JOURNAL OF LIPID RESEARCH
·
2025
·
IF 4.1
Shaojun Pei,Wen Wang,Tingze Feng,Qiuping Wang,Yuhan Wang,Hong-Xu Liu,Xinmiao Liang,Hai-long Piao
S -palmitoylation is a dynamic and reversible post-translational modification that plays crucial roles in cancer progression. Here, we found the oncogene of metadherin (MTDH) modulates lipid metabolism and ferroptosis by its S -palmitoylation. We demonstrate that MTDH is S -palmitoylated at Cys-75 in the endoplasmic reticulum by ZDHHC1/9 and S -depalmitoylated by APT1. The flexible loop and the α-helix length in the MTDH N-terminus affect its S -palmitoylation level. In addition, metabolomics analysis found that the S -palmitoylated MTDH increases intracellular levels of triglycerides, phosphatidylethanolamines, and phosphatidylcholines. However, the non- S -palmitoylation form of MTDH-CS enhanced the interaction of between MTDH and the ferroptosis enhancer of Acyl-CoA synthetase long-chain family member 4 (ACSL4), thereby reducing ferroptosis sensitivity in breast cancer cell. Taken together, targeting MTDH S -palmitoylation may represent a novel strategy for breast cancer therapy.
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DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Daqiang Liu,Xingliang Yin,Leilei Li,Chuanwu Chen,Qiu-Xia Lin,Hong-Xin Zhang,Erkang Liu,Jun-Feng Wang
Ammonia is in high demand and widely used, yet its production still predominantly relies on the energy-intensive Haber–Bosch process, highlighting the urgent need for a milder alternative technology. Photocatalytic N2 fixation shows great promise in this regard despite the challenge of developing high-efficiency catalysts. In this study, we successfully prepared micronano spherical Bi2MoO6/Bi2MoO6–x S-Scheme homojunctions using a simple solvothermal-calcination coupling method, which offer unique advantages for nitrogen fixation catalysis: (i) the micronano structure mitigates the agglomeration issue common in nanomaterials, thereby exposing more active sites; (ii) the in situ constructed S-Scheme homojunction features a high-quality surface and interface structure, enhancing the spatial separation and transport of photogenerated charges and preserving strong redox capabilities; and (iii) the oxygen-rich vacancy structure promotes the N2 adsorption and activation. Thanks to those favorable properties, the Bi2MoO6/Bi2MoO6–x (BMO/BMOOV) S-Scheme homojunction demonstrates exceptional ammonia production efficiency, with a NH4+ generation rate of 238.7 μmol g–1 h–1 under simulated sunlight, which is over 5.2 times higher than that of pristine Bi2MoO6 (BMO) and significantly outperforms other reported similar catalytic systems (see Table S1). This work introduces a simple and versatile method for synthesizing homojunctions, potentially inspiring the development of more efficient photocatalysts for nitrogen fixation and beyond.
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PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Mengna Zhang,Gongshuai Song,Shitong Wang,Lijun Ge,Feijian Liu,Manman Zhang,Hujun Xie,Junli Feng,Qing Shen
Plasmalogens (Pls) are bioactive substances enriched in the brain with a regulatory effect on Alzheimer’s disease (AD), while their metabolomic influence accompanying AD and the underlying mechanisms remain unclear. Here, we extracted and purified Pls (purity of ≥90%) from mussels and applied unbiased metabolomics using ultraperformance liquid chromatography Q-Exactive Orbitrap mass spectrometry to analyze the variation of metabolites in the major metabolic pathways of AD and revealed the cognitive improvement effect of Pls using an experimental AD zebrafish model. The results showed that 37 differential endogenous metabolites were identified, among which glycerophosphocholine, choline, S-adenosylmethionine (SAM), l-glutamine, linoleic acid, 9(S)-HPODE, methionine, and creatine were the major abnormally regulated metabolites, and the first four metabolites were viewed as potential endogenous markers. This study suggested that systemic metabolic profiling could reveal the potential metabolic networks of AD and illuminated the protective effect of Pls on AD through biochemistry mechanisms and metabolic pathways.
