Small
·
2023
·
IF 13.3
Hualin Jiang,Yunjie Yu,Xueqing Duan,Pinghua Chen,Shuai Wang,Xianhua Qiu,Long Ye,Xinman Tu
The rational design of inexpensive metal electrocatalysts with exciting catalytic activity for overall water splitting (OWS) remains a significant challenge. Heterostructures of NiFe layered double hydroxides (NiFe-LDHs) with abundant oxygen defects and tunable electronic properties have garnered considerable attention. Here, a self-supporting heterostructured catalyst (named MoO 3 /NiFe-NF) is synthesized via a hydrothermal method to grow NiFe-LDH with oxygen vacancies (O V ) in situ on inexpensive nickel foam (NF). Subsequently, MoO 3 is anchored and grown on the surface of NiFe-LDH by electrodeposition. The obtained catalysts achieved outstanding oxygen/hydrogen evolution reaction (OER/HER, 212 mV/85 mV@10 mA cm −2 ) performance in 1 m KOH. Additionally, when MoO 3 /NiFe-NF is utilized as the cathode and anode in OWS, a current density of 10 mA cm −2 can be obtained as an ultralow battery voltage of 1.43 V, a significantly lower value compared to the commercial electrolyzer incorporating Pt/C and IrO 2 electrode materials. Finally, density functional theory (DFT) calculations and advanced spectroscopy technology are conducted to reveal the effects of heterojunctions and O V on the internal electronic structure of the electrical catalysts. Mainly, the present study provides a novel tactic for the rational design of remarkable, low-cost NiFe-LDH electrocatalysts with heterostructures for OWS.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EXPERIMENTAL BIOLOGY AND MEDICINE
·
2023
·
IF 3.2
Jinhong Tian,Shuaishuai Zhang,Lu Li,Xueman Lin,Yongmei Li,Kunlu Zhao,Fengxin Zheng,Yongjun Chen,Yang Yang,Ting Wu,Jianxin Pang
Excessive acetaminophen (APAP) application is a major cause of drug-induced liver injury (DILI). Febuxostat (Feb), a drug for reducing uric acid (UA) levels, was demonstrated to relieve hepatic inflammation and reverse organ functions. However, the effect of Feb on APAP-induced DILI and its mechanisms have not been fully explored. In this study, Feb (10 mg/kg) was given to mice by gavage 1 h after APAP (300 mg/kg, i.g.) induction. Serum and liver samples were collected 12 or 3 h after APAP challenge. Feb treatment was found to remarkably improve APAP-induced DILI, as evidenced by reduced serum ALT, AST and UA levels, pathomorphology, inflammatory, and oxidative responses. Consistently, treatment with Feb also reduced the cell injury induced by APAP in LO2 cells. Mechanistically, Feb induced GPX4 expression, activated the Keap1/Nrf2 pathway, and inhibited the TLR4/NF-κB p65 pathway. Feb also inhibited glutathione (GSH) depletion and Jun N-terminal kinase (JNK) activation in the early injury phase. Notably, pretreatment with Feb for 3 days also revealed preventive effects against APAP-induced DILI in mice. Overall, our data revealed a potential health impact of Feb on APAP-mediated DILI in vivo and in vitro, suggesting that Feb might be a potential candidate for treating DILI.
✓ 已验证
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 48
·18342-18353
·
IF 4
Minghao Dou,Mengjie Yao,Kai Ding,Yuye Cheng,Hongyu Shao,Shenjie Li,Yanyan Chen
Heterostructures formed by combining semiconductor materials with different band structures can provide work functions, d-band positions and electronic properties different from bulk materials and are considered as an effective strategy to improve the catalytic activity through electronic modification. In this study, an efficient MoS2/Fe-Ni3S2/NF heterojunction material was prepared by a two-step hydrothermal method. With the help of flake Ni(OH)2 synthesized in the first step, growth sites were provided for flake Ni3S2. The electronic structure of Ni3S2 was optimized by Fe doping, while the construction of the MoS2/Fe-Ni3S2 heterostructure allowed the catalyst to expose more active sites. MoS2/Fe-Ni3S2/NF exhibited a small charge transfer resistance and excellent electrocatalytic performance. At a current density of 10 mA cm−2, only low overpotentials of 148 mV and 118 mV were required for the oxygen precipitation reaction (OER) and hydrogen precipitation reaction (HER), respectively. Notably, when MoS2/Fe-Ni3S2/NF is used as the anode and cathode for overall hydrolysis, only 1.51 V is required to reach a current density of 10 mA cm−2, demonstrating its great potential for application in hydrolysis. This work provides a feasible idea for the rational construction of non-precious metal bifunctional electrocatalysts with excellent performance.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 47
·17826-17833
·
IF 4
Yixuan Li,Peiyan Li,Jiahui Jiang,Ting Zhao,Guancheng Xu,Li Zhang
