CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Xinlin Jiang,Zipeng Wu,Xiaoru Tan,Yichen Lin,Hui Xing,Yinglin Xuan,Dong Ma,Xin Cui
Hyperuricemia-related diabetic wounds are notoriously difficult to treat due to elevated uric acid (UA) levels, excessive reactive oxygen species (ROS), and chronic inflammation. Current therapies often fail to address these underlying causes, underscoring the need for innovative approaches that not only clear UA but also mitigate inflammation and promote tissue regeneration. In this study, we developed a polyrotaxane-based microsphere (HPR MS) system conjugated with 4,5-diamino-2-thiouracil (DT) to achieve high-affinity UA clearance without increasing cytotoxicity. By leveraging the molecular motility of the polyrotaxane structure, featuring β-cyclodextrin (β-CD) shuttles along the F-127 axis, we significantly improved the molecular recognition between DT and UA for enhanced UA absorption efficiency. In vitro experiments confirmed that HPR/DT MS rapidly reduced UA levels compared to control groups. Using a type 2 diabetic wound model, HPR/DT MS treatment effectively reduced UA levels, suppressed COX-2 expression, and transformed the immune microenvironment from a pro-inflammatory to a regenerative state in vivo . This was accompanied by enhanced M2 macrophage polarization, angiogenesis, and improved blood perfusion, resulting in accelerated wound healing. Overall, these findings highlight HPR/DT MS as a promising therapeutic strategy for hyperuricemia-related diabetic wounds, targeting the core pathological factors to improve wound repair.
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PubMed
高影响因子
Small Structures
·
2024
·
IF 13.9
Wenxue Zhao,Aihua Yan,Zigao Su,Fei Huang,Quande Wang,Shihang Li,Shijian Lu,Chuanjian Wang,Tongyang Zhang,Jixu Zhang,Ye Gao,Huaqi Yuan
Photocatalytic water splitting into hydrogen production provides a new avenue to produce clean chemical fuels. However, developing high-efficiency photocatalytic materials still remains a challenge till now. Herein, multiobjective-optimization MoS 2 /Cd-ZnIn 2 S 4 /CdS (MS/CZIS/CS) composites are successfully constructed by an in situ structure-tailored technique. Benefiting from the synergistic feature integrating sulfur vacancy, II-type CZIS/CS heterojunction and Schottky-type MS/CS heterojunction, such composites not only effectively steer photogenerated carrier transfer but also markedly expedite surface reaction kinetics for hydrogen reduction reaction. As a result, an optimal hydrogen evolution rate of 11.49 mmol g −1 h −1 is achieved over the MS/CZIS/CS catalysts, which is approximately 4.79 times higher than that of pristine ZIS (2.40 mmol g −1 h −1 ). This work provides some new inspirations for the steering of carrier transfer and the design of multiobjective-optimization photocatalysts with high efficiency.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Mingtao Tan,Hong Jiang,Rusong Chai,Miao Fan,Zengting Niu,Guotong Sun,Shanchun Yan,Dun Jiang
Heavy metal pollutants are important abiotic environmental factors affecting pest habitats. In this study, Cd pre-exposure significantly increased the tolerance of Lymantria dispar larvae to β-cypermethrin, but did not significantly alter their tolerance to λ-cyhalothrin and bifenthrin. The activation of P450 by Cd exposure is the key mechanism that induces insecticide cross-tolerance in L. dispar larvae. Both before and after β-cypermethrin treatment, Cd exposure significantly increased the expression of CYP6AB224 and CYP6AB226 in L. dispar larvae. Silencing CYP6AB224 and CYP6AB226 reduced the tolerance of Cd-treated L. dispar larvae to β-cypermethrin. Transgenic CYP6AB224 and CYP6AB226 genes significantly increased the tolerance of Drosophila and Sf 9 cells to β-cypermethrin, and the recombinant proteins of both genes could significantly metabolise β-cypermethrin. Cd exposure significantly increased the expression of CnCC and Maf . CnCC was found to be a key transcription factor regulating CYP6AB224 - and CYP6AB226 -activated insecticide cross-tolerance in Cd-treated larvae. Decreasing reactive oxygen species (ROS) levels in the Cd-treated larvae or increasing ROS levels in the untreated larvae reduced or enhanced the expression of CnCC , CYP6AB224 and CYP6AB226 and β-cypermethrin tolerance in L. dispar larvae, respectively. Collectively, Cd exposure confers β-cypermethrin tolerance in L. dispar larvae through the ROS/ CnCC signalling pathway-mediated P450 detoxification. Environmental Implication Heavy metals have been reported to produce cross-tolerance in agricultural insects to insecticides. The growing demand for chemical pest control necessitates expanding research on the widespread occurrence of cross-tolerance to insecticides among pests, particularly forest pests, in areas polluted with heavy metals. In this study, Cd pre-exposure enhanced the cross-tolerance of Lymantria dispar larvae to β-cypermethrin. Cd pre-exposure activated the P450 detoxification system of L. dispar larvae. CYP6AB224 and CYP6AB226 were key detoxify genes to the formation of cross-tolerance. ROS-CnCC signaling pathway was proved to be responsible for activation of detoxify genes.
