EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2014
·
IF 3.432
Jing Wu,Linxi Yu,Feifei Yang,Jingjie Li,Peng Wang,Wenbo Zhou,Liwen Qin,Yunqi Li,Jian Luo,Zhengfang Yi,Mingyao Liu,Yihua Chen
A series of 2,3-diaryl-4-thiazolidinone derivatives were synthesized and evaluated for their antiproliferative properties against two well-known cancer cell lines (A549 as human lung cancer and MDA-MB-231 as human breast cancer). Structure activity relationship (SAR) analysis resulted in the discovery of 2-(3-(arylalkyl amino carbonyl)phenyl)-3-(2-methoxy-phenyl)-4-thiazolidinone derivatives with high potent inhibitory effects on the proliferation of both cancer cell lines. Furthermore, several compounds with potent antiproliferative activities displayed excellent inhibitory activities on migration with an IC 50 of about 0.05 μM on MDA-MB-231 cells in two different migration assays. In particular, compound 39 was indicated to suppress tumor growth and metastasis as well as promote survival rate. Intriguingly, this series of analogs have been indicated to inhibit tumor cell proliferation through inducing cell cycle arrest . These results suggested that the new series of 2-(3-(arylalkyl amino carbonyl)phenyl)-3-(2-methoxyphenyl)-4-thiazolidinone derivatives could be regarded and developed as novel highly potential anticancer agents in the future.
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MATERIALS SCIENCE FORUM
·
2017
·
IF 0
Heng Xue Xiang,Zi Ye Chen,Wei Chen,Zhe Zhou,Bin Sun,Mei Fang Zhu
As a potential material for food packaging, fully biodegradable composite films based on novel functionalized natural polyphenol/Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) were successfully fabricated by solution casting, and also the functionalized natural polyphenol (C18TAx) was synthesized by grafting fatty acid onto natural polyphenol Tannic Acid (TA). The resultant C18TAx with better hydrophobicity was uniformly dispersed into a PHBV matrix. The influence of C18TAx dosage on the mechanical behavior, crystallization behavior and thermal properties of the C18TAx/PHBV composite films was investigated by uniaxial tensile mechanical testing, Differential Scanning Calorimeter (DSC), Polarizing Optical Microscope (POM) and Wide Angle X-ray Diffractometry (WAXD). The results revealed that the x value was about 0.09, showing that about 11/20 phenol hydroxy groups in TA molecules were replaced with fatty acid chains. Compared with those of neat PHBV, the tensile strength and elongation at break of the C18TA0.09/PHBV composite films with 10 wt.% C18TA0.09 content were enhanced by 121%, and 458%, respectively. This improvement was primarily ascribed to intermolecular hydrogen bonding interactions in composite films. This new type of fully biodegradable bio-based composite films shows great potential for food packaging.
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JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2018
·Vol. 85
·期 3
·506-513
·
IF 1.745
Fei Zhifang,Yang Zichun,Chen Guobing,Li Kunfeng
Abstract Polyimide cross-linked silica aerogels with different weight percentages of polyimide were prepared through sol–gel technology and supercritical CO 2 fluid drying technology. Tetraethoxysilane (TEOS) was used as a silica source precursor, 3-aminopropyltriethoxysilane (APTES) end-capped polyimide was used as a cross-linking agent, derived from 3, 3′, 4, 4′-biphenyltetracarboxylic dianhydride (BPDA) and 4, 4′-oxydianiline (ODA). The acid produced during the imidization process catalyzed the hydrolysis reaction without additional catalyst. After condensation reaction catalyzed by ammonium hydroxide solution, the polyimide cross-linked silica gels were obtained and then dried in supercritical CO 2 . The polyimide cross-linked silica aerogels have low density (0.132~0.187 g/cm 3 ), high specific surface area (623–741 m 2 /g), low thermal conductivity (0.0306~0.0347 W/m K at room temperature), relatively high compressive strength (1.03~3.82 MPa) and high thermal decomposition temperature (360 °C). This research provided a simple and efficient method that used the polyimide as a strengthening phase to improve the mechanical properties of TEOS-based silica aerogels.