A self-derivation strategy using conductive substrates is used to prepare one-piece highly efficient bifunctional electrodes, where the chosen substrate acts as both an active catalyst precursor and a conductive carrier. Here, a bifunctional catalyst, porous NiS/Ni9S8/NF-2 nanorods, was synthesized by low-temperature vulcanization after an oxalic acid etching process. To reach a current density of 10 mA cm−2, NiS/Ni9S8/NF-2 requires only a tiny overpotential of 115 mV for the HER and 176 mV for the OER, and demonstrates sustained activity for 100 hours with almost any degradation. The substrate self-derived NiS/Ni9S8/NF-2 catalyst for overall water splitting requires only a small voltage of 1.52 V to deliver 10 mA cm−2 with excellent stability. Experimental results show that the heterostructured electrocatalysts impart good catalytic properties of NiS/Ni9S8/NF-2 by modulating the electronic structure and promoting the reconstruction process from sulfides to hydroxides. This work demonstrates the success of the substrate self-derivation strategy to achieve high catalytic activity and provide a new autogenous growth technique for electrode fabrication.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Ning Lv,Huitao Li,Jinjuan Dong,Xianrui Liu,Tianbao Li,Jujie Luo
Bi nanoflakes on Ni foam (NF) for supercapacitors (SCs) are prepared by simple one-step microwave irradiation without further calcination. XRD and XPS results reveal the successful synthesis of Bi crystal. SEM and EDS results uncover the growth of Bi and the constituent elements of the complexes. The Bi anode on NF (Bi/NF) not only enables an ultra-large specific capacity of 4651 F g −1 (1 A g −1 ) and a capacity maintenance rate of 75% (after 1000 cycles), but it also exhibits outstanding catalytic hydrogen precipitation reaction, reaching an overpotential of −136 mV versus the reversible hydrogen electrode at −10 mA cm −2 and Tafel slope of 114.4 mV dec −1 . The Bi anode is gathered into the asymmetric SC, which demonstrates an ultra-high energy density of 125 Wh kg −1 (power density of 640 W kg −1 ) in an alkaline electrolyte.
✓ 已验证
产品关联
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2023
·
IF 4.1
Xinyu Liu,Qianqian Fu,Zhichao Li,Hui Wang,Jianwei Ren
To address the growing demand for efficient and stable energy storage in the context of green energy, in this study, an acid etching method was employed to in-situ grow Ni(OH) 2 nanosheet arrays on a nickel foam (NF) substrate. Subsequently, negatively charged Ti 3 C 2 T x MXene nanosheets were electrophoretically deposited onto the Ni(OH) 2 /NF surface to result in a MXene/Ni(OH) 2 /NF composite electrode material. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations revealed the homogeneous dispersion distribution of nanosheets on the material surface. The composite material exhibited high electrical conductivity and good hydrophilicity by rapid water infiltration within 150 ms. Furthermore, the Motte-Schottky effect establishes a distinctive pathway for electron transfer , which leads to the creation of electron vacancies or ‘holes’ on the MXene surface. This phenomenon significantly boosts MXene's electrochemical activity and enhances its affinity for OH − ions in the electrolyte, which consequently improves the performance of electrochemical capacitors . Electrochemical tests verified that the prepared MXene/Ni(OH) 2 /NF electrode displayed an areal specific capacitance of 0.223 mAh cm −2 at a current density of 1 mA cm −2 . The electrode displayed excellent rate performance with a capacity retention rate of 71 % when the current density was increased by five times. In addition, the assembled asymmetric capacitor with MXene/Ni(OH) 2 /NF electrode demonstrated an excellent cycling stability with only a 16.38 % capacity loss after 5000 cycles. It also exhibited the remarkable specific capacitance and long-term stability by achieving a high energy density of 43.68 Wh kg −1 and a power density of 424.96 W kg −1 . These results highlight the electrode's exceptional performance in terms of energy storage and power delivery.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 19
·14771
·
IF 5.6
Pan Lei,Zhiyang Li,Qiuwei Hua,Ping Song,Lun Gao,Long Zhou,Qiang Cai
