COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Yawei Shi,Guobin Song,Anqi Li,Jun Wang,Haonan Wang,Ya Sun,Guanghui Ding
A series of composite aerogels with different precursor mass ratios were prepared from graphene oxide (GO) and chitosan (CS) by conducting the crosslinking step after lyophilization, the method of which was recently found beneficial to enhance the adsorptive properties of aerogels . The composite aerogels were then employed for the adsorption of methyl orange (MO) and methylene blue (MB) from water, and the one prepared at GO:CS= 1:2 (w/w) was selected as the optimal compromising the adsorption and mechanical properties. The maximum adsorption amounts of MO and MB were calculated to be 543.4 and 110.9 mg/g at 25 °C. Especially, the effects of pH on adsorption of MO and MB in both single and binary systems were investigated in detail. The aerogel possessed pH-responsive feature for single dye adsorption, tending to adsorb MO at low pH while to adsorb MB at high pH. In the binary system, the pH-responsive feature remained and selective adsorption was observed at low initial dye concentration. In contrast, synergistic adsorption occurred instead at high initial concentration, and MB and MO could be efficiently removed simultaneously in the whole pH range of 3–11.
研究领域:
环境科学
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材料科学
·
化学工程
·
水处理
·
吸附技术
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Furong Cheng,Qingqing Pan,Wenxia Gao,Yuji Pu,Kui Luo,Bin He
Mitochondrial drug delivery has attracted increasing attention in various mitochondrial dysfunction-associated disorders such as cancer owing to the important role of energy production. Herein, we report a lysosomal pH-activated mitochondrial-targeting polymer nanoparticle to overcome drug resistance by a synergy between mitochondrial delivery of doxorubicin (DOX, an anticancer drug) and erlotinib-mediated inhibition of drug efflux. The obtained nanoparticles, DE-NPs could maintain negative charge and have long blood circulation while undergoing charge reversal at lysosomal pH after internalization by cancer cells. Thereafter, the acidity-activated polycationic and hydrophobic polypeptide domains boost lysosomal escape and mitochondrial-targeting drug delivery, leading to mitochondrial dysfunction, ATP suppression, and cell apoptosis. Moreover, the suppressed ATP supply and erlotinib enabled dual inhibition of drug efflux by DOX-resistant MCF-7/ADR cells, leading to significantly augmented intracellular DOX accumulation and a synergistic anticancer effect with a 17-fold decrease of IC50 relative to DOX. In vivo antitumor study demonstrates that DE-NPs efficiently suppressed the tumor burden in MCF-7/ADR tumor-bearing mice and led to negligible toxicity. This work establishes that a combination of mitochondrial drug delivery and drug efflux inhibition could be a promising strategy for combating multidrug resistance.
研究领域:
肿瘤学
·
药理学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 48
·17451-17460
·
IF 7.393
Tao Wang,Fenglei Sun,Zike Jiang,Jing Wang,Yanyan Ma,Haitao Lin,Hongmin Lv,Shanshan Xu,Jinhua Li,Guangjun Zhou
pH sensors based on up-conversion nanoparticles (UCNPs) are widely studied due to their effective elimination of background signals. However, ratiometric pH measurement depending on blue and red luminescence under NIR irradiation has been seldom reported for the lack of simultaneous strong blue and red emissions for traditional UCNPs. In this work, we designed NaGdF4:Yb,Tm@NaYF4:Yb,Eu@NaYF4:Yb,Nd@NaYF4 core–triple shell (CTS) UCNPs as fluorescent materials to realize blue/red ratiometric pH measurement. On the basis of Gd3+-mediated interfacial energy transfer and Yb3+-mediated energy migration, CTS particles present intense luminescence and a high red/blue (615 nm/450 nm) peak intensity ratio of 0.47 at 808 nm excitation. Composed of these particles and pH indicator bromocresol green, the pH sensor exhibits ratiometric responses in a pH range of 4–7 according to blue/red luminescence intensity ratios, avoiding the common errors as well as potential mutual fluorescence signal interference. Owing to strong overall luminescence and additional red emission of CTS UCNPs distinctly improving the signal-to-noise ratio, this ratiometric sensor reveals high sensitivity. Moreover, the employed excitation wavelength of 808 nm can not only eliminate autofluorescence signals, but also alleviate severe temperature rise in biosamples under continuous irradiation, ensuring accurate pH determination. More intriguingly, a CCD RGB camera serves as a collector to record luminescence signals, further promoting commercial feasibility. The successful application of CTS UCNPs on sensors indeed realizes blue/red ratiometric measurement towards pH under 808 nm irradiation, also pointing out a novel way for pH sensors with high sensitivity and accuracy.
