CHEMOSPHERE
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2018
·
IF 4.427
Zhipan Wen,Yalei Zhang,Gang Cheng,Yingru Wang,Rong Chen
In this study, nanosized ordered magnetic mesoporous Fe-Ce bimetal oxides (Nanosized-MMIC) with highly well-ordered inner-connected mesostructure were successfully synthesized through the KIT-6 template method. This Nanosized-MMIC displayed excellent adsorption capacities for As(V), Cr(VI) and AO7, and the corresponding calculated maximum adsorption capacities of material were 111.17, 125.28 and 156.52 mg/g, respectively. As(V) and Cr(VI) removal by Nanosized-MMIC were slightly dependent on the ionic strength but highly solution pH-dependent, the coexistent silicate and phosphate ions competed remarkably with both As(V) and Cr(VI) for the adsorption active site. Mechanisms indicated As(V) and Cr(VI) formed inner-sphere complexes on Nanosized-MMIC interface via the electrostatic interaction and surface complexation, while the total organic carbon (TOC) change demonstrated that AO7 could be removed completely and no organic intermediates formed through the adsorption process. In addition, Nanosized-MMIC also possessed superior adsorption performance in As(V)/Cr(VI)-AO7 binary systems, and the reusable and regeneration properties indicated that the obtained nanomaterials could maintain at a comparatively high level after several recycling. Finally, fixed-bed experiments suggested the Nanosized-MMIC was expected to have a promising excellent nano-adsorbent with high application potential for co-existed toxic heavy metals and organic dyes removal in practical wastewater treatment .
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BIOPOLYMERS
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2018
·Vol. 109
·期 7
·e23223
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IF 1.99
Yue Yang,Zuyuan Luo,Ying Zhao
The scaffolds for stem cell-based bone tissue engineering should hold the ability to guide stem cells osteo-differentiating. Otherwise, stem cells will differentiate into unwanted cell types or will form tumors in vivo. Alginate, a natural polysaccharide with great biocompatibility, was widely used in biomedical applications. However, the limited bioactivity and poor osteogenesis capability of pristine alginate hampered its further application in tissue engineering. In this work, a bone forming peptide-1 (BFP-1), derived from bone morphogenetic protein-7, was grafted to alginate polymer chains to prepare peptide-decorated alginate porous scaffolds (pep-APS) for promoting osteo-differentiation of human mesenchymal stem cells (hMSCs). SEM images of pep-APS exhibited porous structure with about 90% porosity (pore size 100–300 μm), which was appropriate for hMSCs ingrowth. The adhesion, proliferation and aggregation of hMSCs grown on pep-APS were enhanced in vitro. Moreover, pep-APS promoted the alkaline phosphatase (ALP) activity of hMSCs, and the osteo-related genes expression was obviously up-regulated. The immunochemical staining and western blot analysis results showed high expression level of OCN and Col1a1 in the hMSCs grown on pep-APS. This work provided a facile and valid strategy to endow the alginate polymers themselves with specific bioactivity and prepare osteopromoting scaffold with enhanced osteogenesis ability, possessing potential applications in stem cell therapy and regenerative medicine. Graphical
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RSC Advances
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2016
·Vol. 6
·期 20
·16500-16506
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IF 3.289
Min Su,Haiyun Liu,Shenguang Ge,Na Ren,Longhua Ding,Jinghua Yu,Xianrang Song
In this work, a novel paper-based electrochemiluminescence (ECL) immunosensor for ultrasensitive and selective detection of corresponding antigens on living cells was developed employing AuPd nanoparticles as a signal amplifier and macroporous Au-paper working electrodes (Au-PWE) for efficient cell capture. The porous AuPd nanoparticles are chosen as label nanomaterials due to their controllable three-dimensional porosity and peroxidase like activity, large surface area, superior conductivity, and favorable catalytic activity to H2O2 which could enhance the ECL intensity for signal amplification. CdTe QDs and luminol groups as ECL probes were linked with the antibodies to recognize the corresponding antigens on the cell surface and the wide potential range between them compared to conventional antigens sensors could prevent interfacing with each other. Using this strategy, human carcinoembryonic (CEA) and alphafetoprotein (AFP) antigens on living MCF-7 cancer cells as models were quantified serially through a potential scanning way. Significantly, this strategy may be quite promising in cancer early diagnosis due to the excellent analytical performance.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2025
·
IF 4.6
Xiaojing Yang,Tingyi Qiao,Fengping Hou,Nan Dong
Spermidine has emerged as a promising biomarker for the early-stage diagnosis of cancer in humans. A novel extractive spectrophotometric analytical method has been developed for the determination of spermidine in urine samples. This technique leverages the selective extraction of spermidine from complex matrices using a cucurbit[7]uril-truxene derivative (Q[7]-Cs-Tr) as a fluorescent extractant. The Q[7]-Cs-Tr forms a stable host-guest complex with spermidine, facilitating its extraction from the aqueous phase to the organic phase. The formation of this complex results in a decrease in the fluorescence intensity of the Q[7]-Cs-Tr in the organic phase. Key factors influencing extraction efficiency, including the type of dispersed organic solvent, extractant concentration, solution pH, extraction times, and equilibrium time, were thoroughly investigated. The method demonstrated minimal interference from various metal ions, anions, amino acids, and other biogenic amines. It also exhibited a low limit of detection (8.6 nM), excellent linearity (R 2 = 0.9972), and high repeatability (RSD = 2.4 % intra-day, RSD = 3.6 % inter-day). The proposed method was successfully applied to determine spermidine levels in urine samples, yielding satisfactory recoveries ranging from 96.3 % to 103.5 %. Compared to existing methods, this approach is simple, reliable, highly sensitive, and exhibits low interference, making it a potential robust tool for clinical diagnostics.
