INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Bolin Lian,Yuanyuan Li,Qilei Yang,Lanlan Xie,Qian Zhang,Yanjie Liu,Xiuhua Zhao,Shujun Li
Phloretin loaded porous starch (Ph-PS) were prepared for its application in food. The effects of Ph-PS in vitro release and its ability against AAPH-induced oxidative stress in vivo zebrafish model were investigated. Ph-PS was prepared by absorption method, the physical and chemical characterization showed that PS decreased the crystallinity of Ph obviously. Ph-PS exhibited higher release amount and faster release rate of Ph compared to free Ph in vitro release study. What's more, the effect of Ph-PS reduced ROS generation and lipid peroxidation was better than that of free Ph in zebrafish model. These findings suggest Ph-PS is a new and simple strategy to improve dissolution rate and antioxidant ability of Ph.
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DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Liping Rong,Xiaohui Fan,Gang Wang,Huanhuan Li,Dayong Zhang,Danni Luo,Sheng Li,Zhiguo Li
Improving the bond strength of wood emulsion adhesives is an ongoing challenge for the wood-processing industry. In this study, PVAc/PS core-shell emulsion particles are functionalized by forming coordination complexes between natural biomaterial tannic acid (TA) and Fe 3+ . The functionalized emulsion particles are assembled on the surface of the core template SiO 2 to form a “superstructure” through hydrogen bonding between the phenolic hydroxyl groups in the TA and the hydroxyl groups on the surface of SiO 2 , which can enhance the cohesive strength of the emulsion adhesive layer, thereby increasing the peel strength of wood adhesives. The results indicated that the functionalized emulsion particles were most effectively assembled on core template SiO 2 particles when the ratio of TA to Fe 3+ was 1:1 and the encapsulation rate of the assembled SiO 2 particles was 150 %. The glass transition temperatures (Tg1 and Tg2), storage modulus, tensile strength, and hardness of the assembled PVAc/PS emulsion film were measured by DSC, DMA, tensile testing machine, and durometer. These properties increased by 11.6 %, 5.3 %, 14.9 %, 127.6 %, and 46.3 %, respectively, compared to those of the PVAc/PS emulsion film. Further, the shear strength of the assembled PVAc/PS emulsion for bonding wood blocks and the peel strength for bonding thin veneers increased by 33.8 and 35.7 %, respectively, compared to those of the PVAc/PS emulsion. This study confirmed that using a modular assembly to improve PVAc/PS emulsion bonding properties can help formulate high-performance waterborne emulsion adhesives with promising applications in the field of thin-wood veneer bonding. This strategy provides an effective method to design and build environmentally friendly, low-cost, and high-performance water-based emulsion adhesives.
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高影响因子
POLYMER
·
2017
·
IF 3.684
Yuanyuan Tao,Hanying Zhao
Shell-sheddable polymeric assemblies are a type of self-assembled structures formed by amphiphilic block copolymers with cleavable linkages at the junction points. The shell-sheddable self-assemblies have been used as nanocarriers for drugs and inorganic nanoparticles . In this research, synthesis and self-assembly of amphiphilic tadpole-shaped block copolymer with disulfide bonds at the junction points were investigated. Dialkyne-terminated polystyrene (Da-PS) was synthesized by reversible addition-fragmentation chain transfer polymerization and thiol-disulfide exchange reaction. The tadpole-shaped block copolymer was synthesized by bimolecular coupling between azido-terminated PEG and Da-PS. Size exclusion chromatograph , FTIR, 1 H NMR and matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass analysis results all indicated successful synthesis of the polymer. The tadpole-shaped block copolymer self-assembles into vesicles in aqueous solution. The disulfide bonds at the junction points can be cleaved by a reducing agent, resulting in aggregation of the assemblies.
