Food Bioscience
·
2025
·
IF 5.9
Luhui Wang,Zihao Wei,Changhu Xue
Co-administration of natural anti-inflammatory active ingredients is a prospective strategy for intervening in ulcerative colitis (UC). Resveratrol (Res) possesses synergistic efficacy with vitamin D3 (Vd) in combating UC. However, it is difficult for Vd and Res to sequentially reach the small intestine and colon after oral administration to exert their synergistic anti-colitis effects due to their poor solubility, instability, and sensitivity to the gastrointestinal environment. Herein, Res and Vd were co-encapsulated in solid-in-oil-in-water emulsions (S/O/W-E), where the aqueous phase consisted of carboxymethyl starch/propylene glycol alginate complexes, the oil phase was coconut oil, and the solid phase was carboxymethyl konjac glucomannan-coated gliadin nanoparticles. The encapsulation efficiency of Res and Vd was determined to be 95.1 % and 94.7 %, respectively. The in vitro release results confirmed that the prepared S/O/W-E not only effectively protected Res and Vd from degradation under gastric conditions but also ensured that the encapsulated Vd and Res are released sequentially in the small intestine and colon. Furthermore, co-encapsulating Res and Vd in S/O/W-E could dramatically relieve symptoms in dextran sodium sulfate-induced UC mice and ameliorate UC by regulating inflammatory cytokine expression and oxidative stress levels. The present study demonstrates that S/O/W-E with programmed sequential release is a promising delivery vehicle to alleviate colitis by combining different action modes of different anti-inflammatory active ingredients, providing new insights into the synergistic amelioration of UC.
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NEUROSCIENCE LETTERS
·
2020
·
IF 2.274
Ji-Duo Shen,Yue-Wen Zhang,Bao-Ying Wang,Li Bai,Shuai-Fei Lu,Lei-Lei Zhu,Ming Bai,Yu-Cheng Li,Er-Ping Xu
Growing evidence suggested that energy deficiency might be involved in the pathophysiological mechanism of depression. Energy deficiency, mainly results from mitochondrial damage, can lead to the dysfunction of synaptic neurotransmission, and further cause depressive-like behavior. The antidepressant effect of resveratrol had been widely demonstrated in previous studies; however, the underlying mechanism remains poorly understood. The present study aimed to investigate whether the antidepressant effects of resveratrol involved in the energy levels and neurotransmission in the hippocampus. We found that resveratrol and fluoxetine significantly attenuated depressive-like behaviors induced by chronic unpredictable mild stress (CUMS), which evidenced by the increased sucrose preference and the reduced immobility time in a forced swimming test. In addition, resveratrol increased hippocampal ATP levels, decreased Na + -K + -ATPase and pyruvate levels, and upregulated the levels of mitochondrial DNA (mtDNA), mRNA expression of sirtuin (SIRT)1 and peroxisome proliferator-activated receptor γ coactivator (PGC)1α. Furthermore, resveratrol and fluoxetine increased serotonin (5-HT) levels and downregulated the mRNA expression of 5-HT transporter (SERT) in the hippocampus. The decreased protein expression of growth-associated protein (GAP)-43 induced by CUMS was also ameliorated by resveratrol and fluoxetine. These findings demonstrated the antidepressant effects of resveratrol and suggested that resveratrol was able to promote mitochondrial biogenesis, enhance ATP and 5-HT levels, as well as upregulate GAP-43 expression in the hippocampus.
