ACTA BIOCHIMICA POLONICA
·
2020
·Vol. 67
·期 2
·203-211
·
IF 1.42
Yu Bao,Zhi Li,Si-Hao Chen,Li-Zhi Gao,Zu-Lan Liu,Lan Cheng,Yan Peng,Xiao-Ling Tong,Fang-Yin Dai
Artemisinin has a significant role in treatment of malaria, as well as effective anti-inflammatory and anti-cancer activities. However, such problems as poor water solubility and easy recrystallization limit its application. In this study, polyethylene glycol, a solvent which is widely used in pharmaceutics, was introduced to prepare an artemisinin dissolution. Under the action of hydrogen bonding in 12% polyethylene glycol 4000 solvent, the maximum solubility of artemisinin could reach up to 1 mg/mL. Meanwhile, biological functions of such artemisinin solution were evaluated. The obtained artemisinin solution had a significant inhibitory effect on Gram-positive bacteria, Gram-negative bacteria and fungi. As for the anti-inflammatory property, 0.031 mg/mL artemisinin solution had an obvious inhibitory effect on nitric oxide release in inflammatory cells, and the survival rate of cells was greater than 50%. Low concentration of the obtained artemisinin solution (0.031 mg/mL) had no significant cytotoxicity, while it displayed selective inhibition in cancer cells. IC50 for human hepatoma cells BEL-7404, SMMC7721 and Hep G2 is 0.0016 mg/mL, 0.0084 mg/mL and 0.0541 mg/mL, respectively. In conclusion, the 12% PEG4000-assisted artemisinin solution has a good biological effect and it can be further applied in pharmaceutics, biomaterials and medicine.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2021
·
IF 3.517
Xue Li,Shuxin Xu,Haojiang Wang,Anjie Dong
For the past few years, organic-inorganic hybrid nanocarriers have been widely explored for effective drug delivery and preferable disease treatments. In this article, hydrothermal method was utilized to prepare fine dispersed layered double hydroxide (Mg-Al LDH) suspension. Polyethylene glycol (PEG) was grafted on the surface of LDH lamella in order to improve the dispersibility of LDH. Besides, the anti-cancer drug gemcitabine was grafted on the surface of LDH lamellas through chemical grafting. Hence a novel new type of organic-inorganic hybrid drug delivery system LDH-mPEG-Gemcitabine was obtained. In addition, the siRNA was intercalated into the LDH interlamination by ion exchange method to realize drug and gene co-delivery. The loading capacity of LDH and LDH-mPEG-Gemcitabine was evaluated by agarose gel electrophoresis. The characterization by laser particle size analyzer, TEM, FT-IR, XRD, in vitro cell viability and in vitro drug release demonstrated that LDH-mPEG-Gemcitabine possessed fine dispersibility, uniform morphology and particle size, fine biocompatibility, ideal drug loading and releasing capacity and held great potential to be used as a desired co-delivery system for drug and gene.
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2015
·Vol. 15
·期 6
·4058-4069
·
IF 1.556
Zhang Huafang,Xiao Yan,Cui Shengmiao,Zhou Yuefang,Zeng Ke,Yan Mina,Zhao Chunshun
In this study, three types of galactosylated cholesterol (i.e., gal-PEG194-chol, gal-PEG1000-chol and gal-PEG2000-chol) were synthesized with one terminal of polyethylene glycol of various chain lengths conjugated to the galactoside moiety, and the other terminal conjugated to the cholesterol.
The galactose-modified liposomes were prepared by thin film-hydration method and doxorubicin (DOX) was loaded to the liposomes by using a ammonium sulfate gradient procedure. The liposomal formulations with galactosylated cholesterol were characterized. Flow cytometry and laser confocal scanning
microscopy analyses showed that the galactose-modified liposomes facilitated the intracellular uptake of liposomes into HepG2 via asialoglycoprotein receptor (ASGP-R) mediated endocytosis. Cytotoxicity assay showed that the cell proliferation inhibition effect of galactose-modified liposomes
was higher than that of the unmodified liposomes. Additionally, the study on frozen section of liver showed that the galactose-modified liposomes enhanced the intracellular uptake of liposomes into hepatocytes. Taken together, these results suggested that liposomes containing such galactosylated
cholesterol (i.e., gal-PEG-chol), had a great potential as drug delivery carriers for hepatocyte-selective targeting.
