MOLECULES
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2021
·Vol. 26
·期 16
·4982
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IF 4.412
Wenjing Zhu,Wenling Fan,Xiaotong Zhang,Meiqi Gao
This study aimed to prepare a sustained-release solid dispersion of poorly water-soluble resveratrol (RES) with high melting point in a single hot melt extrusion step. A hydrophobic–hydrophilic polymeric blend (Eudragit RS and PEG6000) was used to control the release of RES. With the dispersive mixing and high shear forces of hot melt extrusion, the thermodynamic properties and dispersion of RES were changed to improve its solubility. The effects of the formulation were investigated through univariate analysis to optimize the preparation of the sustained-release solid dispersion. In vitro and in vivo studies were performed to evaluate the prepared RES/RS/PEG6000 sustained-release solid dispersion. The physical state of the solid dispersion was characterized using differential scanning calorimetry and X-ray diffraction. Surface properties of the dispersion were visualized using scanning electron microscopy, and the chemical interaction between RES and excipients was detected through Fourier-transform infrared spectroscopy. Results suggested that the optimized sustained-release solid dispersion was obtained when the mass ratio of RES-polymeric blend was 1:5, the ratio of PEG6000 was 35%, the barrel temperature was 170 °C, and the screw speed was 80 rpm. In vitro studies demonstrated that the solid dispersion showed a good sustained release effect. The cumulative release of RES reached 82.42% until 12 h and was fit by the Weibull model. In addition, the saturated solubility was 2.28 times higher than that of the bulk RES. In vitro studies demonstrated that the half-life increased from 3.78 to 7.09 h, and the bioavailability improved to 140.38%. The crystalline RES was transformed into the amorphous one, and RES was highly dispersed in the polymeric blend matrix.Keywords:solid dispersion;resveratrol;hot melt extrusion;dissolution;sustained-release
研究领域:
药剂学
·
生物制药
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JOURNAL OF POWER SOURCES
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2022
·
IF 9.794
Fengwei Bai,Yan Li,Ziyu Chen,Yongchao Zhou,Chengzong Li,Tao Li
High-voltage lithium (Li)-metal batteries with cell-level energy density over 350 Wh kg −1 are promising energy storage systems . However, the aggressive interphase chemistries associated with highly reactive Li-metal anode and high-voltage cathodes impede their practical applications. Herein, we demonstrate the targeted stabilization of solid electrolyte interphase (SEI) and cathode electrolyte interphase (CEI) in high-voltage Li-metal batteries by asymmetrically sustained-releasing different additives. An asymmetric sustained-release film loaded with lithium bis-(oxalate)borate (LiBOB) and LiNO 3 on each side is investigated as a proof-of-concept. The sustained-releasing of LiBOB and LiNO 3 can maintain a localized concentration at the high-voltage cathode and Li-metal anode fronts respectively, thus forming a stable B-containing CEI and N-containing SEI. As such, issues like dendrites growth, parasitic side reactions and transition metals dissolution under high-voltage are addressed simultaneously. Based on this strategy, the 30 μm Li|LiNi 0.5 Co 0.2 Mn 0.3 O 2 (4.1 mAh cm −2 ) batteries deliver a capacity retention of 80% after 173 cycles under a cut-off voltage of 4.5 V.
研究领域:
储能系统
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电池技术
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材料科学
·
电化学
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高影响因子
ACS Applied Bio Materials
·
2025
·
IF 4.7
Zhao Wang,Khawar Ali Shahzad,Ding Li,Boyu Cai,Zilin Huang,Maoxiang Xu,Jiaojiao Li,Dong Chen,Fei Tan
Monascin, a natural and safe drug, exhibits potent anti-inflammatory, hypolipidemic, and antioxidative effects. However, their therapeutic potential and underlying mechanisms in allergic rhinitis (AR) remain unexplored. The intranasal delivery of monascin for treating AR faces the challenge of rapid clearance. Herein, to achieve sustained and prolonged release, we developed monascin-encapsulated poly(lactic co glycolic acid) nanoparticles (PLGA-MS) by the mechanical double emulsion technique, enabling effective local delivery of monascin for the treatment of AR. Histopathological staining, flow cytometry, ELISA, and network pharmacology were used to assess therapeutic effects and potential mechanisms of monascin in treating AR. In vitro and in vivo experiments revealed that PLGA-MS exhibited enhanced stability, excellent drug encapsulation capacity, and sustained drug release. PLGA-MS treatment showed a significant therapeutic effect in AR mice by decreasing inflammatory cells in nasal tissue and regulating IgE, histamine, and a variety of cytokines. PLGA-MS treatment decreased T helper 2 cells (Th2) and T helper 17 cells (Th17) while promoting and increasing Tregs (regulatory T cells). Further analysis showed elevated levels of IL-10 and TGF-β expression in Tregs post-treatment. Results of the CCK-8 assay, pathological analysis of vital organs, and serum analysis of liver and kidney functions demonstrated the biosafety of PLGA-MS. Additionally, network pharmacology identified immune response pathways that may support PLGA-MS’s immunomodulatory effects in AR. Our study presented a biomaterial-facilitated intranasal delivery system for monascin, offering an effective therapeutic strategy for AR.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2019