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CHINESE CHEMICAL LETTERS
·
2025
·
IF 8.9
Haoran Yu,Liang Cao,Jiajia Wang,Jian Guo,Ji Zhang,Shan-Tao Zhang
Piezoelectric materials have wide commercial applications involving our everyday lives. The common categorized “soft” and “hard” piezoelectric materials have distinct even contradictory performance parameters typically exemplified by piezoelectric coefficient d 33 and mechanical quality factor Q m . However, for some special devices operated in resonant mode, simultaneously high or at least balanced performance parameters are needed. Here, we show the transition from “soft” to “hard” performance in 2 mol% Sm doped (0.36- x )Pb(Ni 1/3 Nb 2/3 )O 3 - x Pb(Mn 1/3 Nb 2/3 )O 3 -0.28PbZrO 3 -0.36PbTiO 3 quaternary solid solution piezoceramics, for which the d 33 and planar electromechanical coupling factor k p decrease, while Q m and Curie temperature T c increase monotonously with increasing x value. As the results, balanced performance with moderate d 33 = 446 pC/N, k p = 0.49, Q m = 425, and T c = 170 °C are achieved around x = 0.03. This work not only shows the feasibility for combining “soft” and “hard” performance by forming appropriate solid solutions, but also provides a suitable material basis for further simultaneously optimizing piezoelectric parameters.
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European Physical Journal-Special Topics
·
2022
·Vol. 231
·期 6
·1215-1219
·
IF 2.891
Li Ruidong,Deng Jinxiang,Chen Liang,Kong Le,Wang Xiaolei,Meng Junhua,Sun Junjie,Zhang Xiaoxia,Zhang Jie,Wang Guisheng,Yang Qianqian,Gao Hongli
In this paper, rubrene:MoO \(_{3}\) mixed films were deposited on quartz glass and p-Si substrates using thermal evaporation technique. We fabricated the devices based on rubrene:MoO \(_{3}\) mixed films in the form of Al/rubrene:MoO \(_{3}\) /p-Si/Al. The electrical characteristics of the rubrene:MoO \(_{3}\) film (with 1:1 weight ratio)-based devices were measured using Hall system. The results indicate the enhanced hole concentration and hole carrier mobility. In addition, the presence of charge transfer complexes leads to an increase of the conductivity and the contact between sample and electrode is almost Ohmic contact. To investigate the effect of MoO \(_{3}\) , the rubrene:MoO \(_{3}\) mixed films with different concentrations of MoO \(_{3}\) were deposited using thermal evaporation technique and the Schottky barrier devices based on rubrene:MoO \(_{3\, }\) mixed films were fabricated. The electrical characteristics demonstrate that the charge transfer complex had been formed when rubrene and MoO \(_{3}\) mixed. Our results demonstrated improvement of the contact between electrode and sample in electronic devices.
研究领域:
材料科学
·
电子工程
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Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Liu Wei,Yuan Shan,Jin Miaomiao,Xian Mo
Fluorine has become an important element for the design of synthetic molecules for use in medicine, agriculture, and materials. The introduction of fluorine atoms into organic compound molecules can often give these compounds new functions and make them have better performance. Despite the many advantages provided by fluorine for tuning key molecular properties, it is rarely found in natural metabolism. We seek to expand the molecular space available for discovery through the development of new biosynthetic strategies that cross synthetic with natural compounds. Towards this goal, 2-fluoro-3-hydroxypropionic acid (2-F-3-HP) was first synthesized using E. coli coexpressing methylmalonyl CoA synthase (MatBrp), methylmalonyl CoA reductase (MCR) and malonate transmembrane protein (MadLM). The concentration of 2-F-3-HP reached 50.0 mg/L by whole-cell transformation after 24 h. 2-F-3-HP can be used as the substrate to synthesize other fluorides, such as poly (2-fluoro-3-hydroxypropionic acid) (FP3HP). Being entirely biocatalytic, our procedure provides considerable advantages in terms of environmental and safety impacts over reported chemical methods.
