Lipids in Health and Disease
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2023
·Vol. 22
·期 1
·1-16
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IF 4.5
Li Hanxiao,Dong Yingyue,Han Chunmiao,Xia Lisha,Zhang Yue,Chen Tongsheng,Wang Huamin,Xu Guoheng
Background Previous studies demonstrated that mast cells with their degranulated component heparin are the major endogenous factors that stimulate preadipocyte differentiation and promote fascial adipogenesis, and this effect is related to the structure of heparin. Regarding the structural and physiological properties of the negatively charged polymers, hexasulfonated suramin, a centuries-old medicine that is still used for treating African trypanosomiasis and onchocerciasis, is assumed to be a heparin-related analog or heparinoid. This investigation aims to elucidate the influence of suramin on the adipogenesis.Methods To assess the influence exerted by suramin on adipogenic differentiation of primary white adipocytes in rats, this exploration was conducted both in vitro and in vivo. Moreover, it was attempted to explore the role played by the sulfonic acid groups present in suramin in mediating this adipogenic process.Results Suramin demonstrated a dose- and time-dependent propensity to stimulate the adipogenic differentiation of rat preadipocytes isolated from the superficial fascia tissue and from adult adipose tissue. This stimulation was concomitant with a notable upregulation in expression levels of pivotal adipogenic factors as the adipocyte differentiation process unfolded. Intraperitoneal injection of suramin into rats slightly increased adipogenesis in the superficial fascia and in the epididymal and inguinal fat depots. PPADS, NF023, and NF449 are suramin analogs respectively containing 2, 6, and 8 sulfonic acid groups, among which the last two moderately promoted lipid droplet formation and adipocyte differentiation. The number and position of sulfonate groups may be related to the adipogenic effect of suramin.Conclusion sSuramin emerges as a noteworthy pharmaceutical agent with the unique capability to significantly induce adipocyte differentiation, thereby fostering adipogenesis.
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Inorganic Chemistry Frontiers
·
2023
·Vol. 11
·期 1
·98-106
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IF 7
Xiaoqu Wang,Limin Wang,Karuppasamy Kohila Rani,Xinglan Peng,Yu Ning,Xiaotian Liu,Youjun Fan,Du-Hong Chen,Wei Chen
Delicately fabricating efficient electro-catalysts to boost the catalytic kinetics of the oxygen evolution reaction (OER) is essential for realizing the efficient performance of water splitting into hydrogen to alleviate environmental issues and the energy crisis. Here, heterogeneous and hollow microspheres (denoted as CoS2/MS2-HPMS, M = Fe, FeCo) were obtained by the sulfurization of Fe3+-decorated ZIF-67 hollow microspheres (ZIF-67-HMS). At a current density of 10 mA cm−2, the prepared CoS2/MS2-HPMS showed an overpotential of 217 mV for the OER, which is lower than that of commercial RuO2 (336 mV). Density functional theory calculations demonstrated low reaction free energies of the intermediates of the OER and significant charge accumulation at the heterojunction interface between CoS2 and FeCoS2. This work establishes a method for the assembly of nanoparticles and the construction of heterojunctions.
