INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2023
·
IF 5.8
Shangmin Yu,Xinying Wang,Linlin Lv,Tongyan Liu,Qingxiang Guan
Depression is a chronic mental disorder which threatens human health and lives. However, the treatment of depression remains challenging largely due to blood brain barrier (BBB), which restricts drugs from entering the brain, resulting in a poor distribution of antidepressants in the brain. In this work, a novel brain-targeted drug delivery system was developed based on borneol-modified PEGylated graphene oxide (GO-PEG-BO). GO-PEG-BO was characterized and proved to possess excellent biocompatibility . By incorporating borneol , GO-PEG-BO could penetrate BBB efficiently by opening tight junctions and inhibiting the efflux system of BBB. The targeted distribution of GO-PEG-BO in the brain was observed by an in vivo biodistribution study. Moreover, GO-PEG-BO exhibited a neuroprotective effect, which is beneficial to the treatment of depression. Ginsenoside Rg1 (GRg1), which can relieve depressive symptoms but difficult to cross BBB, was loaded to GO-PEG-BO for the therapy of depression. In depressive rats, GRg1/GO-PEG-BO improved stress-induced anhedonia, despair and anxiety, and comprehensively relieved the depressive symptoms. In conclusion, GO-PEG-BO could serve as a promising nanocarrier for brain-targeted drug delivery, and provide a new strategy for the therapy of depression.
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PubMed
高影响因子
POLYMER
·
2023
·
IF 4.6
Xianting Wang,Hongyi Tu,Haofeng Xiao,Junyi Lu,Jie Xu,Guangxin Gu
A novel P–N flame-retardant (PON) was synthesized by nucleophilic substitution reaction using diphenyl phosphoryl chloride and piperazine as raw materials. Its chemical structure was characterized by Fourier transform infrared spectroscopy (FTIR), liquid-state nuclear magnetic resonance (NMR), high resolution mass spectrometry (HEMS) and elemental analysis , and its thermal stability by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Subsequently, five char-forming agents, namely pentaerythritol (PER), chitosan (CTS), lignin (LI), graphene (GN) and expandable graphite (EG), were selected to form five intumescent flame-retardants in a 1:1 mass ratio with PON. Polystyrene (PS) composites were prepared by melt blending method. The synergistic effect of PON and different char-forming agents on thermal stability, combustion behavior and flame retardancy of PS composites were systematically investigated. The results showed that the PS/10% PON/10% EG composite had the highest limiting oxygen index (LOI) value of 25.8%, and the cone calorimetric test showed that the peak heat release rate (pHRR), total heat release rate (THR), and total smoke release (TSP) of the composite were reduced by 74.6%, 24.4% and 43.6%, respectively, compared with neat PS, and this composite exhibited the most excellent flame retardancy. Finally, the flame-retardant mechanism of PS/10% PON/10% EG composite was discussed and proposed by the results of scanning electron microscope (SEM), thermogravimetric analysis coupled to Fourier transform infrared spectroscopy (TG-IR), and pyrolysis-gas chromatography-mass (PY-GC/MS) measurements in detail.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Xueming Yang,Chunbo Li,YongFu Ma,He Chi,Zongjie Hu,Jianfei Xie
Phase change materials (PCMs) are widely used in the field of thermal management and energy storage, but both low thermal conductivity and leakage problem limit their broad applications. In this work, a 3D porous graphite (PG) foam was prepared by a pressing and drying method with solid mixture of graphite powder and ammonium bicarbonate (NH 4 HCO 3 ), and it was used as the thermal conductive skeleton and shape stabilizer of PCMs. PG/paraffin composite PCMs (CPCMs) were then prepared by the vacuum impregnation of liquid paraffin into PG foam. It showed that the skeleton of 3D PG foam greatly improves the thermal conductivity of CPCMs. The prepared PG/paraffin CPCMs exhibited an ultra-high thermal conductivity of 19.27 Wm -1 K −1 at a volume fraction 35.55% of graphite, which is about 76.08 times higher than that of paraffin. The heat conduction mechanism of the PG/paraffin CPCMs are analyzed, and it is found that Maxwell-Eucken model can be used to accurately predict its thermal conductivity. Moreover, the CPCMs show good performance of thermal shape stability and exhibit superior anti-leakage characteristic. The proposed method for the preparation of 3D PG foam is robust, and the excellent performance of their based CPCMs will be promising in the field of heat dissipation and thermal storage.
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高影响因子
Carbon Letters
·
2023
·Vol. 33
·期 7
·2153-2159
·
IF 4.5
Cao Song
Dimethyl silicone oil is widely used due to its excellent thermal stability and good wetting properties. In this study, a series of thermal conductive materials was prepared by physically blending and chemically loading graphene as a thermal conductive filler into dimethyl silicone oil, and their thermal conductivity and tribological properties were investigated. The thermal conductivity of the composites was tested by a thermal conductivity meter and a thermal imaging camera, while the tribological properties of the composites were evaluated using a CSM friction and wear tester. The results showed that both thermal conductivity and tribological properties were improved to a certain extent. The particle size and amount of graphene had a significant influence on the thermal conductivity. For graphene with a single particle size, the thermal conductivity increased with increasing graphene content. The friction coefficient under dry friction conditions was significantly reduced by adding graphene to the silicone oil, as revealed by the friction and wear test.