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BULLETIN OF MATERIALS SCIENCE
·
2019
·Vol. 42
·期 1
·1-5
·
IF 1.264
Zhou Wei,Xie Qian,Li Junjie,Zhengwei Cao,Peng Feng
A simple and economic \(\hbox {CO}_{{2}}\) bubbling crystallization reactor for preparation of strontium carbonate \((\hbox {SrCO}_{3})\) was designed. Through monitoring pH and conductivity, hollow \(\hbox {SrCO}_{{3}}\) fibres without any morphology control agents were successfully obtained. The effects of temperature and \(\hbox {CO}_{{2}}\) flow rate on the morphology of \(\hbox {SrCO}_{{3}}\) were analysed. This study presents a new method for carbonate crystal control and growth.
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INORGANIC CHEMISTRY
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2022
·
IF 5.436
Jingjing Zhai,Fen You,Suting Xu,Ao Zhu,Xiaohui Kang,Yat-Ming So,Xiaochao Shi
A PNP-pincer ligand provides a versatile ligation framework, which is highly useful in organometallic chemistry and catalytic chemistry. In this work, by a de novo strategy, a simple and efficient synthetic pathway, has been developed to prepare the new iminodibenzyl-based PNP pincer proligand imin-RPNP(Li or H) (R = isopropyl, phenyl). By employing salt metathesis or direct alkyl elimination, we successfully synthesized a series of iminodibenzyl-PNP rare-earth-metal (Ln = Sc, Y, Dy, Ho, Er, Tm, Lu) complexes and characterized them by NMR and X-ray diffraction analyses. Upon addition of a borate and triisobutylaluminum (TIBA), the rare-earth-metal complexes 2-Y, 2-Dy, 2-Ho, 2-Er, and 2-Tm bearing the imin-PhPNP ligand exhibited unexpectedly high 3,4-selectivity (up to 95%) for the polymerization of 1,3-dienes (isoprene and myrcene); in particular, the chosen yttrium complex 2-Y promoted the 1,3-diene polymerization in a living manner. A computational study suggested that the sterically congested configuration around the metal center imposed by the imin-RPNP ligand might be the main reason for this unusual selectivity.
研究领域:
有机金属化学
·
催化化学
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Food Bioscience
·
2026
·
IF 6.2
Mengrui Wang,Yaokang Wu,Xueqin Lv,Jianghua Li,Long Liu,Guocheng Du,Jian Chen,Yanfeng Liu
3-Hydroxy-3-methylbutyrate (HMB), a key L-leucine metabolite, alters protein metabolic balance during the growth of new muscle tissue and exhibits anti-catabolic effects, garnering widespread attention as a dietary supplement for sarcopenia treatment and sports training. Here, we identified an efficient 4-hydroxyphenylpyruvate dioxygenase from Allokutzneria albata ( Aa HPPD) via molecular docking and whole-cell reaction yield verification. By coupling this enzyme with an efficient L-amino acid deaminase derived from Proteus vulgaris ( Pv LAAD) for whole-cell biocatalysis, 8.66 mM HMB was produced from 25 mM L-leucine, achieving a molar conversion of 34.6%. To coordinate the expression of pathway enzymes, ribosome binding site combinations were optimized, increasing the molar conversion to 56.5%. Additionally, for the rate-limiting enzyme Aa HPPD, distal mutations enhancing thermostability were identified using the Protein Repair One Stop Shop server and Disulfide by Design 2. The co-expression of the double mutant Aa HPPD Q65L/E99D and Pv LAAD resulted in a 61.24% conversion rate. To further improve catalytic activity, four sites identified via alanine scanning were subjected to grouped saturation mutagenesis based on spatial location. The final strain, co-expressing Aa HPPD Q65L/E99D/L260I/V306I and Pv LAAD, achieved a molar conversion of 73.73% for HMB production using 25 mM L-Leu as substrates within 10 h under optimal whole-cell conditions. This study established an efficient method for HMB production via whole-cell catalysis and provided a feasible strategy for engineering the thermostability and activity of the rate-limiting enzyme, as well as synergistically optimizing the expression levels of cascade enzymes.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yuanchu Qin,Mude Zhu,Yi Tang,Xueqin Chen,Fu Wang,Xiaoyun Fan