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FOOD CHEMISTRY
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2025
·
IF 9.8
Huiyu He,Rui Wang,Rongbin Nie,Nan Dong
Pretreatment technology suffers from drawbacks such as tedious operation, low efficiency, and poor selectivity. Hence, we presented a singly capped cucurbit[7]uril-mediated magnetic solid phase extraction (Q[7]-MagSPE) combined with high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) for multiresidue analysis of 20 pesticides. The Q[7]-MagSPE was constructed by assembling Q[7] onto the gold magnetic nanoparticles (GoldMag) via the reaction between one of the electron-rich carbonyl portals of Q[7] and gold. The host-guest interaction activity of supramolecules, the high dispersibility and easy separability of GoldMag were integrated in the Q[7]-MagSPE. The detection limits for 20 pesticides were lower than 10.3 ng/kg, and the recoveries were 71.55 – 110. 6 % . Moreover, the reusability of the Q[7]-GoldMag and effect of washing times on the pesticide residue were evaluated to be satisfactory. Therefore, the Q[7]-MagSPE provides a rapid and robust pretreatment method for the multiresidue determination of pesticides in vegetables, which is of great significance for food safety.
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JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Ciming Wang,Huiqun Ju,Xiaolong Zhou,Pengrui Zhang,Zixuan Xue,Lianjing Mao,Fei Shao,Yan Jing,Yongzhong Jia,Jinhe Sun
6 Li and 7 Li, two natural isotopes of lithium, play an important role in the nuclear industry. Here, a system of ionic liquid-crown ether was fabricated for lithium isotope separation and the 6 Li isotope separation coefficient can reach 1.406 that showing a good prospect for lithium isotope separation by this method of electromigration. Interestingly, the single crystal containing crown ether and lithium, in which 7 Li was enriched, was obtained from the experiments. It is contrary to popular wisdom and can be attributed to the steric hindrance effect. This provides a new route to separate lithium isotopes, that is electromigration coupling with crystallization.
研究领域:
核科学
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材料科学
·
化学工程
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Jingzhou Guo,Junwei Yang,Yuanzuo Zou,Yuan Pu,Dan Wang
The 9,9-Dihexyl-2,7-dibromofluorene (F6-Br) is an important intermediate product in the synthesis of functional polyfluorenes for various applications. The solvent/antisolvent method has been one of the efficient methods to purify organic molecules for advanced applications, for which the solubility data of solutes in different solvents are the basis of purification. In this work, the solubility values of F6-Br in 12 kinds of solvents in the temperature range of 283.15–323.15 K and atmospheric pressure were determined by using the isothermal saturation method. The selected solvents were methanol, ethanol, acetonitrile, n-butanol, isopropanol, dichloromethane, dimethyl sulfoxide, 1,4-dioxane, ethyl acetate, n-hexane, tetrahydrofuran, chloroform, and toluene. The measured solubility data were correlated by the modified Apelblat equation. The maximum value of mean square deviation was 3.95 × 10–3, which retains practical guiding significance. The purification of F6-Br via solvent/antisolvent precipitation processing was demonstrated, and the involvement of rotating packed-bed-based technology significantly intensified the process efficiency, which showed promising application value for industrial production.