研究领域:
神经生物学
·
代谢组学
·
药理学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Chucheng Zhou,Jinshan Wei,Yi Li,Hexing Lin,Ji Zhou,Ya-yun Li
Photocatalytic removal of antibiotic such as ciprofloxacin from polluted water is of great value for eco-environment protection. To further enhance the piezoelectric effect in photocatalysis, we designed and synthesized a ternary heterojunction piezoelectric photocatalyst through uniformly loading MoS 2 nanosheets onto BiFeO 3 (BFO) nanofibers, namely MoS 2 /Bi 2 S 3 /BFO. Piezoresponse force microscopy and Kelvin probe force microscopy demonstrated its enhanced piezoelectric properties, showing a maximum amplitude displacement of 395.51 pm under a voltage of 9.91 V and a surface potential difference of 66.50 mV. Finite element simulations indicated that the ternary heterojunction could achieve a larger piezoelectric potential. Piezoelectric photocatalytic degradation experiments revealed that MoS 2 /Bi 2 S 3 /BFO achieved a ciprofloxacin degradation efficiency of 96.6 % within 75 min, significantly higher than that of pure piezoelectric catalysis (25.5 %) and photocatalysis (60.5 %). Analysis of intermediate products and detection of active species ( OH and O 2 − ) during degradation suggested an S-Scheme migration pathway of photogenerated charge carriers, enhancing the piezoelectric photocatalytic performance of the material. This study provides an efficient ternary heterojunction composite piezoelectric photocatalyst for the antibiotic degradation and energy conversion, thus offers a new approach for developing novel BFO-based composite piezoelectric photocatalysts.
研究领域:
环境科学
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材料科学
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PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2021
·
IF 10.588
Mengru Du,Wenbo Zhao,Ruonan Ma,Hangbo Xu,Yupan zhu,Chongxin Shan,Kaikai Liu,Jie Zhuang,Zhen Jiao
Waterborne diseases caused by pathogenic microorganisms pose severe threats to human health. ZnO nanoparticles (NPs) hold great potentials as an effective, economical and eco-friendly method for water disinfection , but the exact antimicrobial mechanism of ZnO NPs under visible-light illumination is still not clear. Herein, we investigate the visible-light-driven photocatalytic inactivation mechanism of amino-functionalized hydrophilic ZnO (AH-ZnO) NPs against Staphylococcus aureus ( S. aureus ) in aqueous environment from the perspective of electron transfer theory. The results show that the antibacterial effects of AH-ZnO NPs are dependent on the AH-ZnO NPs concentration and treatment time. The bulk ORP value and released Zn 2+ concentration in AH-ZnO NPs solutions increase with AH-ZnO NPs concentration. The SEM and intracellular protein leakage results indicate that AH-ZnO NPs can adhere to S. aureus surface without causing obvious cell membrane disruption. The photoluminescence (PL) intensity and fluorescence lifetime of AH-ZnO NPs are remarkedly decreased after adding S. aureus , which confirms the electron transfer from S. aureus to AH-ZnO NPs. Moreover, the ΔPL intensity is closely correlated with the inactivation efficiency, demonstrating that the interfacial electron transfer in S. aureus /AH-ZnO NPs composites contributes to the antibacterial activity, which is speculated to disrupt the normal respiratory electron transfer chain of S. aureus , thereby causing intracellular ROS generation, cell membrane depolarization and eventually apoptosis-like death.
研究领域:
环境科学
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纳米技术
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微生物学
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材料科学
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DOI
PubMed
高影响因子
BIOORGANIC CHEMISTRY
·
2022
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IF 5.307
Hongjun Zhang,Zeguang Cheng,Litian Wei,Xinjun Yu,Zhao Wang,Yinjun Zhang
A gene encoding an esterase from Bacillus aryabhattai (BaCE) was identified, synthesized and efficiently expressed in the Escherichia coli system. A semi-rational protein engineering was applied to further improve the enzyme’s enantioselectivity. Under the guidance of the molecular docking result, a single mutant BaCE-L86Q and a double mutant BaCE-L86Q/G284E were obtained, with its E max value 6.4 times and 13.9 times of the wild-type BaCE, respectively. The recombinant BaCEs were purified and characterized. The overwhelming E value demonstrated that BaCE-L86Q/G284E was a promising biocatalyst for the biological resolution to prepare ( S )-indoline-2-carboxylic acid.