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高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 52
·期 36
·12808-12818
·
IF 4
Yanan Li,Jiqi Zheng,Jiaze Yan,Yanyan Liu,Ming Guo,Yifu Zhang,Changgong Meng
Diphenylamine (DPA) is a harmful pesticide widely used to control post-harvest scald of fruits. In this study, rapid and sensitive determination of DPA was realized by the development of an effective electrochemical sensor, which was fabricated by coupling La-doped NiWO4 nanoparticles (La/NiWO4) with reduced graphene oxide (rGO), and the obtained rGO/La/NiWO4 nanocomposite was modified on glassy carbon electrodes (GCEs). The morphologies, structures and compositions were well characterized, and the effects of La doping and the introduction of rGO on the crystal structure and electrochemical performance were discussed. The incorporation of both La and rGO was found to enhance the active surface area and improve conductivity, resulting in the enhanced electrocatalytic performance of rGO/La/NiWO4/GCE, including a wide linear range (0.01–500 μM), a low detection limit (0.0058 μM) and high sensitivity (1.778 μA μM−1 cm−2). The fabricated sensor was further used for DPA detection in fresh apple extract to evaluate its practicality and demonstrated excellent recoveries ranging from 99.52 to 104.70%.
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PubMed
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2023
·Vol. 25
·期 20
·2300519
·
IF 3.6
Wenjie Cheng,Caihong Xue,Guilin Zhou,Xiaomin Wang,Yong Huang,Yuehua Ma,Hui Nan,Heqi Li,Hong Lin
A new type of water corrosion-resistant coating which is similar to the “egg inlaid egg tray” structure is successfully prepared. Modified chitosan (MCS) and graphene oxide (GO) are crosslinked with waterborne epoxy resin to form a unique 3D “tray” hybrid structure, and the crosslinking reaction is catalyzed by modified nano-SiO 2 (MSiO 2 ) with an egg-like morphology. The uniformly dispersed MSiO 2 can provide crosslinking reaction sites and is firmly “fixed” in the composite coating, thus not only catalyzing the crosslinking reactions with good performance, but also improving the interaction between itself and the as-formed GO-MCS structure. Consequently, with the help of “fixed catalytic in situ crosslinking reactions” and synergistic effect between MSiO 2 and GO-MCS, the coating not only shows an improved corrosion resistance with a large impedance modulus at low frequency (|Z| 0.01 Hz ) of 1.8 × 10 6 Ω cm 2 , but also possesses good thermal stability and high hydrophobicity. The protective effect of the composite coating on the substrate is more comprehensive and multiple.
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高影响因子
Journal of Energy Storage
·
2023
·
IF 9.4
Haidong Xie,Chunping Hou,Yuqing Qu,Hui Tian,Hui Lu,Jiandong Wu,Shaolin Yang,Yong Ma
SiO x has become one of the most promising anode materials for lithium ion batteries due to its high specific capacity, abundant natural resources and suitable lithium insertion and extraction voltage. However, the low conductivity and the poor cycle performance seriously hinder its practical application. In here, a simple and effective method is proposed to disperse SiO x between carbon materials including flake graphite, reduced graphene oxide (rGO) and carbon nanotubes (CNTs), and then micron-sized N-SiO x /graphite/rGO-CNTs@C (N-SiO x /C@C) composite with dense structure is prepared by coating and pyrolysis of pitch. The synergistic effect of various carbon materials is beneficial to improve the conductivity of the material, and maintain the structural integrity during the cycle. The obtained N-SiO x /C@C anode exhibits high reversible capacity (980.2 mAh·g −1 ), excellent cycle stability (70 % capacity retention after 500 cycles at 0.5 A·g −1 ) and excellent rate performance (491.9 mAh·g −1 specific capacity of at 5 A·g −1 ). The strategy provided here effectively improves the electrochemical performances of SiO x , and the prepared materials show great application potential in the field of lithium ion batteries.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 34
·16022-16029
·
IF 3.3
Xingguo Deng,Jingchao Li,Bo Zhao,Zhihua Li
In this study, a silver metal–organic framework (Ag-MOF) was immobilized on graphene oxide (GO) sheets via an ultrasonication process. The Ag-MOF@GO composite showed enhanced physicochemical properties, including an improved surface area and lower agglomeration, as confirmed using characterization techniques such as X-ray diffraction (XRD), the Brunauer–Emmett–Teller (BET) method, and scanning electron microscopy (SEM). Malachite green (MG) is a typical cationic dye, which can be toxic, cause environmental damage and threaten human health. Therefore, the adsorption capacities of Ag-MOF and Ag-MOF@GO for the MG dye were also evaluated at room temperature. Kinetic analysis revealed a significant increase in the adsorption capacity and rate of adsorption of Ag-MOF@GO compared with Ag-MOF. The addition of GO increases the surface area of Ag-MOF@GO and reduces the agglomeration effect, resulting in an improved adsorption capacity. Ag-MOF@GO showed a greater than 90% regenerability after three cycles.