·
IF 3.973
Mingshu Cui,Luyao Xie,Shiwen Zhang,Lu Chen,Yanru Xi,Yumei Wang,Yingyu Guo,Lu Xu
The present work reported two synthesized chiral mesoporous silicas (CMSs) with opposite chirality for loading, release, and antibacterial activities of levofloxacin (LOFL). Herein, helical CMS nanorods were prepared by the sol-gel method using CTAB as a template and either n -heptanol or n -nonanol as a co-structure-directing agent (CSDA). The synthesized CMSs were characterised by transmission electron microscopy (TEM), small-angle X-ray scattering (SAXS), induced circular dichroism (ICD), and nitrogen adsorption/desorption. X-ray diffraction (XRD) was applied to confirm amorphous state transformation after drug loading, and thermal gravimetric analysis (TGA) was used to quantify the LOFL loading capacity. In vitro drug release studies from the loaded CMSs showed significant differences in the release behaviour for LOFL. Moreover, LOFL-loaded CMSs significantly sustained LOFL release with Fickian diffusion mechanism. Both the drug-loaded CMSs inhibited bacterial growth successfully when tested with strains of Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Therefore, the prepared CMSs could find application as suitable vehicles for drug delivery systems to exert the therapeutic effects of LOFL and achieve different release behaviours.
研究领域:
材料科学
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药物递送
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微生物学
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高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Huanqi Wu,Yiqin Zhang,Yangyang Zhou,Xiangmeng Xiao,Yupei Gu,Wen Qin
CUR Pickering emulsion exhibited uniformity and stability. • CUR Pickering emulsion enhanced CS-based coating bioactivity and sustained release. • PE/CS coating maintained postharvest quality for plum fruits. Curcumin is a promising natural preservative, but its poor solubility and susceptibility to photo-oxidation limit its application in active coatings. This study developed a cellulose nanofiber-stabilized curcumin Pickering emulsion incorporated into chitosan for postharvest plum preservation. The Pickering emulsion prepared at a water-to-oil ratio of 40:10 ( w / w ) exhibited uniform droplet distribution and good electrostatic stability. Its incorporation enhanced the mechanical performance and water resistance of PE/CS coating films, while FTIR and XRD analyses indicated hydrogen-bonding interactions within the composite matrix. Notably, PE/CS coating films showed sustained curcumin release in 50% ethanol, reaching 65% after 96 h. This controlled-release behavior was associated with enhanced antimicrobial and antioxidant activities, as reflected by inhibition zones above 10 mm and DPPH/ABTS + scavenging rates exceeding 98%. PE/CS coating effectively delayed flesh browning, water loss, and firmness decline in plums, providing a Pickering emulsion-based strategy for active fruit preservation. Download: Download high-res image (177KB) Download: Download full-size image
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INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Dianfa Zhao,Jie Liu,Lijuan Zhang,Yunshan Zhou,Yuxu Zhong,Yang Yang,Chengcheng Huang,Yong’an Wang
Maintaining a long-term continuous and stable reactivator blood concentration to treat organophosphorus nerve agent poisoning using acetylcholinesterase (AChE) reactivator pralidoxime chloride (2-PAM) is very important yet difficult. Because the flexible framework of MIL-88B(Fe) nanoparticles (NPs) can swell in polar solvents, pralidoxime chloride (2-PAM) was loaded in MIL-88B(Fe) NPs (size: ca. 500 nm) by stirring and incubation in deionized water to obtain 2-PAM@MIL-88B(Fe), which had a maximum drug loading capacity of 12.6 wt %. The as-prepared composite was characterized by IR, powder X-ray diffraction (P-XRD), scanning electron microscopy (SEM), ζ-potential, Brunauer–Emmett–Teller (BET), and thermogravimetry/differential thermal analysis (TG/DTA). The results showed that under constant conditions, the maximum drug release rates of 2-PAM@MIL-88B(Fe) in absolute ethanol, phosphate-buffered saline (PBS) solution (pH = 7.4), and PBS solution (pH = 4) at 150 h were 51.7, 80.6, and 67.1%, respectively. This was because the composite showed different swelling behaviors in different solvents. In PBS solution with pH = 2, the 2-PAM@MIL-88B(Fe) framework collapsed after 53 h and released 100% of 2-PAM. For mice after intragastric poisoning with sarin (a neurotoxic agent), an atropine-assisted 2-PAM@MIL-88B(Fe) treatment experiment revealed that 2-PAM@MIL-88B(Fe) continuously released 2-PAM for more than 72 h so that poisoned AChE was continuously and steadily reactivated. The reactivation rate of AChE was 56.7% after 72 h. This composite is expected to provide a prolonged, stable therapeutic drug for the mid- and late-stage treatment of neurotoxic agent poisoning.
