JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2019
·
IF 1.479
Si Chen,Jin Hu,Feng Wang,Hui Liu
The spherical mesoporous silica nanoparticles (MSNs) with good dispersity and uniform pore structure were prepared and functionalized by amino and 2-bromoisobutyrate successively. The random copolymer brushes of 1′-(2-acryloxyethyl)-3′,3′-dimethyl-6-nitrospiro-(2H-1-benzopyran-2,2′-indoline) (SPMA) and methacrylic acid (MAA) on the surface of MSNs were obtained via chemical hydrolysis of the precursor random copolymer MSNs-g-P(SPMA-co-tert-butyl methacrylate (tBMA)) in acidic conditions. The pH or light stimuli-responsive behavior and the dual-responsive process were recorded by UV-Vis absorption spectroscopy and dynamic light scattering (DLS). Furthermore, doxorubicin (DOX) as model drug molecule was loaded into the polymer brushes (as the nanocarrier), and the controlled release processes of DOX under the external stimulations were studied to some extent.
研究领域:
材料科学与工程
·
药剂学
·
纳米医学
✓ 已验证
DOI
高影响因子
Materials
·
2020
·Vol. 13
·期 18
·3950
·
IF 3.057
Minmin Chen,Jinxia Hu,Cancan Bian,Chenghao Zhu,Chen Chen,Zhijun Guo,Zhimin Zhang,Godfred Amfo Agyekum,Zhuoqi Zhang,Xichuan Cao
As a drug delivery system (DDS), traditional mesoporous silica nanoparticles (MSNs) suffer from bioaccumulation in vivo and premature drug release in systemic circulation due to low degradation rate and lack of protective gatekeeper. Herein, we developed a safe and intelligent DDS with characteristics of pH-responsive biodegradation and controlled drug release based on mesoporous silica composite nanoparticles (MSCNs) capped with ZnO quantum dots (ZnO QDs). Acidic degradable MSCNs were successfully synthesized by doping Ca2+and PO43−into the MSNs’ framework. The in vitro doxorubicin hydrochloride (DOX) release was inhibited at neutral pH 7.4 but triggered significantly at pH 5.0 due to the dissociation of ZnO caps. The internalization behavior and cytotoxicity of 4T1 cells indicated MSCNs-ZnO could efficiently deliver DOX into the cells with significant antitumor activity. Such a DDS with pH-responsive biodegradation and controlled drug release has promising potential for cancer therapy.Keywords:mesoporous silica composite nanoparticles (MSCNs);ZnO QDs;pH-responsive biodegradability;pH-responsive drug delivery
研究领域:
纳米技术
·
药物递送
·
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2021
·
IF 5.89
Yu Juan,Xu Chaoqun,Lu Chuanwei,Liu Qian,Wang Jifu,Chu Fuxiang
Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Conghua Yi,Qinghe Xu,Dongjie Yang,Miao Wang
In this work, we developed a novel technique to prepare pH-responsive charge reversal nanospheres based on softwood kraft lignin (SKL) through two steps modification and high efficient self-assembly. SKL was first grafted with imidazole groups by Mannich reaction and further fabricated into acetylated histidine-modified lignin (Ace-SKL-HIS) via acetylation reaction. Ace-SKL-HIS nanospheres (Ace-SKL-HIS NPs) were prepared by fast vacuum evaporation method, their effective diameters (ED) were around 100 nm, exhibited low Polydispersity Index(PDI, <0.2) and good shape. Ace-SKL-HIS NPs demostrated excellent pH response performance with charge reversal under acidic environment. Then, curcumin was applied as a model drug to prepare drug-loaded nanospheres ( [email protected] ). The drug loading degree (DL%) and encapsulation efficiency (EE%) were 22.34 % and 70.76 %, respectively. The in vitro release behavior of curcumin exhibited excellent pH dependent release property, 76.82 % release at pH 5.7 while only 12.92 % at pH 7.4 in 120 h. Furthermore, in vitro cytotoxicity studies showed that [email protected] had potent anti-tumor effect, with IC 50 of 28.16 μg/ mL. This study constructed a promising nanocarrier platform for cancer drug delivery, which paved a new way to the high value-added application of lignin.
研究领域:
纳米技术
·
药学
·
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2014
·Vol. 21
·期 5
·3597-3611
·
IF 3.033
Wang Xue-San,An Quan-Fu,Zhao Feng-Yang,Zhao Qiang,Lee Kueir-Rarn,Qian Jin-Wen,Gao Cong-Jie
Novel polyelectrolyte complexes based on sulfated carboxymethyl cellulose and chitosan were prepared, containing strongly charged (sulfate (OSO 3 )) and weakly charged (carboxylate (COO − )) groups (SPECs). SPEC homogeneous membranes (SPECMs) for the pervaporation dehydration of ethanol–water mixtures were investigated. The chemical structures and compositions of SPECMs were characterized by Fourier transform infrared spectroscopy and X-ray photoelectron spectra. The swelling behavior and separation performance of SPECMs in low pH feed were evaluated. It was found that the SPECMs containing OSO 3 groups were resistant to acidic feeds and showed very good separation performance even in low pH feed. For instance, the water content in permeate for SPECM-0.35 reached as high as 95.8 wt%, which was much higher than the 60 wt% for SPECM-0 in the dehydration of water–ethanol mixtures with pH 2. The result was attributed to the interplay between the stable complexation formed by OSO 3 groups and the improved ionization degree of COO − groups in SPECMs. Moreover, the SPECMs maintained their operation stability against acidic feeds. The SPECMs could find considerable potential application in the pervaporation dehydration of acidic feeds, especially for enhancing the conversion of ester condensation.
