CELLULAR SIGNALLING
·
2026
·
IF 4.7
Qiu-shuang Ma,Xiao-man Zhao,Wan-ying Zhang,Li-jun Shao,Yi-fan Liu,Li-ya Feng,Xiao-xia Yang,Xiu-li Guo
Enolase 1 (ENO1) is overexpressed in hepatocellular carcinoma (HCC) and correlates with poor patient prognosis, as evidenced by TCGA and Kaplan-Meier (KM) analysis. This study demonstrates that targeting ENO1 with its specific inhibitor, ENOblock, markedly enhances the antitumor efficacy of sorafenib in HCC cells. The combination of sorafenib and ENOblock significantly suppresses cell proliferation, migration, invasion, and angiogenesis in vitro and in vivo . Mechanistically, sorafenib and ENOblock synergistically promote ferroptosis by concurrently regulating the Keap1/Nrf2/NQO1 and TFR1/C-MYC/NCOA4/FTH1/LC3 pathways, independent of xCT/GPX4 pathway. These effects are characterized by elevated levels of reactive oxygen species (ROS), iron ions, and malondialdehyde (MDA). In vivo tumorigenic models further confirm that the enhanced therapeutic effect of sorafenib by ENOblock. Our findings not only elucidate a novel ferroptosis-based mechanism underlying sorafenib response in HCC, but also position ENOblock-sorafenib combination as a promising preclinical proof- of-concept strategy targeting ENO1 for HCC intervention.
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Neuroscience Bulletin
·
2020
·Vol. 37
·期 5
·701-719
·
IF 4.326
Yang Hong,Xiong Feng,Song Yi-Ge,Jiang Hai-Fei,Qin Hai-Bin,Zhou Jing,Lu Sha,Grieco Steven F.,Xu Xiangmin,Zeng Wen-Bo,Zhao Fei,Luo Min-Hua
Anterograde viral tracers are powerful and essential tools for dissecting the output targets of a brain region of interest. They have been developed from herpes simplex virus 1 (HSV-1) strain H129 (H129), and have been successfully applied to map diverse neural circuits. Initially, the anterograde polysynaptic tracer H129-G4 was used by many groups. We then developed the first monosynaptic tracer, H129-dTK-tdT, which was highly successful, yet improvements are needed. Now, by inserting another tdTomato expression cassette into the H129-dTK-tdT genome, we have created H129-dTK-T2, an updated version of H129-dTK-tdT that has improved labeling intensity. To help scientists produce and apply our H129-derived viral tracers, here we provide the protocol describing our detailed and standardized procedures. Commonly-encountered technical problems and their solutions are also discussed in detail. Broadly, the dissemination of this protocol will greatly support scientists to apply these viral tracers on a large scale.
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PubMed
高影响因子
ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
·
2022
·Vol. 238
·期 1
·13-14
·
IF 0.365
Zhihong Zhu,Lilei Zhang
C 14 H 12 BrClN 2 O, monoclinic, P 2 1 / c (no. 14), a = 13.4072(6) Å, b = 8.6103(5) Å, c = 12.3824(6) Å, β = 100.475(4), V = 1405.60(12) Å 3 , Z = 4, R gt
( F ) = 0.0499, wR ref
( F
2 ) = 0.1215, T = 173 K.
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Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 10
·6205-6213
·
IF 12.732
Jiacheng Xing,Danhua Yuan,Hanbang Liu,Yansi Tong,Yunpeng Xu,Zhongmin Liu
The synthesis of TS-1 zeolites is regarded as a milestone in zeolite history, and it has led to the revolution of the green oxidation system of using H2O2 as an oxidant, leaving only water as the byproduct. However, because of the highly hydrolyzable titanium source, the preparation of TS-1 requires complex synthesis conditions. Moreover, the difference in the hydrolysis rate between the silicon source and titanium source tends to increase the difficulty of titanium insertion into the framework, and it is easy to generate extra-framework Ti species during the synthesis. Here, a high-quality TS-1 zeolite with a large external surface area and free of extra-framework Ti species has been successfully synthesized by using a kind of novel polymer containing titanium and silicon. Due to the high hydrolysis resistance of the polymer reagent, a good matching of the hydrolysis rate between the silicon source and the titanium source is realized during crystallization, which facilitates the incorporation of titanium into the framework. Furthermore, the TS-1 zeolite exhibited excellent catalytic performance in n-hexane oxidation with hydrogen peroxide as the oxidant. This method of synthesizing zeolites from polymers is expected to be widely applied for the synthesis of other titanium-containing zeotype materials.
