MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 12
·1-10
·
IF 6.232
Hu Shuisheng,Lin Yuxia,Teng Jing,Wong Wing-Leung,Qiu Bin
A new electrocatalytic biosensor (MOF-74(Cu) NS-CC) based on the in situ deposition of MOF-74(Cu) nanosheet on carbon cloth via a bottom-up synthetic approach in a glass tube was developed. The electrocatalytic activity of the deposited MOF-74(Cu) NS was demonstrated in the oxidation of glucose to gluconate under alkaline conditions. The results revealed that the proposed method of in situ formation of MOF-74(Cu) NS onto a carbon cloth surface in a multi-layer solution is capable to generate a stable MOF-74(Cu) NS-CC electrode with excellent sensing performance. When the as-synthesized MOF-74(Cu) NS-CC was applied directly as the working electrode for glucose sensing, it showed much higher conductivity and redox activity than MOF-74(Cu) NS-GCE. With the potential applied at 0.55 V (vs. Ag/AgCl), this new electrocatalytic biosensor exhibits an excellent linear relationship between current density and concentration of glucose. Moreover, a wide linear range of detection (1.0 to 1000 μM) was observed. The limit of detection was found to be 0.41 μM (S/ N = 3). The response sensitivity is 3.35 mA mM −1 cm −2 when the concentration of glucose is in the range 1–100 μM and 3.81 mA mM −1 cm −2 for the 100–1000 μM concentration range. This study provides a low-cost, easy to prepare, and reproducible methodology for the synthesis of highly redox-active nanomaterials based on the in situ formation of two-dimensional MOF-74(Cu) NS for the development of new electrocatalytic biosensors.
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高影响因子
ANALYTICA CHIMICA ACTA
·
2021
·
IF 6.558
Liping Gao,Yong Li,Zhen-Zhong Huang,Hongliang Tan
Stimuli-responsive hydrogel has been emerged as a popular tool for chemical sensing due to its unique mechanical properties. In this work, we fabricated an ascorbic acid (AA)-responsive alginate hydrogel for the visual detection of alkaline phosphatase (ALP). This alginate hydrogel ( [email protected] /Fe 3+ ) was crosslinked with Fe 3+ , and rhodamine B (RhB) was encapsulated into the hydrogel as an indicating reagent to assistant visual detection. Because of the weak affinity of Fe 2+ to alginate, the presence of reductive AA can trigger the dissolution of [email protected] /Fe 3+ to give an observable red color in the sol solution. On this basis, by using ascorbic acid 2-phosphate as a substrate of ALP, which can be hydrolyzed by ALP to produce AA, the gel-sol transition process of [email protected] /Fe 3+ was further modulated by ALP. This finding leads to a simple visual method for ALP detection with a low detection limit of 0.37 mU/mL and an excellent selectivity over other proteins. Compared with conventional colorimetric assays , this visual sensor shows the distinct advantages of simple fabrication, cost-effectiveness and easy to implement. We believe that this study can provide a new insight into the fabrication of responsive alginate hydrogel for promising applications in chemical sensing and biomedical fields.
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JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 10
·6327-6336
·
IF 4.22
Yang Ziyin,Bai Xiao
Searching for novel sensing material for highly sensitive nonenzymatic detection of glucose is important. In this paper, it is the first time that AgCoO 2 /MWCNTs was exploring as electrocatalyst for glucose oxidation. Structural characterizations reveal that AgCoO 2 and MWCNTs are interconnected with a three-dimensional porous structure, which leads to attractive electrocatalytic activity for glucose oxidation. The sensor based on AgCoO 2 /MWCNTs is found to exhibit excellent analytical performances for glucose with an extremely high sensitivity of 8214.3 μA mM −1 cm −2 and a wide linear range of four orders of magnitude. Such results indicate that AgCoO 2 /MWCNTs can be employed as a promising material for electrochemical sensing of glucose and also opens avenues for applications of AgCoO 2 in the fields of electrochemical sensing.