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高影响因子
POLYMER COMPOSITES
·
2023
·Vol. 44
·期 9
·5369-5380
·
IF 5.2
Shuo Li,Wei Wu,Dietmar Drummer,Yi Wang,Zijian Lu,Xintong Zhao
With the development of integrated circuits, the miniaturization and integration of electronic devices has become a development trend, and the demand for heat dissipation is also increasing. Graphene three-dimensional aerogels prepared from graphene has been widely used in the field of thermal management materials, but graphene aerogels also face the disadvantages of poor compatibility with resin matrix and high thermal resistance. In this study, a hybrid filler for depositing copper nanoparticles on the surface of graphene aerogel was prepared, and the hybrid aerogel filler showed excellent thermal conductivity, reduced the interfacial thermal resistance and contact thermal resistance, improved the interfacial thermal resistance with epoxy resin, and improved the interfacial compatibility. Under a low load of 2.5 wt%, the thermal conductivity of the prepared composite is as high as 2.09 Wm −1 K −1 , which is about 11 times that of pure epoxy resin. It provides a simple idea for preparing high-thermal conductivity three-dimensional graphene epoxy resin composites with high thermal conductivity.
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高影响因子
Inorganic Chemistry Frontiers
·
2023
·Vol. 10
·期 14
·4209-4220
·
IF 7
Yujun Wu,Xiaoyang Wang,Bianbian Tian,Wei Shuang,Zhengyu Bai,Lin Yang
Optimizing the adsorption energy of intermediates by precisely modulating the coordination structure of single-atom M–Nx–C electrocatalysts to significantly improve the oxygen reduction reaction (ORR) performance still remains a great challenge. In this work, guided by density functional theory (DFT) calculations, an axial coordination FeN5 single-atom catalyst was constructed by way of an FeN4 species anchored with the N atom from nitrogen-doped graphene to promote the ORR catalytic performance. The special coordination structure of FeN5 can significantly optimize the adsorption of the reaction intermediate and reduce the overpotential of the ORR process compared to that of the FeN4 planar structure, which is commonly used. Hence, the constructed axial coordination FeN5 single-atom catalyst shows extraordinary ORR catalytic performance (Eonset/Ehalf-wave = 0.992/0.916 V vs. reversible hydrogen electrode (RHE), JL = 6.06 mA cm−2 and a 93.9% current retention after 15 h) and a maximum power density of 141 mW cm−2 in a zinc–air battery, which is superior to those of commercial Pt/C. These findings provide new insights into the construction of high-efficiency ORR catalysts from the design of a single atom coordination environment.
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高影响因子
Soft Matter
·
2023
·Vol. 19
·期 24
·4536-4548
·
IF 3.4
Shu-Ming Cui,Saud Hashmi,Wen-Qiang Li,Stephan Handschuh-Wang,Cheng-Tian Zhu,Shi-Chang Wang,Yan-Fei Huang,Guang-Ming Zhu,Florian J. Stadler
Pickering emulgels stabilized by graphene oxide (GO) with didodecyldimethylammonium bromide (DDAB) as an auxiliary surfactant and liquid paraffin as the oil phase have proved to be an excellent 3D printable ink. This paper elucidates the structure of such emulgels by a combination of microscopy before and after intensive shear as well as broadband dielectric spectroscopy and rheology in the linear and nonlinear regime. An increase of the DDAB surfactant and GO-contents leads to a systematic increase of modulus and viscosity, a reduction of the limits of the nonlinear regime and a more complicated variation of the normal forces, with negative normal forces at high shear rate for low GO-contents and positive normal forces at high GO-contents. The interfacial jamming behavior studied by morphology, rheology and dielectric spectroscopy is explained based on droplet deformation, jamming and recovery phenomena.
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PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Xuehan Xiao,Zongxue Yu,Ximei Zhu,Juan Wang,Qingcan Xiang
Microwave synthesis was taken to synthesis A-SEP@TiO 2 which has a steady chemical property. The A-SEP@TiO 2 composite materials and GO (with different proportion)were mixed and then pumped on commercial PVDF membranes to filter. Finally, the composite membrane A-SEP@TiO 2 /GO was obtained Under electrostatic self-assembly. Due to the superhydrophilicity and underwater super hydrophobicity of the surface of A-SEP@TiO 2 /GO membrane, A-SEP@TiO 2 /GO composite has shown great potential in the field of oil in water. The separation rates of four different emulsions (petroleum ether, toluene, Mesitylene, n-hexane) are all above 90%. With the steady chemical properties, A-SEP@TiO 2 /GO composite membrane is able to separate oil from water in harsh environment in long-run. After being immersed in 1 mol/L acid and alkali salt solution for one month respectively, all the sample membranes showed a better stability than commercial PVDF membranes. Also, the oil and water removal flux of A-SEP@TiO 2 /GO composite membrane only decreased by less than 10%, and that was why the composite membranecan can still maintain good cleaning performance even after ten times’ repetition of experiments,. Moreover, the membrane could efficiently remove dyes and heavy metal ions. Therefore, it has a great application prospect in complex water environment treatment.
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高影响因子
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