and information encryption.
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Nanoscale
·
2020
·Vol. 12
·期 32
·17064-17073
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IF 6.895
Jinghua Li,Daoming Zhu,Weijie Ma,Yang Yang,Ganggang Wang,Xiaoling Wu,Kunlei Wang,Yiran Chen,Fubing Wang,Wei Liu,Yufeng Yuan
Hepatocellular carcinoma is the fourth leading cause of cancer-related deaths globally. Advanced nanomaterials have emerged as effective approaches to liver cancer therapy such as photothermal therapy. However, limited penetration depth of photothermal agents (PTAs) activated in the NIR-I bio-window and thermoresistance due to heat shock proteins restrict the therapeutic efficacy of PTT in HCC. Herein, we prepared a Bi@ZIF-8 (BZ) nanomaterial by a simple one-step reduction method. Then, gambogic acid, a natural inhibitor of Hsp90, was efficiently loaded onto the BZ nanomaterial via physical mixing. The characterization of the nanomaterial and release of GA due to pH change or NIR-light irradiation were separately studied. Photothermal conversion efficiency was calculated, and therapeutic studies were carried out in vitro and in vivo. This nanomaterial exhibited a significantly enhanced drug release rate when the temperature was increased under acidic conditions and had good light stability under laser irradiation and a photothermal conversion efficiency of about 24.4%. In addition, this novel nanomaterial achieved good therapeutic effects with less toxicity in vitro. The BZ nanomaterial loaded with GA caused tumor shrinkage as well as disappearance and effectively downregulated Hsp90 expression in tumors in vivo. Moreover, this novel nanomaterial exhibited good biocompatibility and potential for application in low-temperature PTT with excellent tumor destruction efficacy.
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PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
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IF 5.6
Bin Gui,Nan Jiang,Huan Pu,Fanglu Zhong,Xin Huang,Zhiwen Wang,Qianhui Liu,Hao Wang,Yanxiang Zhou,Qing Zhou,Qing Deng
Prostate cancer is the second most common malignancy in men, often presents at advanced stages, where treatment options are limited due to surgical intolerance and resistance to androgen deprivation therapy. Mild photothermal therapy (PTT) at 42–49°C selectively eliminates tumors while sparing normal tissues, but its efficacy is reduced by heat shock protein (HSP70) upregulation, which inhibits apoptosis. To address these limitations, we developed 2TToD@NPs, a multifunctional nanosystem combining second near-infrared (NIR-II) fluorescence imaging, mild PTT, and chemotherapy. The nanosystem, comprising an aggregation-induced emission agent (2TT-oC26B) and doxorubicin (DOX), targets prostate cancer cells via folic acid modification. Upon laser irradiation, 2TT-oC26B generates strong NIR-II fluorescence and thermal energy for imaging and mild PTT. Concurrently, DOX enhances tumor sensitivity to PTT by downregulating HSP70, reduces thermal resistance, induces DNA damage, and generates reactive oxygen species, triggering apoptosis. This synergistic approach overcomes the limitations of single-modality therapies. Our findings suggest that the multifunctional nanosystem effectively integrate precise imaging and targeted therapy, offering a promising strategy for advanced prostate cancer diagnosis and treatment.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Tong Feng,Lijia Liang,Hui Zhou,Yuanlin Jin,Zhangwen Long,Dacheng Zhou,Xiaqing Jiang,Bitao Liu,Jianbei Qiu
The rapid advancement of near-infrared light source technology has positioned phosphor-converted light-emitting diodes (PC-LEDs) operating within the near-infrared spectrum at the forefront of interdisciplinary research, with extensive applications in biomedicine, food quality assessment, and agricultural monitoring. However, the development of light sources that cover the second near-infrared spectral window (NIR-II, 1000–1700 nm) continues to encounter significant technical challenges. Inspired by chemical unit co-substitution strategy, we successfully developed a broadband NIR-II phosphor designated as (Li 0.7 Mg 0.3 )(Ga 0.7 Mg 0.3 )TiO 4 :0.003Ni 2+ ((L 0.7 M 0.3 )(G 0.7 M 0.3 )T:0.003Ni 2+ ) through [Mg 2+ -Mg 2+ ] dual-site substitution in orthorhombic LiGaTiO 4 (LGT) normal spinel. This co-substitution strategy resulted in an impressive enhancement of the internal quantum efficiency by 29.77 %–64.8 %, while maintaining thermal stability without significant attenuation at elevated temperature. To validate its practical utility, we fabricated prototype for a NIR phosphor-converted LED by integrating (L 0.7 M 0.3 )(G 0.7 M 0.3 )T:0.003Ni 2+ a commercial 340 nm chip. The resulting device demonstrates promising potential for applications in food safety inspection and deep-tissue infrared imaging. This work provides a perspective for designing broadband high-efficiency NIR-II phosphors via modulation of crystal field environment.
