Energy & Environmental Science
·
2024
·
IF 32.4
Liqun Wang,Jingting Jin,Wenzhi Li,Cunshuo Li,Leyu Zhu,Zheng Zhou,Lulu Zhang,Xia Zhang,Liang Yuan
Direct conversion of methane into high value-added products is of great practical significance. The synergistic effect in catalysts with dual-active components show potential to increase the methanol yield and selectivity. In this work, Cu–Pd/anatase is in situ generated and exhibits a relatively high methanol yield rate of ∼31 800 μmol gcat−1 h−1 and near-exclusive selectivity of liquid products (methanol). The reaction mechanism behind the heterogeneous catalysis process has been investigated. It is confirmed that copper ions hold the ability to produce hydrogen peroxide which can be further promoted by anatase. Chlorine ions can promote the stable adsorption of CO and the formation of *CH3 intermediates, facilitating high activity and selectivity for methanol production. Pd and Cu cooperatively dissociate methane, which promotes the formation of key configuration metal-CH3. The ˙CH3 intermediate desorption will be facilitated on Cu–Pd/anatase through the manner of electron regulation, which is proved by the combination of density functional theory calculations and in situ infrared spectroscopy. Methanol is formed when a ˙CH3 is desorbed from a copper site and combines with a hydroxyl radical.
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高影响因子
Biomedicines
·
2025
·Vol. 13
·期 5
·1021
·
IF 3.9
Ranran Chai,Kewei Zheng,Ting Xu,Hui Wang,Xiaobo Cheng,Chong Lu,Yu Kang
Background:Tumor-associated macrophages (TAMs) are prevalent in advanced ovarian cancer tissues and ascites, significantly influencing disease prognosis. However, the mechanisms driving TAM polarization and their tumor-promoting effects remain poorly understood.Methods: The subcellular distribution of SNX10 in ovarian cancer tissues was analyzed using single-cell datasets (GSE147082, GSE58937). The Kaplan–Meier Plotter and GEPIA2 databases were used to evaluate SNX10’s prognostic relevance. Lentivirus-mediatedSNX10overexpression in THP-1 cells was employed in tumor cell–macrophage co-culture experiments. Transwell assays and flow cytometry assessed SNX10’s effects on ovarian cancer cell metastasis and cisplatin-induced apoptosis. RNA sequencing, Western blotting, lysosomal pH detection, lipid droplet staining, and RT-qPCR were performed to explore SNX10’s molecular mechanisms in TAM polarization and immune modulation.Results: SNX10 was specifically expressed in TAMs, promoting their polarization into the M2 phenotype. This enhanced the migration and invasion of ovarian cancer cell lines A2780 and A2780/CP70 while reducing cisplatin-induced apoptosis. SNX10 decreased lipid droplet content, downregulated p-mTOR1, and impaired lysosomal function in TAMs. Additionally, SNX10 differentially modulatedPD-L1mRNA expression in platinum-sensitive and platinum-resistant ovarian cancer cells.Conclusions: SNX10 regulates the mTOR1/lysosome pathway in TAMs, influencing lipid metabolism and indirectly modulating ovarian cancer cell metastasis. It also altersPD-L1mRNA expression, suggesting a role in shaping the tumor immune microenvironment.
研究领域:
肿瘤学
·
免疫学
·
分子生物学
·
癌症研究
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DOI
PubMed
高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Wenzhe Yuan,Xiaoli Jiang,Jiayang Qin,Shenglan Wang,Mengxue Liu,Jiayi Jin,Feng Geng,Xiaohong Pan,Jing Zhang
Combining immunotherapy with photodynamic therapy (PDT) can optimize their synergistic therapeutic efficacy against triple-negative breast cancer (TNBC), but the limited accumulation of photosensitizers at the tumor site and the off-target binding of PD-L1 antibody with hematopoietic cells and normal tissues severely reduce the therapeutic efficacy and increase the systemic toxicity, leading to failure in the clinical treatment. Therefore, engineered Escherichia coli Rosetta(DE3) expressing PD-L1 nanobody (Rosetta(pPD-L1nb)) are constructed and covalently conjugated with a photosensitizer, chlorin e6 (Ce6), to develop hybrid bacteria (CeRosetta(pPD-L1nb)). As a facultative anaerobe, CeRosetta(pPD-L1nb) can targetedly accumulate and colonize at the hypoxic and hypernutrient microenvironment of tumor, consistently synthesize PD-L1nb and compete for nutrition consumption with tumor cells to inhibit tumor growth. Under light irradiation, CeRosetta(pPD-L1nb) can not only generate reactive oxygen species (ROS) to directly eliminate tumor cells and induce the infiltration of immune cells into tumors and the immunogenic cell death (ICD) to activate adaptive immune responses, but also spatiotemporally release PD-L1nb due to the PDT-induced lysis in the tumor site to reverse the immunosuppressive tumor microenvironment and activate the systemic antitumor immune response, therefore exert synergistic antitumor effects of anti-PD-L1 therapy and PDT. Altogether, the hybrid bacteria CeRosetta(pPD-L1nb) can serve as an all-in-one strategy for optimizing the synergistic therapeutic efficacy in the combination therapy of TNBC.