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Frontiers in Microbiology
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2023
·
IF 5.2
Shengting Zhang,Xiuling Hu,Chunting Zhang,Yani Ju,Xin Liu,Yunlin Wei
Antiviral drug development is important for human health, and the emergence of novel COVID-19 variants has seriously affected human lives and safety. A bacteriophage—a bacterial virus with a small and simple structure—is an ideal experimental candidate for studying the interactions between viruses and their hosts. In this study, the effects and mechanisms of catecholamines on phages were explored, and dopamine (DA) was found to have general and efficient anti-infection effects. A clear dose-dependent effect was observed when different phages were treated with DA, with higher DA concentrations exhibiting stronger anti-phage activity. The half maximal inhibitory concentration values of DA for vB-EcoS-IME167, T4 Phage, and VMY22 were determined as 0.26, 0.12, and 0.73 mg mL −1 , respectively. The anti-phage effect of DA increased with treatment duration. In addition, the anti-infection activities of DA against vB-EcoS-IME167, T4 Phage, and VMY22 were increased by 10 5 , 10 4 , and 10 4 folds compared to that of the control. This ability of DA was observed only in phages and not in the host bacteria. Morphological changes of phages were observed under transmission electron microscopy following their treatment with DA, and considerable changes in adsorption were confirmed via quantitative reverse transcription polymerase chain reaction. These results suggest that the anti-phage effect of DA is primarily due to the destruction of the external structure of the phage. This study, to the best of our knowledge, is the first to report the universal anti-phage infection effect of dopamine, which provides novel information regarding DA and forms a basis for further research and development of antiviral drugs. Moreover, it provides a new perspective for the research about the defense and counter-defense of bacteria and bacteriophages.
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ACS Applied Electronic Materials
·
2023
·
IF 4.7
Yubo Peng,Xudong Jin,Pingjun Zeng,Min Zhao,Zhipeng Gao,Jian-long Ji,Xiaona Li,Weiyi Chen
Recently, artificial photosynapses have attracted much attention from researchers because they have the ability to perceive, process, and remember information about the external environment, which can greatly improve the efficiency of visual information processing. This work prepared the artificial optical synaptic transistors based on organic electrochemical transistors (OECTs) and CsPbBr3 quantum dots (QDs) synthesized at room temperature. The fabricated device here could successfully imitate the visual functions by mimicking the important synaptic features such as excitatory postsynaptic currents, paired-pulse facilitation, spiking-rate-dependent plasticity, spiking-number-dependent plasticity, and short-term memory to long-term memory transition. Employing the device, we also simulated the capabilities of the human visual system of light adaptation, image recognition, and preprocessing. The investigations in this work indicated that CsPbBr3 QDs have a high potential application in fabricating artificial photosynapses of the type of OECTs to imitate human vision due to the simpler fabrication process.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2021
·
IF 5.816
Lifang Chen,Rizwan Ur Rehman Sagar,Jun Chen,Juan Liu,Sehrish Aslam,Farhat Nosheen,Tauseef Anwar,Naveed Hussain,Xinmei Hou,Tongxiang Liang
Hydrogen production from water splitting is highly desired for the green and clean energy device but remains a great challenge. In this regard, cobalt-phthalocyanine (PyCoPc) and composite of PyCoPc with graphene oxide (GO) were fabricated and used as catalyst for the energy conversion. The as-synthesized PyCoPc/GO exhibits an efficient hydrogen evolution reaction due to the low overpotential ~253 mV at a 10 mA cm −2 current density with a Tafel slope ~96 mV dec −1 in alkaline media . Our study reveals that the active area of the catalyst was controlled with the help of π − π stacking interaction between GO and PyCoPc. Technologically, a highly efficient PyCoPc catalyst was developed for hydrogen evolution reaction.