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TALANTA
·
2020
·
IF 5.339
Xinrong Jiang,Xiaoming Chen,Tao Wang,Yuexin Li,Aiwu Pan,Jianmin Wu
Metabolites in the body fluid are becoming a rich source of disease biomarkers. Developing an effective and high throughput detection and analysis platform of metabolites is of great importance for potential biomarker discovery and validation. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) has been successfully applied in rapid biomolecules detection in large scale. However, non-negligible background interference in low molecule-weight region still constitutes a main challenge even though various nanomaterials have been developed as an alternative to traditional organic matrix. In this work, a novel composite chip, silicon nanowires loaded with fluorinated ethylene propylene (FEP@SiNWs) was fabricated. It can serve as an excellent substrate for nanostructure-initiator mass spectrometry (NIMS) detection with ultra-low background noise in low molecular weight region (<500 Da). Ion desorption efficiency and internal energy transfer of FEP@SiNWs were studied using benzylpyridinium salt and tetraphenylboron salt as thermometer chemicals. The results indicated that a non-thermal desorption mechanism might be involved in the LDI process on FEP@SiNWs. Owing to the higher LDI efficiency and low background interference of this novel substrate, the metabolic fingerprint of complex bio-fluids, such as human saliva, can be sensitively and stably acquired. As a proof of concept, FEP@SiNWs chip was successfully used in the detection of salivary metabolites. With the assistance of multivariate analysis, 22 metabolic candidates (p < 0.05) which can discriminate type 2 diabetes mellitus (2-DM) and healthy volunteers were found and identified. The role of these feature metabolites in the metabolic pathway involved in 2-DM was confirmed by literature mining. This work demonstrates that FEP@SiNWs-based NIMS might be served as an efficient and high throughput platform for metabolic biomarker exploration and clinical diagnosis.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 14
·146511
·
IF 3.721
Peihong Deng,Jinxia Feng,Jinyun Xiao,Jun Liu,Xue Nie,Junhua Li,Quanguo He
In this study, a new electrochemical sensor was fabricated and characterized based on a glassy carbon electrode (GCE) modified with ceria (CeO2) nanoparticles decorated with electrochemical reduced graphene oxide (denoted as Ceria-ErGO/GCE). The results showed that a large number of spherical ceria nanoparticles with a diameter of 20–200 nm are well wrapped by gossamer like ErGO nanosheets. Compared with ceria and ErGO, ceria-ErGO nanocomposites have a synergistic effect on the charge transfer between the electrode and the solution interface. Ultrasensitive and selective determination of dopamine (DA) can be realized at the Ceria-ErGO/GCE. Under the optimum conditions, the calibration curve for the peak current of DA oxidation vs its concentration showed in three fragmented ranges of 6.0 nM–0.1 μM; 0.1 μM–2.0 μM and 2.0 μM–20 μM, respectively. The limit of detection of 3.0 nM (S/N = 3) was obtained under 90 s accumulation. In addition, the advantages of the sensor are easy regeneration of electrode surface, fast and convenient electrode preparation, low cost, sensitive and reliable determination results. This method is particularly suitable for the fast detection of DA in commercial pharmaceuticals and clinical urine as well as serum samples.
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CHROMATOGRAPHIA
·
2020
·Vol. 83
·期 9
·1121-1131
·
IF 1.596
Pang Xiaoya,Liu Haiyan,Yu Huan,Zhang Miaomiao,Bai Ligai,Yan Hongyuan
A method for preparing a metal–organic framework (MOF)–polymeric monolith was established by in situ radical polymerization with derivatized UiO-66-2COOH and N- isopropylacrylamide (NIPAAm) as co-monomers. It was worth noting that the obtained monolith possessed characteristics of relatively uniform porous structure and a high surface area (84.16 m 2 g −1 ). The adsorption capacity of the monolith increased from 22.87 to 44.92 mg −1 due to the addition of MOF. The monolith was used as adsorbent and coupled with HPLC for the online purification and extraction of ursolic acid (UA) in medicinal plant. The limit of detection (LOD, S / N = 3) and the limit of quantification (LOQ, S / N = 10) were 0.17 μg mL −1 and 0.57 μg mL −1 , respectively; the relative standard deviation (RSD) of intra-day and inter-day assays for five plant samples were 1.00–3.67% and 2.43–5.76%, respectively; a good accuracy was demonstrated by the recovery of 92.2–103.28%. The results indicated that the MOF–polymer monolith was feasible for the online enrichment and purification of UA in plant.