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Jie Song,Yingnan Zhou,Lijun Chen,Zhiwen Yuan,Yuhua Niu,Xi Li,Liangxian Huang
This study employed β-cyclodextrin (β-CD) for the hydrophilic modification of iron tetraoxide (Fe3O4) magnetic materials. Subsequently, potassium humate (KHA) and carboxymethyl cellulose (CMC) were used as raw materials. A β-CD@Fe3O4/KHA/CMC/AM/MAH hydrogel with magnetic properties which can be easily recycled was synthesized for the slow release of glyphosate (GLY). FTIR, XRD, TG and VSM analyses demonstrated that the hydrogel possesses good thermal stability and magnetic properties with a saturation magnetization strength of 29.77 emu g−1. The equilibrium solubility of the hydrogel in pH = 7.4 and pH = 8.5 buffer was 24.58 g g−1 and 25.83 g g−1, respectively. The maximum release of GLY was recorded at 63.31% and 67.78%, with the drug release behavior under different loading gels following the Fickian diffusion mechanism. A pot planting experiment indicated that the water content of plants treated with the β-CD@Fe3O4/KHA/CMC/AM/MAH drug-loaded gel decreased by 51.69%. Additionally, soluble protein levels decreased to 2.69 mg g−1, chlorophyll content decreased to 0.486 mg g−1, SOD levels decreased to 43.81 U g−1, and MDA increased to 4.02 μmol g−1, effectively inhibiting the growth of grass and providing a theoretical basis for achieving slow drug release.
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高影响因子
Sustainable Materials and Technologies
·
2025
·
IF 9.2
Xue Wei,Ziqi Han,Xiaobo Min,Zhihong Liu,Qihou Li,Longgong Xia
CdTe thin-film solar cells, as a core component of photovoltaic devices, have been commercially deployed for over 30 years with global installations surpassing 30 GWp. Decommissioning has surged since 2010, showing major material recovery potential from retired modules. However, CdTe thin-film solar cells feature ultra-precise architectures with micron-sized CdTe/CdS/SnO 2 functional layers deposited on glass substrates. This structural complexity and ultralow metal concentrations create significant technical barriers for metal recovery. Current recycling technologies in both literature and practice exhibit insufficient constituent recovery and secondary waste generation, necessitating advanced separation technologies. This study developed an innovative recycling process achieving multi-component recovery: intact glass substrates, high-purity Te powder (99.9 wt%), CdS precipitates (99.0 wt%), and sodium thiostannate (Na 2 SnS 3 ) solutions. There were four steps: (1) Decommissioned modules were heated in air at 300 °C for 1 h to degrade EVA and recover intact back glass; (2) Front glass with functional layers further reacted with NaHS at 400 °C, converting CdTe/CdS/SnO₂ into Te/CdS/SnS₂ powder and recovering clean front glass; (3) Mixed powder was processed at 500 °C for 2 h (<10 Pa), yielding >99.9 wt% Te with 98.31 % ± 2.11 % recovery; (4) Na₂S leaching (140 g/L, L/S = 10:1, 40 °C, 2 h) yielded 99.0 wt% CdS precipitate and Na₂SnS₃ solution with >99 % metal recovery. Material balance analysis and life cycle assessment demonstrated that the proposed technology exhibits superior cost-effectiveness and minimized environmental footprint, while maintaining industrial scalability.