研究领域:
生物医学工程
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材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2012
·
IF 5.625
Hongying Zhao,Yujing Wang,Yanbin Wang,Tongcheng Cao,Guohua Zhao
A novel electro-Fenton (E-Fenton) system with the Fe 3 O 4 @Fe 2 O 3 /activated carbon aerogel (ACA) composite cathode was firstly constructed in this study. Its application on degrading imidacloprid exhibited highly catalytic efficiency over a wide applicable pH range from 3 to 9. The removal of imidacloprid and TOC achieved to 90% within 30 and 60 min, respectively. The nature of composite cathode was examined by BJH, XRD, SEM, TEM, XPS and FTIR techniques. ACA with high surface area of 2410 m 2 g −1 and multiplicated porosities composed of micropores and mesopores worked not only as cathode but also as Fenton catalyst support, enhancing oxidation activity. We proposed reasonable E-Fenton oxidation mechanisms with Fe 3 O 4 @Fe 2 O 3 /ACA cathode at acidic and basic conditions. At pH 3, it followed a Haber–Weiss mechanism that the dissolved iron ions and surface Fe(II) sites catalyzed the decomposition of H 2 O 2 to generate hydroxyl radicals ( OH). While at pH 9, it was expected the formation and deactivation of H 2 O 2 complex as well as the catalytic decomposition of H 2 O 2 with surface Fe(III) and Fe(II) sites to produce both superoxide anion ( O 2 − /HO 2 ) and hydroxyl radicals ( OH), involving an in situ recycling of iron oxide (FeO·Fe 2 O 3 → Fe 2 O 3 ).
研究领域:
环境科学
·
化学工程
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2021
·
IF 9.147
Junmeng Lu,Xinglian Xu,Xue Zhao
In the current study, the interfacial rheological properties of alkali pH-shifted MP under pH 11.0 → 7.0, pH 11.5 → 7.0 and pH 12.0 → 7.0 have been firstly investigated. The molecular weight and microstructure of myofibrillar protein (MP) treated by alkali pH-shifting were investigated by gel-permeation chromatography (GPC) and transmission electron microscopy (TEM). Results indicated a swollen, organized and aggregated structure of refolded MP. Overall, the molecular change in refolded MP led to faster protein adsorption towards the O/W interface, enhanced intermolecular interaction between adsorbed proteins and improved elasticity of interfacial film compared to native MP. After β-mercaptoethanol (β-ME) was added, the advantage of refolded MP in diffusion phase no more existed due to the disruption of aggregation and decreased molecular size, besides the penetration and rearrangement were interfered because the disruption of disulfide bond inhibited the formation of interfacial protein layers. With the protein concentration increasing, MP molecules crowding at O/W (oil in water) surface limited the development of a highly elastic network. As revealed by Tween 20 displacement, MP layers with higher interfacial elasticity were more resistant to displacement. Moreover, after displacement the coalescence stability of emulsion droplet was enhanced but the mechanical strength of interfacial MP layer was reduced. Altogether MP (0.04 or 0.2 mg/mL) treated by pH 11.0 → 7.0 exhibited the best adsorption performance and interfacial properties, which were important in stablizing emulsions. Thus, interfacial behavior regulation by alkali pH-shifting may be a applicable process for developing meat protein-based emulsions in food industry.