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DRUG DELIVERY
·
2020
·
IF 4.902
Zerong Li,Wenmei Qiao,Chenghao Wang,Heqiao Wang,Mengchao Ma,Xinyu Han,Jingling Tang
In this study, we investigated the feasibility of dipalmitoylphosphatidylcholine-coated lipid nanoparticles (DPPC-LNs) as a carrier for preferential accumulation into lungs of Resveratrol (Res), a potentially promising drug for the treatment of pulmonary arterial hypertension (PAH). Res-loaded DPPC-LNs were prepared following a thin film hydration-ultrasonic dispersion technique using glyceryl monostearate as lipid core. DPPC can reduce the interactions between nanoparticles and pulmonary surfactant. The optimal formulation was prepared and characterized for physicochemical properties, storage stability and in vitro release profiles. The optimal formulation was evaluated for uptake by pulmonary arterial smooth muscle cells (PASMCs) using fluorescence microscopy. The efficacy of Res-loaded DPPC-LNs in reducing hyperplasia was tested in 5-HT induced proliferated PASMCs. The drug absorption profiles upon intratracheal administration were monitored in healthy rats. Optimized spherical DPPC-LNs – with mean size of 123.7 nm, zeta potential of –19.4 mV and entrapment efficiency of 94.40% – exhibited an 80% cumulative drug release over 48 h. Fluorescence microscopic study revealed an time-dependent enhancement of cellular uptake of Rh123-labeled DPPC-LNs by PASMCs. PASMC proliferation induced by 5-HT was significantly inhibited by Res-loaded DPPC-LNs. Optimized DPPC-LNs appeared to be safe when incubated with PASMCs. Besides, plasma and lung tissue data analysis indicated higher value of accumulation after intratracheal administration of Res-loaded DPPC-LNs in comparison with the intravenously dosed Res solution, indicating longer retention of Res in the lungs and their slower entry to the systemic blood circulation. DPPC-LNs could be a viable delivery system for site-specific treatment of PAH.
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INDUSTRIAL CROPS AND PRODUCTS
·
2018
·
IF 3.849
Wei Liu,Yanyan Lv,Shuai Tian,Mengwei Zhang,Ting Shu,Nan Hu,Zhaoliang Wu
In this work, foam fractionation has been proposed to recover resveratrol from the leaching liquor of Polygonum cuspidatum . Resveratrol is a natural polyphenol without surface activity. For achieving the adsorption of resveratrol on the gas-liquid interface, a biological surfactant of partially ethylated β-cyclodextrin (partially Eβ-CD) was prepared. First, the inclusion behavior between partially Eβ-CD and resveratrol was investigated. Resveratrol molecular could easily enter into the cavity of partially Eβ-CD from its wide rim due to the possible driving forces of charge transfer and dipole-dipole interactions. The experiments of foam properties suggested that partially Eβ-CD could decrease the surface tension of aqueous solution, thus generating stable foam. By using partially Eβ-CD as collector and frother, foam fractionation was performed. Under the suitable conditions of partially Eβ-CD concentration 0.680 g/L, loading liquid volume 250 mL, volumetric air flow rate 40 mL/min, pore diameter of gas distributor 0.45 mm and pH 4.0, the enrichment ratio and the recovery percentage of resveratrol reached 2.79 and 73.84%, respectively. The concentration of resveratrol in the foamate was as high as 0.050 g/L. This work is expected to provide a new strategy to effectively recover a non-surface-active material from its aqueous solution, and to facilitate the industrialization of foam fractionation.
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Food & Function
·
2024
·
IF 5.1
Xiaodong Sun,Shenglan Feng,Bingqing Qin,Junjie Ye,Lixia Xie,Jianjun Gui,Ming Sang
Parkinson's disease (PD) is a neurological disorder characterized by motor and gastrointestinal dysfunctions. Resveratrol is a potent antioxidant and anti-inflammatory phytoalexin known for its health-promoting benefits. However, little is known about its potential in treating PD by modulating the microbial gut-brain axis, and its clinical application has been limited due to poor water solubility, rapid metabolism, and limited systemic bioavailability. Our study aimed to evaluate the therapeutic potential of RHSD, a resveratrol-cyclodextrin inclusion complex, in treating PD through the gut-brain axis in human SNCA-transgenic (A53T) mice PD models. Building on our previous study, we prepared RHSD and compared its efficacy with uncoated resveratrol for PD treatment. The study results demonstrated that RHSD exhibited several advantages in improving motor function, alleviating cognitive impairment, restoring intestinal barrier function, and inhibiting neuropathy. Subsequently, a series of analyses, including fecal microbiota metagenomic sequencing, non-target metabolic assays, host transcriptome sequencing, and integrative analysis were performed to reveal the potential therapeutic pathways of RHSD in A53T mice. The metagenomic sequencing results indicated a significant increase in the levels of Lactobacillus murinus, Lactobacillus reuteri, Enterorhabduscaecimuris, Lactobacillus taiwanensis, and Lactobacillus animals following RHSD administration. Furthermore, metabolomics profiling showed that the levels of gut microbiome metabolites were reversed after RHSD treatment, and differential metabolites were significantly correlated with motor function and intestinal function in PD mice. The integrated analysis of microbial metabolites and host transcriptomics suggested that abnormal amino acid metabolism, mitochondrial dysfunction, oxidative stress, and neuroinflammation in the PD model were associated with the diffusion of abnormal metabolites. This study illustrates the profound impact of RHSD administration on rectifying gut microbiota dysbiosis and improving the A53T mouse model. Notably, we observed significant alterations in the proliferation and metabolism of multiple probiotic strains of Lactobacillus. Furthermore, our research supports the hypothesis that microbiota-related metabolites may regulate the transcription of host genes, including dopamine receptors and calcium stabilization. Consequently, our findings underscore the potential of RHSD as a promising therapeutic candidate for the treatment of PD through the modulation of several signaling pathways within the microbiota–gut–brain axis.