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Bioengineering & Translational Medicine
·
2022
·Vol. 8
·期 2
·e10414
·
IF 10.684
Peng Luo,Jiarui Fang,Dazhi Yang,Lan Yu,Houqing Chen,Changging Jiang,Rui Guo,Tao Zhu,Shuo Tang
Bone injury caused changes to surrounding tissues, leading to a large number of osteoclasts appeared to clear the damaged bone tissue before bone regeneration. However, overactive osteoclasts will inhibit bone formation. In this study, we prepared methacrylylated gelatin (GelMA)-based hydrogel to co-crosslink with OP3-4 peptide, a receptor activator of NF-κB ligand (RANKL) binding agent, to achieve the slow release of OP3-4 peptide to inhibit the activation of osteoclasts, thus preventing the long-term existence of osteoclasts from affecting bone regeneration, and promoting osteogenic differentiation. Moreover, CXCL9 secreted by osteoblasts will bind to endogenous VEGF and inhibit vascularization, finally hinder bone formation. Thus, anti-CXCL9 antibodies (A-CXCL9) were also loaded in the hydrogel to neutralize excess CXCL9. The hydrogel slow released of OP3-4 cyclic peptide and A-CXCL9 to simultaneously inhibiting osteoclast activation and promoting vascularization, thereby accelerating the healing of femur defect. Further analysis of osteogenic protein expression and signal pathways showed that the hydrogel may be through activating the AKT-RUNX2-ALP pathway and ultimately promote osteogenic differentiation. This dual-acting hydrogel can effectively prevent nonunion caused by low vascularization and provide long-term support for the treatment of bone injury.
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ACS Nano
·
2023
·
IF 17.1
Hongfu Cao,Manyu Chen,Xiaolin Cui,Yuan Liu,Yuhan Liu,Siyan Deng,Tun Yuan,Yujiang Fan,Qiguang Wang,Xingdong Zhang
As chondrocytes from osteoarthritic cartilage usually exhibit aging and senescent characteristics, targeting aging chondrocytes could be a potential therapeutic strategy. In this study, exosomes derived from umbilical cord-derived mesenchymal stem cells (UCMSC-EXOs) combined with the chondrocyte-targeting capacity and controlled-release system were proposed for osteoarthritis (OA) treatment via rejuvenating aging chondrocytes. The essential functional miRNAs within UCMSC-EXOs were investigated, with the p53 signaling pathway identified as the key factor. To improve the therapeutic efficiency and retention time of UCMSC-EXOs in vivo, the exosomes (EXOs) were engineered on membranes with a designed chondrocyte-targeting polymers, and encapsulated within thiolated hyaluronic acid microgels to form a “two-phase” releasing system, which synergistically facilitated the repair of OA cartilage in a rat model. Together, this study highlighted the rejuvenating effects of UCMSC-EXOs on OA chondrocytes and the potential to combine with chondrocyte-targeting and sustained-release strategies toward a future cell-free OA treatment.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Ziqin Cao,Yangnan Chen,Shaoyun Bai,Zhiyun Zheng,Yan Liu,Shuangying Gui,Shuang Shan,Jiabao Wu,Ning He
The treatment of dry eye mainly includes instillation of cyclosporine A (CsA) nanoemulsion or the use of punctal plugs. Therefore, in this study, a novel injectable in situ organogel plug was developed using CsA as a model drug, stearic acid , injectable soybean oil, and N -methyl-2-pyrrolidinone (NMP) (1.25:10:0.6, w/v/v) as gel materials, to provide a dual mechanism for dry eye treatment. The formulated CsA injectable in situ organogel (CsA-OG) was evaluated in terms of stability, in vitro release, rheology, ocular irritation, punctal occlusion tests, and ocular distribution assessment. In vivo ocular distribution investigations showed that CsA-OG achieved considerably higher C max (1.94, 1.92 and 1.97-fold respectively) and AUC 0-72h in the cornea, conjunctiva, and sclera (2.49, 2.27 and 2.15-fold respectively) than ciclosporin eye drops ( p < 0.05). In vitro model evaluation demonstrated significant decrease in flow flux to 52.78 % at 2 min after CsA-OG injection. According to evaluation of the in vivo model, the organogel plug can completely block the lacrimal passages and greatly decrease the lacrimal drainage rate ( p < 0.05). The above results suggest that these intracanalicular CsA-OG plugs can offer more extensive clinical applications than existing lacrimal drainage plugs and may act as a drug delivery system .