研究领域:
食品科学
·
蛋白质化学
·
胶体科学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Tao Yan,Xiaoqing Chen,Taiheng Zhang,Jingang Yu,Xinyu Jiang,Wenjihao Hu,Feipeng Jiao
Wastewater discharged in human daily life, and oil spill accidents occurred frequently. The novel interface materials used for controllable oil/water separation have gained more and more attention. In this work, a facile, environmentally friendly approach is presented to fabricate a magnetic textile fabric with pH-controllable wettability between superhydrophobicty and superhydrophilicity. We prepared this magnetic textile fabric by immersing in lauric acid (LA)-TiO 2 composites and Fe 3 O 4 nanoparticles. The resulted pH-conrtollable textile fabric possessed selective separation performance for oil/water mixtures with efficiency higher than 99% and high flux for oil (11,000 L h −1 m −2 ). Moreover, the magnetic material is recyclable, the detailed experiments were conducted in this work for 25 cycles of oil/water mixture separation remaining unchangeable separation efficiency (>98%). For neutral water (e.g., at pH 7), the novel Fe 3 O 4 /LA-TiO 2 textile fabric demonstrated superhydrophobicity/ superoleophilicity in air. For alkaline water (e.g., at pH 12), the textile fabric showed superhydrophilicity and underwater superoleophobicity. The Fe 3 O 4 /LA-TiO 2 textile fabric could separate a series of light or heavy oil/water mixtures with high separation efficiency up to 99.1%, high oil flux of 7400–11,000 L h −1 m −2 and water flux of 5300–5700 L h −1 m −2 . In addition, thermal stability (∼180 °C) and long exposure to ultraviolet rays showed that the textile fabric was stable in harsh environment. The textile fabric can be easily removed through a magnet due to its magnetic properties. It can be concluded from the results that Fe 3 O 4 /LA-TiO 2 textile fabric is a good candidate for practical applications, such as water restoration and oil-spill treatment.
研究领域:
材料科学
·
环境工程
·
纳米技术
·
表面化学
·
功能纺织品
✓ 已验证
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2020
·
IF 4.321
Ying-Zheng Zhao,Meng-Ting Lin,Qing-Hua Lan,Yuan-Yuan Zhai,He-Lin Xu,Jian Xiao,Longfa Kou,Qing Yao
Disulfiram (DSF) is an FDA-approved anti-alcoholic drug that has recently proven to be effective in cancer treatment. However, the short half-life in the bloodstream and the metal ion-dependent antitumor activity significantly limited the further application of DSF in the clinical field. To this end, we constructed a silk fibroin modified disulfiram/zinc oxide nanocomposites (SF/DSF@ZnO) to solubilize and stabilize DSF, and, more importantly, achieve pH triggered Zn2+ release and subsequent synergistic antitumor activity. The prepared SF/DSF@ZnO nanocomposites were spherical and had a high drug loading. Triggered by the lysosomal pH, SF/DSF@ZnO could induce the rapid release of Zn2+ under the acidic conditions and caused nanoparticulate disassembly along with DSF release. In vitro experiments showed that cytotoxicity of DSF could be enhanced by the presence of Zn2+, and further amplified when encapsulated into SF/DSF@ZnO nanocomposites. It was confirmed that the significantly amplified cytotoxicity of SF/DSF@ZnO was resulted from pH-triggered Zn2+ release, inhibited cell migration, and increased ROS production. In vivo study showed that SF/DSF@ZnO nanocomposites significantly increased the tumor accumulation and prolonged the retention time. In vivo antitumor experiments in the xenograft model showed that SF/DSF@ZnO exerted the highest tumor-inhibition rate among all the drug treatments. Therefore, this exquisite study established silk fibroin-modified disulfiram/zinc oxide nanocomposites, SF/DSF@ZnO, where ZnO not only acted as a delivery carrier but also served as a metal ion reservoir to achieve synergistic antitumor efficacy. The established DSF nanoformulation displayed excellent therapeutic potential in future cancer treatment.