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Bioresources and Bioprocessing
·
2021
·Vol. 8
·期 1
·1-9
·
IF 4.578
Zhang Xiaowang,Tan Zhuotao,Li Chaojian,Qi Siyu,Xu Mengjiao,Li Ming,Xiong Wenlong,Zhuang Wei,Liu Dong,Zhu Chenjie,Ying Hanjie
Background Lactones are important compounds in the field of medicine, material and chemical industry. One of the promising accesses to these flexible scaffolds is NAD(P) + -dependent alcohol dehydrogenases-catalyzed oxidative lactonization of diols, which relies on the construction of an efficient NAD(P) + regeneration system. Results In this study, a novel system combining horse liver alcohol dehydrogenase (HLADH) with the synthetic bridged flavin cofactor was established for biosynthesis of lactones. The reaction conditions of this system were optimized and a variety of lactones including chiral lactones were efficiently obtained from various diols. Compared to the previously reported NAD(P) + -regeneration systems, this system showed better regeneration efficiency and product yield. A two-phase system was further applied to solve the problem of product inhibition, and 80% yield was obtained at the condition of 300 mM substrate. Conclusions This study provides an efficient method to synthesis of lactones from diols under mild conditions. We believe this system will be a promising alternative to promote the synthesis of other valuable compounds. Graphic abstract
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Green Energy & Environment
·
2021
·
IF 8.207
Yifei Wang,Wending Pan,Kee Wah Leong,Shijing Luo,Xiaolong Zhao,Dennis Y.C. Leung
Hydrogel electrolyte is especially suitable for solid-state Al-air batteries targeted for various portable applications, which may, however, lead to continuous Al corrosion during battery standby. To tackle this issue, an ethanol gel electrolyte is developed for Al-air battery for the first time in this work, by using KOH as solute and polyethylene oxide as gelling agent. The ethanol gel is found to effectively inhibit Al corrosion compared with the water gel counterpart, leading to stable Al storage. When assembled into an Al-air battery, the ethanol gel electrolyte achieves a much improved discharge lifetime and specific capacity, which are 5.3 and 4.1 times of the water gel electrolyte at 0.1 mA cm −2 , respectively. By studying the gel properties, it is found that a lower ethanol purity can improve the battery power output, but at the price of decreased discharge efficiency. On the contrary, a higher polymer concentration will decrease the power output, but can bring extra benefit to the discharge efficiency. As for the gel thickness, a moderate value of 1 mm is preferred to balance the power output and energy efficiency. Finally, to cater the increasing market of flexible electronics, a flexible Al-air battery is developed by impregnating the ethanol gel into a paper substrate, which can function normally even under serious deformation or damage.
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ACS Applied Materials & Interfaces
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2021
·
IF 9.229
Ping Wen,Yongzhen Lei,Qianqian Yan,Yunyan Han,Mingjin Fan
Tribofilm configuration under the boundary lubrication region is an essential concern to gain insight into the tribological enhancement of the two-dimensional (2D) nano materials toward base oils. In this work, several alkyl carboxylic acids modified 2D triazine-based covalent organic frameworks (ATC) nano platelets were fabricated and served as lubrication additives. When carbon atoms add up to 16, the best lubricating performance is exhibited at an additive concentration of 0.05 wt % and the friction coefficient and wear volume are, respectively, reduced by 56.0% and 89.6% as compared to those of pure PAO 10 base oil. The analysis of the focused ion beam-transmission electron microscope (FIB-TEM) on the worn surface reveals that an alternately multilayer tribofilm consisting of 2D platelet additives and oxides and/or metallic soap salts is formed on the frictional interface of steel substrate, with a well-ordered arrangement along the sliding direction, which dominates the contributions of the excellent lubrication.
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CHEMISTRY OF MATERIALS
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2021
·
IF 9.811
Lin Huang,Zikang Ye,Lei Yang,Jiongzhao Li,Haiyan Qin,Xiaogang Peng
Localization of exciton wavefunctions away from the inorganic–organic interface is proposed for synthesizing colloidal spheroidal quantum dots (QDs) with an ultranarrow photoluminescence (PL) peak width. This strategy is demonstrated by synthesizing uniform-alloy CdxZn1–xSe and CdxZn1–xSe/ZnSe/ZnS core/shell QDs. For blue-emitting QDs, the ensemble PL full width at half-maximum (fwhm) reaches 10.2 nm and the corresponding single-dot PL fwhm is 5.2 nm. The ensemble and single-dot PL fwhm values for green-emitting QDs are 16.3 and 9.7 nm, respectively. These record-low PL fwhm values for spheroidal QDs are close to the requirements for ideal displays. To control the composition homogeneity, the synthetic scheme is separated into four consecutive steps, namely, nucleation of monodisperse CdSe core QDs, epitaxial growth of thickness-controlled CdSe/ZnSe core/shell QDs with a low degree of spontaneous alloying, Cu-catalyzed alloying for uniform-alloy QDs, and additional epitaxy of outer ZnSe and ZnS shells onto uniform-alloy CdxZn1–xSe QDs. Among all metal ions tested, copper ions are identified to be the best catalysts for forming uniform-alloy CdxZn1–xSe QDs, which can enter a QD rapidly to initiate alloying and effectively exit a QD after the alloying process under the experimentally feasible conditions.