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SAR AND QSAR IN ENVIRONMENTAL RESEARCH
·
2024
·
IF 2.3
C. Hu,Y. Zhai,H. Lin,H. Lu,J. Zheng,C. Wen,X. Li,R.S. Ge,Y. Liu,Q. Zhu
Resveratrol is converted to various metabolites by gut microbiota. Human and rat liver 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) are critical for glucocorticoid activation, while 11β-HSD2 in the kidney does the opposite reaction. It is still uncertain whether resveratrol and its analogues selectively inhibit 11β-HSD1. In this study, the inhibitory strength, mode of action, structure–activity relationship (SAR), and docking analysis of resveratrol analogues on human, rat, and mouse 11β-HSD1 and 11β-HSD2 were performed. The inhibitory strength of these chemicals on human 11β-HSD1 was dihydropinosylvin (6.91 μM) > lunularin (45.44 μM) > pinostilbene (46.82 μM) > resveratrol (171.1 μM) > pinosylvin (193.8 μM) > others. The inhibitory strength of inhibiting rat 11β-HSD1 was pinostilbene (9.67 μM) > lunularin (17.39 μM) > dihydropinosylvin (19.83 μM) > dihydroresveratrol (23.07 μM) > dihydroxystilbene (27.84 μM) > others and dihydropinosylvin (85.09 μM) and pinostilbene (>100 μM) inhibited mouse 11β-HSD1. All chemicals did not inhibit human, rat, and mouse 11β-HSD2. It was found that dihydropinosylvin, lunularin, and pinostilbene were competitive inhibitors of human 11β-HSD1 and that pinostilbene, lunularin, dihydropinosylvin, dihydropinosylvin and dihydroxystilbene were mixed inhibitors of rat 11β-HSD1. Docking analysis showed that they bind to the steroid-binding site of human and rat 11β-HSD1. In conclusion, resveratrol and its analogues can selectively inhibit human and rat 11β-HSD1, and mouse 11β-HSD1 is insensitive to the inhibition of resveratrol analogues.
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高影响因子
NEUROCHEMICAL RESEARCH
·
2024
·Vol. 50
·期 1
·1-12
·
IF 3.7
Chen Hao,Zhao Haosen
Spinal cord injury (SCI) represents a severe trauma to the central nervous system, resulting in significant disability and imposing heavy burdens on families and society. Pathophysiological changes following SCI often trigger secondary injuries that complicate treatment. Bone marrow mesenchymal stem cells (BM-MSCs) have become a focal point of research due to their multifunctionality and self-renewal capabilities; however, their survival and neuroprotective functions are compromised in inflammatory environments. Resveratrol, known for its anti-inflammatory, anti-aging, and anti-oxidative stress properties, has been extensively studied. This research focuses on the anti-inflammatory effects of resveratrol post-SCI and its combined application with BM-MSCs to treat rat spinal cord injuries, exploring both efficacy and mechanisms. In vivo experiments investigated changes in the Sirt-1 signaling pathway post-SCI, while in vitro studies examined the effects of resveratrol on BM-MSCs under inflammatory conditions. The assessment included recovery of motor function, neuronal survival, and apoptosis in SCI rats treated with resveratrol alone or in combination with BM-MSCs. Findings reveal a correlation between Sirt-1 and inflammation signaling pathways post-injury. Resveratrol significantly enhanced the survival and efficacy of BM-MSCs in inflammatory environments by upregulating Sirt-1 and downregulating NF-κB and other inflammatory markers, thereby reducing apoptosis. Combined treatment with resveratrol and BM-MSCs showed superior outcomes in motor function recovery and neuronal survival compared to treatment with BM-MSCs alone. This study offers a novel therapeutic strategy for SCI, enhancing stem cell survival and function through modulation of the Sirt-1/NF-κB pathway, providing a theoretical and experimental foundation for clinical applications.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Dongcheng Li,Xuan Yuan,Xiaoqing Yang,Peiying Shi,Jiajia Wu,Yiqi Zhang,Zhiyuan Dai,Xiuping Dong,Yanbin Lu