研究领域:
生物医学工程
·
药学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2020
·
IF 5.115
Li He,Fangzhen Qing,Maode Li,Daitian Lan
Purpose The aim of this study was to develop an “all-in-one” nanoplatform that integrates at the second near-infrared (NIR-II) region dye IR1061 and anticancer drug paclitaxel (PTX) into an apoferritin (AFN) nanocage (IR-AFN@PTX). Simultaneously, folic acid (FA), tumor target molecule, was conjugated onto IR-AFN@PTX to be IR-AFN@PTX-FA for tumor-targeted and pH/NIR-II-triggered synergistic photothermal-chemotherapy.Methods IR1061 was firstly reacted with PEG and then conjugated with AFN to be IR-AFN. Then, FA was conjugated onto the surface of IR-AFN to be IR-AFN-FA. At last, PTX was incorporated into IR-AFN-FA to fabricate a nanoplatform IR-AFN@PTX-FA. The NIR-II photothermal properties and pH/NIR-II triggered drug release were evaluated. The ability of IR-AFN@PTX-FA to target tumors was estimated using optical bioluminescence. In vitro and in vivo synergistic therapeutic effects of pH/NIR-II-triggered and tumor-targeted photothermal-chemotherapy were investigated in 4T1 tumor model.Results IR-AFN@PTX-FA showed excellent water solubility and physiological stability, which significantly enhanced the solubility of both IR1061 and PTX. After 5 min of laser irradiation at 1064 nm, IR-AFN@PTX-FA exhibited an effective photothermal effect compared with laser irradiation at 808 nm, even when blocked with 0.6 cm thick chicken breast. Cellular uptake experiments showed IR-AFN@PTX-FA utilized clathrin-mediated and caveolae-mediated endocytosis pathways to enter 4T1 cells, and was then delivered by the endosome to the lysosome. NIR-II laser irradiation and pH could synergistically trigger PTX release, inducing significant tumor inhibition in vitro and in vivo.Conclusion As a novel “all-in-one” nanoplatform, IR-AFN@PTX-FA was found to selectively target tumors and showed very efficient NIR-II photothermal effects and pH/NIR-II triggered drug release effects, showing a remarkable, synergistic photothermal-chemotherapy effect.
研究领域:
生物医学工程
·
药学
·
肿瘤学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Hongzhi Gu,Qingwei Huang,Jinli Zhang,Wei Li,Yan Fu
Heparin serves as both reductant and stabilizer for biogenic synthesis of ultrasmall Pt nanoclusters. The surface remaining heparin enhances the affinity of Pt nanoclusters with the substrate 3,3′,5,5′-tetramethylbenzidine, thereby contributing to outstanding peroxidase mimicking activity in near-neutral media. Heparin-reduced Pt nanoclusters exclusively exhibit peroxidase mimicking activities without oxidase-like characteristics. The most efficient Pt nanozyme was reduced at 80 °C by adopting the [K 2 PtCl 4 ]/[heparin] of 1, showing the K m of 165 mM for H 2 O 2 and 0.016 mM for TMB. This developed Pt nanozyme displays a marked superior in both peroxidase-like activity and peroxidase specificity under near-neutral environment over previously reported Pt nanozymes. Based on these two considerable features of heparin-Pt nanozyme, a colorimetric test was developed for directly monitoring glucose at pH 6. This work proposes an efficient way to construct peroxidase mimetics at near-physiological pH without the interference of dissolved oxygen.
