Small
·
2025
·
IF 12.1
Mianyi Xiang,Yamin Liu,Ziyang Yang,Jinlei Jiang,Weicheng Wang,Yao Hu,Daxiang Cui,Qichao Li
Electronic noses (e-noses) have become indispensable analytical platforms for gas detection. However, conventional e-nose systems face significant limitations in portable and wearable implementations due to their bulk and high-power consumption. Herein, a single-sensor-based multifunctional e-nose system is reported by integrating a micro-electromechanical system (MEMS) gas sensor with a flexible printed circuit board (FPCB). Specifically, the ZnO-ZnSnO 3 raspberry-like microspheres (ZZSRM) are utilized as the gas-sensitive materials, and the gas selectivity of the sensor is enhanced through a dual-temperature modulation strategy. Additionally, a gas classification model based on the MiniRocket algorithm has been developed, enabling efficient feature extraction and low-complexity classification of response signals, thereby satisfying the real-time processing demands of embedded devices. Moreover, a silent communication method is proposed, which maps breathing frequency to Morse code for information transmission in specific scenarios. Experimental results demonstrate that the wearable system achieves high-precision classification and concentration prediction for eight volatile organic compounds (VOCs), while simultaneously enabling robust recognition of exhaled signals and instantaneous conversion of Morse code into legible alphabetic characters. By combining the gas sensor with artificial intelligence (AI) technology, this work establishes a multifunctional flexible e-nose that merges portable gas detection and silent communication, offering a novel technological framework for environmental monitoring and human-machine interaction.
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FOOD CHEMISTRY
·
2026
·
IF 9.8
Xixi Wu,Yiting Gao,Lijia Li,Mengjie Geng,Fei Teng
This study aimed to enhance the stability and functional properties of W/O/W emulsions through a biphasic gelation strategy. An emulsified gel system was constructed with soybean lipophilic protein-chitosan hydrochloride complex (SLP-CHC) as the emulsifier, beeswax as the oil-phase gelling agent, and curdlan/anhydrous calcium chloride as the aqueous-phase gelling agent. The microstructure and physicochemical properties were characterized, and in vitro digestion experiments were conducted to evaluate the protective and delivery capacities for vitamin B 12 (VB 12 ) and vitamin E (VE). The biphasic gel exhibited a dense network, high viscoelasticity (G' > G”), and superior water/oil-holding capacity. Encapsulation efficiencies reached 95.92% for VB 12 and 69.51% for VE, with enhanced stability under heat and pH stress compared to single-phase gels. In vitro digestion confirmed effective gastric protection and intestinal release, leading to high bioaccessibility for both vitamins. This study provides a novel approach for the co-delivery of polar and non-polar bioactive compounds.
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FUEL
·
2023
·
IF 7.4
Muhammad Yousaf,Yuzheng Lu,Majid Niaz Akhtar,Ali Sarosh Khawaja,Khalid Mujasam Batoo,Sajjad Hussain,Asma Noor,Muhammad Akbar,Hu Enyi,M.A.K Yousaf Shah,Naveed Mushtaq,Bin Zhu
Lattice defects in rare earth (RE) doped single-phase semiconductor materials play a key role in structural modifications and physicochemical characteristics, resulting to enhance the ionic conductivity. In this work, we synthesized lanthanum doped samarium oxide with different mole ratios and applied it as a ceramics membrane fuel cell device to enable high peak power density (PPD) at low operational temperatures (520–400 °C). The samples are capable of triple charge H + /O 2− /e − conduction and enhance the catalytic function of the cell in terms of HOR and ORR kinetics by producing lattice defects. The fabricated Sm 1.5 La 1.5 Fe 5 O 12 (2-SLFO) fuel cell device exhibits a high OCV of 1.13 V with a maximum PPD of 864.26 mW/cm 2 at 520 °C. Durability measurement verifies that 2-SLFO-based fuel cell device can be worked for 60 h under fuel cell conditions (H 2 /air) at 520 °C. The first principle calculations using density functional theory (DFT) demonstrate that the higher oxygen vacancy concentration in the 2-SLFO sample may cause to the higher charge-transfer kinetics, subsequent in the enhancement of ions transportation of the fabricated fuel cell device.
研究领域:
材料科学
·
电化学
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能源材料
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固态离子学
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燃料电池技术
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Acta Crystallographica Section C-Structural Chemistry
·
2018
·Vol. 74
·期 9
·1058-1067
·
IF 8.678
Tan X.-J.,Wang D.,Lei X.-G.,Chen J.-P.
