International Journal of Electrochemical Science
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2023
·
IF 1.5
Shenying Xu,Wenpo Li,Xiuli Zuo,Dongdong Zheng,Xingwen Zheng,Shengtao Zhang
The inhibition effect of 2-(2-Hydroxyphenyl)benzothiazole (HBT), a newly synthesized benzothiazole derivative, on mild steel in 1 M HCl medium has been investigated by utilizing weight loss measurements, electrochemical methods and morphology characterization. The results indicate that HBT exhibited a superior corrosion inhibition efficiency, which reached approximately 95% with the addition of 0.07 mM HBT. Electrochemical tests illustrate that HBT is a mixed-type inhibitor. According to the Langmuir adsorption isotherm, the thermodynamic and kinetic parameters of the adsorption process complied with a physical-adsorption mechanism. Furthermore, computational calculations based on density functional theory reveal the relation between the electronic properties and the inhibition efficiency. In combination with the value of pKa , the protonic form of HBT in corrosive medium was predicted.
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CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2022
·Vol. 101
·期 7
·3813-3820
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IF 2.5
Rong Xu,Qingming Song,Chuang Li,Junfeng Li,Hongjun Yang,Jian Chen,Zhipeng Mao
2-Chloro-2-methylbutane is an important organic compound widely used as a starting material in organic synthesis. It is mainly produced by the addition reaction of isoamylene and hydrochloric acid. As a raw material, isoamylene has a low boiling point and an extremely low flash point, making it a high-risk material in large-scale industrial productions. In this paper, a highly efficient production of 2-Chloro-2-methylbutane was realized using a continuous flow micro-channel reactor. Through the back pressure system of the reactor, the fluid pressure was increased, which elevated the reaction temperature, and enhanced the rate of reaction. The obtained optimal reaction conditions for the process were a reaction temperature of 90°C, pressure of 0.67 MPa, residence time of reactants of 15 min, n (hydrochloric acid): n (isoamylene) = 2.80:1.00, and v (hydrochloric acid): v (isoamylene) = 4.40:1.76. Compared with a batch process, the micro-channel process significantly shortened the reaction time and conversion a continuous and an efficient production. Computational analysis using computational fluid dynamics (CFD) simulation software was used to simulate the two-phase flow in the micro-channel reactor, and the results were consistent with the experimental results.
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RSC Advances
·
2022
·Vol. 12
·期 15
·9342-9350
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IF 4.036
Yuyi Zhang,Wei Zhang,Yajie Bian,Yiting Liu,Xiaolei Zhang,Mengdi Chen,Bingwen Hu,Qingyuan Jin
Zeolitic imidazolate framework-8 (ZIF-8) is one of the most promising metal–organic frameworks because of its excellent high porosity, stability and geometrically well-defined structure. However, the application of ZIF-8 in the field of fluorescent molecular sensing has not been intensively explored. Our work demonstrates the versatility of ZIF-8 as a carrier material, which can be used for small molecule [2-(2-hydroxyphenyl)-1H-benzimidazole (HPBI)] capture and fluorescence enhancement. ZIF-8 displays luminescent behavior changes when combined with HPBI, as the emission peaks of ZIF-8 and HPBI are located in the same range for resonance enhancement of fluorescence. The results of the experiment indicate that the fluorescence enhancement effect will change in the presence of different concentrations of HPBI. We propose that the pore structure of ZIF-8 could provide an opportunity for the adsorption of HPBI molecules, and eventually the adsorption would saturate. The high porosity of ZIF-8 provides the path to HPBI aggregation or entrance into the ZIF-8 internal structure. Our results suggest that ZIF-8 may offer great promise for molecular fluorescence sensing.