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CHEMOSPHERE
·
2023
·
IF 8.8
Wenshan He,Run Jiang,Siqi Li,Minglu Zhang,Tingting Zhang,Xiaobiao Zhu,Xiaohui Wang
Chlortetracycline (CTC), a widely used typical tetracycline antibiotic, has raised increasing concerns due to its potential health and environmental risks. Biodegradation is considered an effective method to reduce CTC in environment. In this study, a strain Aspergillus sp. LS-1, which can efficiently degrade CTC, was isolated from CTC-rich activated sludge . Under optimal conditions, the maximum removal efficiency of CTC could reach 95.41%. Temperature was the most significant factor affecting the degradation efficiency of LS-1. The 19 products were identified in the CTC degradation by strain LS-1, and three degradation pathways were proposed. All the degradation pathways for CTC exhibited ring-cleaving, which may accelerate the mineralization of CTC. To gain more comprehensive insights into this strain, we obtained the genome of LS-1, which had high GC content (50.1%) and completeness (99.3%). The gene annotation revealed that LS-1 contains some vital enzymes and resistance genes that may carry functional genes involved in the CTC degradation. In addition, other antibiotic resistance genes were found in the genome of LS-1, indicating that LS-1 has the potential to degrade other antibiotics. This study provides a more theoretical basis for the investigation of CTC degradation by fungi and new insights into the biodegradation of CTC.
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高影响因子
FUEL
·
2018
·
IF 4.908
Qing-Qing Teng,Xian-Yong Wei,Yi-Bing Sun,Sheng-Kang Wang,Jing-Hui Lv,Zhan-Ku Li,Zhong-Qiu Liu,Zhi-Min Zong
Catalysts trifloromethanesulfonic acid (TFMSA)/treated attapulgite powder (TAP), Ni/TAP, and Ni-TFMSA/TAP with different Ni and TFMSA loadings were prepared. The typical catalysts were characterized with multiple instruments and used for catalyzing hydroconversion of di(1-naphthyl)methane (DNM), which was used as a coal-related model compound. The suitable loadings of Ni and TFMSA in Ni-TFMSA/TAP were determined to be 28.6% of Ni and 33% of TFMSA. Under optimal reaction conditions of 5 MPa of initial hydrogen pressure, 240 °C, and 4 h over Ni-TFMSA/TAP, DNM was completely converted, producing decalin and 1-methyldecalin as the main products. The result suggests that Ni-TFMSA/TAP is highly active for both cleaving the C ar -C alk bond in DNM and hydrogenating the resulting naphthalene and 1-methylnaphthalene under mild conditions. Based on the identification of reaction products, the catalytic mechanism for DNM hydroconversion was discussed.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
·
IF 5.876
Wanli Zhao,Yuanhui Long,Yunqing He,Jiabing Cai,Mingxian Liu
Highly stretchable hydrogel shows great potential for wearable strain sensors. However, the rapid propagation of bacteria while using wearable sensors may threaten health. In this work, HNTs@HKUST-1 composites were prepared by the incorporation of halloysite nanotubes (HNTs) during the synthesis of HKUST-1. HNTs depressed the crystal growth of the HKUST-1, which leads to the 2D nanosheet morphology. HNTs@HKUST-1 serves as a reinforcing agent for polyacrylamide (PAAm) hydrogels, and PAAm-HNTs@HKUST-1 has high tensile strain properties (elongation at break of 912.5% and tensile strength of 22.4 kPa). The Cu 2+ in HKUST-1 endows remarkable conductivity and excellent antibacterial properties to the composite. The composite hydrogels were then developed as human motion detection sensors with antibacterial property to prevent microbial infection, which show recyclability, high sensitivity, and fast responsiveness. So, they have great potential as flexible antibacterial materials to monitor movements of the human body in real-time.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Meng Zhang,Menglan Dou,Yingying Xia,Zhan Hu,Beijing Zhang,Yongxia Bai,Jia Xie,Qifeng Liu,Changping Xie,Dadong Lu,Shuai Hou,Jianguo He,Jun Tao,Ranfeng Sun
In the current work, a series of 1-trifluoromethyl cinnamyl alcohol derivatives were designed and synthesized and their antifungal activities were evaluated. The bioassay result showed that most compounds exhibited excellent antifungal activity in vitro at 10 μg mL–1. Next, photostable and easily synthesized compound 2 with broad-spectrum antifungal activity in vitro was selected as a potential candidate to evaluate its antibacterial and antifungal activities. The EC50 values of compound 2 against eight fungal plant pathogens in vitro ranged from 3.806 to 17.981 μg mL–1; at the same time, compound 2 could effectively control Podosphaera xanthii, Odium heveae Steinm, Puccinia striiformis West, and Puccinia sorghi in pot experiments. In addition, compound 2 exhibited excellent antibacterial activities in vitro and in vivo against Xanthomonas oryzae pv. oryzae. Furthermore, the absorption and translocation of compound 2 in wheat plants were determined by the high-performance liquid chromatography method. The result showed that compound 2 could be translocated acropetally as well as basipetally in wheat plants. Finally, it was found that compound 2 had no cross-resistance with carbendazim, azoxystrobin, and boscalid.
