SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
·
IF 4.098
Meng Xia,Fengjin Shi,Yinghui Xia,Jing Sun,Xian-En Zhao,Shuyun Zhu
A ratiometric fluorescence assay for alendronate (ALDS) has been designed with Ce 4+ -triggered cascade chromogenic reaction. This strategy involves three processes: (1) Ce 4+ oxidizes ascorbic acid (AA) into dehydroascorbic acid (DHAA), which then condenses with o -phenlenediamine (OPD) to generate fluorescent 3-(dihydroxyethyl)furo[3,4- b ] quinoxaline-1-one (DFQ), presenting the maximum emission at 434 nm; (2) As oxidase-mimics, Ce 4+ can oxidize OPD into fluorescent 2,3-diaminophenazine (DAP) which shows a strong emission at 568 nm; (3) ALDS inhibits the oxidation ability of Ce 4+ towards OPD, thus inhibiting the generation of DAP. Accordingly, a homogeneous ratiometric fluorescence system with dual emission comes into being and the presence of ALDS can change the fluorescence intensity ratio obviously. With F 434 / F 568 as readout, ALDS can be detected sensitively with the detection limit of 30 nM. Moreover, this ratiometric method was used to analyze ALDS in both human serum and pharmaceutical samples.
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MICROCHEMICAL JOURNAL
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2020
·
IF 3.594
Ziyin Yang,Xiao Bai
This paper reports the synthesis of S-doped thin Co 3 O 4 shell with Au flower as core for nonenzymatic glucose sensing, where Au@Co 3 O 4 was obtained through assembly process triggered by redox reaction of Co 2+ and Au 3+ , and then S was doped into Co 3 O 4 shell via a hydrothermal process. The morphology, composition and structure of Au@Co 3 O 4 -S were characterized by transmission electron microscopy and X-ray diffraction, which showed that the core–shell structure was composed with Au core flower and S-doped thin Co 3 O 4 shell. Electrochemical property of Au@Co 3 O 4 -S toward glucose was explored, and an excellent electrocatalytic performance with a wide linear range of 0.2 μM–3.1 mM, a high sensitivity of 1127.3 μA mM −1 cm −2 and a low detection limit of 0.09 μM (S/N = 3) was obtained, which may be due to that the low conductivity of Co 3 O 4 was mitigated by conductive Au core flower and S doping, therefore making thin Co 3 O 4 shell provide more effective active sites for glucose reaction. Considering such excellent results, Au@Co 3 O 4 -S was proven as a promising material for electrochemical sensing of glucose.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2020
·
IF 3.232
Shasha Feng,Fubin Pei,Yi Wu,Jingjing Lv,Qingli Hao,Tinghai Yang,Zhaoyang Tong,Wu Lei
A novel ratiometric fluorescent sensor based on Förster resonance energy transfer (FRET) platform was designed for riboflavin (RF) detection. The graphitic carbon nitrides quantum dots - Zn-MOF composite (g-CNQDs@Zn-MOF) was used as the fluorescent probe . In the FRET system, g-CNQDs@Zn-MOF and RF acted as donor and acceptor, respectively. The probe exhibited high sensitivity and good selectivity to RF, and had been successfully used for the detection of RF in milk and vitamin B 2 tablets. The detection limit of the sensor was 15 nM. The strategy expanded the application of MOF in sensing filed and provided a new method for the detection of RF.