The neuroinflammatory response after intracerebral hemorrhage (ICH) causes a large amount of neuronal loss, and inhibiting the inflammatory response can improve the prognosis. In previous laboratory studies and clinical trials, ursolic acid (UA) inhibited the inflammatory response, but whether it can be administered to inhibit the neuroinflammatory response after cerebral hemorrhage is unknown. The aim of this study was to investigate the effects of ursolic acid after cerebral hemorrhage. Online databases were used to obtain potential therapeutic targets of ursolic acid for the treatment of cerebral hemorrhage, and possible mechanisms were analyzed by KEGG, GO, and molecular docking. A rat model of cerebral hemorrhage was established using collagenase, and an in vitro cerebral hemorrhage model was constructed by adding hemin to BV2 cell culture medium. Enzyme-linked immunosorbent assay (ELISA), Western blotting (WB), immunofluorescence, TUNEL staining, and calcein/PI staining were used to investigate the degree of microglial M1 polarization, changes in the levels of inflammatory factors, activation of the NF-κB pathway, and changes in the indicators of cellular death after ursolic acid treatment. In addition, phorbol 12-myristate 13-acetate (PMA) was used to activate the NF-κB pathway to verify that ursolic acid exerts its anti-neuroinflammatory effects by regulating the NF-κB/NLRP3/GSDMD pathway. Network pharmacology and bioinformatics analyses revealed that ursolic acid may exert its therapeutic effects on cerebral hemorrhage through multiple pathways. Together, in vivo and in vitro experiments showed that ursolic acid inhibited microglial M1 polarization and significantly reduced the levels of p-NF-κB, GSDMD-N, cleaved caspase-1, TNF-α, IL-6, and IL-1β, which were significantly inhibited by the use of PMA. Ursolic acid inhibits microglial pyroptosis via the NF-κB/NLRP3/GSDMD pathway to alleviate neuroinflammatory responses after cerebral hemorrhage.Keywords:ursolic acid;neuroinflammation;cerebral hemorrhage;microglial;pyroptosis
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2023
·
IF 6.7
Yihang Wu,Zixiu Liu,Zhenxiu He,Jumei Yi,Xingfang Qiao,Chunbin Tan,Yajing Xing,Yaobo Zeng,Dajian Yang,Junlin Yin,Baomin Fan,Guangzhi Zeng
Ulcerative colitis is a chronic inflammatory disease with a remitting-relapsing clinical course, it has evolved into a global burden given its high incidence worldwide. Cantharidin (CTD) derivatives are a class of compounds whose structures characterized with a 7-oxabicyclo [2.2.1]heptane core. Though potent cytotoxicity CTD and its derivatives showed, their clinical usage as anti-cancer drugs was limited by the toxicity in organs. In order to find new CTD analogues with good activity and lower toxicity, 21 CTD analogues with or without alkynyl substitution at C5 position of 7-oxabicyclo [2.2.1]heptane core were synthesized, some compounds showed better in vitro anti-inflammatory activity compared to CTD and norcantharidin (NCTD). Based on the structure-activity relationship results of in vitro experiment, analogue 3i was chosen for further study. Results from the acute toxicity in mice showed that 3i was hypotoxic with the single-dose MTD (maximum tolerated dose) for oral administration is over 1852 mg/kg, at least 35-fold lower than that of NCTD. Mechanism study indicated that 3i could potently inhibit TNF-α induced activation of NF-κB signaling by down-regulation the expression levels of phosphor- IKK, IκBα , and NF-κB p65 , and alleviated dextran sulfate sodium-induced colitis in mice. This study indicated that CTD analogues with alkynyl substitution at C5 position of 7-oxabicyclo [2.2.1]heptane core is a kind of new compounds with good anti-inflammatory activity and lower toxicity in vivo, and might be used as therapeutic agents for inflammatory diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Shaojie Zhang,Qian Zhang,Chong Li,Na Xing,Pengfei Zhou,Yukun Jiao
Anemarrhena asphodeloides polysaccharide (AAP70–1) was reported to have immunomodulatory effects in our previous report. To further improve the immunomodulatory effects of AAP70–1, an A. asphodeloides polysaccharide-zinc complex (AAP-Zn) was synthesized using a ZnCl 2 modification method, and the potential mechanisms by which AAP-Zn activates macrophages were investigated. The results showed that the structural features of AAP-Zn were similar to those of AAP70–1 with a Zn content of 0.2 %, confirming that Zn mainly interacted with AAP70–1 by forming Zn O coordination bonds and Zn…OH bonds. In addition, the administration of AAP70–1 and AAP-Zn effectively improved the immunomodulatory effects by enhancing phagocytosis and upregulating the mRNA expression of cytokines (TNF- α , IL-6, IL-1 β , and IL-18), as well as increasing the production levels of nitric oxide (NO) and reactive oxygen species (ROS) in zebrafish embryos. The intracellular mechanism by which AAP-Zn activates macrophages was found to involve activation of the NF- κ B and MAPK signaling pathways. Our findings suggest that AAP-Zn may be a potential immunopotentiator in the field of biomedicine or functional foods.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2023
·
IF 7.8
Yue Zong,Song Su,Ruijun Zhang,Yan Sun,Jiayu Tian,Bart Van der Bruggen