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ACS Nano
·
2024
·
IF 15.8
Xingping Quan,Chang Liu,Jinfen Chen,Yiyang Li,Zhen Yuan,Ying Zheng,Greta S. P. Mok,Ruibing Wang,Yonghua Zhao
Thromboembolic stroke constitutes the majority of brain strokes, resulting in elevated mortality and morbidity rates, as well as significant societal and economic burdens. Although intravenous thrombolysis serves as the standard clinical treatment, its narrow therapeutic window and the inflammatory response induced by tissue plasminogen activator (tPA) administration limit its efficacy. In the initial stages of stroke, the abrupt cessation of blood flow leads to an energy metabolism disorder, marked by a substantial decrease in adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide phosphate (NADPH) levels, causing irreversible damage to neural cells. In this study, we introduce a neutrophil-mimetic, microalgae-derived upconversion photosynthetic nanosystem designed for targeted treatment of thromboembolic stroke. This system features upconversion nanoparticles coated with a thylakoid membrane and wrapped in an activated neutrophil membrane, further decorated with ROS-responsive thrombolytic tPA on its surface. The neutrophil-mimetic design facilitates high targeting specificity and accumulation at the thrombus site after intravenous administration. Upon exposure to elevated levels of reactive oxygen species (ROS) at the thrombus location, the nanosystem promptly demonstrated potent thrombolytic efficacy through the surface-modified tPA. Furthermore, near-infrared II (NIR-II) laser irradiation activated the generation of ATP and NADPH, which inhibited inflammatory cell infiltration, platelet activation, oxidative stress, and neuronal injury. This constructed nanoplatform not only showcases exceptional targeting efficiency at the stroke site and controllable release of the thrombolytic agent but also facilitates ATP/NADPH-mediated thrombolytic, anti-inflammatory, antioxidative stress, and neuroprotective effects. Additionally, it offers valuable insights into the potential therapeutic applications of microalgae-based derivatives in managing thromboembolic stroke.