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高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Ziheng Yang,Xiuhua Chen,Shaoyuan Li,Wenhui Ma,Yi Li,Zudong He,Huanran Hu,Tong Wang
Recycling of kerf-loss slurry waste has become a meaningful and urgent issue in recent years. In this study, a novel hybrid material was prepared by Ag-assisted chemical etching kerf loss silicon waste and subsequently functionalized by a facile three-step graft process of 3-aminopropyltrimethoxy-silane, maleic anhydride, and ethylenediamine, named as EDA-MAH-APTES-NPSi, which could work as an effective adsorbent for removal of Cd(Ⅱ) from aqueous solution. The effect of initial pH, absorption duration, and metal ion concentrations on absorption performance were investigated. The adsorption equilibrium achieved after 120 min, the maximum adsorption capacity reached up to 210.01 mg/g and pH was at 5.5. The adsorption kinetic was fitted in the pseudo-second-order model and the Freundlich equation provided an accurate description for adsorption behavior. The XPS and FT-IR analysis manifested that Cd(Ⅱ) removal might be ascribed to the adsorption on the surface organic functional group by chemical chelating reaction and the ion exchange reaction. The EDA-MAH-APTES-NPSi maintained excellent adsorption capacity which decreased approximately 15.3 % (from 40.5–34.3 mg/g) after five successive regenerated cycles. The work confirms the potential of Cd(Ⅱ) removal from aqueous solution based on the modified NPSi and opens up a new way for recycling silicon cutting waste.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 31
·30938-30948
·
IF 2.8
Guo Shuangzhen,Dan Zhigang,Duan Ning,Chen Guanyi,Gao Wubin,Zhao Weijie
A novel magnetic silica gel adsorbent (Fe 3 O 4 -Si-COOH) was successfully prepared by introducing carboxyl group in situ to improve the performance for Pb(II), Zn(II), and Cd(II) adsorption. Infrared spectroscopy (IR), scanning electron microscope (SEM), transmission electron microscope (TEM), thermo-gravimetric analyzer (TGA), the Brunauer-Emmett-Teller (BET) surface area, X-ray diffraction (XRD), and vibrating sample magnetometer (VSM) characterizations suggested that Fe 3 O 4 -Si-COOH has been successfully prepared. The adsorption performance was evaluated by batch experiments with different initial concentrations, ionic strength, contact time, and pH. The adsorption kinetics data followed pseudo-second-order model and exhibited a three-stage intraparticle diffusion mode. Isothermal adsorption equilibrium data were best fitted by the Freundlich model and the adsorption capacity were 155, 110, and 93 mg/g (initial concentration 210 mg/L) for Pb(II), Zn(II), and Cd(II), respectively. The result of X-ray photoelectron spectroscopy (XPS) survey spectrum suggested that the main adsorption mechanism is that the H + of carboxyl groups exchanged with heavy metal ions in the adsorption processes. In addition, the adsorbed Fe 3 O 4 -Si-COOH could be regenerated and the adsorption capacity of reused Fe 3 O 4 -Si-COOH could maintain 80.3% after five cycles. Hence, the Fe 3 O 4 -Si-COOH could be a kind of potential material for removing Pb(II), Zn(II), and Cd(II) from wastewater.
Graphical abstract
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高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2018
·
IF 2.795
Lelin Zeng,Yan Liu,Tao Yang,Yunquan Yang,Kewen Tang
Low selectivity and weak stability constantly restrict the industrial application of emulsion liquid membrane (ELM) for metal ions separation. This study proposed an improved ELM system, in which selectivity and stability were simultaneously enhanced for separation of Cd(II)/Cu(II) by adding citric acid and its salt as retardant and buffer difunctional additives. Initially, the separation coefficient ( β Cd/Cu ) in the blank experiment was only 1.15 in 15 min, which indicated that P507 exhibited a poor selectivity as a carrier. After adding citrate additives, the β Cd/Cu of the improved ELM system increased to more than 395.19 for two reasons. Firstly, the selectivity was enhanced by the selective chelation of citrate radicals on the Cu(II) ions, which were trapped in feed solution. Conversely, the Cd(II) ions were preferentially extracted by the P507 and then stripped into internal phase. Secondly, the stability was also improved, because the pH variation in the feed solution caused by the instability of membrane breakage was effectively controlled by the citrate additives as a pH buffer. Important variables in the citrate-enhanced ELM system including total citrate concentration, P507 concentration, dosage ratio of H 3 Cit to Na 3 Cit, H 2 SO 4 concentration, and metal ion concentration were studied, respectively. The scale-up continuous experiment was executed in a pilot-scale modified rotating disc contactor with β Cd/Cu of 859.61, which indicated that the citrate-enhanced ELM has considerable industrial application potential for efficient and steady separation of Cd(II)/Cu(II).