研究领域:
肿瘤学
·
生物医学工程
·
药理学
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DOI
PubMed
高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
·
2026
·
IF 6.8
Lianghui Zhan,Qian Liu,Changjun Zhang,Jinbao Pu,Ligang Ren
Ethnopharmacological relevance Hedysarum polybotrys Hand.-Mazz. (Hongqi, HQ) is a prized Qi-tonifying herb in Traditional Chinese Medicine (TCM), historically employed to enhance the body's resistance and modulate immune function. While its anti-tumor properties are recognized, the specific immunomodulatory mechanisms by which HQ empowers Natural Killer (NK) cells to combat prostate cancer (PCa) remain under-explored. Aim of the study To systematically elucidate the material basis and molecular mechanisms through which the aqueous extract of HQ enhances NK cell-mediated cytotoxicity against PCa cells, utilizing an integrated approach of multi-omics and experimental validation. Methods The chemical profile of HQ aqueous extract was characterized using UHPLC-MS/MS untargeted metabolomics. Network pharmacology and transcriptomic analyses (RNA-seq) were integrated to predict core targets and signaling pathways. Specific interactions were simulated via molecular docking. Validations were performed using an in vitro co-culture model of NK-92 and PC-3 cells. Assays included CCK-8, LDH release, flow cytometry (apoptosis, surface markers), ELISA (cytokines), and Western blot. Results A total of 69 compounds were identified in HQ, with Genistein and Isoliquiritigenin highlighted as key active constituents. HQ treatment significantly enhanced NK-92 cell cytotoxicity against PC-3 cells, evidenced by increased LDH release and PC-3 apoptosis. Mechanistically, HQ upregulated the expression of cytolytic effectors (Perforin, Granzyme B) and pro-inflammatory cytokines (IFN-γ, TNF-α, IL-17A). Crucially, HQ treatment achieved a "dual-effect": it reactivated the PI3K/AKT signaling pathway in NK cells (confirmed by increased p-PI3K and p-AKT levels) while concurrently downregulating the immunosuppressive PD-1/PD-L1 checkpoint axis. Conclusion This study demonstrates that HQ potentiates NK cell anti-tumor immunity against prostate cancer through a dual mechanism involving PI3K/AKT pathway activation and PD-1/PD-L1 axis inhibition. These findings provide modern pharmacological evidence supporting the traditional use of HQ for enhancing immune surveillance in cancer therapy.
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DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2023
·
IF 11.1
Lujie Zuo,Shufan Yu,Rongjun Zhang,Hongwei Li,Yu Wu,Rufat Abiev,Zhao Sun,Zhiqiang Sun
Methanol is a competitive candidate for in-situ hydrogen supply; however, the techniques of methanol-to-hydrogen production are suffered from high reforming temperatures and catalyst deactivation . In this work, the chemical looping oxidative reforming of methanol is conducted using a Pd–Cu-based catalytic oxygen carrier (PdO–CuO–CuMn 2 O 4 ). Synergistic enhancement of lattice oxygen induction and Pd–Cu alloy activation is confirmed, thereby achieving efficient methanol reforming at a temperature as low as 200 °C. Under such low temperatures, the hydrogen production rate can reach an average of 11.2 times higher than that of CuO/ZnO/Al 2 O 3 . Moreover, the catalytic oxygen carrier remains relatively satisfying redox durability after 30th cycle. SEM and AFM measurements reveal the high degree of roughness at the PdO–CuO–CuMn 2 O 4 surface, in which the methanol activation can be effectively promoted. XRD and XPS measurements verify the formation of Pd–Cu alloy, as proved by the charge transfer from Pd to Cu. During the redox looping, Pd–Cu alloy is formed and re-separated to be PdO and CuO, thus remaining homogenous distribution of the active phase on an atomic scale. Meanwhile, the lattice oxygen also plays a crucial role in methanol activation, synergistically enhancing the low-temperature reforming of methanol. This study provides a new implication for designing functionalized catalytic oxygen carrier materials , which will substantially promote in-situ hydrogen supply for proton exchange membrane fuel cells.