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RSC Advances
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2020
·Vol. 10
·期 54
·32919-32926
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IF 3.119
Pengli Zuo,Zhongguang Chen,Fengling Yu,Jinyu Zhang,Wei Zuo,Yanli Gao,Qingyou Liu
Heteroatom doping in carbon dots (CDs) was found to be an efficient way to regulate the structure of electronic energy levels and enhance the fluorescence characteristics of CDs. Nevertheless, most reported fabrication processes of heteroatom-doped CDs are rigorous and complex. Herein, a facile and novel strategy was developed to rapidly prepare nitrogen and phosphorus co-doped CDs (N,P-CDs) using acetic acid as the carbon source, and arginine, 1,2-ethylenediamine (EDA) and diphosphorus pentoxide as the dopants, respectively. The optical, morphological and structural characterizations of the synthesized N,P-CDs were investigated via UV and photoluminescence spectroscopy, X-ray photoelectron spectroscopy, TEM, and FT-IR spectroscopy. The N,P-CDs display outstanding fluorescence stability under high ionic strength (1.6 M KCl), and long time UV irradiation, indicating that they can be used as favorable candidates for fluorescent probes. The fluorescence of N,P-CDs was selectively quenched by chloramphenicol (CAP) with a short response time. The linear range of the response to CAP was from 0.8 to 70 μM with a limit of detection of 0.36 μM (S/N = 3). Notably, the fabricated N,P-CDs were employed for the highly selective and sensitive detection of CAP in milk samples, indicating their potential applications in biologically related areas.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2020
·Vol. 412
·期 27
·7515-7524
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IF 3.637
Zhang Yang,Wang Yuedan,Qing Xing,Wang Yao,Zhong Weibing,Wang Wenwen,Chen Yuanli,Liu Qiongzhen,Li Mufang,Wang Dong
Multi-walled carbon nanotubes (MWCNT) play a synergistic role with conducting polymer in practical applications such as biological sensing. In this paper, multi-walled carbon nanotube and polypyrrole (PPy) composites were prepared on a fiber surface for the first time, and their morphology and electrical properties were characterized. Compared with PPy-coated fiber, the presence of carbon nanotubes induced the growth of large areas of PPy nanowires. In addition, fiber organic electrochemical transistors (FECTs) based on PPy and MWCNT were assembled, showing a higher on/off ratio, better stability, and greater flexibility. The lactate biosensor based on FECTs exhibits high sensitivity, with a correlation coefficient of R = 0.9889, quick response time of 0.6–0.8 s, a wide linear response range of 1 nM–1 mM, and excellent selectivity for lactate. Furthermore, the lactate concentration in human sweat was successfully detected by a FECT-based sensor. The hybrid fibers can be easily woven and placed on fabric simply by stitching. This favorable performance of the FECT-based sensor makes it suitable for noninvasive sensing of lactate. Therefore, it provides a promising platform for future use in healthcare and detection applications.
Graphical abstract
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SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Zhan-Jun Lu,Yarong Cheng,Yuan Zhang,Xuefeng Wang,Pengcheng Xu,Haitao Yu,Xinxin Li
Free bilirubin level is a significant indicator for the diagnosis of jaundice related diseases. Herein, ceria nanocubes are synthesized as catalyst for the direct electrochemical sensor of free bilirubin. The sensor is fabricated by simply modifying screen-printed electrodes with ceria nanocubes and carbon blacks. Owing to the catalytical activity of ceria nanocubes and conductivity of carbon blacks, this sensor can detect free bilirubin with high sensitivity and selectivity in a short response time. Under the optimized condition, the current of DPV peak is proportional to the bilirubin concentration up to 100 μM, with a LOD of 0.1 μM in phosphate buffer and 1 μM in human serum sample. The non-enzymatic sensor also shows good reproducibility and stability at room temperature. Moreover, only 5 μL test sample is required, the small sample consumption may facilitate the blood collection procedure. The sensor could be a potential candidate device for the point of care testing on free bilirubin in clinic.
