Crystals
·
2024
·Vol. 14
·期 5
·431
·
IF 2.4
Zhenggang Zou,Jiaolin Weng,Chun Liu,Yiyang Lin,Jiawei Zhu,Yijian Sun,Jianhui Huang,Guoliang Gong,Herui Wen
Inorganic scintillation crystals have been widely used in applications of high-energy physics, nuclear medical imaging, industrial nondestructive inspection, etc. In this work, a single crystal Ba3Y(PO4)3(BYP) with 1.0 at% Ce3+-doping concentration was first grown by the Czochralski method, and the electronic structure was calculated using first principles based on density functional theory. In addition, a series of Ce3+-doped BYP phosphors were synthesized, and the fluorescence emission under UV excitation was measured through low-temperature spectroscopy, containing double-peaked emission from 5d–4f transition and self-trapped exciton recombination. A comparison of the UV and X-ray-excited fluorescence spectra reveals the existence of oxygen vacancies as well as F+ centers in the crystal. The air annealing of the crystal effectively reduces the thermoluminescence defects but reduces the emission intensity under UV or X-ray excitation. The BYP:Ce crystal shows a fast decay lifetime of 15.5 ns, and the fast component is as short as 8 ns. The results show that the Ce3+-doped BYP crystal has potential as a kind of scintillator with fast decay properties.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2011
·
IF 2.089
Xue Wang,Jianming Pan,Wei Guan,Jiangdong Dai,Xiaohua Zou,Yongsheng Yan,Chunxiang Li,Wei Hu
A simple method for selective recognition of 3-chlorophenol (3-CP) from aqueous solution has been developed using a surface molecularly imprinted polymer (MIP) as sorbent. Characterization of the obtained MIP was achieved by Fourier transform infrared spectroscopy (FTIR). Kinetic, thermodynamic, dynamic adsorption, and selectivity experiments were investigated in this study. Kinetic experimental data were well-described by the pseudosecond-order kinetic model. The obtained Arrhenius activation energy Ea from the kinetic data indicated a physisorption mechanism, and the negative values of ΔHo demonstrated that the adsorption of 3-CP onto MIP was exothermic. Equilibrium experimental data of MIP fitted the Langmuir isotherm well. The MIP showed outstanding affinity toward 3-CP in aqueous solution, and the optimum pH value for binding has been found around the neutral range. When methanol was used as eluent, the adsorbed 3-CP eluted easily from MIP. The total dynamic capacity of the imprinted sorbent was calculated to be 1137.58 mg·g–1. The breakthrough of 3-CP started after 60 mL, and the breakthrough capacity was 756.8 mg·g–1. Meanwhile, selectivity experiments demonstrated that MIP showed high affinity to target molecules over competitive CPs (2,6-dichlorophenol and 2,4,6-trichlorophenol).
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2011
·Vol. 124
·期 1
·109-115
·
IF 1.24
Jikui Wang,Guofeng Cai,Xudong Zhu,Xiaping Zhou
The oxidative chemical polymerization of 3, 4-ethylenedioxythiophene (EDOT) was conducted at room temperature in the presence of poly(styrene sulfonate) (PSS) as the doping agent, sodium supersulphate (Na 2 S 2 O 8 ) and ferric sulphate(Fe 2 (SO 4 ) 3 ) as the compound oxidant and deionized water as the solvent. In order to remove sodium ion (Na + ), ferric ion (Fe 3+ ), and sulfate ion (SO4 2− ), certain amount of ion exchanger was added after 24 h, the dark blue poly(3, 4-ethylenedioxythiophene) (PEDT)/PSS solution was obtained. The influence of different proportions of EDOT and PSS, different proportions of EDOT and the compound oxidant, different stirring rates on the morphology, and surface resistivity were discussed. The influence of pH value of the PEDT/PSS solution, the coating thickness, and soak time on the surface resistivity was investigated. Recipe and experimental conditions were optimized and the PEDT/PSS solution was obtained with excellent performance which has relatively low in surface resistance, good water tolerance, and light transmittance. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2012
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Molbank
·
2024
·Vol. 2024
·期 2
·M1818
·
IF 0.6
Zhongwei Wang,Luxiao Zhou,Peng He,Yukun Qin
This study presents a novel approach in the realm of catalytic organic synthesis by integrating biomass catalytic conversion with organic synthesis techniques. UtilizingN-acetylglucosamine as the primary feedstock, the first phase of the research involves its catalytic transformation into 5-hydroxymethylfurfural (HMF). The subsequent phase employs a condensation reaction between HMF and 3,3-Dimethyl-2-butanone to synthesize a new compound, (E)-1-(5-(hydroxymethyl) furan-2-yl)-4,4-dimethylpent-1-en-3-one. This two-step process not only demonstrates the feasibility of converting biomass into valuable chemical precursors but also exemplifies the synthesis of novel compounds through green chemistry principles. The successful execution of this methodology offers fresh insights and opens new avenues for advancements in catalytic organic synthesis, emphasizing sustainability and efficiency.