研究领域:
材料科学
·
药物递送系统
·
高分子化学
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yingjie Zhan,Kun Wu
Polystyrene (PS) nanospheres are non-covalently modified by PDDA, and a series of flexible nanocomposite films are fabricated with MXene nanosheets through electrostatic self-assembly and further hot-pressing. Due to the strong surface reactivity and the large specific surface area of the f-PS nanospheres, they are completely encapsulated by MXene nanosheets by serval interaction forces. This prevents the MXene nanosheet defect of easily stacked and agglomerated and maximizes the high thermal conductivity of MXene. SEM characterization verifies that a compact and long-range ordered thermal conductive path is formed in the microstructure of the nanocomposite film, as well as effectively improves interface compatibility, and reduces the generation of interfacial thermal resistance. At the same time, combined with the morphology results of the prepared nanostructures, the effects on thermal conductivity, flame retardant properties and mechanical properties are analyzed in detail. When the amount of filler is 90 wt%, the in-plane thermal conductivity increases dramatically to 40.39 W m −1 K −1 , which is 74.8 times that of f-PS. What's more, the 90M/f-PS nanocomposite film exhibited satisfactory flame retardancy and thermostability, decreasing the PHRR from 300 to 58 W g −1 and 70.0 wt% residue. This study provides a facile route for the design of thermal management interface materials with high thermal conductivity and flame retardant properties.
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高影响因子
JOURNAL OF LUMINESCENCE
·
2026
·
IF 3.8
Hongjian Chen,Huanjiang Niu,Yunpeng Wang,Jiannan Jia,Songle Wang,Yuwen Yuan,Pragati Awasthi,Xvsheng Qiao,Shisheng Ling,Zhenzhen Ge,Dong Chen,Wenkun Dong,Guodong Qian,Xianping Fan,Yubing Dong
Lanthanide complexes based fluorescent microspheres are widely used in lateral flow immunoassay (LFIA) measurements of small melecules, such as methamphetamine (MET), due to their efficient fluorescence. However, the easily occurred aggregation of lanthanide complexes often leads to concentration quenching effect of fluorescence, which severely deteriorate the biodetection performance of fluorescent microspheres. Here, in order to optimize the distribution of lanthanide complexes, the crosslinked agent dimethacrylate (EGDMA) is introduced in the microspheres polymerization. By adjusting the concentration of EGDMA, the aggregation of lanthanide complexes is reduced, which inhibits fluorescence quenching effect and enhances fluorescence intensity of the fluorescent microspheres. Such fluorescent microspheres thus achieve highly sensitive detection of MET, with showing a detection limit of 0.048 ng mL −1 with excellent stability. This study provides a new idea for the optimal design of lanthanide complexes dispersed fluorescent latex beads, which is expected to promote the development of advanced In Vitro Diagnostics (IVD) technologies to rapid and precise screening of small molecules.
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高影响因子
Neurochemical Journal
·
2026
·Vol. 20
·期 1
·97-112
·
IF 0.6
Lifang Li,He Xiaoyi,Zhang Jiaqi,Wang Xiao,Li Guoying,Yang Junhua
Mild traumatic brain injury (mTBI) originates from tensile injury of axons caused by rapid forces. ATPase phospholipid transporting 8A2 (ATP8A2) maintains membrane asymmetry, and its dysregulation leads to phosphatidylserine (PS) exposure. Neuronal injury induced by ATP8A2 mutation or knockout resembles the pathological phenotype of mTBI, indicating its involvement in the pathological process of mTBI. Given that the PS/MFG-E8/VNR pathway mediates microglial phagocytosis, this study aimed to investigate whether blocking VNR can alleviate mTBI-induced synaptic loss and cognitive impairments, and clarify the underlying mechanism. We induced traumatic brain injury (TBI) in C57BL/6J mice using a weight-drop model, assessed neurological function by neurological deficit scoring (NSS) at 4 h, 1 day and 3 days after injury, and detected brain edema, neuroinflammation, pathological changes and by brain water content measurement, ELISA, HE staining, immunofluorescence and Western blotting. Cerebral edema, neuroinflammation, pathological changes and ATP8A2, microglia and synapse-related proteins were detected by ELISA, HE staining, immunofluorescence and Western blotting. Blocking the VNR receptor altered the outcomes of synaptic loss and cognitive behavioral abnormalities, but did not change the result of increased inflammatory factor levels in the prefrontal cortex. Blocking the PS/MFG-E8/VNR pathway promotes cognitive functional recovery in mTBI model mice by inhibiting microglial phagocytosis of synapses in the prefrontal cortex.