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高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 6
·B388
·
IF 3.12
Jingdang Chai,Jie Zhang,Yangping Wen,Lie Zou,Xinxin Zhang,Xing Xin,Muhan Zhou,Jingkun Xu,Ge Zhang
An electrochemical sensor based on PEDOT:PSS-β-CD-SWCNT-COOH/GCE for highly sensitive analysis of shikonin (SHI) in PBS buffer solution was reported. PEDOT:PSS-β-CD-SWCNT-COOH composite was obtained by using poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS), β-Cyclodextrin (β-CD) and carboxylated single-walled carbon nanotube (SWCNT-COOH) to modify glassy carbon electrode (GCE) and characterized by scanning electron microscopy and electrochemical impedance spectroscopies. In optimized conditions, PEDOT:PSS-β-CD-SWCNT-COOH had a high sensitivity to SHI and it could detect SHI in linear ranges 6 nM to 30 μM with a low detection limit of 1.8 nM. And a series of experiments showed that the modified electrode exhibited good repeatability, reproducibility, and selectivity to electrochemical determination of SHI.
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高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Weili Wang,Qi Lu,Xiaoliang Ren,Canxiang Liu,Juan Jin,Shuyuan Yin,Jiming Zhang,Jianhua Zhou
A novel chitosan derivative was synthesized by crosslinking reaction of chitosan Schiff base and sodium alginate, and then used as adsorbent for Cd(II) ion. The structure of chitosan derivative was fully characterized and the adsorption behavior of Cd(II) ion was also investigated. The equilibrium and kinetic data fitted well the Langmuir and pseudo-second-order model. The estimated maximum adsorption capacity is 262.47 mg/g. Thermodynamic parameters indicates that at higher temperatures, the process is spontaneous, hence the adsorption is easy. Additionally, the regenerated adsorbent after five cycles could retain 87.15% of the adsorption capacity compared with the freshly prepared adsorbent.
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高影响因子
DYES AND PIGMENTS
·
2020
·
IF 4.613
He Li,Donglin Li,Bowen Qin,Wenliang Li,Haoyan Zheng,Xiaoying Zhang,Jingping Zhang
An extremely stable pillar-layered metal-organic framework (MOF), [Cd 4 (NDC) 3 (4-Hptz) 2 (H 2 O) 2 ]·H 2 O (1), has been successfully designed and synthesized (4-Hptz = 5-(4-pyridyl)-tetrazolate, NDC = 1,4-Naphthalenedicarboxylic acid). Compound 1 can detect Cr 3+ in water by fluorescence enhancement, which is the first known case of MOF. This is of great significance for our study on new fluorescent probes .
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高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2014
·Vol. 25
·期 3
·535-543
·
IF 1.077
Zhou Yong-Hong
Three new multi-dimensional coordination polymers, namely, [Cd(SIP)(HBPP)(BPP) 0.5 (H 2 O)·H 2 O] n ( 1 ), [Zn(L)(BIB) 0.5 ] n ( 2 ), and {[Cd 2 (L) 2 (BIB) 2 ](H 2 O) 7 } n ( 3 ) (H 3 SIP = 5-sulfo-1,3-benzenedicarboxylate, BPP = 1,3-bis(4-pyridyl)propane, H 2 L = 4-oxyacetate-benzoic acid, and BIB = 1,4-bis(imidazol-1-yl)-butane), were hydrothermally synthesized by self-assembly of the flexible N-donor ligand and the polycarboxylate ligands. Single crystal X-ray analyses reveal that complexes 1 – 3 possess different structural features. The Cd(II) atom in complex 1 is seven-coordinated by two bidentate chelating carboxylate groups and two nitrogen atoms as well as one water molecule. The adjacent Cd(II) atoms are bridged by two carboxylate groups to form 1D chains running along different directions, which are connected by BPP ligands to generate 2D network. The resulting 2D networks are further linked by hydrogen-bond interactions, affording a 3D supramolecular architecture. In complex 2 , the [Zn 2 (COO) 4 ] units are bridged by L 2− ligands to generate 1D double chain structure and then linked by BIB ligands to give 2D grid framework. In complex 3 , the [Cd(L 2 )] n and [Cd(BIB)] n helixes are alternately arranged, leading to the formation of a 2D bilayer structure.
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高影响因子
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