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NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 44
·期 47
·20797-20805
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IF 3.288
Hongmi Liu,Rujie Xiong,Peng Zhong,Guangli Li,Jun Liu,Jingtao Wu,Ying Liu,Quanguo He
In this study, an ultrasensitive voltammetric sensor was constructed for the simultaneous detection of dopamine (DA) and uric acid (UA) using shuttle-like α-Fe2O3 nanoparticle/nitrogen-doped graphene nanocomposites (Fe2O3–NG). The surface morphologies, crystalline structures, and electrochemical properties of Fe2O3–NG were investigated by scanning electron microscopy, powder X-ray diffraction, cyclic voltammetry, and AC impedance spectroscopy. Coupling shuttle-like α-Fe2O3 with NG nanosheets not only enlarges the electrochemically active surface area and prevents the agglomeration of α-Fe2O3 NPs or NG nanosheets, but also increases the electroconductivity of α-Fe2O3 NPs and boosts its catalytic ability, thereby affording more electroactive sites for the adsorption and oxidation of target analytes. As expected, the Fe2O3–NG/GCE shows extraordinary electrocatalytic oxidation capacities toward DA and UA over two wide dynamical response concentration ranges of 0.5–10 μM and 10–100 μM, with low detection limits (LOD) of 0.080 and 0.075 μM for DA and UA, respectively. Moreover, the Fe2O3–NG/GCE shows high anti-interference ability against several potential interferences and retains stable voltammetric responses for at least a week. Finally, the Fe2O3–NG/GCE achieves the simultaneous determination of DA and UA in human serum with reliable results.
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Nano Research
·
2020
·Vol. 14
·期 3
·879-886
·
IF 8.183
Zhao Shen Fei,Hu Fang Xin,Shi Zhuan Zhuan,Fu Jing Jing,Chen Yue,Dai Fang Yin,Guo Chun Xian,Li Chang Ming
It is critical for fabricating flexible biosensors with both high sensitivity and good selectivity to realize real-time monitoring superoxide anion (O 2 •− ), a specific reactive oxygen species that plays critical roles in various biological processes. This work delicately designs a Mn 3 (PO 4 ) 2 /MXene heterostructured biomimetic enzyme by assembling two-dimensional (2-D) Mn 3 (PO 4 ) 2 nanosheets with biomimetic activity and 2-D MXene nanosheets with high conductivity and abundant functional groups. The 2-D nature of the two components with strong interfacial interaction synergistically enables the heterostructure an excellent flexibility with retained 100% of the response when to reach a bending angle up to 180°, and 96% of the response after 100 bending/relaxing cycles. It is found that the surface charge state of the heterostructure promotes the adsorption of O 2 •− , while the high-energy active site improves electrochemical oxidation of O 2 •− . The Mn 3 (PO 4 ) 2 /MXene as a sensing platform towards O 2 •− achieves a high sensitivity of 64.93 µA·µM −1 ·cm −2 , a wide detection range of 5.75 nM to 25.93 µM, and a low detection limit of 1.63 nM. Finally, the flexible heterostructured sensing platform realizes real-time monitoring of O 2 •− in live cell assays, offering a promising flexible biosensor towards exploring various biological processes.
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BIOSENSORS & BIOELECTRONICS
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2020
·
IF 10.257
Bingfang Wang,Yuanyuan Luo,Lei Gao,Bo Liu,Guotao Duan
Accurate detection of glucose is essential for the diagnosis of diabetes, wherein effective and sensitive biosensors for glucose detection are needed. Here, we fabricated a glucose sensor based on field-effect transistor (FET) with bimetallic nickel-copper metal-organic frameworks (Ni/Cu-MOFs) as its channel layers which were grown in-situ through a simple one-step hydrothermal method and modified with glucose oxidase (GOD) by using glutaraldehyde (GA) as linkers. Due to the synergistic effect of Ni ions and Cu ions in MOFs, the sensor (GOD-GA-Ni/Cu-MOFs-FET) showed good field effect performance and great responses to glucose through enzymatic reactions . It displayed a piecewise linear relationship in the wide range (1 μM–20 mM), and provided high sensitivity (26.05 μAcm −2 mM −1 ) in the low concentration (1–100 μM) and a low detection limit (0.51 μM). The sensor also had these advantages of high specificity, excellent reproducibility, good short-term stability and fast response time. Especially, it is indicated that the Ni/Cu-MOFs-FETs with high performance have the potential to be available sensors, paving the way for the application of bimetallic MOFs in biosensing.