A global glide disorder has been discovered during an X-ray investigation of the crystal structure of (Z)-2-[(E)-(4-methoxybenzylidene)hydrazinylidene]-1,2-diphenylethanone (MHDE, C22H18N2O2) at room temperature. In another crystal, however, such disorder disappears (still at room temperature). Even though the disorder may be partly due to the poor quality of the harvested crystal, the structure can shed light on the nature of disorder. With the help of quantum chemical calculations, it is found that the global disorder seems to be connected with the need for stabilization of the somewhat rigid but mobile and unstable molecular structure. The most relevant feature driving the packing of the disordered structure concerns the slight perturbations (such as glide) of two or more disorder components (fractional occupancies) distributed throughout the crystal.
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JOURNAL OF MOLECULAR STRUCTURE
·
2026
·
IF 4.9
Mingqiao Liu,Xinyue Wang,Haiyang Zhang,Chunhua Yin
Novel VES/substituted β-CD inclusion complexes were successfully prepared. • Substituent effects and stoichiometric transitions co-govern binding modes. • The dimethyl-β-cyclodextrin proves most effective for carrying the VES. • DM-β-CD tail-to-tail dimers form dynamic hydrogen bonds in 1:2 complexes. • Encapsulation highly enhances VES water solubility and antioxidant activity. This study aimed to enhance the aqueous solubility and stability of vitamin E succinate (VES) through cyclodextrin encapsulation. Inclusion complexes of VES with β-cyclodextrin (β-CD), hydroxypropyl-β-cyclodextrin (HP-β-CD), and dimethyl-β-cyclodextrin (DM-β-CD) were prepared via freeze-drying. Structural analyses confirmed successful encapsulation. Phase solubility studies revealed 1:1 complexes for β-CD and HP-β-CD, while a more stable 1:2 complex formed with DM-β-CD. The VES/DM-β-CD complex showed a 108-fold solubility increase and significantly improved antioxidant activity, with DPPH and ABTS radical scavenging activities increased by 61.6% and 59.6%, respectively. Molecular simulations of various dimer orientation indicated that DM-β-CD dimers achieved the most complete encapsulation and highest binding affinity, particularly in the tail-to-tail (TT) conformation, which is driven by enhanced van der Waals interactions and dynamic hydrogen bonds. DM-β-CD is concluded to be the most effective carrier for optimizing VES delivery and functional performance. Download: Download high-res image (363KB) Download: Download full-size image
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JACS Au
·
2026
·
IF 8.5
Yu Qin,Huiling Liu,Yan Zhang,Fei Li,Zhiwei Deng,Zhengshan Luo,Yuhao Zhuang,Kai Fu,Zhenbo Yuan,Yijian Rao
Sustainable and scalable production of plant natural products remains a major challenge at the interface of synthetic biology, metabolic engineering, and drug discovery, often constrained by plant-membrane-bound cytochrome P450s. To overcome the bottleneck in P450-catalyzed methylenedioxy-bridge (MDB) formation, we designed a concise, modular Escherichia coli pathway to the alkaloid berberine that bypasses multiple native steps and enables high-level accumulation of the P450-dependent intermediate. We then implemented integrated engineering of CjCYP719A1, including expression optimization, structure-guided design, consensus mutagenesis, and machine learning, to obtain a variant with 8.9-fold higher activity and improved thermostability. This enabled a berberine titer of 353 mg/L in scaled-up preparations, the highest reported to date, demonstrating industrial potential. Furthermore, mechanistic studies reveal their improved catalytic activity and thermostability. Together, this work provides a practical framework for functional expression and systematic optimization of plant-derived P450s to enable efficient production of plant natural products in E. coli.