Canned skipjack tuna is a nutrient-dense food source. However, the pronounced fishy odor significantly hinders consumer acceptance among Chinese consumers. Phenolic compounds have demonstrated efficacy in odor mitigation for aquatic products. This study systematically evaluates three natural phenolic compounds, specifically resveratrol, epigallocatechin gallate, and rosmarinic acid, elucidates their deodorizing efficacy and potential mechanisms of action in skipjack tuna. Gas chromatography-mass spectrometry analysis revealed that the contents of key aldehydes decreased to varying degrees. Multispectral analysis demonstrated that phenolic compounds spontaneously interacted with both lipoxygenase and myofibrillar protein, inducing conformational changes through hydrophobic interactions, hydrogen bonding, and van der Waals forces. Furthermore, molecular docking and molecular dynamics simulations provided additional insights into the binding modes and dynamic interactions between phenolic compounds and both lipoxygenase as well as myofibrillar protein, confirming the formation of stable complexes. This research aims to offer novel insights into the deodorizing effects of polyphenols on skipjack tuna.
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Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Rui Yang,Yurong Yan,Zheng Wu,Yong Wei,Hao Song,Lian Zhu,Chenchen Zhao,Na Xu,Jijiang Fu,Kaifu Huo
Although titanium and its alloys are widely used in bone surgeries, the implantation failures caused by sterile inflammation still occur. The excessive reactive oxygen species (ROS) in the peri-implant region are considered to cause inflammation and impede the osseointegration of titanium implants. In this study, a coating of resveratrol-loaded titania nanotube (TNT-Res) for eliminating ROS was fabricated on titanium surface through electrochemical anodization and following surface adsorption of resveratrol. The resveratrol concentration of released from TNT-Res coating was controlled by modulating the loading amount. The ROS production in macrophage cell lineage RAW 264.7 and bone mesenchymal stem cells (BMSCs) were significantly decreased when cultured on TNT-Res coatings. The pro-inflammatory factors, including tumor necrosis factor α (TNF-α) and interleukin 1β (IL-1β), and NO produced by RAW 264.7 cells were reduced when cells were cultured on TNT-Res coatings. These results proved that the TNT-Res coating can effectively eliminate ROS and inhibit inflammation. Moreover, the osteogenic indicators, including alkaline phosphatase (ALP) production, extracellular calcium deposition, and osteogenesis-related gene expression, including collagen І (Col-І), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2), were significantly promoted for TNT-Res groups, which demonstrated that the TNT-Res coating can enhance the osteogenic differentiation of BMSCs. Additionally, the phosphorylation of nuclear factor κ-B (NF-κB) were down-regulated both in RAW 264.7 cells and BMSCs, which indicated that the TNT-Res coating could inhibit inflammation and promote osteogenesis by inhibiting the activation of NF-κB signaling pathway. The TNT-Res coating could be an effective implant surface for improving osseointegration ability of titanium implants.