研究领域:
纳米技术
·
生物化学
·
材料科学
·
分析化学
✓ 已验证
DOI
高影响因子
Advanced Materials Interfaces
·
2020
·Vol. 7
·期 22
·2001147
·
IF 4.948
Lei Tang,Zhixiang Zeng,Gang Wang,Luli Shen,Lijing Zhu,Yingxin Zhang,Qunji Xue
Responsive smart surfaces with controllable wettability have a high potential application in self-cleaning and oil-water separation. In this work, a new and simple method is reported to fabricate a pH-responsive superwettability surface. And the self-cleaning performance from air to water after oil contamination in a dry state is studied. Wettability regulation can be achieved by controlling the ratio of carboxyl groups with protonation or deprotonation state in acid or basic solutions. Rough surface with 40% carboxyl content (X COOH = 0.4) shows the most significant response. The surface is superoleophilic underwater after wetted in acid solution in advance but superoleophobic underwater with basic solution pre-wetted. Oil desorption can be achieved under the superoleophobic state to realize the self-cleaning effect on a rough surface with a complex process. The dynamic self-cleaning process can be achieved by changing the pH value of the solution. This pH-responsive surface also has a good self-cleaning effect for the common water and solid pollutants. Moreover, a smart separation system with the ability to realize selective oil-water separation under two different states is prepared. It is believed that the results reported could broaden the understanding of self-cleaning systems and open a new perspective in controlling wettability.
研究领域:
材料科学
·
环境工程
✓ 已验证
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2019
·
IF 5.589
Fuwei Sun,Haibo Liu,Hanlin Wang,Daobing Shu,Tianhu Chen,Xuehua Zou,Fangju Huang,Dong Chen
Natural iron-bearing minerals have been proven to be effective for activating H 2 O 2 to produce OH, which can be used to degrade organic pollutants . In this study, the performance of siderite to degrade sodium sulfadiazine via catalytic H 2 O 2 degradation was investigated at different solution pH values from 3 to 9. An interesting discovery was made: the performance of the siderite-H 2 O 2 system was excellent under acidic, neutral, and even alkaline conditions. The influence of various factors (e.g. initial concentration, anions, natural organic matters, etc.) on the system under different pH conditions was investigated, which confirmed that siderite exhibited an excellent catalytic performance. By combining EPR characterization with scavenger research, it was proposed that dissolved iron (Fe 2+ ) mainly initiated the homogenous Fenton reaction to degrade pollutants under acidic conditions, while structural Fe 2+ species present in siderite triggered Fenton-like reactions under neutral or even alkaline conditions. From the SEM and XPS characterizations, oxidation and dissolution of Fe 2+ on the surface were also observed, confirming our inference concerning the different reaction mechanisms. The experimental findings show that this siderite-H 2 O 2 system can be used in solutions with pH values from 3 to 9 and that siderite plays a positive role in soil and groundwater remediation when H 2 O 2 is used as an oxidant.
研究领域:
环境科学
·
化学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-13
·
IF 9.429
Gu Jun,Zhao Gang,Yu Jiangkun,Xu Pei,Yan Jiabin,Jin Zhengshuai,Chen Sheng,Wang Yong,Zhang Leshuai W.,Wang Yangyun
Although combination chemoimmunotherapy shows promising clinical results for cancer treatment, this approach is largely restricted by variable objective response rate and severe systemic adverse effects of immunotherapeutic antibody and chemotherapeutic drugs. Therefore, an in situ-formed therapeutic silk-chitosan composite scaffold is fabricated in this study to allow local release of the chemotherapeutic drug doxorubicin (DOX) and JQ1 (small molecular inhibitor used for the extraterminal protein BRD4 and bromodomain) with control release kinetics. DOX-JQ1@Gel contains a pH-degradable group that releases therapeutics in a weak acidic tumor microenvironment. The released DOX could directly kill tumor cells or lead to immunogenic cell death, thereby triggering the response of antitumor immunity. Meanwhile, chemotherapy-triggered antigen release and JQ1-mediated PD-L1 checkpoint blockade cumulatively contribute to trigger the response of antitumor immunity. Finally, the DOX-JQ1@Gel is locally injected to evaluate its synergistic cancer therapeutic effect, which is expected to improve objective response rate of immunotherapy and minimize systemic side effects.Graphical Abstract
研究领域:
癌症治疗
·
药学
·
生物材料
·
免疫学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）