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高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2018
·
IF 2.891
Hui Ran,Zheng-zhong Lin,Cheng-yi Hong,Jun Zeng,Qiu-Hong Yao,Zhi-Yong Huang
Rapid detection of malachite green (MG) by fluorescence probes of CdTe quantum dots (QDs) coated with molecularly imprinted polymer (MIP) has been reported, but low sensitivity, slow response and narrow linear range were the main disadvantages for these MIP@QDs probes. Here, an ultra-sensitive ratiometric fluorescence probe based on self-assembly functionalized polystyrene (PS) and core-shell structured MIP was developed for the detection of MG in fish. After modified with poly(diallyldimethylammonium chloride) and hexadecyl trimethyl ammonium bromide, CdTe QDs and silica encapsulated carbon quantum dots (CDs@SiO 2 ) with negative charges, used as detection and reference fluorophores, were respectively self-assembled on the surface of PS to form PS-QDs&CDs. And a core-shell structured MIP layer was fabricated on the surface of PS-QDs&CDs to form a ratiometric fluorescence probe of MIP@PS-QDs&CDs with sol-gel method using MG, (3-aminopropyl)triethoxy-silan and tetraethyl orthosilicate as template, functional monomer and cross-linker, respectively. With intensive fluorescence densities of QDs&CDs in nucleus, the fluorescence emission of probe at λ em of 630 nm could be linearly quenched by MG, while the fluorescence emission at λ em of 430 nm remained unchanged. The probe of MIP@PS-QDs&CDs owned good fluorescence stability (RSD ≤2.3%), fast response time (5 min), wide linear range (0.1–32 μmol L −1 ) and low detection limit (5.6 μg kg −1 ), and has been applied to the detection of MG in fish samples with recoveries of 94.3–110.2%. The result validated that the as-prepared probe of MIP@PS-QDs&CDs had an excellent performance for MG detection in fish samples.
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高影响因子
COMPOSITES COMMUNICATIONS
·
2020
·
IF 4.915
Yanlin Li,Wenyuan Duan,Ai Fujisaka,Toshihiro Moriga,Xuegang Lu,Sen Yang
Monodisperse Fe 3 O 4 @PS colloidal particles with hollow core/shell structure and high saturation magnetization were successfully fabricated by a facile chemical approach. Owing to magnetic nature of iron oxide core and positively charged polystyrene shell, the colloidal particles in suspension assembled into ordered array and showed dual-response behavior to magnetic and electric field. When the cooperation between magnetic and electric field matched well, the photonic crystals showed better structural color and higher reflectivity . Consequently, as-synthesized Fe 3 O 4 @PS colloids have great potentials in some high-tech fields such as color sensors, color display, camouflage, electronic papers, and so on.
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高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2017
·Vol. 302
·期 11
·1700241
·
IF 2.863
Haiyang Liao,Haiyan Zhang,Gai Qin,Haoqun Hong,Zhenghui Li,Yingxi Lin,Liuqing Li
Thermal runaway is a hazardous behavior of lithium-ion batteries under extreme conditions and is mainly cause for restraint of its commercial applications in development of high-power and high-rate lithium-ion batteries. In this paper, a new dual-functions coating layer fabricated from polystyrene-poly(butyl acrylate) copolymer encapsulated silica nanoparticles as “thermal shutdown switch” with a reasonable shutdown temperature of ≈80 °C is designed and coated on polypropylene separator. The shell polymer owing to its self-adhesion upon glass transition temperature ( T g ) can retard off the Li + conduction between the electrodes, thus prevents cell from thermal runaway, the core nanoparticles protect the separator from significantly thermal shrinkage when the cell temperature keeps going up. Moreover, the coated separator has no negative affection on the normal electrochemical performance of the batteries, thereby implying that this coating layer provides a simple and effective approach to control the safety of commercial lithium-ion batteries by internal self-protecting.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2017
·
IF 5.951
Wenbo Du,Juan Guo,Huaming Li,Yong Gao
A kind of manipulative oil in water Pickering emulsion stabilized by heterogeneously modified cellulose nanocrystals (CNCs) and its application as a template for the creation of functional polystyrene microspheres were presented in this study. First, 18-carbon alkyl long chains were selectively introduced at the reducing ends of CNCs through a two-step chemical process including the hydrazone reaction and the amidation reaction. The as-obtained heterogeneously modified CNCs (CNC–C18) were then used as emulsifiers for the formation of oil in water Pickering emulsions. Compared with the pristine CNCs used in this study, CNC–C18 exhibited a high emulsifying performance. Highly stable oil in water Pickering emulsions could be formed at a low content of CNC–C18 nanoparticles. Because of the pH-responsive stability of the C═N bond linkages between 18-carbon alkyl chains and CNCs, the introduced 18-carbon alkyl chains could be cleaved completely at a suitable acid condition, and this endowed the formed Pickering emulsions with a pH-triggered de-emulsification character. Upon the replacement of n-hexane with a styrene/divinyl benezene mixed oil, cross-linked PS microspheres with amino-rich surfaces were created by the Pickering emulsion directed-radical copolymerization reaction, followed by acid treatment. The current work revealed CNCs could be used as a promising green and widely available resource for the fabrication of stimuli-responsive particle emulsifiers.