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ANALYST
·
2021
·Vol. 146
·期 5
·1689-1697
·
IF 4.616
Zhengrong Niu,Honghong Rao,Xin Xue,Mingyue Luo,Xiuhui Liu,Zhonghua Xue,Xiaoquan Lu
Fenton-like reaction systems have been proven to be efficient as powerful promoters in advanced oxidation processes (AOPs) due to their generated reactive oxygen species (ROS), such as ˙OH and ˙O2−, which can further oxidize a specific chromogenic substrate like 3,3′,5,5′-tetramethylbenzidine (TMB) to generate sensitive color readout and thereby demonstrate more potential in the colorimetric analysis field. However, the inherent drawback of the low rate-limiting step of Fe3+/Fe2+ conversion in the Fenton-like reaction and its resultant inefficiency for H2O2 decomposition hinder its practical applications. We herein communicate an analyte-activated catfish effect based catalysis strategy to promote the Fenton-like reaction, in which dopamine, like a catfish, was added to activate the Fenton-like reaction. By definition, the conversion rate of Fe3+ to Fe2+ in the proposed Fenton-like reaction can be significantly accelerated through a specific DA-mediated electron transfer process which further promotes the reaction activity in the Fenton-like reaction to generate more ˙OH and ˙O2− radicals. As a result, the produced ˙OH and ˙O2− radicals in such a reaction system can significantly oxidize TMB indicator into its oxidation product (TMBox) and therefore indicate the corresponding target-dependent color and photothermal signal readout, enabling the successful fabrication of a more sensitive and stable colorimetric and photothermometric DA sensor. More significantly, this strategy can greatly advance the practical application of Fenton-like reactions in the fields of colorimetric and photothermometric bioassays.
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Scientific Reports
·
2020
·Vol. 10
·期 1
·1-12
·
IF 3.998
Chu Youqun,Huang Zhangkao,Wang Xinhang,Zhou Menglei,Zhao Fengming
We report the fabrication of silver nanoparticles evenly imbedded into TiN submicrospheres via one-pot solvothermal reaction and subsequent nitridation for electrochemical detecting of hydrogen peroxide. The precursor of TiO 2 submicrospheres and high dispersion of silver nanoparticles are regulated by the alcoholysis of tetrabutyl titanate and reducibility of enol in vitamin C. The ion nitriding promoted the conductivity and micro-nano porous structure on the surface of TiN submicrospheres, which increase the dispersity of silver nanoparticles and make contributions to avoid aggregations. More importantly, the electrochemical response of Ag-TiN submicrospheres to H 2 O 2 was remarkably enhanced due to the co-effects of Ag and N-doping. It provides a superior sensing performance for electrochemical detection of hydrogen peroxide at − 0.3 V with a high sensitivity of 33.25 μA mmol L −1 cm −2 , wide linear range of 0.05–2100 μM and low detection limit of 7.7 nM. The fabricated sensor also reliably applied in detection of H 2 O 2 in milk samples with good reproducibility, repeatability and storage stability.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2020
·Vol. 21
·期 24
·9529
·
IF 4.556
Shanxia Jin,Liping Liu,Mengying Fan,Yaru Jia,Ping Zhou
Pollen grain was explored as a new carrier for enzyme immobilization. After being modified with boric acid-functionalized titania, the pollen grain was able to covalently immobilize glycosylated enzymes by boronate affinity interaction under very mild experimental conditions (e.g., pH 7.0, ambient temperature and free of organic solvent). The glucose oxidase and horse radish peroxidase-immobilized pollen grain became a bienzyme system. The pollen grain also worked as an indicator of the cascade reaction by changing its color. A rapid, simple and cost-effective approach for the visual detection of glucose was then developed. When the glucose concentration exceeded 0.5 mM, the color change was observable by the naked eye. The assay of glucose in body fluid samples exhibited its great potential for practical application.Keywords:enzyme immobilization;boronate affinity;pollen grain;glucose detection
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