研究领域:
化学工程
·
材料科学
·
有机化学
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JOURNAL OF LUMINESCENCE
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2019
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IF 2.961
Yuan Zhong,Shujie Gai,Yimei Yang,Mao Xia,Ye Zhang,Fanshan Qiu,Fang Xiang,Zhi Zhou
Green phosphor is an essential component in phosphor-converted white light-emitting diodes (pc-LEDs). Herein, a novel green-emitting phosphate phosphor Sr 8 ZnY(PO 4 ) 7 :Eu 2+ (SZYP:Eu 2+ ) was synthesized through hydrothermal reaction method. The crystal structure, photoluminescence properties as well as thermal stability of SZYP:Eu 2+ were investigated systematically. SZYP:Eu 2+ can be efficiently excited by n-UV light in the range from 220 to 550 nm and shows a broad emission band centered at 520 nm with a full width at half maximum of 86 nm. The optimized doping concentration of Eu 2+ was determined to be 0.02 mol. With the increase of Eu 2+ content, a subtle red shift about 4 nm in emission spectra was detected. SZYP:Eu 2+ also shows comparable thermal stability (45% at 150 °C) and it can be further varied to 44, 40 and 51% by co-doping with Pr 3+ , Tm 3+ and Yb 3+ , respectively. The white LED device blended with SZYP:Eu 2+ shows excellent electroluminescence (EL) properties. The low correlated color temperature (4791 K) and ultrahigh color rendering index (95.8) imply that this phosphor may find a potential application in high-quality white LEDs.
研究领域:
材料科学
·
光学工程
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2016
·
IF 3.773
Fangrong Zhang,Xiaoyi Wang,Xiangting Xu,Min Li,Jianping Zhou,Wei Wang
In the past decades, reconstituted high density lipoprotein (rHDL) has been successfully developed as a drug carrier since the enhanced HDL-lipids uptake is demonstrated in several human cancers. In this paper, rHDL, for the first time, was utilized to co-encapsulate two hydrophobic drugs: an anticancer drug , paclitaxel (PTX), and a new reversal agent for P-gp (P-glycoprotein)-mediated multidrug resistance (MDR) of cancer, N -cyano-1-[(3,4-dimethoxyphenyl)methyl]-3,4-dihydro-6,7-dimethoxy- N ′-octyl-2(1H)-isoquinoline-carboximidamide (HZ08). We proposed this drug co-delivery strategy to reverse PTX resistance. The study aimed to develop a biomimetic nanovector, reconstituted high density lipoprotein (rHDL), mediating targeted PTX-HZ08 delivery for cancer therapy. Using sodium cholate dialysis method, we successfully formulated dual-agent co-delivering rHDL nanoparticles (PTX-HZ08-rHDL NPs) with a typical spherical morphology, well-distributed size (~ 100 nm), high drug encapsulation efficiency (approximately 90%), sustained drug release properties and exceptional stability even after storage for 1 month or incubation in 10% fetal bovine serum (FBS) DMEM for up to 2 days. Results demonstrated that PTX-HZ08-rHDL NPs significantly enhanced anticancer efficacy in vitro , including higher cytotoxicity and better ability to induce cell apoptosis against both PTX-sensitive and -resistant MCF-7 human breast cancer cell lines (MCF-7 and MCF-7/PTX cells). Mechanism studies demonstrated that these improvements could be correlated with increased cellular uptake of PTX mediated by scavenger receptor class B type I (SR-BI) as well as prolonged intracellular retention of PTX due to the HZ08 mediated drug-efflux inhibition. In addition, in vivo investigation showed that the PTX-HZ08-rHDL NPs were substantially safer, have higher tumor-targeted capacity and have stronger antitumor activity than the corresponding dosage of paclitaxel injection. These findings suggested that rHDL NPs could be an ideal tumor-targeted nanovector for simultaneous transfer of insoluble anticancer drug and drug resistance reversal agents. The PTX-HZ08-rHDL NPs co-delivery system might be a new promising strategy to overcome tumor drug resistance.