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JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 60
·期 9
·1468-1479
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IF 3.046
Ming Duan,Gang Wu,Tianbin Gu,Xiaohui Jiang,Lei Zhao,Limei Zhou,Yunwen Liao,Qiang Pu
Present work reports a new type of poly( N -alkyl-2-[4-hydroxybut-2-ynyl] pyridinium bromides) (designated as Po-n, n = 8, 12, 16 of carbon atoms in the alkyl chain). Po-n were synthesized and characterized by FTIR, GPC, and NMR analysis. The possible polymerization mechanism was proposed and supported by theoretic calculation. A preliminary probe was performed on the conductivity and anticorrosive ability of the conjugated polymer. The results showed that these polymers demonstrated poor conductivity, however the conductivity was enhanced by graphene doping. Po-n are good inhibitors for X70 steel corrosion in HCl solution. So, the conjugated polymers may play important roles in the fields of optoelectronic devices and steel corrosion inhibition. Graphical
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JOURNAL OF CHROMATOGRAPHY A
·
2021
·
IF 4.759
Yuhao Han,Panpan Chen,Zhichao Li,Xiao Wang,Chenglong Sun
Ultraviolet (UV) light-catalyzed Paternò-Büchi (PB) reaction has been developed as an efficient lipid C=C double bond (DB) derivatization strategy, which can accurately assign the position of C=C bond in unsaturated lipids when coupled with tandem mass spectrometry (MS/MS). Inspired by this, here we proposed a novel visible-light induced [2+2] cycloaddition reaction combined with ESI-MS/MS and MALDI-MS/MS to identify lipid C=C position isomers. Benz[g]isoquinoline-5,10-dione (BIQD) and 6,9-difluorobenzo[g]isoquinoline-5,10-dione (DF-BIQD) were developed as a new type of [2+2] cycloaddition reagent, which can not only react with C=C bond under 254 nm UV light irradiation, but also quickly combine with lipid C=C bond under the irradiation of 405 nm visible-light and > 400 nm compact fluorescent lamp visible-light. High cycloaddition reaction conversion efficiency can be achieved by irradiating under compact fluorescent lamp light for 2 min. Moreover, we discovered that 437 nm, 489 nm, 545 nm, 581 nm, and 613 nm monochromatic light appearing in compact fluorescent lamp can individually induce the [2 + 2] cycloaddition reaction between DF-BIQD and unsaturated lipids. Using this method, we found that the expressions of lipid DB-positional isomers in rat heart, brain, lung, spleen, thymus, kidney, liver and plasma vary greatly. The relative content of FA-18:1 (Δ9) in rat heart is only 1.49 times that of FA-18:1 (Δ11), while the relative content of FA-18:1 (Δ9) in rat plasma is 5.20 times that of FA-18:1 (Δ11). The above results offer new insight into the development of photocatalytic reagent for visible-light induced [2+2] cycloaddition and structural lipidomic studies.
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Foods
·
2023
·Vol. 12
·期 22
·4137
·
IF 5.2
Siru Chen,Yankun Fu,Tianlin Wang,Zhenglin Chen,Peijun Zhao,Xianqing Huang,Mingwu Qiao,Tiange Li,Lianjun Song
2’-Fucosyllactose (2’-FL), the functional oligosaccharide naturally present in milk, has been shown to exert health benefits. This study was aimed to investigate the effect of 2’-fucosyllactose (2’-FL) on the browning of white adipose tissue in 3T3-L1 adipocytes and C3H10T1/2 cells. The results revealed that 2’-FL decreased lipid accumulations with reduced intracellular triglyceride contents in vitro. 2’-FL intervention increased the mitochondria density and the proportion of UCP1-positive cells. The mRNA expressions of the mitochondrial biogenesis-related and browning markers (Cox7a,Cyto C,Tfam,Ucp1,Pgc1α,Prdm16,Cidea,Elovl3,Pparα,CD137,andTmem26) were increased after 2’-FL intervention to some extent. Similarly, the protein expression of the browning markers, including UCP1, PGC1α, and PRDM16, was up-regulated in the 2’-FL group. Additionally, an adenosine monophosphate-activated protein kinase (AMPK) inhibitor, compound C (1 μM), significantly decreased the induction of thermogenic proteins expressions mediated by 2’-FL, indicating that the 2’-FL-enhanced beige cell formation was partially dependent on the AMPK pathway. In conclusion, 2’-FL effectively promoted the browning of white adipose in vitro.Keywords:adipocytes browning;2’-fucosyllactose;obesity;UCP1;AMPK
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Shanlong An,Xin Huang,Nuo Li,Qiangwei Li,Tieyue Qi,Rujie Wang,Lidong Wang
2-amino-2-methyl-1-propanol (AMP) combines the advantages of the faster reaction rate of primary/secondary amines and the high absorption capacity of tertiary amines, making it a highly promising alternative to monoethanolamine (MEA). However, at high AMP concentrations, the absorption products are prone to solid crystallization, resulting in unstable operation of the carbon capture system. In this work, by adding a small amount of diethylenetriamine (DETA) to AMP, the crystallization of reaction products can be effectively controlled and AMP-DETA absorbent possesses a high absorption rate, low regeneration energy, and low metal corrosion rate. Wetted-wall column tests were performed to comprehensively evaluate the mass transfer kinetics and the effect of crucial conditions, and the diffusion coefficient, gas–liquid mass transfer coefficient, enhancement factor, and mass transfer resistance distribution were obtained. The effect of the addition of DETA on the solubility of HCO 3 − was verified. DETA carbamate was more likely to form intermolecular hydrogen bonds with HCO 3 − , thus reducing the formation of dimeric or multichain macromolecules between HCO 3 − molecules through hydrogen bonds and inhibiting the crystallization of high concentration HCO 3 − . HCO 3 − can accelerate the desorption rate by participating in the deprotonation of protonation amines. The results demonstrated that the average regeneration energy of the AMP–DETA absorption system was reduced by 21.2 % relative to that of 5 M MEA, and its metal corrosion rate was 0.07 mm/a, which was only 7.9 % of MEA under the same conditions. The results contribute to the industrial application of AMP–DETA.
