JOURNAL OF MOLECULAR LIQUIDS
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2024
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IF 5.3
Chen Wang,Yuran Gui,Meihui Wu,Tong Wu,Haiping Wang,Wanxia Gao,Jiang Zheng,Na Zhao,Yibin Zhang,Xiji Shu,Jinting Shang
Hydrogen sulfide (H₂S) is a colorless compound with a characteristic rotten egg odor that serves as a significant indicator of pathological processes and food spoilage. In this study, we developed a novel probe SCN for H 2 S detection. When exposed to H 2 S, the Probe SCN selectively cleaves the oxygen-nitrile bond, resulting in a strong red fluorescence emission at 662 nm, which can be attributed to recovery from the intramolecular charge transfer (ICT) effect. This probe demonstrated outstanding features, including a substantial Stokes shift (236 nm) and a low detection limit of 0.41 μM. We successfully used the Probe SCN to detect H 2 S changes in common food samples such as eggs, fish, pork, and shrimp. Furthermore, the Probe SCN can also be used to detect H 2 S in living cells and mice. These findings confirmed the effectiveness of the SCN probe as a real-time tool for H 2 S detection and related imaging applications.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Zhixin Jia,Jingbin Zhang,Zengtao Ji,Jiaran Zhang,Xinting Yang,Ce Shi,Xia Sun,Yemin Guo
Hydrogen sulfide (H 2 S) contamination of food has raised widespread public health concerns, leading to substantial medical and economic burdens. Herein, a 2D/0D heterojunction fluorescent probe (TCTG) with Schottky barriers (SB) is designed and synthesized, utilizing Ti 3 C 2 T x MXene-loaded graphene quantum dots (GQDs), for the detection of H 2 S during food spoilage. The microstructures observed through SEM and TEM reveal that uniformly sized GQDs are evenly attached to the surface of a monolayer Ti 3 C 2 T x . The chemisorption between GQDs and Ti 3 C 2 T x facilitates charge transfer and the formation of SB, resulting in intramolecular charge transfer (ICT) effects. With the introduction of H 2 S, TCTG (50%) exhibits the highest sensitivity, selectivity, and anti-interference properties, with ultra-fast fluorescence transient reaction (3s) and remarkably low detection limit of 41.82 ppb as well as noticeable color change. When TCTG (50%) reacted with H 2 S, the ICT effects are inhibited, leading to the recovery of photoinduced electron transfer (PET) and fluorescence quenching. Notably, probe TCTG is effectively utilized to detect changes in H 2 S levels in raw foods to assess their quality. Overall, the significance of this study is its potential to revolutionize food spoilage detection, offering a fast, reliable, and sensitive method to ensure food safety and reduce associated health and economic burdens.
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ACS Sensors
·
2024
·
IF 8.2
Yangyang Huo,Limin Qiu,Tianqi Wang,Hui Yu,Wenyuan Yang,Xiangting Dong,Ying Yang
The development of a portable, low-cost sensor capable of accurately detecting H2S gas in exhaled human breath at room temperature is highly anticipated in the fields of human health assessment and food spoilage evaluation. However, achieving outstanding gas sensing performance and applicability for flexible room-temperature operation with parts per billion H2S gas sensors still poses technical challenges. To address this issue, this study involves the in situ growth of MoS2 nanosheets on the surface of In2O3 fibers to construct a p–n heterojunction. The In2O3@MoS2-2 sensor exhibits a high response of 460.61 to 50 ppm of H2S gas at room temperature, which is 19.5 times higher than that of the pure In2O3 sensor and 322.1 times higher than that of pure MoS2. The In2O3@MoS2-2 also demonstrates a minimum detection limit of 3 ppb and maintains a stable response to H2S gas even after being bent 50 times at a 60° angle. These exceptional gas sensing properties are attributed to the increase in oxygen vacancies and chemisorbed oxygen on In2O3@MoS2-2 nanofibers as well as the formation of the p–n heterojunction, which modulates the heterojunction barrier. Furthermore, in this study, we successfully applied the In2O3@MoS2-2 sensor for oral disease and detection of food spoilage conditions, thereby providing new design insights for the development of portable exhaled gas sensors and gas sensors for evaluating food spoilage conditions at room temperature.