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Gels
·
2021
·Vol. 7
·期 1
·21
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IF 4.702
Xingxia Xu,Weihong Lu,Jian Zhu,Xiangqiang Pan,Xiulin Zhu
A new kind of on-demand dissolution hydrogel is successfully synthesized by modification of chitosan using γ-selenobutyrolactone. The chitosan hydrogel with different selenium contents is formed by ring opening of γ-selenobutyrolactone with the amines of D-glucosamine units on the chitosan backbone. The structure of the hydrogel was confirmed by1H NMR, XRD and XPS. Its physical and biological properties were evaluated by rheology characterization, degradation tests and cytotoxicity test. The hydrogel showed excellent biocompatibility and good degradation properties under oxidation or reduction conditions. All the evidence demonstrated that this type of material has good prospects for dressing applications.Keywords:chitosan;hydrogel;diselenide;on-demand dissolution
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TALANTA
·
2021
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IF 6.057
Ya Gao,Yu Huang,Junliang Ge,Lei Sun,Anwei Zhou,Shujun Feng,Yurui Xu,Xinghai Ning
An accurate measurement of sweat glucose is a promising alternative to invasive finger prick blood test, and may provide effective self-monitoring of blood glucose with good patient compliance. Herein, an interrelated catalytic enzyme system has been developed, termed as CataFlower, which is composed of nanoflower MoS 2 (peroxidase) decorated with GOx (glucose oxidase) and MnO 2 (oxygen generator), and exhibits synergistic oxidative capability for sensitively monitoring sweat glucose. CataFlower can not only generate oxygen in situ to maximize GOx activity, but promote peroxidase-triggered H 2 O 2 oxidation of methylene blue , resulting in sensitive colorimetric detection of glucose. We identify that CataFlower can precisely detect glucose with a detection limit of 10 μM, allowing for measuring glucose levels in different biological samples, such as blood and urine. Particularly, CataFlower is capable of monitoring dynamic changes in sweat glucose with high sensitivity and accuracy during exercise. Therefore, CataFlower provides a stepping stone to eliminate invasive blood tests, significantly improving the diagnosis and management of diabetes mellitus.
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Energy Storage Materials
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2021
·
IF 17.789
Zhong Fang,Yang Yang,Tianle Zheng,Nan Wang,Congxiao Wang,Xiaoli Dong,Yonggang Wang,Yongyao Xia
High-energy-density CF x /Li batteries have attracted wide applications, but encountered poor environmental adaptability at high/low temperatures. Guided with unique electrolyte-involved reaction mechanism, propylene carbonate (PC)/methyl butyrate (MB) co-solvent formulation was optimized to tune the desolvation barrier and stability for wide temperature operation. Weak affinity of Li + -MB and unique solvation structure of electrolyte, which facilitated easy desolvation at both high rate and low temperature, were uncovered with theoretical calculations and spectra characterizations. Desolvation process from intermediate and percolation-type reaction were clearly revealed with in-situ FT-IR and ex-situ TEM. The synergistic effect of handy desolvation with fast kinetics at the interface enabled excellent rate performance (1C, 834 mAh g −1 ) at +25°C and high capacity (240 mAh g −1 ) at low temperature of -70°C. Simultaneously, the stability of electrolyte assisted to realize high-temperature tolerance up to +95°C. The mechanism-guided electrolyte design offers deep understanding and novel strategy to improve CF x /Li batteries for wide temperature applications.
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