COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Mengmeng Xu,Yuan Liu,Zhe Tang,Xiaolin Yu,Li Gao,Bo Yang,Yan Wang,Xuehui Dong,Qianqian Yu,LinGe Wang
Rational surface engineering of nanocatalysts offers new solutions against antibiotic-resistant infections. We designed and fabricated hierarchical MnO₂@Au@ZIF-67 nanoparticles (NPs) with triple interfacial functionalities for synergistic antibacterial therapy. The acid-responsive ZIF-67 surface degrades in infected wounds, releasing Co²⁺ to catalyze •OH generation via Fenton-like reactions at the material-bacteria interface. Simultaneously, ultrasmall Au surfaces deplete glucose through oxidase-mimetic catalysis, producing gluconic acid that accelerates ZIF-67 dissolution. The MnO₂ core surface decomposes H₂O₂ to supply O₂, enhancing Au catalysis and alleviating hypoxia. Comprehensive surface characterization (TEM, SEM, XPS, XRD) confirmed structural integrity and reactive sites. In vitro , the NPs achieved > 99 % bacterial killing (S. aureus/E. coli ) through ROS-mediated membrane disruption (validated by SEM/CLSM). In vivo , they enabled 98.45 % bacterial clearance and accelerated wound healing via collagen reorganization (H&E/Masson staining). This surface-engineered platform demonstrates how interfacial catalytic cascades can be harnessed for effective non-antibiotic antimicrobial applications.
研究领域:
纳米医学
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催化治疗
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抗菌材料
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伤口愈合
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纳米催化剂
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活性氧
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Xu Xu,jing Li,Yaodong Zhang
A novel and simple ratio fluorescence detection method for H2O2 and glucose was proposed on the basis of the Aggregation-induced luminescence effect of the Aggregation-induced emission (AIE) molecule 4-formyl-3-hydroxybenzoic acid (FHBA) in ZIF-8 and the mechanism of Fluorescence resonance energy transfer (FRET) between the complex FHBA@ZIF-8 and Diallyl phthalate (DAP). First, glucose was oxidized to H2O2 under the catalysis of glucose oxidase. The latter further oxidized o-phenylenediamine in the presence of horseradish peroxidase to generate DAP yellow fluorescent compound (560 nm). The fluorescence of FHBA@ZIF-8 at 445 nm can be effectively quenched because the ultraviolet absorption spectrum of DAP overlaps well with the emission spectrum of FHBA@ZIF-8. Therefore, a highly sensitive ratiometric fluorescence detection method for detecting H2O2 and glucose was constructed using the change of the ratio of fluorescence intensity at two wavelengths (F560/F445). The linear range of H2O2 detection by this method is 1–150 μM, and the detection limit is 0.21 μM. The linear range of glucose detection is 1–100 μM, and the detection limit is 0.17 μM. The method was successfully applied to the detection of glucose in human serum samples, and it has broad potential in clinical diagnosis and research
研究领域:
生物化学
·
医学诊断
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分析化学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 10
·1-9
·
IF 5.3
Zeng Zhaobin,Wang Haibin,Cai Chongming,Xiang Lin,Zhou Haohuan,Xie Ziyi,Guo Bangming
Methods based on photoelectrochemical immunoassay have been utilized for the quantitative monitoring of neuron-specific antigen (NSE) with neuroblastoma patients, but most provide only low sensitivity. In this contribution, a simple and feasible photoelectrochemical immunoassay based on ZIF-8-derived double-shelled hollow ZnS nanocages (ZnS NCs) was applied to the split-type photocurrent measurement of NSE in biological fluids, accompanied by an enzyme-catalyzed system for synergistic amplification. Glucose oxidase (GOx)-labeled anti-NSE secondary antibody was utilized to form a sandwiched immunoreaction on capture antibody-coated microplate, whereas ZnS NCs with strong and stable photocurrents were employed to generate the detectable photocurrent. Subsequently, GOx catalyzed the glucose substrate to produce hydrogen peroxide, thereby causing the change in the photocurrent of double-shelled hollow ZnS nanocages. Followed by optimizing experimental conditions, the photoelectrochemical immunoassay displayed good photocurrent responses within the dynamic range 1.0–10000 pg mL −1 at a low detection limit of 0.59 pg mL −1 NSE. Good reproducibility and high specificity were acquired for determination of NSE standards. Such a highly favourable analytical performance could be achieved even in human serum samples at different dilutions.