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Cell Chemical Biology
·
2020
·
IF 7.739
Giorgia Croppi,Yueyang Zhou,Rong Yang,Yunfei Bian,Mingtao Zhao,Youtian Hu,Benfang Helen Ruan,Jing Yu,Fang Wu
Summary H 2 S-producing enzymes in bacteria have been shown to be closely engaged in the process of microbial survival and antibiotic resistance. However, no inhibitors have been discovered for these enzymes, e.g., 3-mercaptopyruvate sulfurtransferase (MST). In the present study, we identified several classes of inhibitors for Escherichia coli MST (eMST) through high-throughput screening of ∼26,000 compounds. The thiazolidinedione-type inhibitors were found to selectively bind to Arg178 and Ser239 residues of eMST but hardly affected human MST. Moreover, the pioglitazone of this class concentration dependently accumulates the 3-mercaptopyruvate substrate and suppresses the H 2 S and reactive sulfane sulfur products in bacteria. Importantly, pioglitazone could potentiate the level of reactive oxygen species in cellulo and consequently enhance the antimicrobial effects of gentamicin and macrophages in culture. This study has identified the bioactive inhibitor of eMST, paving the way for the pharmacological targeting of eMST to synergistically control the survival of E. coli .
研究领域:
微生物学
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药理学
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细菌致病机制
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抗菌治疗
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Ning Shi,Yan Tong,Boyang Xu,Xiaohu Ge,Yueqiang Cao,Yu Han,Yunda Chen,Anxin Luo,Xiaochan Wang,Gang Liu,Xiande Zhao,Guo Zhao
Worldwide, approximately 1.3 billion tons of food are wasted yearly, with food spoilage accounting for up to one-third of the total. However, there is no effective way to monitor the freshness of fresh food. Here, a flexible, high-sensitive, wireless NFC-based sensor system for real-time assessment of fresh food freshness was developed by detecting H 2 S concentration changes (ppb-level) via a smartphone. A threshold adjustment theory (TAT) was proposed and optimized to relate NFC-tag sensor readability to H 2 S concentration, providing a practical solution for monitoring fresh food quality throughout the supply chain. The NFC-tag sensors were integrated into salmon packages and successfully used to monitor the freshness of salmon for five consecutive days at 0–5 °C. The salmon exhibited a response of 115.4 % by day 4 and was judged to be spoiled. This low-cost, miniature, wireless NFC-tag sensor is easy to integrate into food packaging and offers a promising solution for combating food spoilage and reducing wastage globally.
研究领域:
食品科学与技术
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传感器与检测技术
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无线通信
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智能包装
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食品安全
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JOURNAL OF CATALYSIS
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2025
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IF 6.5
Yu Tian,Haodi Yang,Fei Wang,Ping Ning,Kunlin Li,Kai Li
Increasing the oxygen vacancy (Ov) content and inducing lattice oxygen activation are critical for enhancing the oxidation performance of transition metal oxides. However, precisely regulating these properties remains a significant challenge. In this study, a stepwise pyrolysis method was employed on a colloidal complex formed by citric acid coordinated with Fe(NO 3 ) 3 ·9H 2 O to synthesize Fe 2 O 3 -X catalysts comprising a mixture of α- and γ-Fe 2 O 3 characterized by abundant surface oxygen vacancies and activated lattice oxygen. The resulting Fe 2 O 3 -1 presented excellent low-temperature H 2 S selective catalytic oxidation (H 2 S-SCO) performance, achieving selective oxidation of H 2 S at 130°C with removal efficiency and sulfur selectivity exceeding 95 % and 85 %, respectively, within 60 h. Characterization results show that the γ-Fe 2 O 3 induced by citric acid forms a crystal interface with the α-Fe 2 O 3 . At the interface, the asymmetrically coordinated lattice oxygen is more likely to be released from the catalyst, thereby enhancing the oxidation ability of the catalyst. Furthermore, the synthesis method effectively modulates the catalyst’s surface basicity, resulting in an optimal distribution of basic sites that mitigates catalyst poisoning and deactivation. This study presents a straightforward approach for synthesizing Fe 2 O 3 catalysts with enhanced oxidation ability, offering valuable insights for developing more efficient transition metal catalysts.