研究领域:
纳米技术
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生物医学工程
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神经科学
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药学
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光化学
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Journal of Materials Chemistry B
·
2024
·
IF 6.1
Yan Lu,Rui Xu,Wei Liu,Xiling Song,Wanqin Cai,Yuan Fang,Wei Xue,Siming Yu
Recently, bacterial infections have become a global crisis, greatly threatening the health of human beings. The development of a non-antibiotic biomaterial is recognized as an alternative way for the effective treatment of bacterial infections. In the present work, a multifunctional copper peroxide (CP) nanodot-decorated gold nanostar (GNS)/silica nanorod (SiNR) Janus nanostructure (GNS@CP/SiNR) with excellent antibacterial activity was reported. Due to the formation of the Janus nanostructure, GNS@CP/SiNR displayed strong plasmonic resonance absorbance in the near infrared (NIR)-II region that enabled the nanosystem to achieve mild photothermal therapy (MPTT). In acidic conditions, CP decorated on GNS@CP/SiNR dissociated rapidly by releasing Cu2+ and H2O2, which subsequently transformed to ˙OH via the Fenton-like reaction for chemodynamic therapy (CDT). As a result, GNS@CP/SiNR could effectively inhibit both Gram-negative Escherichia coli (E. coli) and Gram-positive Staphylococcus aureus (S. aureus), and eradicate the associated bacterial biofilms by exerting the synergistic MPTT/CDT antibacterial effect. Moreover, GNS@CP/SiNR was also demonstrated to be effective in treating wound infections, as verified on the S. aureus-infected full thickness excision wound rat model. Our mechanism study revealed that the synergistic MPTT/CDT effect of GNS@CP/SiNR firstly caused bacterial membrane damage, followed by boosting intracellular ROS via the severe oxidative stress effect, which subsequently caused the depletion of intracellular GSH and DNA damage, finally leading to the death of bacteria.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2024
·
IF 8
Shulong Wang,Yanni Luo,Jianniao Tian,Fanggui Ye,Zhihui Luo,Shulin Zhao
Metformin is currently the most commonly used oral drug for the treatment of diabetes. However, excessive use can up-regulate hydrogen sulfide (H 2 S) levels in the liver, which subsequently leads to severe liver injury and hepatotoxicity. Therefore, using endogenous H 2 S as a target molecule of an intelligent triggering sensor, a nano-probe that can recognize H 2 S with high specificity, and achieve non-invasive and highly specific in situ second near-infrared (NIR-II) photoacoustic (PA) imaging of hepatotoxicity induced by metformin would be welcomed in the field. In this work, we designed and synthesized a smart-responsive PA sensor based on metal-organic framework as bioreactor to dynamically monitor the changes in H 2 S levels induced by metformin. Molecular sieve imidazole framework-8 (ZIF-8) was selected as the coating layer, and the unique pore size of ZIF-8 was used to improve the selectivity of the sensor to H 2 S. The designed CuO x NPs@MOFs sensor turned on the PA signal of the sensor in NIR-II by in situ sulfation with overexpressed endogenous H 2 S in injured liver tissues. More importantly, the changes in the PA signal could non-invasively monitor liver injury in real time and with high sensitivity. Utilizing the unique structure in the MOFs sensor to selective recognize H 2 S molecules, ultra-sensitive monitoring and PA imaging of H 2 S in vitro and in vivo were achieved.
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CRYSTENGCOMM
·
2020
·Vol. 22
·期 38
·6330-6338
·
IF 3.117
Chunyan Cheng,Yueshan Xu,Gejihu De,Jianxun Wang,Wei Wu,Yuexing Tian,Shasha Wang
Rare-earth doped upconversion nanoparticles (UCNPs) have attracted wide-ranging interest due to their potential applications in bioimaging and biolabeling, where a high emission intensity and small particle size are needed. However, common synthesis processes can be somewhat complex or require additional reactants, and the use of small-size NPs is limited by their weak luminescence intensity. In this work, uniform, monodisperse ∼5 nm β-NaGdF4:20% Yb/2% Er NPs were synthesized via a simple one-pot synthesis method in the high boiling-point solvents 1-octadecene (ODE) and oleic acid (OA) using a single dose of NaF at an ultralow NaF concentration of NaF/RE = 4. The effects of NaF/RE, the reaction temperature, and the reaction time on the size and phase of the particles were investigated. High-quality β-NaGdF4:20% Yb/2% Er@β-NaGdF4:20% Yb/10% Nd core–shell NPs with a size of ∼13 nm, enhanced UC luminescence, long UC lifetimes (τ) for green (τ ≈ 150 μs) and red (τ ≈ 105 μs) emission under 980 and 808 nm excitation, revealed via lifetime imaging, and obvious emission in the near-infrared (NIR) II region were synthesized. The synthesized core–shell NPs may result in a decrease in the overheating effect and allow for a deep penetration depth when further used for bioimaging applications. This work could inspire the synthesis of other high-quality RE-doped UCNPs via adding a single dose of a small amount of NaF and could lay the foundation for the use of Gd-based UCNPs in biomedical applications.
研究领域:
材料科学
·
生物医学工程
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