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TETRAHEDRON
·
2017
·
IF 2.651
Wen-Yong Han,Jia Zhao,Jian-Shu Wang,Bao-Dong Cui,Nan-Wei Wan,Yong-Zheng Chen
A facile and practical [3+2] cycloaddition/ring contraction for the construction of structurally diverse CF 2 H-containing spirocyclopropyloxindoles was developed. Starting from isatin-derived 3-ylideneoxindoles and in situ generated CF 2 HCHN 2 , the desired products were obtained in good to excellent results (up to 99% yield and >99:1 trans/cis ) in the absence of metal catalyst . The potential application of the protocol was also demonstrated by the synthesis of the CF 2 H-substituted analog of HIV-1 NNRTI inhibitor.
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Metabolites
·
2024
·Vol. 14
·期 8
·449
·
IF 3.4
Min Li,Zhenfang Shang,Yonglan Ma,Huijun Zhao,Zhijing Ni,Zhaojun Wei,Xiu Zhang
This study investigates the growth tolerance mechanisms ofChlorella pyrenoidosato 3-fluorophenol and its removal efficiency by algal cells. Our results indicate thatC. pyrenoidosacan tolerate up to 100 mg/L of 3-fluorophenol, exhibiting a significant hormesis effect characterized by initial inhibition followed by promotion of growth. InC. pyrenoidosacells, the activities of superoxide dismutase (SOD) and catalase (CAT), as well as the levels of malondialdehyde (MDA) and reactive oxygen species (ROS), were higher than or comparable to the control group. Metabolic analysis revealed that the 3-fluorophenol treatment activated pathways, such as glycerol phospholipid metabolism, autophagy, glycosylphosphatidylinositol (GPI)-anchored protein biosynthesis, and phenylpropanoid biosynthesis, contributed to the stabilization of cell membrane structures and enhanced cell repair capacity. After 240 h of treatment, over 50% of 3-fluorophenol was removed by algal cells, primarily through adsorption. Thus,C. pyrenoidosashows potential as an effective biosorbent for the bioremediation of 3-fluorophenol.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Wei Zhang,Qingmiao Yu,Hongpu Xue,Yue Rao,Yi Bao,Xiangwei Ding,Meiyang Zhao,Danqing Wu,Yujie He,Jinju Geng
While biodegradation shows promise for removing 17β-estradiol-3-sulfate (E2–3S) from wastewater, its underlying mechanisms remain poorly understood. We systematically elucidated E2–3S biodegradation from both microbial community and individual strain perspectives by constructing microbial co-occurrence networks across diverse reaction environments and isolating degrading bacteria from activated sludge. The results showed that activated sludge achieved E2–3S removal greater than 90 %, though estrogenic activity reduction varied with reaction environments. Network analysis, connectivity and centrality analyses identified Pseudomonas species as the keystone taxon driving estrogenic activity reduction, supported by synergistic interactions with Azonexus , Dechloromonas and Obscuribacter species to maintain redox homeostasis and nutrient availability. We further isolated non-pathogenic Pseudomonas CE2S, which demonstrated exceptional E2–3S degradation (> 90 %) and estrogenic activity reduction (> 70 %) across concentration gradients. Two major degradation pathways were proposed for strain CE2S, including deconjugation, hydroxylation, and oxidative ring cleavage reactions, ultimately yielding low-estrogenic-activity products. To our knowledge, this work provides the first comprehensive mechanistic understanding of E2–3S biodegradation spanning community to strain levels, and reports the first isolation of an activated sludge bacterium capable of simultaneous E2–3S degradation and estrogenic activity reduction. These findings provide critical insights for understanding E2–3S biodegradation and developing bioaugmentation strategies for optimal E2–3S removal.