研究领域:
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 17
·7210-7217
·
IF 3.288
Yueyue Chen,Chan Wang,Yalan Xu,Guoxia Ran,Qijun Song
Real-time monitoring of intracellular pH is urgently required for studying cell metabolism and apoptosis. Carbon dot-based fluorescence probes are the most likely candidates to fulfil such an application, as they possess excellent chemical inertness, low cytotoxicity, high resistance to photobleaching, good biocompatibility, and tuneable emission wavelength. Our research program aims to develop tailor-designed red emissive carbon dots (r-CDs) using technology innovations in synthetic strategies. The r-CDs showing responses to pH were prepared through direct calcination of 1,2,4-triaminobenzene as the only carbon source. Measurements of fluorescent emission wavelength and quantum yield were carried out to optimize the carbonized temperature and heating time. The obtained r-CDs can sensitively respond to pH both in colorimetric and fluorometric modes, namely, with the increase of pH from 4.0 to 8.0, the color of the r-CD solution under ambient light changed from red to orange and then to yellow, and the corresponding fluorescence varied from purple to orange then to yellow under UV irradiation, which can be easily observed by the naked eye. Experimental characterization along with density functional theory (DFT) simulation study reveal that the pH response originates from the reversible transformation between azo and quinone structures during the protonation process. This solid-state preparation is not only simple in procedures and ready to scale up production, more significantly the resulting r-CDs exhibit a number of distinct advantages, and have great potential for biological sensing applications.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yuan Jiao,Bingyan Wang,Yifang Gao,Xiaona Liu,Shaomin Shuang,Chuan Dong,Wenjun Li,Tianwei Qian
A new type of red photoluminescent carbon dots (R-CDs) with high quantum yield of 46.9% was favorably developed by introducing the luminophore of resazurin into the framework. The obtained R-CDs exhibit excitation-independent behavior, advantageous dispersion and outstanding optical performance. It is worth noting that the proposed R-CDs demonstrate a particular response to S 2 O 5 2- over other competitive species accompanied by a naked-eye color change from red to orange. Fluorescence quenching of R-CDs is determined to be S 2 O 5 2- concentrations dependence with ultra-fast response time and low detection limit. The as-developed R-CDs is further employed in building a smartphone imaging colorimetry platform for portable recognition of S 2 O 5 2- in real samples with considerable accuracy. Furthermore, the specially prepared R-CDs also display a significant fluorescence enhancement behavior with the increase of pH in the linear range of 5.4–6.2 with a pKa of 5.86. These findings may offer a distinctive strategy for the development of long-wavelength emission carbon dots and help to expand their application in food safety inspection.
研究领域:
分析化学
·
食品安全
·
材料科学
✓ 已验证
DOI
高影响因子
MACROMOLECULES
·
2010
·
IF 4.539
Zhizhang Guo,Xingyu Chen,Jianyu Xin,Duo Wu,Jianshu Li,Chenlong Xu
The influence of molecular weight and arm number of star polymers on the buildup and pH-dependent morphology changes of multilayer films assembled from star poly[2-(dimethylamino)ethyl methacrylate] (PDMAEMA) and linear poly(styrenesulfonate) (PSS) was systematically investigated. Well-defined star PDMAEMA, consisting of β-cyclodextrin (CD) core and different arm number (21, 14, and 7) were successfully synthesized via atom transfer radical polymerization (ATRP). It is found that star polymers with certain arm number deposit more mass with the increase of molecular weight. As for the star polymers with almost the same arm length but different arm number, film assembled from 14-arm star PDMAEMA exhibits the fastest growth and the most significant morphology changes upon the pH 2.75 treatment. It is assumed that the interdiffusion of PSS controlled by star PDMAEMA with different structures should be responsible for the different buildup and pH-dependent morphology changes of the multilayer films.
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
OPTICAL FIBER TECHNOLOGY
·
2013
·Vol. 20
·期 1
·28-31
·
IF 1.187
Jiao-Yang Li,Xu-Guang Huang,Wei Xu,Dong-Rui Xiao,Ze-Bing Zhong
A biocompatible fiber-optic pH sensor based on Fresnel reflection technique and a sensing coating is presented. Sodium alginate and polyethylenimine are alternatively deposited on the sensing fiber end to form the sensing coating via a layer-by-layer electrostatic self-assembly technique. An optical switch is added to the measurement system for the convenience of fast calibration. A linear, monotonic and fast response in a large pH range (from pH 5.87 to pH 10.55) is obtained with the resolution of 0.01 pH unit. The sensitivity of the pH sensor is 0.018 R.I.U/pH. It is not influenced by fluctuations of light source.