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CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yuanyuan Chen,Chang Zhang,David Julian McClements,Yanyan Zhou,Xuguang Yin,Runpu Shen,Xin Tang,Kewu Zhu,Xiang Luo
This study developed novel maltodextrin-vitamin E succinate (DE19-VES) conjugates were synthesized at different mass ratios of VES to maltodextrin (5 % and 10 %) as multifunctional emulsifiers for resveratrol encapsulation. Compared to nanoemulsions stabilized by octenyl succinic anhydride-modified starch (OSA S), those stabilized by DE19-VES conjugates exhibited significantly smaller droplet sizes, higher encapsulation efficiencies, and superior physical stability. Crucially, the DE19-VES conjugates imparted exceptional antioxidant properties to the nanoemulsions, enhancing radical scavenging activity, oxidative stability, and markedly improved protection of encapsulated resveratrol against degradation. In vitro digestion demonstrated significantly enhanced resveratrol bioavailability from DE19-VES-stabilized nanoemulsions versus OSA S. Cytotoxicity evaluation using human gastric mucosal epithelial cells (GES-1) confirmed that all formulations were non-toxic. These results highlight the dual functionality (emulsification and potent antioxidant activity) of the engineered maltodextrin conjugates, establishing their strong potential as advanced carbohydrate-based emulsifiers for protecting and delivering sensitive bioactives in pharmaceuticals, functional foods, and supplements.
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Foods
·
2026
·Vol. 15
·期 9
·1475
·
IF 6
Ying Liang,Yaqian Yuan,Jia Wang,Wenxue Chen,Weijun Chen,Qiuping Zhong,Jianfei Pei,Chun Chen,Xiong Fu,Rongrong He,Haiming Chen
The primary processing shapes the taste characteristics of coffee beans, while the regulation pathways remain unclear. Coffee beans processed by five methods—dry processing (DP), wet processing (WP), red honey (RH), black honey (BH) and anaerobic fermentation (AF)—were evaluated using electronic tongue analysis, sensory evaluation, and untargeted metabolomics. Sensory evaluation scores for mouthfeel, balance, and overall were higher in BH and AF. Conversely, the WP and DP exhibited heightened bitterness and astringency responses on the electronic tongue sensors, particularly for the former. The multigroup metabolomic comparison identified 808 DMs, and WGCNA revealed eight sensory-related modules containing 467 hub metabolites, mainly amino acids and derivatives, organic acids, alkaloids, and phenolic acids. KEGG analysis demonstrated that pathways such as caffeine metabolism and glycerophospholipid metabolism were the main pathways responsible for the metabolic differences. Further correlation analysis revealed potential flavor components closely associated with key taste characteristics. 1,3,4,5-tetrahydroxycyclohexanecarboxylic acid and Tyr demonstrated positive associations with bitterness, while TPC, TFC, Gly, and Met exhibited negative correlations with bitterness and astringency. Glu demonstrated a positive correlation with umami. These findings elucidate the material basis by which the primary processing modulates non-volatile compounds and taste perception, offering new insights into enhancing coffee quality.
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CHEMISTRY & BIOLOGY
·
2015
·Vol. 22
·期 11
·1461-1469
·
IF 6.645
Shan Feng,Yuling Chen,Fan Yang,Lei Zhang,Yiyi Gong,Gulishana Adilijiang,Yan Gao,Haiteng Deng
Protein glutathionylation is an important post-translational modification that regulates many cellular processes, including energy metabolism, signal transduction, and protein homeostasis. Global profiling of glutathionylated proteins (denoted as glutathionylome) is crucial for understanding redox-regulated signal transduction. Here, we developed a novel method based on click reaction and proteomics to enrich and identify the glutathionylated peptides in Escherichia coli and Drosophila lysates, in which 937 and 1,930 potential glutathionylated peptides were identified, respectively. Bioinformatics analysis showed that the cysteine residue next to negatively charged amino acid residues has a higher frequency of glutathionylation. Importantly, we found that most proteins associated with metabolic pathways were glutathionylated and that the glutathionylation sites of metabolic enzymes were highly conserved among different species. Our results indicate that the glutathione analog is a useful tool to characterize protein glutathionylation, and glutathionylation of metabolic enzymes, which play important roles in regulating cellular metabolism, is conserved.