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DESALINATION
·
2025
·
IF 9.8
Tong Zhou,Nan Zhang,Qi Li,Guoyao Li,Haidong Sun,Chenglan Zhang,Juan Li,Hezhou Liu,Huanan Duan
The rapid increase in the commercialization of electric vehicles and portable electronics has markedly raised the demand for lithium resources. Extracting lithium from brine has become a critical pathway to address future lithium production challenges. However, the lithium extraction efficiency of conventional technologies is limited by the low levels of Li + and the high Mg 2+ /Li + ratio present in brine. A method involving one-step electrolysis with a solid-state electrolyte has been introduced for the direct and efficient extraction of metallic lithium. Li 1.3 Al 0.3 Ti 1.7 (PO 4 ) 3 (LATP) is considered a highly promising selective membrane for large-scale lithium extraction from brine sources due to its low cost, excellent stability, and high ionic conductivity. Herein, LATP electrolytes were synthesized through the optimization of solid-state reaction conditions. The resulting LATP pellets exhibited a high relative density of 98.29 % and an impressive ionic conductivity of 3.88 × 10 −4 S cm −1 . The lithium extraction device utilizing LATP as a selective membrane achieved a remarkable current efficiency of 97.4 % and a high lithium production rate of 40.4 μg h −1 cm −2 . After lithium extraction process, the LATP pellets retained the ionic conductivity of 2.69 × 10 −4 S cm −1 and preserved the sodium super ion conductors (NASICON) crystal structure. This study presents an efficient Li + selective membrane for extracting lithium directly from natural brine.
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BRITISH JOURNAL OF PHARMACOLOGY
·
2022
·Vol. 179
·期 20
·4792-4808
·
IF 9.473
Yujing Wang,Liaoxi Tan,Kejun Jiao,Chu Xue,Qinglian Tang,Shan Jiang,Younan Ren,Hao Chen,Tarek Mohamed Abd El-Aziz,Khalid N. M. Abdelazeem,Ye Yu,Fang Zhao,Michael X. Zhu,Zhengyu Cao
Background and Purpose Atopic dermatitis (AD) is one of the most common chronic inflammatory cutaneous diseases with unmet clinical needs. As a common ingredient found in several medicinal herbs with efficacy on cutaneous inflammatory diseases, Scutellarein (Scu) has been shown to possess anti-inflammatory and anti-proliferative activities. We aimed to evaluate the therapeutic efficacy of Scu against AD and its underlying molecular mechanism. Experimental Approach Efficacy of Scu on AD was evaluated in 2,4-dinitrofluorobenzene (DNFB) and carvacrol-induced dermatitis mouse models. Cytokine mRNA and serum IgE levels were examined using qPCR and ELISA, respectively. Voltage clamp recordings were used to measure currents mediated by transient receptor potential (TRP) channels. In silico docking, site-direct mutagenesis, and covalent modification were used to explore the binding pocket of Scu on TRPV3. Key Results Subcutaneous administration of Scu efficaciously suppresses DNFB and carvacrol-induced pruritus, epidermal hyperplasia and skin inflammation in wild type mice but has no additional benefit in Trpv3 knockout mice in the carvacrol model. Scu is a potent and selective TRPV3 channel allosteric negative modulator with an apparent affinity of 1.18 μM. Molecular docking coupled with site-direct mutagenesis and covalent modification of incorporated cysteine residues demonstrate that Scu targets the cavity formed between the pore helix and transmembrane helix S6. Moreover, Scu attenuates endogenous TRPV3 activity in human keratinocytes and inhibits carvacrol-induced proliferative and proinflammatory responses. Conclusion and Implications Collectively, these data demonstrate that Scu ameliorates carvacrol-induced skin inflammation by directly inhibiting TRPV3, and TRPV3 represents a viable therapeutic target for AD treatment. Graphical
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PROTEIN AND PEPTIDE LETTERS
·
2018
·Vol. 25
·期 8
·776-782
·
IF 1.039
Huang Xiaoting,Liu Haiyang,Fang Wei,Lin Yan,Tan Ying
Background: Carbohydrate antigen 15-3 (CA15-3), a specific breast cancer-related biomarker in serum, can provide direct information to monitor a patient's postoperative status and can predict recurrence and metastasis of breast cancer. The conventional Enzyme-Linked Immunosorbent Assay