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高影响因子
ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2017
·Vol. 74
·期 4
·515-526
·
IF 2.467
Xiang Rong,Shi Junqiong,Yu Yi,Zhang Hongbo,Dong Congcong,Yang Yanjun,Wu Zhongxing
To investigate the effect of bisphenol A (BPA) on Cylindrospermopsis raciborskii (Cyanobacteria) and Scenedesmus quadricauda (Chlorophyta), we grew the two species at BPA concentrations of 0, 0.1, 1, 2, 5, 10, and 20 mg/L and examined their growth, lipid peroxidation, antioxidant enzyme activity, and chlorophyll a fluorescence. The 96-h EC 50 values (effective concentration causing 50% growth inhibition) for BPA in C. raciborskii and S. quadricauda were 9.663 ± 0.047, and 13.233 ± 0.069 mg/L, respectively. A significant reduction in chlorophyll a concentration was found in C. raciborskii and S. quadricauda when BPA concentrations were greater than 1 and 2 mg/L, respectively. Furthermore, F
v / F
m , Δ F / F
m ′, and qP decreased significantly at 10 mg/L BPA in C. raciborskii but started to decrease at 10 mg/L in S. quadricauda. The changes in chlorophyll fluorescence parameters ( α , rETR max ) that were obtained from the rapid light response curves of both algae species showed similar responses to F
v / F
m , Δ F / F
m ′, and qP under BPA-induced stress. Values for all of the chlorophyll fluorescence parameters in S. quadricauda were higher than in C. raciborskii ; however, the nonphotochemical quenching measured in C. raciborskii was considerably higher than it was in S. quadricauda . In addition, lipid peroxidation (determined as MDA content) and antioxidant enzyme activities (SOD and CAT) increased in both species as the BPA concentration increased. These results suggest that C. raciborskii is more sensitive to the effects of BPA than S. quadricauda and that photosystem II might be a target for the activity of BPA in vivo.
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PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Wenqian Zhang,Shengming Zhang,Samuel Knoedler,Wenhao Han,Kangkang Zha,Hui Li,Adriana Christine Panayi,Michael Alfertshofer,Bong-Sung Kim,Weixian Hu,Yanzhi Zhao,Qian Feng,Yuval Rinkevich,Bobin Mi,Guohui Liu
Efferocytosis is a critical process whereby macrophages residing in the wound area play a key role in the efficient clearing and degradation of apoptotic neutrophils. This process is followed by a phenotypic transition toward an anti-inflammatory state, essential for inflammation resolution and tissue repair. The cystine/glutamate antiporter SLC7A11 has recently been identified as an inhibitor of efferocytosis, and its blockade has been found to enhance wound healing. In this study, we demonstrated that tiliroside, a plant-derived glycoside containing flavones, binds directly to SLC7A11 and pyruvate kinase isozyme M2 (PKM2). This was established by molecular docking predictions and activity-based protein profiling (ABPP). Cytological experiments revealed that tiliroside promoted the process of efferocytosis and led to glycolysis-related macrophage reprogramming. To facilitate targeted drug delivery to macrophages at diabetic wound sites, we designed a novel hybrid biomaterial. This hybrid biomaterial, prepared as Gel@Til iRGD&PS@PLGA NPs is manufactured by loading tiliroside (Til)-conjugated iRGD&PS double modified lipid nanoparticles (iRGD&PS@PLGA NPs) into a pH-responsive hydrogel matrix. The administration of Gel@Til iRGD&PS@PLGA NPs in diabetic cutaneous wound models has been shown to significantly promote tissue regeneration through the promotion of efferocytosis and glycolysis-related macrophage reprogramming. Therefore, this study introduces a novel approach to diabetic wound management by leveraging the promotion of efferocytosis.
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高影响因子
危险品化学品经营许可证（带存储）