Graphical
研究领域:
肿瘤学
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免疫学
·
生物分析化学
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分子诊断
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纳米医学
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转化医学
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临床检验医学
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Chunmei Xu,Mengran Lou,Rui Liu,Taotao Lv,Yang Wang,Ruiying Wang,Hongtao Liu,Xia Kong
Metal-nitrogen-carbon (M–N–C) catalysts are promising alternatives to precious metal-based bifunctional catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in Zn-air batteries (ZABs). Herein, FeCo@nitrogen doped carbon nanotube/nitrogen doped reduced graphene oxide (FeCo@NCNT/N-rGO) catalyst with unique 3D heterostructure was synthesized through one-step pyrolysis of FeCo-ZIF-8 precursor anchored on graphene oxide (FeCo-ZIF-8/GO). Benefiting from the coupling of FeCo dual-metal sites with nitrogen-doped carbon substrates, the FeCo@NCNT/N-rGO catalyst achieved extraordinary bifunctional oxygen electrocatalytic activity, exhibiting a high ORR half-wave potential (E 1/2 ) of 0.881 V (vs. RHE), which was superior to the Pt/C catalyst (0.838 V), and OER overpotential of 343 mV at 10 mA cm −2 , merely inferior to RuO 2 by 33 mV. The resulting ΔE (defined as E j=10 − E 1/2 ) reaches an impressively low value of 0.69 V, highlighting its superior reversible oxygen electrocatalytic performance. Meanwhile, achieving a high-power density of 240 mW cm −2 and open circuit voltage (OCV) of 1.488 V in ZAB applications, superior to that of Pt/C + RuO 2 in ZAB (1.447 V; 143 mW cm −2 ). Flexible solid-state ZAB with FeCo@NCNT/N-rGO achieves 1.416 V OCV and 47.4 mW cm −2 power density, remaining stable even when bent 180°. This study guides design of dual-site non-precious metal bifunctional oxygen catalysts.
研究领域:
电化学
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材料科学
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能源存储与转换
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纳米技术
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产品关联
DOI
高影响因子
Biosensors-Basel
·
2022
·Vol. 12
·期 10
·830
·
IF 5.743
Juanjuan Huang,Yiyun Yao,Yanling Chen,Tianran Lin,Li Hou,Dianping Tang
Copper peroxide/zeolitic imidazolate framework/polydopamine nanoparticles (CP/ZIF-8/PDA)-based fluorescence-linked immunosorbent assay (FLISA) was designed for the sensitive and high-throughput determination of carcinoembryonic antigen (CEA) by self-supplied H2O2generation. Specifically, the CEA aptamer was modified on the surface of CP/ZIF-8/PDA to form an immunoprobe. The structures of CP and ZIF-8 could be broken under acidic conditions, and produced the Cu2+and H2O2due to the dissociation the CP. A subsequent Fenton-type reaction of Cu2+and H2O2generated hydroxyl radical (·OH). o-phenylenediamine (OPD) was oxidized by the ·OH to form 2, 3-diaminophenazine (DPA) with a significant fluorescence signal. CP/ZIF-8/PDA could be used as an efficient Fenton-type reactant to generate a large amount of ·OH to promote OPD oxidation. The sensitive detection of CEA could be realized. Under optimal conditions, the FLISA platform displayed a linear detection range from 0.01 to 20 ng mL−1with a detection limit of 7.6 pg mL−1for CEA. This strategy has great application potential for sensitive and high-throughput determination for other biomarkers in the field of biomedicine.Keywords:fluorescence-linked immunosorbent assay;Fenton-type reaction;carcinoembryonic antigen
研究领域:
生物医学工程
·
分析化学
·
生物传感器
·
癌症诊断
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DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2018
·Vol. 20
·期 25
·3601-3608
·
IF 3.304
Somboon Chaemchuen,Kui Zhou,Bibimaryam Mousavi,Marzieh Ghadamyari,Philippe M. Heynderickx,Serge Zhuiykov,Mekhman S. Yusubov,Francis Verpoort