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DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Xinyou Zhang,Yutong Yang,Jianxin Wang,Jianjiao Xin,Wendi Wang,Yao Chen,Guangming Yin,Hong Pan
Among various cathode materials, sulfurized polyacrylonitrile (SPAN) is considered a highly promising cathode for Lithium-sulfur (Li-S) batteries due to its unique covalent sulfur fixation mechanism, which fundamentally suppresses polysulfide dissolution and the shuttle effect. However, conventional SPAN materials typically limit sulfur chains to short S 2 -S 4 structures to maintain a solid-solid reaction, restricting their theoretical capacity. Moreover, the material's insulating nature and significant volume changes during cycling greatly limit its electrochemical performance and practicality. To address these issues, this study designed and synthesized a high-elasticity water-based binder based on a 2-ethylhexyl acrylate/acrylic acid/methyl methacrylate (2-EHA-AA-MMA) terpolymer. Abundant carboxyl groups (-COOH) in its molecular chain form stable S-O covalent bonds with sulfur chains in SPAN. Combined with PAN's terminal fixation of sulfur chains, this achieves a synergistic “long-chain capacity enhancement and strong anchoring shuttle suppression” effect. It stabilizes long S 6 chains, improving cycling stability and reversible capacity, while also directing S 6 conversion directly to Li 2 S 3 , bypassing soluble Li 2 S 4 intermediates to suppress shuttle effects at the source. Experimental results show that the SPAN cathode with this binder delivers a high specific capacity of 850.3 mAh g −1 at 0.1 C, with 68.4% capacity retention after 100 cycles and effective polysulfide shuttle suppression.
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高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Tingting Yu,Bing Yang,Rong Zhang,Chenyu Yang,Arramel,Jizhou Jiang
The upsurge of interest in the emergence of photocatalytic fuel cell systems (PFC) presents an efficient and environmentally friendly approach to wastewater treatment. In this work, a Z-scheme coupled with an S-scheme heterojunction electrode was used in the PFC, utilizing TiO 2 /GO/g-C 3 N 4 as the photoanode and BiOAc 1– x Br x /BiOBr as the photocathode. We systematically align the band structures between the anode and cathode, which facilitates the electron transfer between the electrodes. Our attempt successfully demonstrates that collaborative power generation facilitates the high efficiency of tetracycline hydrochloride (TC) degradation at both electrodes. The photoanode achieved a 94.87 % degradation rate for TC, while the photocathode exhibited a 96.33 % degradation rate after 2 h, surpassing pristine BiOBr and BiOAc by factors of ∼5.3 and ∼3.8, respectively. Furthermore, this work proposed a mechanism for electron generation, transport, and pollutant degradation mechanism in the PFC. Intermediate substances generated during the degradation of TC were analyzed through high-performance liquid chromatography-mass spectrometry (HPLC-MS) and ultraviolet photoelectron spectroscopy (UPS), while the optimal degradation pathway was confirmed using density functional theory (DFT). The findings of this work establish the feasibility of efficiently degrading pollutants through PFC treatment, introducing a novel system where various heterojunctions in bipolar materials collaborate with photocatalysis to effectively generate electricity and enhance pollutant removal.
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高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Qing Zhou,Meinan Yan,Yuzhou Sun,Yujiao Ma,Zihan Zhang,Haoyu Xu,Xiaoyun Teng,Chao Gao,Wei Yu
In this paper, we reported a novel precursor solution for the preparation of Cu 2 ZnSn(S,Se) 4 (CZTSSe) film. Large-grain monolayer CZTSSe film can be obtained by using the precursor solution. The influence of selenization temperature on the properties of CZTSSe films and solar cells were investigated. We found the monolayer CZTSSe film can be prepared with the selenization temperature as low as 510 °C. While an increased selenization temperature was used, the size of the crystalline grains in CZTSSe film increased significantly, but the decomposition of CZTSSe material got more serious. As the increase of the selenization temperature, increased short-circuit current (J SC ) can be achieved for the fabricated solar cell, which could be caused by the improved crystallinity of CZTSSe layer and the enlarged depletion width of solar cell (as much as 391 nm). On the other hand, the open-circuit voltage (V OC) decreased as the increase of selenization temperature, which may relate with the decomposition of CZTSSe material. The best solar cell achieved the efficiency of 11.4% (active area), which was based on CZTSSe film with the selenization temperature of 510 °C.