How to efficiently treat a type of new emerging organic pollutant, carbamazepine (CBZ), with the features of environmental persistence, toxicity, and bioaccumulation, is now posing a challenge to scientists. Piezocatalysis, through the harvesting of mechanical energy, has a high capacity to degrade organic pollutants and is gaining increasing attention. Herein, a novel piezo material Cd 4 BiO(BO 3 ) 3 (CBB) with a 3-chromophore asymmetric structure showing an excellent CBZ degradation activity has been synthesized. The removal efficiency can reach 96.2% in 60 min, which is 4.13 times that of tetragonal phase BaTiO 3 (BTO) under the same conditions. The superior catalytic performance can be attributed to the easily polarized 3-chromophore asymmetric structure units of CBB, d 10 Cd 2+ ion, stereochemically active lone pair of Bi 3+ , and π-delocalization of BO 3 , which can generate a very strong internal alternating piezoelectric field under the action of ultrasonic vibration. Driven by this internal electric field force, the excited free charges can be easily separated and transferred to the surface of the material to take part in the redox reactions. Besides, CBB also exhibits high stability and excellent removal efficiency for rhodamine B (Rh B) and tetracycline (TC). Hydroxylation and aldehyde oxidation are the main processes of CBZ degradation. The eco-toxicity of CBZ and its intermediates was evaluated using T.E.S.T. software. This study shows that the easily strongly polarized borate material has a potential application in the piezocatalytic degradation of organic pollutants.
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POLYMER COMPOSITES
·
2022
·Vol. 43
·期 11
·7871-7881
·
IF 3.531
Dongdong Zeng,Yuhang Su,Jiaqi Dong,Xiaojun Ma,Lili Yu,Youjun Lv
In this study, four typical biocomposites from lignin blended with poly-3-hydroxybutyrate-3-hydroxyhexanoate (PHBH) using inorganic nanoparticles (INPs) (SiO 2 , MMT, CaCO 3 , and BN) as fillers were evaluated, which enhanced the thermal, mechanical, and barrier properties of composites. The results revealed that the selection of suitable INPs doped into the lignin/PHBH (L/P) composites was an important approach to achieve available function. MMT/L/P nanocomposites were significantly higher than those of untreated L/P composites in thermal stability (T max exceed 10%) and barrier properties (water vapor and oxygen resistance increased by 48% and 46%), and BN particles increased the initial thermal decomposition temperature by 8%. The elongation at break of CaCO 3 /L/P and BN/L/P composites were increased by 344% and 319%, while SiO 2 /L/P composites had the best tensile strength (18.8 MPa). Besides, the INPs/L/P nanocomposites in this paper exhibited excellent ultraviolet (UV) resistance and might become potential anti-UV packaging materials for grease foods.
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TENSIDE SURFACTANTS DETERGENTS
·
2021
·Vol. 58
·期 6
·468-474
·
IF 1.049
Zhonghua Zuo,Ming Zhou,Mao Liao,Pengao Peng,Jingfeng Zhang
Surfactants are very often used in tertiary oil production. However, the conventional surfactants cannot be used in high salinity reservoirs of tertiary oil production because the high salinity leads to the deactivation of the surfactants. Gemini sulpho-betaine surfactants have been developed to meet the requirements of tertiary oil production in such reservoirs. In this study, the Gemini sulphobetaine surfactant (bis{[(N-methyl-N-(3-alkoxy-2-hydroxy)propyl-N-(3-sulfonate)propyl]methylene}) was prepared by etherification, ring opening reaction and sulfonation reaction with decyl alcohol, epichlorohydrin, N,N’-dimethyl ethylene diamine and 1,3-propanesultone. The experimental conditions obtained are: the ratio of 1,3-propanesulfonic acid lactone to tertiary amine intermediate = 2.3 : 1, reaction temperature = 70°C and reaction time = 11 h. The analysis of the infrared spectrum showed that the structure of the synthesised substance corresponds to that of a Gemini sulphobetaine surfactant. The chemical shifts of the groups were determined by 1 HNMR structural characterisation of the products. The surface tension, emulsifying properties, foaming properties and wetting properties were investigated. The results showed that the surfactant has good foaming properties and good compatibility in a high salt environment.
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