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FASEB JOURNAL
·
2017
·Vol. 31
·期 4
·1756-1766
·
IF 5.498
Haijie Liu,Chunxiao Wan,Yanan Ding,Ranran Han,Yating He,Jinting Xiao,Junwei Hao
Experimental autoimmune neuritis (EAN) is a CD4 + T-cell–mediated autoimmune inflammatory demyelinating disease of the peripheral nervous system. It has been replicated in an animal model of human inflammatory demyelinating polyradiculoneuropathy, Guillain-Barré syndrome. In this study, we evaluated the therapeutic efficacy of a selective inhibitor of the immunoproteasome subunit, low-MW polypeptide 7 (PR-957) in rats with EAN. Our results showed that PR-957 significantly delayed onset day, reduced severity and shortened duration of EAN, and alleviated demyelination and inflammatory infiltration in sciatic nerves. In addition to significantly regulating expression of the cytokine profile, PR-957 treatment down-regulated the proportion of proinflammatory T-helper (T h )17 cells in sciatic nerves and spleens of rats with EAN. Data presented show the role of PR-957 in the signal transducer and activator of transcription 3 (STAT3) pathway. PR-957 not only decreased expression of IL-6 and IL-23 but also led to down-regulation of STAT3 phosphorylation in CD4 + T cells. Regulation of the STAT3 pathway led to a reduction in retinoid-related orphan nuclear receptor γ t and IL-17 production. Furthermore, reduction of STAT3 phosphorylation may have directly suppressed T h 17-cell differentiation. Therefore, our study demonstrates that PR-957 could potently alleviate inflammation in rats with EAN and that it may be a likely candidate for treating Guillain-Barré syndrome. —Liu, H., Wan, C., Ding, Y., Han, R., He, Y., Xiao, J., Hao, J. PR-957, a selective inhibitor of immunoproteasome subunit low-MW polypeptide 7, attenuates experimental autoimmune neuritis by suppressing T h 17-cell differentiation and regulating cytokine production. FASEB J . 31, 1756–1766 (2017) www.fasebj.org
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JOURNAL OF MICROENCAPSULATION
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2024
·
IF 3
Lili Li,Lin Jing,Zijun Tang,Jingguo Du,Yonglong Zhong,Xu Liu,Mingqing Yuan
Aim To construct a novel nano-carrier with dual ligands to achieve superior anti-tumour efficacy and lower toxic side effects.Methods Liposomes were prepared by thin film hydration method. Ultraviolet, high performance liquid chromatography, nano-size analyser, ultrafiltration centrifugation, dialysis, transmission electron microscope, flow cytometry, Cell Counting Kit-8, confocal laser scanning microscopy, transwell, and tumorsphere assay were used to study the characterisations, cytotoxicity, and in vitro targeting of dg-Bcan targeting peptide (BTP-7)/pHA-temozolomide (TMZ)/tetra(4-carboxyphenyl)porphyrin (TCPP)-Lip.Results BTP-7/pHA-TMZ/TCPP-Lip was a spheroid with a mean diameters of 143 ± 3.214 nm, a polydispersity index of 0.203 ± 0.025 and a surface charge of −22.8 ± 0.425 mV. The drug loadings (TMZ and TCPP) are 7.40 ± 0.23% and 2.05 ± 0.03% (mg/mg); and the encapsulation efficiencies are 81.43 ± 0.51% and 84.28 ± 1.64% (mg/mg). The results showed that BTP-7/pHA-TMZ/TCPP-Lip presented enhanced targeting and cytotoxicity.Conclusion BTP-7/pHA-TMZ/TCPP-Lip can specifically target the tumour cells to achieve efficient drug delivery, and improve the anti-tumour efficacy and reduces the systemic toxicity.
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Carbon Letters
·
2025
·
IF 5.8
Hu Chaoshuai,Liu Yuanxin,Zhang Jian,Zhu Yaming,Yin Xitao,Zhao Xuefei
Using durian shell as a carbon source and triethanolamine as a nitrogen dopant, nitrogen-doped carbon dots (N-CDs) were prepared via the hydrothermal method. First, by exploring different reaction times, reaction temperatures, and carbon source/dopant ratios to synthesize nitrogen-doped carbon dots, it is concluded that the best process conditions are 200 ℃, reaction time being 15h, and the dopant addition amount being 2mL. Structure and characteristics of the synthesized CDs were analyzed using X-ray photoelectron spectroscopy, Fourier-transform infrared, fluorescence (FL), ultraviolet–visible absorption, and Raman spectra. The N-CDs showed blue FL with a quantum efficiency of 4.28%. The FL characteristics of the N-CDs were utilized for ion detection, which demonstrated that \({\text{MnO}}_{4}^{ - }\) and \({\text{Cr}}_{{2}} {\text{O}}_{7}^{2 - }\) ions caused distinct FL quenching through static quenching, while other ions had no significant quenching effect. The detection limits for \({\text{MnO}}_{4}^{ - }\) and \({\text{Cr}}_{{2}} {\text{O}}_{7}^{2 - }\) were 37.5 and 46.2 nM, respectively. The N-CDs were subsequently employed to detect these ions in actual water samples, producing satisfactory results. Therefore, the preparation of N-CDs using durian shell as raw material and its application in practical detection work have good application feedback, which not only provides a new way for the reuse of fruit and vegetable wastes but also provides a new detection means for environmental monitoring pollutants.
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