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PubMed
高影响因子
Chemistry-An Asian Journal
·
2020
·Vol. 15
·期 8
·1272-1276
·
IF 4.056
Yueming Cao,Peipei Li,Tengteng Wu,Meiling Liu,Youyu Zhang
Graphical HKUST-1 (Cu−BTC, BTC=benzene-1,3,5 tricarboxylate) was selected as an electrocatalyst for the reaction of conversion N 2 to NH 3 under ambient conditions. At −0.75 V vs. reversible hydrogen electrode, it achieves excellent performance with high NH 3 yield (46.63 μg h −1 mg −1 cat. or 4.66 μg h −1 cm −2 ) and Faraday efficiency (2.45%). Electrolytic ammonia synthesis from nitrogen at ambient conditions is appearing as a promising alternative to the Haber-Bosch process which is consuming high energy and emitting CO 2 . Here, a typical MOF material, HKUST-1 (Cu−BTC, BTC=benzene-1,3,5-tricarboxylate), was selected as an electrocatalyst for the reaction of converting N 2 to NH 3 under ambient conditions. At −0.75 V vs. reversible hydrogen electrode, it achieves excellent catalytic performance in the electrochemical synthesis of ammonia with high NH 3 yield (46.63 μg h −1 mg −1 cat. or 4.66 μg h −1 cm −2 ) and good Faraday efficiency (2.45%). It is indicated that the good performance of the HKUST-1 catalyst may originate from the formation of Cu(I). In addition, the catalyst also has good selectivity for N 2 to NH 3 .
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CERAMICS INTERNATIONAL
·
2021
·
IF 4.527
Jinpeng Ma,Ke Zhu,Da Huo,Bingzhong Shen,Yang Liu,Xudong Qi,Enwei Sun,Rui Zhang
The performances of 1–3 piezocomposite materials under various poling conditions were compared and analysed. The dielectric , piezoelectric , and electromechanical properties of 1–3 piezocomposite materials were studied with variations in the electric field amplitude ( E p ), poling frequency ( f ), and number of cycles ( C ). It was found that the piezoelectric coefficient ( d 33 ), free dielectric constant ( ε 33 T / ε 0 ), and electromechanical coupling factor ( k t ) of 1–3 piezocomposite materials exhibit an increase of 21.4%, 13%, and 10.7%, respectively, under the optimum alternating current poling (ACP) condition ( f = 1.25 Hz, E p = 2 kV/mm, C = 16), compared with that of the samples poled using the direct current polarisation (DCP) method. The studies of the domain pattern indicate that the performance enhancement originates from the remarkable regularly striped domain structure and high domain wall density in ACP-poled samples. Our results suggest that the ACP method is effective in enhancing the performance of composite piezoelectric materials , which possess great benefits and potential for application in acoustic/medical transducers.
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Reaction Kinetics Mechanisms and Catalysis
·
2012
·Vol. 108
·期 2
·531-544
·
IF 0.829
He Min-Qiang,Pan Ai-Xia,Xie Ji-Min,Jiang De-Li,Yuan Xin-Hua,Chen Min
Phosphotungstic heteropoly acid (PW) supported on various oxides (SiO 2 , TiO 2 , K-10 montmorillonite and γ-Al 2 O 3 ) were synthesized and used as catalysts for Friedel–Crafts acylation of pyrene with acetic anhydride to 1-acetylpyrene for the first time. The as-prepared catalysts were characterized by specific surface area measurement, X-ray diffraction, infrared spectroscopy, and temperature programmed desorption of ammonia. SiO 2 -supported phosphotungstic heteropoly acid (PW/SiO 2 , 40 wt%) was found to be the most active catalyst in the acylation giving 91.8 % yield and 100 % selectivity for 1-acetylpyrene at reaction temperature of 60 °C under ambient pressure. The effect of PW Loading, PW/SiO 2 amount, molar ratio of reactants, reaction temperature and reaction time on the catalytic acylation reaction were studied in detail to optimize the process parameters. The reusability of the PW/SiO 2 catalyst was appraised, and the possible pathway for the production of the Friedel–Crafts acylation of pyrene with acetic anhydride catalyzed by phosphotungstic heteropoly acid was also discussed briefly.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Yi Yang Xu,Lei Meng,Miao Miao Zhao,Chu Xin Peng,Fei Yen
While all of the polymorphs of pure NH 4 I and KI are non-polar, we identify that (NH 4 ) 0.95 K 0.05 I is ferroelectric and (NH 4 ) 0.87 K 0.13 I and (NH 4 ) 0.83 K 0.17 I are pyroelectric through measurements of their pyroelectric current and complex dielectric constant. The order to disorder phase transitions occur near 245 K. Magnetic susceptibility measurements indicate that the proton orbitals of the NH 4 + continue to become ordered in the ground state in the (NH 4 ) 1–x K x I system up to x ≤ 0.17. The polar phases are proposed to stem from K + ions disrupting the symmetry of proton-orbital-lattice interactions between the NH 4 + and I – ions. Our work introduces a new pathway for the ordered phases of ammonium-based compounds to potentially become ferroelectric.
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