研究领域:
催化化学
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环境化学
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材料科学
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无机化学
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 9
·612
·
IF 5.4
Zhang Ning,Hu Xuelian,Guo Shuaijie,Lu Yiwei,Tang Yiwei,Wang Shuo,Ma Tianyi
Multi-modal sensing platforms have gained significant attention due to enhanced accuracy and self-calibration capabilities, particularly within complex matrices. Targeting the demand for the real-time detection of the food spoilage marker hydrogen sulfide (H 2 S), we introduce a triple-mode sensing platform engineered via 3,4-dihydroxyhydrocinnamic-acid-directed interfacial assembly of flower-like MOF@UCNPs heterostructures that synergize intense up-conversion luminescence with potent peroxidase-mimetic activity. Sulfide selectively coordinates with the Cu 2+ nodes embedded in the MOF, concurrently (i) shutting down nanozyme catalysis, (ii) restoring up-conversion emission, and (iii) attenuating UV–vis absorbance; complementary RGB alterations captured by a smartphone furnish the third read-out. The assay delivers limits of detection of 0.06 μM (fluorescence), 0.22 μM (absorbance) and 0.90 μM (RGB imaging) with excellent linearity, and achieves satisfactory recoveries in complex food matrices. By tracking H 2 S released from meat and eggs stored at different temperatures, real-time freshness assessment is realized on a smartphone. This work not only provides a robust food freshness monitoring tool but also offers a versatile blueprint for rational design of multifunctional nanomaterials toward point-of-need analyte detection. Graphical
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SENSORS AND ACTUATORS B-CHEMICAL
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2024
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IF 8
Qian Wang,Wenting Zhang,Mingzhe Cai,Yafei Ma,Ajuan Yu,Sheng Chen,Shusheng Zhang
The reactive sulfur species (RSS), in particular Cys, Hcy , GSH, and H 2 S, play an essential role in lots of critical physiological and pathological processes. To elucidate their complex interrelationships in signaling and metabolic pathways, suitable molecular tools to simultaneously distinguish Cys, Hcy , GSH, and H 2 S are urgently needed. Herein, we developed a novel cascade reaction-assisted trinal-site fluorescent probe BCS by connecting three functional fragments for simultaneously distinguishing Cys, Hcy , GSH, and H 2 S. The probe BCS exhibited red fluorescence in the absence of the four biological RSS. However, with the attendance of Cys, Hcy , GSH, and H 2 S, the probe showed different fluorescence patterns, including blue, blue/red, green/red, and no fluorescence, respectively. More importantly, based on the different RSS-induced fluorescence patterns and multi-color fluorescence imaging, probe BCS was used to discriminate and visualize all four biological RSS in both HepG2 cells and zebrafish. It is expected that probe BCS will have applications in the diagnosis and research of RSS-related diseases in the future.
研究领域:
生物化学
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分子生物学
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医学诊断
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2023
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IF 5.8
Liqun Jiang,Ziyao Wang,Yan Wang,Shuo Liu,Ya Xu,Cong Zhang,Lei Li,Sujia Si,Bingmei Yao,Wenjin Dai,Huiyang Li
The re-education of tumor-associated macrophages (TAMs) is an effective strategy to inhibit the growth and metastasis of lung cancer. We have reported that chitosan could re-educate the TAMs and then inhibit cancer metastasis; however, the re-exposure of chitosan from the chemical corona on their surface is critical for this effect. In this study, a strategy was proposed to re-expose the chitosan from chemical corona, and a sustained H 2 S generation was applied to enhance the immunotherapy of chitosan. To achieve this objective, an inhalable microsphere (namely F/Fm) was designed, which could be degraded by the matrix metalloproteinase in lung cancer, releasing two kinds of nanoparticles ; in an external magnetic field, these nanoparticles can aggregate with each other, and β-cyclodextrin on the surface of one nanoparticle can be hydrolyzed by amylase on the surface of another nanoparticle, leading to the re-exposure of chitosan in the inner layer of β-cyclodextrin and the release of diallyl trisulfide for H 2 S generation. In vitro , the expression of CD86 and secretion of TNF-α by TAMs was increased by F/Fm, proving the re-education of TAMs, and the apoptosis of A549 cells was promoted with the migration and invasion being inhibited. In the Lewis lung carcinoma-bearing mouse, the F/Fm re-educated the TAMs and provided a sustained generation of H 2 S in the region of lung cancer, effectively inhibiting the growth and metastasis of lung cancer cells. This work provides a new strategy for the treatment of lung cancer in combination of re-education of TAMs by chitosan and the adjuvant chemotherapy by H 2 S.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
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IF 5.8
Bo Zhou,Ben-Xu Jia,Ming-Jin Zhang,Yan-Jun Tan,Wei-Yuan Liang,Xiang Gan,Hong-Tao Li,Xiaoli Yang,Xing-Can Shen
Zn 2+ and H 2 S are essential to maintain normal prostate function, and sometimes can evolve into weapons to attack and destroy prostate cancer (PCa) cells. Nevertheless, how to achieve the targeted and effective release of Zn 2+ and H 2 S, and reverse the concentration distribution within PCa tumor cells still highly challenging. Herein, combined with these pathological characteristics of prostate, we proposed a tumor microenvironment (TME) responsive Zn 2+ -interference and H 2 S-mediated gas synergistic therapy strategy based on a nanoplatform of tannic acid (TA) modified zinc sulfide nanoparticles ( [email protected] ) for the specific treatment of PCa. Once the constructed pH-responsive [email protected] internalized by cancer cells, it would instantaneously decomposed in acidic TME, and explosively release excess Zn 2+ and H 2 S exceeding the cell self-regulation threshold. Meanwhile, the in situ produced Zn 2+ and H 2 S synergistic enhancement of cell apoptosis, which is evidenced to increase levels of Bax and Bax/Bcl-2 ratio, release of Cytochrome c in cancer cells, contributing to inhibit the growth of tumor. Moreover, the TA in cooperation with Zn 2+ specifically limits the migration and invasion of PCa cells. Both in vitro and in vivo results demonstrate that the Zn 2+ -interference in combination with H 2 S-mediated gas therapy achieves an excellent anti-tumor performance. Overall, this nanotheranostic synergistic therapy provides a promising direction for exploring new strategies for cancer treatment based on specific tumor pathological characteristics, and provides a new vision for promoting practical cancer therapy.