研究领域:
材料科学
·
能源科学
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高影响因子
ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Hong Li,Feng Shao,Xinzhu Wen,Yusen Ding,Chao Zhou,Yafei Zhang,Hao Wei,Nantao Hu
Developing scalable and facile techniques to design and construct unique structures of cathodes with high performance is challenging for the practical Li-S batteries. In this work, highly effective and scalable cathodes based on curved graphene/MXene bi-nanosheets-constituted fibers is demonstrated for long-lifetime Li-S batteries. Wet-spinning is introduced to design and fabricate sulfur cathodes based on graphene/MXene hybrid fibers, in which sulfur is uniformly distributed and intimately enveloped between graphene and MXene nanosheets. The high chemical affinity towards polysulfides enabled by MXene is demonstrated by experiments and density functional theory (DFT) calculations. The assembled cells show high sulfur utilization (the discharge capacity of 1483.1 mAh g −1 at 0.1 C), high rate performance (733.3 mAh g −1 at 2 C) and excellent long cycle stability (0.043% per cycle decay at 1 C over 1000 cycles). Moreover, a reversible areal capacity of 5 mAh cm −2 is achieved under a high sulfur loading of 5.6 mg cm −2 , revealing its great potential for practical applications. This study gives a valuable guidance to design advanced sulfur cathodes for high-performance Li-S batteries.
研究领域:
材料科学
·
能源存储技术
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高影响因子
JOURNAL OF CATALYSIS
·
2022
·
IF 8.047
Shengxin Chen,Yingwei Li,Zicheng Wang,Ying Jin,Ruixia Liu,Xingang Li
Hollow structure nanoreactors take advantage of catalyst loading and enhanced activity by shell construction. In this work, functionalized poly(ionic liquid)s (PILs) with hollow spherical structures were synthesized by polymerization- and quaternization-based approaches. These hollow structure PILs (HPILs) could be controllable designed from IL monomer easily, giving HPILs various properties. In the subsequent selective oxidation of cyclohexane , the HPILs acting as nanoreactors could efficiently improve the activity of metal salt catalysts (CoCl 2 ) and displayed adjustable selectivity for cyclohexanone, cyclohexanol (KA) or adipic acid (AA) by different types of HPILs. In kinetic study , it follows first-order reaction kinetics which CoCl 2 /HPIL-C12 had a lower the activation energy of 29.1 kJ/mol. Importantly, these nanoreactors storing the catalysts could be recovered and reused more than 7 times without significant loss of activity. A theoretical model for the hollow spherical reactor was further established to support the advance of the HPILs reactor, which could also help to predict reaction process in other core-shell catalytic system. Due to controlled substrate transfer and enhanced radical generation in HPILs, the reaction process could be adjusted to enhance the conversion of cyclohexane and selective oxidation to AA.
研究领域:
化学工程
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材料科学
·
催化反应
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DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2021
·Vol. 168
·期 11
·114504
·
IF 4.316
Yinling Wang,Nannan Ma,Mingli Fan,Wujian Tang
Transition metal phosphides (TMP) are excellent non-precious metal electrocatalysts for hydrogen evolution reaction (HER). The generation of PO43− before and during the HER process may be inevitable due to the instability of TMP. To investigate the effect of PO43− on the HER catalytic activity of electrocatalysts in alkaline medium, NiCo-S nanotubes were modified with phytate (PHY) with six phosphate groups via adsorption. The successful modification was verified by zeta potential, FT-IR, element mapping, XPS, etc The NiCo-S/PHY displayed a higher HER activity than original NiCo-S. Under the optimum adsorption time (7 h), the overpotential at 10 mA cm−2 (η10) of NiCo-S/PHY (173 mV) was only half that of the original NiCo-S (346 mV). The role of PO43− was discussed in detail. Moreover, this strategy was extended to NiCo-S grown directly on nickel foam (NiCo-S/NF) and the corresponding NiCo-S/PHY/NF also showed superior HER activity and good stability. This work provides a new strategy to improve the HER activity of electrocatalysts and also a novel perspective for the HER mechanism of TMP.
研究领域:
材料科学
·
电化学
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高影响因子
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