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PEST MANAGEMENT SCIENCE
·
2021
·Vol. 77
·期 6
·2773-2784
·
IF 4.845
Yang Yang,Qiuyan Zhu,Kun Zhang,Suqing Zhao
BACKGROUND Aedes albopictus is a mosquito species and a vector of dengue virus and malaria parasites that represents a significant threat to global public health. Although mosquito populations have been effectively controlled through the use of synthetic insecticides, the emergence of widespread insecticide resistance in wild mosquito populations is a strong motivation to explore new insecticidal chemistries. RESULTS In this study, A. albopictus was treated with a series of novel pyrethroids containing 2-chlorobiphenyl and 2-chlorophenylpyridine via topical application. The relative antimosquito activity of each novel compound was determined, as measured by the LC 50 , and compared with the synthetic pyrethroid bifenthrin. The most antimosquito activity compound (SZ-B-11) was 4.69 times more active than bifenthrin. The novel compounds were also sensitive to wild A. albopictus . In addition, in silico toxicity assessment of aquatic organisms showed that the acute toxicity and chronic toxicity of SZ-B-11 were 31.96 times and 934.40 times lower than those of bifenthrin, respectively. Cytotoxicity assessment demonstrated that all tested compounds were nontoxic against SH-SY5Y cell lines. Furthermore, photolytic results suggested that SZ-B-11 would be photodegraded more easily than bifenthrin and would reduce secondary pollution. CONCLUSION Novel pyrethroids containing 2-chlorobiphenyl and 2-chlorophenylpyridine, through simple synthesis steps, have better antimosquito activity, low resistance, less ecotoxicity, readily degradable characteristics, and may reduce secondary pollution. They are promising insecticides with potential application prospects in agricultural production and environmental protection. © 2021 Society of Chemical Industry
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Catalysis Science & Technology
·
2021
·Vol. 11
·期 13
·4439-4446
·
IF 6.119
Gaofei Liu,Xin Tong,Jialing Wang,Bin Wu,Jianlin Chu,Yongchan Jian,Bingfang He
2-Halogenated-2′-deoxyadenosines are important antiviral and anticancer drugs. However, natural enzymes display low activities in the biosynthesis of 2-halogenated-2′-deoxyadenosines, and the results are unsatisfactory because of the steric impediment created by the halogenated substituent group in purine. In this study, a semi-rational design was performed to enhance the activity of purine nucleoside phosphorylase from Aneurinibacillus migulanus AM007 (AmPNP) for the biosynthesis of 2-halogenated-2′-deoxyadenosines. Small and smart libraries of AmPNP were generated by stepwise site-directed evolution using iterative combinatorial mutations. The best AmPNP mutant, M3 (N233D/E191Q/Y190V/M249I), exhibited a satisfactory phosphorolysis activity towards 2′-deoxyadenosine, with a 144.75-fold improvement compared with that of wild-type AmPNP. In a coupled reaction of the M3 mutant and Brevibacillus borstelensis LK01 pyrimidine nucleoside phosphorylase, the conversion rates remarkably improved and reached 89.94% (cladribine) and 81.24% (2-fluoro-2′-deoxyadenosine) within 10 h, respectively. The substrate-binding cavity of the M3 mutant was reshaped to provide good accessibility for halogenated molecules, which led to a higher activity in the synthesis of 2-halogenated nucleosides. This directed evolution towards overcoming challenges in the biosynthesis of halogenated nucleosides may result in a remarkable economic impact on biotechnological nucleoside production.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Yujie Chen,Rui Sun,Wenhui Zhu,Zhen Zhang,Yali Chen,Shuo Wang,Qiliang Deng