High-quality zeolite imidazole frameworks (ZIF-8, ZIF-67, and bimetallic Zn/Co-ZIF) were synthesized using the spray-drying technique and the mechanism of crystal growth during the whole process is discussed. It is also demonstrated that the crystallization mechanism for N-donor containing ditopic imidazolate (IM) ligands forming ZIF structures is divergent from MOF formation applying carboxylate ligands, and their formation using the spray dry method occurs via a unique mechanism. An intermediate amorphous phase was obtained after spray drying the feed solution, and the crystallographic ZIF structure was obtained during immersion in a solvent. Several characterization techniques, such as FTIR, XRD, SEM, porosity analysis, elemental analysis etc., were applied to examine the characteristic properties of materials, including, intermediate compounds and final products. The results proved that the spray drying procedure is a facile, continuous and effective synthetic route to produce MOFs (ZIFs) in higher quantities with high-quality properties such as high porosity, a large surface area, more active catalyst sites, etc. applying a minimum amount of time and energy which is unusual in common synthesis methods of MOFs.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 52
·期 2
·376-383
·
IF 4.569
Enming Ping,Lingyun Kong,Mengyao Liu,Yunshan Zhou,Lijuan Zhang,Nan Chen
The reaction of porous γ-Al2O3 particles acting as both a sacrificial template and an aluminum source with 1,4-naphthalene diacid (H2NDC) resulted in the formation of γ-AlOOH@Al(OH)(1,4-NDC) composites, in which ZIF-67 was then loaded by the in situ crystallization method, leading to the formation of γ-AlOOH@Al(OH)(1,4-NDC)@ZIF-67 composites. The deliberately designed composite was used to separate H2/D2 at 77 K in a 1 m chromatographic column. The results demonstrated that the optimized composite can achieve the effective separation of H2/D2 in gas chromatography due to the additive effects of kinetic sieving and chemical affinity quantum sieving of Al(OH)(1,4-NDC) and ZIF-67. By optimizing chromatographic separation conditions, the resolution R reached 2.02 with the separation time t = 7.72 min. The composite also showed satisfactory repeatability and reproducibility.
研究领域:
材料科学
·
分离科学
·
物理化学
·
纳米材料
·
能源化学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Peng Wang,Zijing Liu,Yanwei Xing,Bin Fan,Yulong He,Ting Gao,Wenlei Zhang,Yunfei Gao,Shuang Wang,Jinping Li
Electrocatalytic nitrogen reduction reaction (ENRR) is considered as a potential pathway for green synthesis of ammonia. However, the kinetic barriers of ENRR remain a tough challenge, which is imperative to design high effective electrocatalysts for accelerated activation of N N. Herein, the FeS/ZnS/ZIF-8-L with rich heterogeneous interfaces was successfully fabricated by governing the ordered lasso arrangement of Fe and Zn nodes in Fe-2MIM/ZIF-8-L precursor, where Fe and Zn were separately fixed in the confined space of ZIF-8-L and Fe-2MIM. Such intertwined Fe-2MIM/ZIF-8-L structure was beneficial to control the location and concentration of FeS and ZnS after sulfidation pyrolysis. The high-efficiency FeS/ZnS/ZIF-8-L exposed more catalytic active sites and possessed optimal electronic structure resulting in the lowered energy barrier of ENRR and the enhanced adsorption and activation of N 2 , which confirmed by experimental and theoretical characterization results. As a result, FeS/ZnS/ZIF-8-L displayed an optimal NH 3 yield rate of 89.52 μg h −1 mg −1 and Faradaic efficiency of 16.78 %, which surpassed most reported heterostructured ENRR catalysts. Our findings shed a new insight to govern the interfaces density of heterostructured electrocatalysts by predesigning the location of two metals in precursor, which can motivate an in-depth exploration to advanced catalysts for various electrocatalytic reactions.