研究领域:
化学工程
·
催化材料科学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Yaxu Zhao,Shaohua Wang,Wenjing Yuan,Shurui Fan,Zhongqiu Hua,Yi Wu,Xuemin Tian
Gas sensors based on In 2 O 3 were prepared and were found to be very sensitive to methane with Pd loading (Pd-In 2 O 3 ), even at a low temperature of 300 °C. However, Pd-In 2 O 3 sensors suffer from a high cross-sensitive response to NO 2 , CO and ethanol, which are typical interfering gases for the detection of CH 4 . In order to promote the selective response to CH 4 , a filter based on Pt-Al 2 O 3 catalyst film was printed onto the top of Pd-In 2 O 3 sensor layer. It was found that catalytic film coated sensors could selectively respond to methane even in the mixture of methane with CO, NO 2 , and ethanol. The cross-sensitive responses to the interference of VOCs, CO, NO 2 were almost eliminated. According to the catalytic conversion measurement, it was indicated that CO and ethanol were fully and selectively oxidized to CO 2 and H 2 O. In case of NO 2 , it was proposed that nitrogen dioxide molecules may be blocked on the surface of the catalyst film. Based on the oxygen adsorption behavior, it was suggested the printed catalyst film has no change on the basic sensing mechanism of In 2 O 3 based sensors following the general model that is the adsorption of oxygen and interaction with methane molecule and the resulted electron transfer process. Our investigation demonstrated that Pt-Al 2 O 3 printed Pd-In 2 O 3 sensor could be used for the detection of CH 4 leakage and monitor.
研究领域:
材料科学
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环境监测
·
化学工程
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DOI
高影响因子
Molecular Catalysis
·
2018
·
IF 0
Wen-Yu Liang,Lei Liu,Qing Zhou,Da Yang,Yong Lu,Ye Liu
The Pd-catalyzed alkoxycarbonylation of alkenes using water as a promoter has been scarcely reported before. Herein, water instead of Brønsted/Lewis acid was found to effectively improve the catalytic performance of Pd(MeCN) 2 Cl 2 -Xantphos system for alkoxycarbonylation of alkenes. Under the optimal conditions, the best yield of 97% was obtained for the target products (methyl 3-phenylpropanoate and methyl 2-phenylpropanoate) with L/B of 4.3 and TON of 192. With the involvement of water, Pd(MeCN) 2 Cl 2 -Xantphos system also exhibited the moderate to good generality to alkoxycarbonylation of different kinds of alkenes with alcohols. The in situ high pressure FT-IR analysis verified that water played an important role in promoting formation and stability of Pd H active species which was responsible for the efficient alkoxycarbonylation of alkenes. In addition, the ligand effect of Xantphos on this reaction was discussed.
研究领域:
化学
·
催化反应
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DOI
RESEARCH ON CHEMICAL INTERMEDIATES
·
2013
·Vol. 40
·期 4
·1633-1636
·
IF 0.88
Qin Qi-xue,Yang Jian,Yang Bo
Abstract A facile and simple procedure for the synthesis of norathyriol using Pd(II) as a catalyst via two steps under mild conditions is described. The major advantages of this method are the use of a commercially available catalyst, short reaction times, and the simplicity of the reaction and work-up. The overall yield of 36.6 % is acceptable. Graphical Abstract All reactions were monitored by TLC . The UV-Vis spectra of the product and the intermediate are as follows:
研究领域:
有机化学
·
药物化学
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DOI
高影响因子
Chemical Science
·
2025
·
IF 7.4
Guozhou Feng,Yuxin Fan,Lechen Diao,Zhichao Miao,Jin Zhou
Electrocatalytic hydrogenation (ECH) of 5-hydroxymethylfurfural (HMF) to 2,5-bis(hydroxymethyl)furan (BHMF) is regarded as a green synthesis strategy for generating high quality bio-based chemicals. However, simultaneously regulating both the hydrogen (H) coverage and the adsorption behavior of HMF presents a significant challenge, particularly in unraveling the intricate structure–activity relationship and achieving a selective target product. Here, we enhance the availability of hydrogen (H*) and modulate surface electronic interactions with 5-hydroxymethylfurfural (HMF) to facilitate selective electrochemical hydrogenation (ECH) of HMF by introducing palladium as an auxiliary component. Pd–Cu dual sites synergistically enhanced H* supply and HMF activation while suppressing the competing hydrogen evolution reaction. The optimized electrocatalyst exhibits notable catalytic performance, attaining a selectivity of 99.3% and a faradaic efficiency of 97.5% for BHMF at a potential of −1.15 V (vs. Ag/AgCl). Density functional theory (DFT) calculations demonstrate that Pd doping is crucial for enhancing the adsorption of H* and HMF* intermediates, thereby promoting the hydrogenation of HMF through the Langmuir–Hinshelwood (L–H) mechanism under neutral conditions. This work establishes a catalyst design paradigm where atomic-level dopant engineering regulates multistep protonation kinetics, offering fundamental insights into biomass electrorefining.