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ACS Agricultural Science & Technology
·
2025
·
IF 2.9
Jihao Zuo,Yitong Lin,Jinting Cai,Ruopeng Lan,Dongyan Yang,Li Hao,Jingli Cheng,Hongjun Zhou,Xinhua Zhou
Mitigating inefficiencies and environmental pollution caused by weak foliar adhesion and rapid release during pesticide application is a significant challenge in agricultural development. This study addresses this issue by preparing asymmetric wetting Janus mesoporous silica nanocarriers (AWJ-MSN) through the adjustment of hydrophilic and hydrophobic monomer ratios via interfacial modification. Subsequently, asymmetric wetting Janus nanopesticide delivery systems (Thi@AWJ-MSN) were constructed by encapsulating the model pesticide molecule, thiafuramide (Thi). The coexistence of hydrophilic and hydrophobic segments on the AWJ-MSN imparts interfacial activity, enhancing spreadability on plant leaves with different wettability (Brassica chinensis L., Cucumis sativus L., and Arachis hypogaea L.). The droplet impact behavior of the AWJ-MSN on plant leaves and artificial PTFE membrane surfaces was analyzed through normalization, revealing a reduced normalized spreading height (Ht/D0) and an increased normalized spreading diameter (Dt/D0). These findings indicate the enhanced foliar deposition ability of the AWJ-MSN under real-world foliar spraying conditions. Furthermore, the encapsulation of Thi within the nanocarriers protects the active pesticide ingredients, enabling sustained release through quasi-Fickian diffusion and ultimately prolonging the pesticide’s efficacy. This study provides theoretical guidance for the aqueous formulation and reduction of pesticide use, contributing to reduced environmental risks and offering potential applications in agriculture.
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FOOD RESEARCH INTERNATIONAL
·
2015
·
IF 2.818
Yun Shao,Chuan-He Tang
In recent years, there is increasing interest in the development of food-grade Pickering emulsions as promising delivery systems for bioactive compounds . Our previous work reported that most of the proteins in pea protein isolate (PPI) at pH 3.0, present in the nanoparticle form, can effectively perform as a kind of food-grade Pickering stabilizers for oil-in-water emulsions (LWT, 2014). The purpose of this study was to further report that PPI-stabilized emulsions at pH 3.0 exhibited great potential to act as intestine-targeted and sustained-release delivery systems for β -carotene. The emulsions were produced by microfluidization at a specific protein concentration of 6.0% (w/v) and varying oil fractions ( ϕ ) of 0.2–0.6. The results indicated that increasing ϕ was favorable for the gel-like network strengthening of these emulsions. The gel formation was largely related to the droplet flocculation as well as inter-floc attractive interactions. The in vitro simulated digestion results showed that the release of β -carotene during the intestinal digestion of these emulsions could be well modulated by altering ϕ . The gel-like emulsion at ϕ = 0.6 exhibited much lower release of β -carotene, but higher stability towards degradation during the digestion, than that at ϕ = 0.3. The findings provide important information not only for the design of novel delivery systems for lipophilic bioactive components, but also for the development of plant protein-based formulations.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2024
·
IF 5.7
Xingnan Wang,Yang Yang,Yanting Chen,Ting Liu,Jingyi Ren,Hongcai Li,Wenzhi Lei,Shiqi Li,Zhenpeng Gao
A pea protein isolate (PPI)-hyaluronic acid (HA) nanocarrier delivery system was created for quercetin (Que) encapsulation using the pH conversion strategy. The self-assembly of the PPI-HA binary nanocomplex (HPP) were mainly driven by electrostatic and hydrophobic interactions. Que was successfully encapsulated in HPP nanocomposites (Que@HPP), which exhibited preferable redispersibility, and encapsulation efficiency (87.51%), loading capacity (14.50%). Que@HPP provided superior resistance to external environmental stresses (pH, ionic strength, high temperature, light exposure, and long-term storage), while maintaining its primary antioxidant activity after 15 days. Compared to free Que, the encapsulated Que shifted from a crystalline to an amorphous form, diffusing more easily through nanoparticle pores. Moreover, the encapsulated Que (Que@HPP) were stable in simulated gastric fluid (SGF, pH = 1.2) and released slowly in simulated intestinal fluid (SIF, pH = 6.8) compared to naked Que, demonstrating its potential to respond to specific external pH environments. Thus, the fabrication of HPP nanovehicles for Que encapsulation is a viable solution to improve its stability and release behaviors.
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