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CARBOHYDRATE RESEARCH
·
2025
·
IF 2.5
Pengya Du,Shuyu Bi,Fangming Cui,Lixia He,Jiangyan Hou,Jinling Cao,Yanfen Cheng,Feier Cheng,Wenfei Zhao,Cuiping Feng,Shaojun Yun
Resveratrol (Res) is a naturally occurring polyphenolic compound exhibiting a wide range of biological activities. However, its application is limited due to the instability, poor water solubility, and low bioavailability. Therefore, this study aimed to prepare Sparassis latifolia polysaccharides (SLPs) nanoparticles loaded with Res (SLPs-Res NPs) through the self-assembly behavior of SLPs. Our findings revealed that SLPs underwent a conformational transition from triple helix to single strand when exposed to varying concentrations of DMSO. By virtue of this self-assembly characteristic, the spherical or subspherical nanoparticles loaded with Res were successfully fabricated. The optimal preparation conditions included an 80% volume ratio of DMSO, a mass ratio of Res to SLPs at 1:32, and magnetic stirring for 2 h. Under these conditions, the average particle size of SLPs-Res NPs was 230.4 ± 7.8 nm, and the encapsulation efficiency of Res reached (66.69 ± 0.10)%. Hydrogen bonding and hydrophobic forces were involved in the formation of nanoparticles. SLP-Res NPs demonstrated enhanced photothermal stability and desirable sustained-release properties. It also exerted significant inhibitory effects on α-glucosidase activity in vitro and glucose-lowering effects in mice during glucose tolerance tests. This study presents an approach for delivering Res using self-assembled SLPs, demonstrating their potential as effective functional carriers for the encapsulation of hydrophobic bioactive molecules.
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Food Chemistry-X
·
2026
·
IF 9.2
Meng Qiu,Tingting Yang,Guanghua Xia,Jiamei Wang,Zhongyuan Liu,E Liao,Wei Xu,Liming Zhang,Wenmin Wu
Zein nanoemulsions encapsulated curcumin and resveratrol for pH-sensitive smart films. • Cold plasma (CP) modification regulated bioactive release in composite films. • CP at 30 kV endowed films with excellent mechanical, barrier and antioxidant properties. • The films showed pH-responsive color change to volatile amines from tilapia spoilage. Food safety risks associated with spoilage and plastic packaging have driven the development of sustainable intelligent packaging systems. In this study, zein-curcumin-resveratrol‑sodium alginate nanoemulsions were incorporated into chitosan films to construct pH-responsive active indicator films. Cold plasma (CP) modification was applied to regulate surface properties and enhance sensing performance. CP modification increased surface roughness and active sites, improving the interaction between films and volatile amines. The 30 kV CP-modified film exhibited optimal comprehensive properties, with improved mechanical strength (tensile strength of 5.36 ± 0.18 MPa and elongation at break of 46.95 ± 3.14%), antioxidant activities (73.81 ± 1.50% for DPPH and 70.26 ± 1.41% for ABTS), pH responsiveness, barrier properties and UV protection. Moreover, colorimetric responses (ΔE and a* values) showed a significant positive correlation with tilapia TVB-N accumulation (R 2 > 0.95), verifying the quantitative relationship between film discoloration and fish freshness deterioration. This study provides a practical intelligent packaging strategy for real-time aquatic product quality monitoring. Download: Download high-res image (158KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Peng Wang,Zhi-gang Luo,Zhi-gang Xiao,Ahmed S.M. Saleh
Oxidized gellan gum (OGG) hydrogel beads as delivery systems for resveratrol were fabricated by ionic cross-linking with calcium chloride (CaCl 2 ). The degree of oxidation (DO) and CaCl 2 concentration had significant influences on the formation and functional properties of hydrogel beads. The resveratrol encapsulation efficiency (66.43%–79.84%) and loading capacity (4.15%–5.05%) of OGG hydrogel beads were enhanced as DO increased. The hydrogel beads exhibited a uniform spherical shape as observed by scanning electron microscope. Fourier transform infrared spectroscopy analysis confirmed that hydrogen bonds and ionic interaction participated in the formation of hydrogel beads. X-ray diffraction analysis revealed that the physical state of resveratrol was changed from crystalline to amorphous form after encapsulation. Furthermore, the physical stability and antioxidant capacity evaluation demonstrated that the hydrogel bead fabricated with DO80 OGG and CaCl 2 concentration of 1.0 M could provide high protection for resveratrol against degradation by environmental stresses and maintain its antioxidant capacity. The DO and CaCl 2 concentrations could modulate the in-vitro release behaviors of hydrogel beads and obtain a good small intestinal-targeted release of resveratrol at high DO and medium CaCl 2 concentration. These findings suggested that a promising delivery system for encapsulating bioactive ingredients can be fabricated by rational design.
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危险品化学品经营许可证（带存储）