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CRYSTAL RESEARCH AND TECHNOLOGY
·
2020
·Vol. 55
·期 10
·2000039
·
IF 1.169
Zeqiu Xia,Lin Wang,Gaohong He,Xiaobin Jiang
Crystal morphology control is a common concern for the crystal engineering and relevant applications. For example, urate crystallization is important for the study of the hyperuricemia induced gout. Herein, biomimetic hydrogel material with uniform surface and vertical structure is fabricated, which possesses hybrid pH-temperature responsibility for high-efficiency interfacial nucleation and concentration regulation functions. The developed hydrogel layers are prepared to slice type as a functional microplatform and then added into the uric acid dihydrate (UAD) crystal solution to induce monosodium urate monohydrate (MSUM) crystallization. With different dosage of the hydrogel slices (HGS) in the solution, diverse crystal morphologies can be obtained in an efficient manner, such as “flower,” “sphere,” “sticky spheres,” which entirely distinguishes from the one prepared via no-HGS. This work explores a new path for revealing the relevant crystallization mechanism and developing crystal morphology control technology with hydrogel interfacial materials.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
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2020
·Vol. 167
·期 11
·117501
·
IF 3.721
Ziyin Yang,Xiao Bai,Chengcheng Qi
NiCo layered double hydroxide (NiCo-LDH) was explored as electrocatalyst for nonenzymatic detection of H2O2, in which NiCo-LDH with different morphologies were synthesized through a hydrothermal method, and then acid-etched NiCo-LDH (E-NiCo-LDH) was obtained via an acid-base reaction. The morphology, composition and structure were characterized by transmission electron microscopy and X-ray diffraction. Electrochemical measurements reveal that E-NiCo-LDH exhibits an excellent electrocatalytic activity toward H2O2 oxidation and the sensor based on E-NiCo-LDH is able to detect H2O2 in a linear range of 2.0 μM to 1.1 mM with a high sensitivity of 728.6 μA mM−1 cm−2 and a low detection limit of 0.2 μM (S/N = 3). This indicated that E-NiCo-LDH is a promising material for electrochemical sensing of H2O2.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 10
·107505
·
IF 3.721
Peijin Wang,Qian Wu,Caixia Wang,Yuxin Pu,Mao Zhou,Mingxiao Zhang
In this work, a sensitive polyethylenimine functionalized Perylene derivative PTC-PEI, S2O82− and 3D flower-like MoS2 (3D MoS2 NFs) ternary system was fabricated for quantitation of Methotrexate (MTX) based on the quenched electrochemiluminescence (ECL) signals. Specifically, the PTC-PEI was prepared via cross-linking Perylenetetracarboxylic acid (PTCA) and polyethylenimine (PEI). Then, the hybrid nanocomposite PTC-PEI-MoS2 was synthysized through electrostatic absorption effect between PTC-PEI and 3D MoS2 NFs. With the excellent catalytic effect of 3D MoS2 NFs towards the electrochemical reduction process of S2O82− thus resulting in generation of more sulfate radical anions (SO4·−), the ECL signal probe PTC-PEI-MoS2 exhibits higher luminous efficiency compared with PTC-PEI (3-fold enhancement). In addition, electrochemical regenerable property of Mo6+/Mo4+ active sites endows 3D MoS2 NFs excellent signal enhancement efficiency. Under the optimum conditions, a linear range from 10 μM to 1pM with the limit of detection down to 0.15 pM could be obtained in MTX determination. Notably, the proposed strategy provides a new idea for sensitive determination of MTX.