Covalent organic frameworks (COFs) with predesigned bipyridine recognition sites (donated as BPD-COFs) were prepared by using 2, 2’-bipyridine-5, 5’-diamine and benzene-1, 3, 5-tricarbaldehyde as monomers, and the corresponding small molecule model compound (2, 2’-bipyridine-5, 5’-diiminebenzene, donated as BPDB) was synthesized by using benzaldehyde and 2, 2’-bipyridine-5, 5’-diamine. The fluorescence sensing property between BPD-COFs and BPDB were compared as the fluorescence sensing platform for the sensitive, selective and rapid detection of Ni 2+ . The unique structure characteristics such as large conjugated structure, high surface area, regularity pore canals and predesigned bipyridine link endow BPD-COFs with prominent fluorescence emission, enough space and strong specificity for Ni 2+ . The fluorescence quenching degree of BPD-COFs is four times more than that of BPDB. Besides better selectivity, BPD-COFs also displays the prominent advantages, such as the wider concentration range (4.20 × 10 −10 ∼1.26 × 10 -6 M) and lower limit of detection (6.80 × 10 -11 M) compared to that of BPDB (1.00 × 10 -7 ∼5.00 × 10 -7 M, 4.50 × 10 -8 M). Good spiked recoveries (>92.0 %) in chocolate and tea support that BPD-COFs is competent to detect Ni 2+ in real samples. All these results indicate that BPD-COFs is potential as a fast, sensitive, and accurate fluorescence sensing platform for the selective detection of Ni 2+ in complex system.
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NANOTECHNOLOGY
·
2020
·Vol. 31
·期 32
·325502
·
IF 3.551
Nianfeng Shi,Shupei Sun,Bo Zhang,Qian Du,Yanxin Liao,Xiaoming Liao,Guangfu Yin,Zhongbing Huang,Ximing Pu,Xianchun Chen
Co(OH)2 nanosheets/Cu(OH)2 nanorods composite electrodes for non-enzymatic glucose detection were fabricated by electrodepositing Co(OH)2 nanosheets on Cu(OH)2 nanorods substrate grown directly on the copper sheet via a simple one-step reaction. The Co(OH)2 nanosheets/Cu(OH)2 nanorods composite electrode was characterized by scanning electron microscopy, energy dispersive x-ray spectroscopy, x-ray diffraction and x-ray photoelectron spectroscopy. The glucose sensing performance of the composite electrode was investigated by cyclic voltammetry and chronoamperometry. The composite electrode shows high sensitivity of 2366 µA mM−1 cm−2 up to 2 mM with a lower detection limit of 0.17 mM (S/N = 3). The composite electrode is highly selective to glucose in the presence of various substances that always co-exist with glucose in real blood samples. The response of the composite towards human blood serum was in good agreement with that of commercially available glucose sensors, suggesting that a promising electrode material for highly sensitive and selective non enzymatic detection of glucose can be envisioned.
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Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Chengcheng Yin,Xiaoshi Jia,Qin Zhao,Zifan Zhao,Jinyang Wang,Yufeng Zhang,Zhi Li,Hongchen Sun,Zubing Li
Boron-containing mesoporous bioactive glass (B-MBG) scaffolds could be capable of promoting osteogenesis by activating Wnt/β-catenin signaling pathway during the process of bone defect repair. Despite this, more involving molecular controls are still largely unclear. In the present study, we identified that the downstream of Wnt/β-catenin signaling pathway named transcription factor 7-like 2 (TCF7L2) served as a key effector to promote boron-induced bone regeneration and osteogenesis through lipocalin 2 (LCN2). TCF7L2 was highly expressed in osteoblasts when treated with B-MBG scaffold extraction than MBG. LCN2, as a secreted bone factor, positively affected osteogenic differentiation of MC3T3-E1 and osteogenesis in vivo , which could be induced by TCF7L2. In addition, interference of TCF7L2 decreased the osteogenic differentiation of osteoblasts. Finally, we identified that rLCN2 could rescue the poor ability of osteogenic differentiation of MC3T3-E1 whose Tcf7l2 gene was knocked down by lentiviral transfection of shRNA. Our findings provide some new insights into the molecular controls of boron-associated bone regeneration and potential therapeutic targets for the treatment of bone defects.
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