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PubMed
高影响因子
Nano Research
·
2014
·Vol. 7
·期 9
·1337-1343
·
IF 6.963
Xiang Ji,Li Peng,Chong Hanbao,Feng Li,Fu Fangyu,Wang Zhuang,Zhang Shilin,Zhu Manzhou
A simple and efficient solution-based method for the synthesis of Pd-Ni bimetallic nanoparticles (NPs) has been developed. A series of Pd-Ni bimetallic NPs were readily achieved by reduction of PdCl 2 and Ni(acac) 2 (acac = acetylacetonate) in the presence of oleylamine (OAm), oleic acid (OA) and benzyl alcohol. Furthermore, by using high-resolution transmission electron microscopy (HRTEM), energy-dispersive spectrometry (EDS) mapping and X-ray diffraction (XRD), we demonstrate that the as-prepared Pd-Ni bimetallic NPs have core-shell structures with a Pd-rich core and a Ni-rich shell. In addition, the as-obtained Pd-Ni bimetallic NPs with varying compositions show excellent catalytic activities in the Miyaura-Suzuki reaction. When the nickel molar percentage was 0.23 to 0.65, the conversion with the as-obtained Pd-Ni bimetallic catalysts was above 90%. It is believed that this strategy can be employed to produce a variety of other well-defined core-shell type multimetallic nanostructures.
研究领域:
材料科学
·
化学
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DOI
高影响因子
Journal of Physical Chemistry C
·
2012
·
IF 4.805
Yuewu Zhao,Huile Jin,Huan Zhou,Juanjuan Lin,Shun Wang,Jichang Wang
Te@Pd core–shell hybrids were prepared in this study, in which a pine leaf-shaped microstructure was obtained through controlling the synthesis kinetics of single crystal Te. The as-prepared Te was subsequently utilized as the substrate for Pd coating. These core–shell particles were characterized with scanning and transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffraction, and energy dispersive X-ray spectroscopy. When being applied as a catalyst in bromobenzene and phenylboronic acid reaction, 100% conversion of bromobenzene was achieved in less than 3 h, which was much shorter than that required by the reactions using graphene oxide supported Pd catalyst (4 h) or the commercial Pd/C catalyst (>6 h). The Te@Pd core–shell catalyst could be easily recovered from the reaction solution and be used repeatedly. The high catalytic activity of Te@Pd hybrids is attributed to their unique microstructure.
研究领域:
材料科学
·
催化化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 40
·期 1
·372-376
·
IF 3.086
Weidong Jiang,Zhen Xiang,Bin Xu,Xiaojing Li,Fuan Liu,Guangyin Fan
Uniformly dispersed Pd nanoparticles supported on reduced graphene oxide (RGO) have been conveniently synthesized by a facile one-pot approach through the co-reduction of sodium tetrachloropalladate(II) and graphene oxide (GO) using NaBH4 as the reducing agent. The catalytic activity of Pd/RGO was investigated for aqueous hydrodechlorination (HDC) of chlorophenols at room temperature using hydrogen balloon pressure without any additives. Results indicated that Pd/RGO exhibited an excellent activity with a reaction rate of 280.0 min−1 gpd−1 for the hydrodechlorination (HDC) of 4-CP. Furthermore, the Pd nanoparticles supported on RGO can be easily recovered and reused for four times without any obvious leaching and loss of activity.
研究领域:
化学
·
环境科学
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DOI
高影响因子
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