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NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 7
·3616-3627
·
IF 3.3
Song Wang,Yonggang Zhang
Advanced oxidation processes are often applied to a variety of refractory wastewater, but rarely is the electro-Fenton process combined with the activated persulfate process applied to printing and dyeing wastewaters. In this study, we have delicately designed a new advanced oxidation process for the degradation of persistent pollutants in wastewater. The zero-valent iron (ZVI) activated peroxymonosulfate process coupled with an electro-Fenton (EF-PMS) oxidation process is applied to treat methylene blue (MB) wastewater. Its main advantage is to generate more reactive oxygen species (ROS) and reduce the cost of oxidants. Experimentally, it was found that the degradation rate of the MB by the EF-PMS process was significantly higher than that before the coupling, and the mineralization rate can reach 56.84% within 2 h. According to free radical scavenging experiments and electron spin resonance (ESR) spectroscopy, the main ROS in the EF-PMS process were identified as ˙OH, SO4˙− and 1O2, where free radical oxidation played an important role in the removal of MB, accounting for 70.39% of the total removal efficiency. The mechanism of ROS generation and action in the EF-PMS process was investigated, and the pathway of MB degradation was determined by the identification of intermediates. The EF-PMS process was also effective in degrading MB in different water quality backgrounds as well as for process reuse. The removal efficiency of other organic compounds was also evaluated. The results indicate that the EF-PMS process has good potential for application.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2022
·
IF 4.46
Shiyu Zhang,Ying Liu,Ting Liu,Jie Pan,Rong Tan,Zixia Hu,Bowen Gong,Yufen Liao,Peng Luo,Qibing Zeng,Weiwei Li,Jiang Zheng
8-Epidiosbulbin E acetate (EEA), a furan-containing diterpenoid lactone , is one of main component of Dioscorea bulbifera L. (DBL). It has been reported that EEA induces severe hepatotoxicity in mice and that its hepatotoxicity is associated with metabolic activation. The present study demonstrated that exposure to EEA (50, 100 or 200 μM) induced DNA damage, including significant DNA fragmentation, increases of tail DNA and olive tail moment, H2AX phosphorylation and PARP-1 activation, in cultured mouse primary hepatocytes. Similar observation was obtained in mice administered EEA at 50, 100 or 200 mg/kg. Pre-treatment with 10 μM ketoconazole (KTC), 200 μM vitamin C (VC), or 200 μM glutathione ethyl ester (GSH-OEt) reversed the over-production of reactive oxygen species (ROS) induced by EEA and attenuated susceptibility of hepatocytes to EEA-induced cytotoxicity and DNA damage in mouse primary hepatocytes. In contrast, pre-treatment with 1.0 mM L-buthionine sulfoximine (BSO) potentiated over-production of ROS, cytotoxicity and DNA damage induced by EEA. In summary, EEA induced DNA damage in cultured primary hepatocytes and the liver of mice. ROS, possibly along with DNA alkylation , participated in the observed DNA damage.
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JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Xi-Ling Li,Chengqiang Han,Miao Luo,Shuyun Xiao,Jing Li,Chenglong Yu,Shengyu Cheng,Yueying Jin,Yu Han,Kenichiro Todoroki,Qing Shi,Jun Zhe Min
Glycans play important roles in the activity and function of monoclonal antibodies (mAbs). In this study, an isotope labeling method for the relative quantitative analysis of glycans in cetuximab, a chimeric human/mouse IgG1 monoclonal antibody that specifically targets epidermal growth factor receptor, via hydrophilic interaction LC-ultra-high-performance LC-HRMS was established based on Pronase E digestion. To this aim, novel isotope MS probes, i.e., 3-benzoyl-2-oxothiazolidine-4-carboxylic acid (d0-BOTC) and 3-(2,3,4,5,6-pentadeuterio-benzoyl)-2-oxothiazolidine-4-carboxylate acid (d5-BOTC), which include a carboxyl group to target the amino functional group in glycosylamine, were developed. The nonspecific Pronase E enzyme could simultaneously digest the peptide bound to the N - and O -glycans into glycosylamine having only one amino acid. Since the mass difference between the light- and heavy-labeled glycans was 5.0 Da, the relative abundance of their MS peaks was used to achieve the qualitative and relative quantitative analysis of glycans. Sialylglycopeptide was used as a complex glycan model to validate the accuracy of the method. The results demonstrated the good linearity (R 2 ≥ 0.9994) between the experimentally detected MS intensity ratios and the theoretical molar ratios of the d0-BOTC to the corresponding d5-BOTC derivatives in the dynamic range of 0.03-10 and 0.03-20 of three orders magnitude for the d5-BOTC/d0-BOTC ratios. The reproducibility was between 0.16% and 10.70%, and the limit of detection was 13 fmol. The feasibility of the relative quantification method was investigated by analyzing the glycan content in cetuximab, finding good consistency between experimental and theoretical molar ratios (5:1, 3:1, 1:1, 1:3, 1:5) of d0/d5-BOTC-labeled glycans. Finally, 13 glycans were successfully identified in cetuximab by applying this method using an in-house Tracefinder database. This study provides a novel strategy for the high throughput analysis, identification, and functional study of glycans in mAbs.
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