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JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Zhenhao Wang,Xi Jin,Weiqian Guo,Hongwei Liu,Tao Yang,Hui Zeng,Xiliang Luo
The endogenous hydrogen sulfide (H 2 S) can be adopted as an indicator for the indirect detection of sulphate-reducing bacteria (SRB), which considered to be closely related to pipeline corrosion and human intestinal health. Unfortunately, the in-situ detection of endogenous H 2 S from SRB in the complex culture medium still faces huge challenges. Besides nonspecific adsorption from the culture medium of SRB, the problem of electrode passivation by produced elemental sulfur during electrochemical detection processes of H 2 S cannot be ignored. To address these challenges, herein a synergistic sensing platform based on self-cleaning electrode interface and indirect detection strategy (specific H 2 S-induced chemical reaction) is developed. This indirect sensing strategy-assisted self-cleaning electrochemical platform showed a relatively good linear response toward H 2 S in the range of 0.5 − 5 μM, and the corresponding limit of detection (LOD) was calculated to be 5.09 nM. More importantly, the satisfactory self-cleaning electrode interface in indirect detection system (with only a 4.10% decrease in signal over 50 electrochemical repeated cycles) showed the electrode surface not being disturbed by elemental sulfur. Furthermore, this good selectivity of the indirect detection strategy in combination with the reproducibility, stability, and antifouling activity of the self-cleaning interface, enabled a synergistic sensing platform to detect H 2 S directly in the complex culture medium of SRB without time-consuming sample pretreatments . Moreover, this proposed construction strategy of synergetic sensing platform could be explored to other endogenous molecules in complex environment based on different antifouling materials and specific reactions.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Hao Fu,Guangqiang Liu,Haoming Bao,Le Zhou,Hongwen Zhang,Qian Zhao,Yue Li,Weiping Cai
Lead oxide (PbO) nanosheets are of significance in the design of functional devices. However, facile, green, and fast fabrication of ultrathin and homogenous PbO nanosheets with a chemically clean surface is still desirable. Herein, a simple and chemically clean route is developed for fabricating such nanosheets via laser ablation of a lead target in water for a short time and then ambient aging. The obtained PbO nanosheets are (002)-oriented with microsize in planar dimension and ∼15 nm in thickness. They are mostly hexagonal in shape. Experimental observations of the morphological evolution have revealed that the formation of such PbO nanosheets can be attributed to two processes: (i) laser ablation-induced formation of ultrafine Pb and PbO nanoparticles (NPs) and (ii) PbO NP aggregation and their oriented connection growth. Importantly, a composite surface-enhanced Raman spectroscopy (SERS) chip is designed and fabricated by covering a PbO nanosheet monolayer on a Au NP film. Such a composite SERS chip can be used for the fast and trace detection of gaseous H2S in which the PbO nanosheets can effectively chemically trap H2S molecules, demonstrating a new application of these PbO nanosheets. The response of this chip to H2S can be detected within 10 s, and the detection limit is below 1 ppb. Also, this PbO nanosheet-based chip is reusable by heating after use. This study not only deepens the understanding of the NP-based formation mechanism of nanosheets but also provides the renewable SERS chips for the highly efficient detection of trace gaseous H2S.
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危险品化学品经营许可证（带存储）