(ELISA) is an effective approach for CA15-3 detection, but there is a high limit of detection which is more than 1 U mL-1. Therefore, a convenient, highly sensitive and specific CA15-3 detection method is needed for earlier prognoses of breast cancer. Objective: In this work, we aim to
develop a novel sensitive and selective immunofluorescence assay for the highly effective detection of CA15-3. Method: We pre-coat the antibody I onto the solid phase to capture antigen CA15-3. The A10254- labeled antibody II identified by electrophoresis and fluorescence spectra recognized
the antigen CA15-3 and formed the sandwich format. The fluorescence signal of A10254 directly relating to the amount of antigen could be detected and quantified by the microplate reader excited at 440nm. Results: The obtained method for CA15-3 detection showed lower limits of detection
(0.11 and 0.18 U mL-1) in a linear range of 0.25-14 U mL-1 in the buffer and 2% serum, respectively. This assay exhibited a good specificity and reproducibility in 2% serum with lower relative standard deviations in different tested concentrations. Conclusion: The developed immunofluorescence
assay enhanced the performance of the conventional CA15-3 ELISA kit. Moreover, the acceptable accuracy and good reproducibility in diluted serum indicated the assay has great potential for the diagnosis of breast cancer in clinical practice.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Kun Hu,Wei Luo,Chang-Yuan He,Zong-jie Zhao,Hong-Yan Wu,Jian-Han Zhang
A novel oxalate-based piezoelectric crystal, NaBaAl(C2O4)3·5H2O, was successfully synthesized and structurally characterized. The compound crystallizes in the polar space group Pca21, forming a robust three-dimensional framework constructed from [Al(C2O4)3]3– units stabilized by Na+, Ba2+, and coordinated water molecules. Optical diffuse reflectance spectroscopy combined with Tauc’s analysis indicates a direct bandgap of 4.53 eV, while polarized light microscopy measurements yield an experimental moderate birefringence of 0.044, confirming significant optical anisotropy. More notably, piezoelectric measurements reveal a relatively large coefficient of 67.9 pC/N at room temperature, representing an order-of-magnitude enhancement compared with previously reported Al-based piezoelectric crystals. Furthermore, variable-temperature measurements demonstrate the evolution of the piezoelectric response with heating. In addition, PFM measurements confirm polarization switching under applied bias, supporting the piezoelectric assignment. Collectively, these results expand the family of Al-based piezoelectrics and highlight the potential of ligand-engineered frameworks as a viable strategy for developing high-performance piezoelectric materials.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xue Gu,Xinyu Gou,Yan Jiang,Xiangquan Liu,Binbin Zhai,Ruijuan Wen,Zhiyan Ma,Yu Fang
3-Hydroxy-2-butanone (3H2B) is a key gaseous metabolite of Listeria monocytogenes, a potential lung cancer biomarker, and a widely used food flavoring agent, underscoring the demand for real-time monitoring solutions. In this study, we designed a salicylaldehyde-functionalized 1,8-naphthalimide derivative (NI-OH-CHO) and reacted it with 1,3,5-tri(4-aminophenyl)benzene (TAPB) at a liquid/liquid interface to synthesize fluorescent NI-TAPB nanofilms. Upon deprotonation, the nanofilms (NI-TAPB@F) exhibit a reversible and unprecedented fluorescence response to 3H2B. Leveraging this discovery, we developed a fluorescent 3H2B sensor with exceptional performance: ultrahigh sensitivity (detection limit: ∼ 1.8 ppb), rapid response (<8 s), outstanding selectivity, and remarkable stability at room temperature. These advantages stem from the rational design of binding sites and the porous structure of the nanofilms. Furthermore, visual 3H2B detection was achieved using the deprotonated films. Notably, the nanofilms are self-standing, self-adhesive, and flexible, enabling substrate-independent detection by eliminating interference from background color or emission. These properties also facilitate on-site qualitative and quantitative analysis. We anticipate this work will pave the way for the development of portable 3H2B detection devices.
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