研究领域:
电催化
·
材料科学
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纳米技术
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能源化学
·
可持续化学
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产品关联
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2023
·Vol. 33
·期 5
·1219-1233
·
IF 4
Zhang Qian,Qiao Qikai,Wang Zihao,Liu Yuanyuan,Pei Zhen,Guo Jiandong,Fei Pengfei,Zhang Aiqin,Jia Husheng,Xu Bingshe
In order to solve the problem of poor compatibility between modified-ZIF-8 nanoparticles and mask matrix polypropylene (PP) and melt-blown materials, in this work, PP based modified-ZIF-8 antibacterial masterbatch was prepared employing surface modification and torque blending method. IR, SEM, XRD, XPS, DSC results confirm that the antibacterial masterbatch maintains the chemical and crystal structure of modified-ZIF-8 and the thermal stability of PP. Photocatalytic performance indicates that the antibacterial masterbatch basically maintains the photoresponse range of modified-ZIF-8, has narrower band gap and the superior photocatalytic performance than that of modified-ZIF-8. The photocatalytic antibacterial mechanism of ·O 2 − and h + as antibacterial active species is revealed according to the energy band structure and free radical capture experiment. The photocatalytic antibacterial activity of the antibacterial masterbatch against Staphylococcus aureus and Escherichia coli under different dosage holds that the relationship between antibacterial rate and antibacterial agent concentration conforms to Beta distribution, demonstrating second-order kinetic behavior. The antibacterial properties reach the maximum when the loading of modified-ZIF-8 is 2% of the total weight of PP and melt-blown materials. S. aureus and E. coli could be completely killed when the simulated sunlight is irradiated for 30 min. These results indicate that PP based modified-ZIF-8 antibacterial masterbatch has potential application in photocatalytic antibacterial masks.
研究领域:
材料科学
·
化学工程
·
纳米技术
·
光催化
·
抗菌材料
✓ 已验证
DOI
高影响因子
DESALINATION
·
2025
·
IF 9.8
Yanan Song,Rui Zhang,Baoyuan Dong,Yuan Liu,Mingming Zhang,Xiaoxue Hu,Jiake Li,Jianxian Zeng,Kaipeng Cheng,Lelin Zeng,Jie Shen
To address the persistent challenges of low separation efficiency and severe membrane fouling in water treatment, we engineered multifunctional mixed matrix membranes (MMMs) through a facile one-step phase inversion method by incorporating zeolitic imidazolate framework-8 (ZIF-8) nanoparticles (0.1–1.0 wt%) into a polyethersulfone (PES) matrix. The effects of ZIF-8 loading (0.1–1.0 wt%) on the morphology, hydrophilicity, porosity, pore size, water flux of the MMMs were investigated. The optimal MMMs delivered a water flux of 299.2 L/m 2 ·h, surpassing the pure PES membrane by 65.90 %. Furthermore, the optimized MMMs demonstrated a 516 % increase in permeate flux along with a 113 % increase in bovine serum albumin (BSA) rejection rate simultaneous, indicating their potential to break through the trade-off effect. The improved rejection rate of BSA was attributed to size exclusion and electrostatic repulsion, originating from the introduction of ZIF-8 nanoparticles. In addition, the rejection rate of Congo Red (CR), Rhodamine B (RhB) and tetracycline hydrochloride (TCH) elevated from 40.94 %, 15.40 % and 59.33 % to 95.40 %, 37.40 % and 96.80 %, respectively. This enhancement stems from the incorporated ZIF-8 nanoparticles, which simultaneously modulated the MMMs' structure and imparted specific interactions: Electrostatic attraction and π-π stacking to CR, electrostatic repulsion and π-π stacking to RhB, and π-π stacking to TCH. Furthermore, the MMMs exhibited improved antifouling performance with the increased flux recovery ratio and reduced irreversible fouling ratio. This facile one-step engineering strategy provides a scalable and efficient route to fabricate high permeability, multifunctional MMMs with increased rejection and improved antifouling performance for integrated separation of proteins, dyes, and antibiotics in complex wastewater.