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Frontiers in Chemistry
·
2020
·
IF 3.693
Zhao Xinyue,Shan Pengfei,Liu Haiwei,Li Daai,Cai Peihan,Li Zhongyu,Li Zhihui
A synthetic route to prepare a poly(ethylene glycol) with a single cinnamaldehyde acetal unit in the polymer chain, was successfully established using a newly synthesized cinnamaldehyde acetal diethylene glycol (CADEG) as initiator. This HO-PEG(ca)-OH is non-toxic and would be degraded into a cinnamaldehyde and two PEG diols in acid environment. A whole polyethylene glycol based hydrogel was easily fabricated by thiol-ene “click” reaction in alkalescence aqueous solution using acrylate-PEG(ca)-acrylate and 4-arm PEG-SH as raw materials at room temperature. The gel time was dependent on the pH of the solution and its alkalinity can promote gel. The hydrogel can be degradable in acidic conditions and the stronger the acidity, the faster the degradation. This HO-PEG(ca)-OH also can be used in synthesis of cinnamaldehyde containing PEG derivatives, block copolymers or other acid degradable materials.
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AUSTRALIAN JOURNAL OF CHEMISTRY
·
2015
·Vol. 69
·期 1
·112-118
·
IF 1.558
Yu Yang,Yan Wu,Ruirui Li,Ying Ling,Haoyu Tang
A series of random copolypeptides, i.e. poly(γ-propyl-l-glutamate)-graft-(oligo-ethylene-glycol)-random-poly(γ-benzyl-l-glutamate)s (PPLG-g-OEG3-ran-PBLG) with similar main chain lengths and various compositions of OEG and benzyl pendants were synthesized in three steps, including ring-opening polymerization of γ-chloropropyl-l-glutamic acid-based N-carboxyanhydride (CPLG-NCA) and γ-benzyl-l-glutamic acid-based N-carboxyanhydride (BLG-NCA), nucleophilic substitution in the presence of NaN3, and copper-mediated alkyne–azide 1,3-dipolar cycloaddition. 1H NMR, Fourier transform infrared spectroscopy, and gel permeation chromatography results confirmed the molecular structures of the resulting copolypeptides and characterized their molar masses, molar mass distributions, and the OEG/benzyl compositions. Fourier transform infrared spectroscopy and circular dichroism analysis revealed that PPLG-g-OEG3-ran-PBLG samples adopted α-helical conformations both in aqueous solution and solid state. Variable-temperature UV-visible spectroscopy revealed that PPLG-g-OEG3-ran-PBLG samples with high OEG molar content (x ≥ 0.57) possessed lower critical solution temperature-type phase transitions in water. The cloud point temperature, in the range of 22–53°C, can be readily obtained by controlling the OEG/benzyl composition.
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ACS Sustainable Chemistry & Engineering
·
2018
·
IF 6.14
Jifeng Pang,Mingyuan Zheng,Xinsheng Li,Joby Sebastian,Yu Jiang,Yu Zhao,Aiqin Wang,Tao Zhang
Ball milling pretreatment was found to be an efficient method to promote the catalytic conversion of lignocellulosic biomass to ethylene glycol (EG). After 3–6 h ball milling of Miscanthus at 450 rpm, the EG yield reached about 52%, which is comparable to the result of pure cellulose conversion. The reasons of the promotion effect were investigated by characterizing the structure of biomass and the reaction residuals with X-ray diffraction, scanning electron microscopy, particle size distribution analyzer, contact angle measurement, thermogravimetric analysis-differential scanning calorimetry, and Fourier-transform infrared spectroscopy. The mild ball milling liberated (hemi)cellulose from the compact plant tissues without affecting the crystallinity of cellulose. It reduced the size of biomass to 30 μm and improved the accessibility of (hemi)cellulose, leading to a hydrophilic surface and high energy state of biomass for catalytic conversion. During the catalytic conversion, the mass transfer between sugar intermediates and heterogeneous hydrogenation catalysts were improved. Correspondingly, the self-reaction of sugar intermediates, and the reactions between sugar intermediates and lignin fractions were suppressed, resulting in the high EG yield.