How to simultaneously improve the water permeance and antibiotics/minerals selectivity is one of the key issues for promoting the efficiency of drinking water treatment with nanofiltration (NF) technology . In this study, the post-treatment with a ternary complex of ethanol-water-NaOH (denoted as EWN) was used on four commercial NF membranes (NF270, NF90, HS-200C, and DF100) to understand its modification mechanism and promote the tetracycline removal efficiency. It was confirmed that the polyamide layers of all four commercial NF membranes were thinner after EWN post-treatment along with a slight increase in the pore size and enhancement in hydrophilicity and electronegativity . As a result, the water permeation of NF270 was improved by 70% and that of the other three membranes was increased by 19–20% while keeping a high tetracycline rejection of over 99%. Simultaneously, mineral ions such as K + , Ca 2+ , Mg 2+ , and Cl - passed the post-treated commercial NF membranes more easily. This yields a facile strategy for the performance regulation of existing, or commercial NF membranes.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 10
·8682
·
IF 5.6
Zijiao Zhang,Juhan Song,Seung-Hee Kwon,Zhao Wang,Suk-Gyun Park,Xianyu Piao,Je-Hwang Ryu,Nacksung Kim,Ok-Su Kim,Sun-Hun Kim,Jeong-Tae Koh
There has been increasing interest in adjunctive use of anti-inflammatory drugs to control periodontitis. This study was performed to examine the effects of pirfenidone (PFD) on alveolar bone loss in ligature-induced periodontitis in mice and identify the relevant mechanisms. Experimental periodontitis was established by ligating the unilateral maxillary second molar for 7 days in mice (n = 8 per group), and PFD was administered daily via intraperitoneal injection. The micro-computed tomography and histology analyses were performed to determine changes in the alveolar bone following the PFD administration. For in vitro analysis, bone marrow macrophages (BMMs) were isolated from mice and cultured with PFD in the presence of RANKL or LPS. The effectiveness of PFD on osteoclastogenesis, inflammatory cytokine expression, and NF-κB activation was determined with RT-PCR, Western blot, and immunofluorescence analyses. PFD treatment significantly inhibited the ligature-induced alveolar bone loss, with decreases in TRAP-positive osteoclasts and expression of inflammatory cytokines in mice. In cultured BMM cells, PFD also inhibited RANKL-induced osteoclast differentiation and LPS-induced proinflammatory cytokine (IL-1β, IL-6, TNF-a) expression via suppressing the NF-κB signal pathway. These results suggest that PFD can suppress periodontitis progression by inhibiting osteoclastogenesis and inflammatory cytokine production via inhibiting the NF-κB signal pathway, and it may be a promising candidate for controlling periodontitis.Keywords:pirfenidone;periodontitis;osteoclast differentiation;alveolar bone loss;inflammation;NF-κB pathway
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Meng Zhu,Dong-Xing Tan,Xiang-Yu Wang,Qing-Nan Bian,Ben-Shuai Guo,Yan-Min Liu,Gao Deng,Yuan-Yuan Feng
Water electrolysis to produce high-purity hydrogen has been regarded as the most promising and attractive method for renewable energy production. The intrinsic high kinetic barrier of the involved electrode reactions, especially that of the anodic oxygen evolution reaction (OER), however severely hinders the application of the water electrolysis technology for large scale hydrogen production. In this paper, a nano-composite Fe- and Co-based material containing crystalline metal sulfide ((NiFeCo)S) and amorphous metal phosphide ((FeCo)P) was in-situ grown on the surface of foam nickel (NF). The (FC)P-(NFC)S/NF catalyst exhibits ultra-high activities for OER at high current densities in 1.0 M KOH, delivering 500 and 1000 mA cm −2 at ultralow overpotentials of 274 and 280 mV, respectively with a small Tafel slope of 37.8 mV dec −1 . The excellent catalytic activities of (FC)P-(NFC)S/NF far exceed those of the reference single-component (FC)P/NF and (NFC)S/NF catalysts, and also exceed those of most non-noble metal catalysts reported in literature. Besides, the (FC)P-(NFC)S/NF catalyst exhibits high stability with almost no significant activity attenuation after the chronopotentiometric test at both 100 and 500 mA cm −2 for 40 h. The synergistic effects between the metal sulfide and metal phosphide have positive impacts on the OER activity through increasing the surface area, enhancing the reactivity of each active site, improving the electrical conductivity as well as the interface between the crystalline and amorphous phases. The present work provides a new strategy to develop cost-effective and efficient electrocatalysts toward OER and water electrolysis.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）