研究领域:
膜科学
·
环境工程
·
材料科学
·
水处理技术
·
分离过程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xietao Ye,Yeyang Sun,Lin Yang,Chen Chen,Shihao Li,Shuo Dong,Xiaoying Qin,Xiaoqi Li,Congyan Liu,Jiege Huo,Yuping Liu,Yan Chen
The low infiltration and insufficient tumor recognition of cytotoxic-T-lymphocytes (CTLs) are the two primary reasons for the low objective response rate of programmed death-1 protein (PD-1) inhibitors in treating microsatellite-stable colorectal-cancer (MSS-CRC). Ginsenoside Rg1 (Rg1) and atractylenolide-I (Att) can promote CTLs infiltration and recognition of CTLs by facilitating dendritic cells (DCs) maturation and upregulating tumor MHC-I expression, respectively, and the combination of two drugs is expected to improve the efficacy of PD-1 inhibitors. However, due to their poor water solubility and limited tumor targeting, the intratumoral delivery of both drugs faces challenges. Our previously reported a tumor-apoptotic-body-membrane (Ab) modified zeolitic-imidazolate-framework (ZIF) for co-delivering Rg1 and Att (Ab@Rg1/Att-ZIF). It could be transported by monocytes/macrophages into the deep tumor regions, however, partial formulations would be degraded by intracellular lysosomes. To overcome this, we innovatively incorporated inulin into Ab@Rg1/Att-ZIF, constructing an Ab/In@Rg1/Att-ZIF delivery system. By virtue of the Ab and inulin coating on its surface, the system could be specifically phagocytosed by monocytes/macrophages while maintaining stability in the lysosomal. Furthermore, after being transported to CRC tissues, inulin of the Ab/In@Rg1/Att-ZIF is enzymatically degraded by enzymes secreted by intratumoral bacteria, releasing Rg1 and Att to promote DCs maturation and upregulate tumor MHC-I expression, respectively. Ab/In@Rg1/Att-ZIF significantly inhibits tumor growth by enhancing CTLs infiltration and recognition, synergizing with PD-1 inhibitors to achieve a tumor suppression rate of ≈80 %, which is markedly higher than the combined efficacy of Ab@Rg1/Att-ZIF. This study provides new insights for the immunotherapy of MSS-CRC and the intratumoral co-delivery of drugs.
研究领域:
免疫治疗
·
纳米医学
·
药物递送
·
肿瘤学
·
肿瘤微环境
·
癌症免疫学
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Parviz Sukhrobov,Sodik Numonov,Xamxikamar Mamat,Yongtao Li,Thomas Wågberg,Guangzhi Hu
The present study demonstrated a highly sensitive non-enzymatic glucose biosensor in real blood samples based on simple evaluated nickel deposited on N-doped porous carbon modified glassy carbon electrode (Ni/NPC/GCE) by applying electrochemical deposition method. The prepared material initially were characterized by cyclic voltammetry, the morphology structure of the as-prepared samples was observed by SEM, and composition, crystals structure of Ni/NPC were identified by SEM mapping and EDS tests. The Ni/NPC/GCE compared with NPC/GCE and NiNPs/GCE performed the best electrocatalytic behavior towards oxidation of glucose in 0.1 M KOH medium. By applied potential of +0.6 V Ni/NPC/GCE showed very high sensitivity of 3753.78 μAmM -1 cm -2 in linear range of 1-7940 μM with the correlation coefficient of R 2 =0.995. The linear ranges get views above the concentration up to 7940 μM with the detection limit of 0.3 μM (S/N=3). Amperometric time responses of prepared electrode towards different glucose concentrations are 0.8-1.3s. Finally, several positive characteristics such as very high sensitivity, weak working potential, nice anti-interference properties, long stability, good selectivity, and comparison with some other non-enzymatic sensors Ni/NPC/GCE executed high sensitivity, low detection limit and wide linear range to glucose sensing, thus the selected electrode is supplying for future glucose level determination design.
研究领域:
分析化学
·
生物传感器
·
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）