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ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Kai Zhang,Guihua Yang,Gaojin Lyu,Zhixin Jia,Lucian A. Lucia,Jiachuan Chen
Three nanocomposite catalysts such as Ru/graphene, WO3/graphene, and Ru–W18O49/graphene were synthesized by solvothermolysis to increase the ethylene glycol (EG) yield from the hydrothermal conversion of cellulose. The morphology and composition of the nanocomposites were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, energy-dispersive X-ray spectroscopy, Brunauer–Emmett–Teller, scanning electron microscopy, and transmission electron microscopy. The results showed a new nanocomposite made up of graphene nanosheets that supported in situ growth of Ru nanoparticles with an average size of ∼7 nm and W18O49 nanowires with an average diameter of ∼5 nm. Compared to Ru/graphene and WO3/graphene nanocomposites, Ru–W18O49/graphene showed nearly unit conversion of cellulose at a yield of 62.5% of EG when the reaction was carried out at 245 °C for 60 min. Moreover, it could be used at least three times with the high yield of EG in the range of 48.7–62.5%; however, with the increase of recycled runs, the tungsten species on the surface of graphene would be slowly dissolved in the aqueous solution and then the selectivity of this catalyst would gradually decrease. Besides, the one-pot solvothermal synthesis enabled reduction of Ru ions, graphene oxide, and growth of W18O49 nanowires to thus provide a simple approach for the preparation of the graphene-based nanocomposite catalysts.
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GREEN CHEMISTRY
·
2021
·Vol. 23
·期 6
·2427-2436
·
IF 10.182
Jifeng Pang,Bo Zhang,Yu Jiang,Yu Zhao,Changzhi Li,Mingyuan Zheng,Tao Zhang
The complete conversion of hemicellulose, cellulose and lignin in lignocellulosic biomass into value-added chemicals is of great significance in biorefinery processes. Herein, a cascade-step strategy was developed for the conversion of hemicellulose and lignin into mixed organic acids, and cellulose into ethylene glycol. Typical biomass of Miscanthus was first treated with formic acid in the presence of H2O2, giving a formic acid solution and cellulosic biomass. Lignin in Miscanthus was oxidized to low polymerized organic acids through linkage cleavages and aromatic ring ruptures during the treatment process, forming a homogeneous formic acid solution with a weight yield of 95%. Hemicellulose was transformed into maleic acid at 56.2% selectivity via a hydrolysis–dehydration–oxidation process. Both hemicellulose and lignin were degraded into organic acids with an overall weight yield of 92.4%. The cellulose in the solid residue had a hydrophilic surface and is highly accessible to catalysts in the aqueous solution, and it was totally converted into ethylene glycol with a yield of up to 65.7% over a binary catalyst of H2WO4–Ru/C. Relying on such a cascade reaction strategy, the three major components of Miscanthus were transformed into mixed organic acids and ethylene glycol, which provides a potential strategy for complete valorisation of biomass into value-added chemicals.
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FUEL
·
2018
·
IF 4.908
Hang Xu,Dandan Zhang,Fengmin Wu,Xuefeng Wei,Jun Zhang
Deep eutectic solvents (DESs) are receiving increasing attention as ionic liquid analogues because of their environmentally friendly and very low-price characteristics. In this study, metal-based deep eutectic solvents (MDESs) were synthesized by combining cobalt chloride (CoCl 2 ), a hydrogen bond acceptor (HBA) such as choline chloride (ChCl), and hydrogen bond donors (HBDs) such as polyethylene glycol (PEG-200), ethylene glycol (EG), glycerol (GL), and propionic acid (Pr). The MDESs were used for the extractive catalytic oxidative desulfurization (ECODS) of fuels. Solid peroxymonosulfate (PMS) was selected as an oxidant over common ECODS oxidants such as liquid hydrogen peroxide because the former is cheaper, more stable, and less corrosive. The MDESs played dual roles (i.e., extractant and catalyst) during the ECODS process. One of the MDESs prepared (CoCl 2 -ChCl/2PEG) showed fast reaction rates with nearly 100% dibenzothiophene removal under the optimal conditions (6 g of model oil with an initial sulfur content of 500 ppm, 0.9 g of PMS solution, 2 g of CoCl 2 -ChCl/2PEG, 20 °C, and 60 min). The DESs prepared showed an outstanding recycling performance after 6 cycles without a significant decrease in activity. In the ECODS system, the reactivity of the three sulfur substrates studied followed the order: dibenzothiophene (DBT) > 4,6-dimethyldibenzothiphene (4,6-DMDBT) > benzothiophene (BT). In the case of the HBDs, the desulfurization efficiencies followed the sequence: PEG-200 > Pr > EG > GL. The oxidative product was dibenzothiophene sulfone (DBTO 2 ).