研究领域:
生物医学工程
·
传感技术
·
分子生物学
·
转化医学
·
生物材料
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Ting Wang,GuangPing Sun,MingDong Wang,BaoJing Zhou,JiaJun Fu
The major challenges of current drug delivery systems for combination chemotherapy focus on how to efficiently transport drugs to target sites and release multiple drugs in a programmed manner. Herein, we report a novel multidrug delivery system, MSNPs 1, based on mechanized silica nanoparticles, which were constructed through functionalization of mesoporous silica nanoparticles with the acid-cleavable intermediate linkages and the monoferrocene functionalized β-cyclodextrin (Fc-β-CD) as supramolecular nanovalves. MSNPs 1 achieved zero premature release in the physiological pH solution and realized two different release modalities. In modality 1, MSNPs 1 released the encapsulated drugs gemcitabine (GEM) and doxorubicin (DOX) in sequence when they were successively applied to voltage and acid stimuli. The release time and dosage of GEM were precisely controlled via external voltage. The subsequent acid-triggered release of DOX was attributed to breakage of the intermediate linkages containing ketal groups. Modality 2 is the concurrent release of these two drugs directly upon acid exposure. Furthermore, the cell viability experiments demonstrated that MSNPs 1 had an improved cytotoxicity to MCF7 cells in comparison with single DOX- or GEM-loaded mechanized silica nanoparticles. We envisage that MSNPs 1 will play an important role in research and development for a new generation of controlled-release drug delivery system.
研究领域:
药学
·
纳米技术
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Small
·
2022
·Vol. 18
·期 47
·2204557
·
IF 15.153
Jian Zhang,Jiandong Li,Huajie Huang,Wei Chen,Yan Cui,Yonghua Li,Weiwei Mao,Xinbao Zhu,Xing'ao Li
Defect engineering of transition metal dichalcogenides (TMDCs) is important for improving electrocatalytic hydrogen evolution reaction (HER) performance. Herein, a facile and scalable atomic-level di-defect strategy over thermodynamically stable VSe 2 nanoflakes, yielding attractive improvements in the electrocatalytic HER performance over a wide electrolyte pH range is reported. The di-defect configuration with controllable spatial relation between single-atom (SA) V defects and single Se vacancy defects effectively triggers the electrocatalytic HER activity of the inert VSe 2 basal plane. When employed as a cathode, this di-defects decorated VSe 2 electrocatalyst requires overpotentials of 67.2, 72.3, and 122.3 mV to reach a HER current density of 10 mA cm −2 under acidic, alkaline, and neutral conditions, respectively, which are superior to most previously reported non-noble metal HER electrocatalysts. Theoretical calculations reveal that the reactive microenvironment consists of two adjacent SA Mo atoms with two surrounding symmetric Se vacancies, yielding optimal water dissociation and hydrogen desorption kinetics. This study provides a scalable strategy for improving the electrocatalytic activity of other TMDCs with inert atoms in the basal plane.
研究领域:
材料科学
·
电催化
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Guohong Yao,Wendie Bi,Hui Liu
pH-responsive magnetic graphene oxide/poly(N-vinylimidazole-co-acrylic acid) hydrogel (MGO/PNA) was synthesized by random copolymerization of N-vinylimidazole (NVI) and acrylic acid (AA) in the presence of ethylenediamine-modified magnetic graphene oxide (MGO). The resulting hydrogel was systematically characterized by mean of Fourier transform infrared spectrometer, X-ray photoelectron spectroscopy, Raman spectrum, Thermogravimetric analysis, and Scanning electron microscope. The swelling percentage of the hydrogel attained the extremely high value at pH = 2 and pH = 12. The resulting MGO/PNA was used as an easily recyclable adsorbent to remove cationic and anionic dyes, and the effects of solution pH, adsorption time, adsorption temperature, and initial concentration on the adsorption process were systematically investigated. The maximum theoretical adsorption capacities of methyl violet (MV), methylene blue (MB), tartrazine (TZ), and amaranth (AR) were 609.8, 625.0, 613.5 and 609.8 mg/g, respectively. The adsorption behaviors of the hydrogel conformed to Langmuir isothermal model and pseudo-second-order model. The mechanism analysis indicated that the addition of Fe 3 O 4 into the hydrogel not only endowed MGO/PNA with easily recyclable characteristic, but also improved the adsorption capacity of the hydrogel to some degree. MGO/PNA hydrogel could maintain good adsorption effect after five adsorption-desorption cycles, so the hydrogel might have the wide application prospect in adsorption science and technology area.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）