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APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Di Zhu,Huiyuan Ma,Qingfang Zhen,Jianjiao Xin,Lichao Tan,Chunjing Zhang,Xinming Wang,Boxin Xiao
Epinephrine (EP) is a significant neurotransmitter, energizes and maintains the various body systems and plays a pivotal role in the response to stressful conditions of blood pressure and blood sugar level. Herein, a novel epinephrine sensor based on the hierarchical flower-like zinc oxide nanosheets (flower-like ZnO) embedded into three-dimensional ferrocene-functionalized graphene framework (3D graphene@Fc) was successfully prepared, using a facile route of one-pot in situ hydrothermal growth method. Benefiting from the unique structural advantages, meanwhile integrated with synergistic effect of components, the flower-like ZnO/3D graphene@Fc exhibits excellent sensing performance for epinephrine with a wide linear range of 0.02 to 216 μM, a low detection limit of 0.0093 μM, high anti-interference and good cyclic stability. Interestingly, it is unexpectedly found that the flower-like ZnO/3D graphene@Fc has sensing ability for EP’s oxidized derivative (QA) during the oxidation process of EP, along with a linear range of 0.192 to 527 μM and a detection limit of 0.1 μM for QA. More importantly, acceptable recovery obtained from the real sample test, confirming the feasibility of this biosensor for practical application.
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AICHE JOURNAL
·
2020
·Vol. 66
·期 8
·e16280
·
IF 3.519
Xiaobin Jiang,Mingguang Han,Zeqiu Xia,Jin Li,Xuehua Ruan,Xiaoming Yan,Wu Xiao,Gaohong He
Droplet evaporative crystallization on microscale heterogeneous surface is a vivid topic in chemical engineering, bioengineering, nanomaterials, and so on. Here, 3D printed interfacial matrix platform with regular pillar convexity and tunnel structure is fabricated to reveal the mechanism of the interfacial micro droplet crystallization. Element-based rotation volume model is established to simulate the concentration and nucleation barrier distribution during the microscale process. Sodium urate monohydrate and NaCl crystallization on the pillar convex structure both confirm that confined capillary flow in the micro droplet and initial nucleation condition dominate the nucleation, growth control and particle distribution. Droplet crystallization stretches over the tunnel structure reveal an interesting phenomenon that two regions possessing distinct-different nucleation barriers can isolated obtain the crystal particles from nanoscale to even millimeter scale. The fabricated platform and the capillary circulation transfer theory unfold a potential approach to harvest high value-added crystals with specific morphology and desire sizes distribution.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2020
·
IF 7.1
Meng Xia,Xian-En Zhao,Jing Sun,Zhenjia Zheng,Shuyun Zhu
A simple ratiometric fluorescent sensing system for Ce 4+ and alendronate sodium (ALDS) detection is developed with graphene quantum dots (GQDs) combined with the oxidase-mimicking activity of Ce 4+ . As oxidase-mimicking, Ce 4+ can catalyze the oxidization of o -phenylenediamine (OPD) directly without the requirement of H 2 O 2 . The oxidation product (oxOPD) not only exhibits a strong emission at 562 nm but also quenches the fluorescence of GQDs at 444 nm significantly through inner filter effect (IFE). Due to its strong oxidative ability, Ce 4+ can also oxidize ALDS. Thus, ALDS can inhibit the oxidization of OPD by Ce 4+ . The fluorescence at 444 nm can be protected from quenching while that at 562 nm decreases. Thus, a ratiometric fluorescent strategy for quantitative analysis of Ce 4+ and ALDS has been developed. The ratiometric sensing platform exhibits a high sensitivity with the detection limits of 1.0 μM and 33 nM for Ce 4+ and ALDS, respectively. This strategy can detect Ce 4+ and ALDS in practical samples with satisfactory recoveries.
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