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Russian Journal of Physical Chemistry A
·
2018
·Vol. 92
·期 7
·1274-1278
·
IF 0.549
Xiaomeng Liu,Lu Shaoxiang,Xu Hanghui,Ren Lili
Abstract Molybdenum phosphide (MoP), modified by polyethylene glycol (PEG) and citric acid (CA), exhibited 2 to 3 times superior activity than the MoP modified by CA alone. And the optimal activity temperature was reduced from 500 to 450 o C. The catalyst was fully characterized by a variety of techniques including X-ray diffraction (XRD), N 2 adsorption-desorption isotherm, scanning electron microscopy (SEM), transmission electron microscopy (TEM). The results showed that the addition of PEG and CA increased the surface area of MoP and decreased the particle size of MoP. Furthermore, the reaction mechanism also has been discussed by combining the activity data and characterization results.
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Journal of Cleaner Production
·
2017
·
IF 5.715
Xianglong Meng,Lu Li,Kan Li,Pin Zhou,Hongbo Zhang,Jinping Jia,Tonghua Sun
A facile transportation fuel reductive and extractive desulfurization process is studied using polyethylene glycol as extraction solvent , which is economical and environmental friendly, and sodium borohydride as reductant in this work. Several important parameters including sodium borohydride and nickel chloride dosage, stirring rate, temperature and polyethylene glycol/oil volume ratio are investigated. The total sulfur desulfurization efficiency for the simulated fuel reaches nearly 97% in this process after 1 h reaction at the temperature of 10 °C with sodium borohydride/sulfur molar ratio = 15, nickel chloride/sulfur molar ratio = 3, polyethylene glycol/oil volume ratio = 1. Furthermore, the desulfurization efficiency can be enhanced to 99% in a two-step desulfurization process. All components were detected by GC or GC-MS, and the possible desulfurization mechanism is deduced. The results show that sulfur compounds can be removed by direct desulfurization. The desulfurization performance of recycled polyethylene glycol and regenerated polyethylene glycol was also investigated and the desulfurization efficiency was 92% and 90% respectively, indicating polyethylene glycol can be regenerated in this process. Finally, actual transportation fuels (e.g. gasoline, diesel) were investigated and it revealed that polyethylene glycol and sodium borohydride can be applied in actual fuel extractive and reductive desulfurization.
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Materials Today Communications
·
2022
·
IF 3.662
Jianjun Wang,Ting Zhang,Yuxia Shen,Bochao Yang,Jie Lv,Yi Zheng,Yi Wang
In order to develop a new type of dual-functional composite with thermal storage and insulation properties, polyethylene glycol / nanofibrous Kevlar aerogel (PEG/KNA) was fabricated by combining the heat storage advantage of PEG and low thermal conductivity of KNA. The morphology, structure and thermo-physical performances, especially the thermal insulation property and effects of confinement on the phase transition behavior were investigated. The results demonstrate that PEG was trapped and fixed in the pores of KNA by physical interaction. The maximal fusion and solidification latent heat for the leak-free PEG 10K/KAN are 173.77 J·g −1 and 173.79 J·g −1 , while they are 163.10 J·g −1 and 162.33 J·g −1 for PEG 6K/KNA, respectively. The actual values of all PEG/KNA are lower than the theoretical enthalpy, and the heat storage capacity reduce sharply with the decrease of PEG loading amount due to the formation of "non - melting layer" on the interface of KNA films. This portion of PEG in the non-melting layer is amorphous and does not contribute to heat storage. The crystallization rate of PEG/KNA is lower than that of pure PEG due to the confinement effects of KNA. In addition, PEG/KNA demonstrates good stability and excellent thermal insulation performance during cyclic usage. This study not only developed a feasible way for the design of thermal insulation composites, but also provided a deep insight for revelation of confinement effects on the thermophysical properties of composite phase change material .
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