ACS Omega
·
2025
·
IF 4.3
Tai Zhou,Xue Liu,Zhimin Wu,Riley Lyu,Caizhi Peng,Hongyi Zhang,Yajing Xia
Background: Skin wound healing is a common clinical challenge, facing multiple obstacles including delayed healing, local hypoxia, and bacterial infection, which may lead to prolonged nonhealing or wound infection. Traditional therapeutic strategies mostly intervene in single factors, making it difficult to achieve synergistic effects. Therefore, developing an innovative approach to simultaneously address multiple issues is of great significance. Objective: This study aims to develop a multifunctional hydrogel patch (Cu–Fe3O4-loaded HAMA, CFH) by integrating three core functions of promoting healing, supplying oxygen, and antibacterial activity, achieving a “one-for-three” therapeutic effect to provide a more comprehensive solution for wound repair. Methods: Cu–Fe3O4 nanoclusters (NCs) were synthesized via a hot solvent method, and CFH hydrogel patches were constructed using molds. In vitro experiments were performed to verify their biosafety, antibacterial properties, and nanozyme activity. A mouse full-thickness skin defect model was established to validate the wound-healing effect of CFH hydrogel patches in vivo. Results: Cu–Fe3O4 NCs were successfully synthesized, exhibiting good biocompatibility and significantly promoting the proliferation and migration of human skin fibroblasts (HSFs). Meanwhile, the material showed excellent nanozyme activity, effectively catalyzing the decomposition of hydrogen peroxide and glutathione to remarkably improve local oxygen supply in wounds. Antibacterial experiments confirmed significant inhibitory effects against MRSA and Escherichia coli. In vivo experiments further demonstrated that CFH hydrogel patches adhered well to wounds, enabling rapid, efficient, and aseptic wound healing within 14 days. Conclusions: This study successfully developed a multifunctional CFH hydrogel patch based on Cu–Fe3O4 NCs, integrating three functions of promoting cell proliferation, improving oxygen supply, and broad-spectrum antibacterial activity. It provides a safe and efficient novel therapeutic strategy for clinical wound repair, holding important clinical application value.
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高影响因子
PHYSICAL REVIEW B
·
2025
·Vol. 112
·期 7
·075156
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IF 3.7
Wei Wang,Jingjing Gao,Jianguo Si,Nan Zhou,Zhongzhu Jiang,Tianyang Wang,Wenhao Zhang,Degong Ding,Wenhai Song,Chuanhong Jin,Wenjian Lu,Xuan Luo,Yuping Sun
Layered transition-metal dichalcogenide (TMD) materials host a variety of quantum states and exhibit fascinating physical phenomena, such as charge density waves (CDWs) and a metal-insulator transition, which have attracted considerable attention in condensed matter physics. $1T\text{\ensuremath{-}}{\mathrm{TaS}}_{2}$ is an intriguing TMD and has multiple CDW phases. In particular, the commensurate (C) CDW phase, an insulating ground state, has attracted much attention. Herein, we systematically investigate and verify the effect of electron injection through intercalation of Cu atoms in single crystals of the TMD material $1T\text{\ensuremath{-}}{\mathrm{Cu}}_{x}{\mathrm{TaS}}_{2}$ ($0\ensuremath{\le}x\ensuremath{\le}0.05$) by combining electrical transport measurements, scanning tunneling microscopy and spectroscopy measurements, and first-principles calculations. Our experiment results reveal that the charge transfer from Cu atoms to adjacent ${\mathrm{TaS}}_{2}$ layers, which suppresses the CCDW-insulating state, destroys the long-range CDW order, changes the dominant carrier (from $p$ type to $n$ type), and renders $1T\text{\ensuremath{-}}{\mathrm{TaS}}_{2}$ metallic. The itinerant electrons of the intercalated Cu atoms, which induce the metallic state, primarily act as electron donors to raise the Fermi level. Our intercalation results support a scenario in which the doping electron primarily fills an existing band gap, consistent with a band-insulator picture. In addition, the stacking order is important for obtaining an accurate electronic structure, namely, the density of states. Our work provides opportunities for enriching the electronic phase diagram and exploring exotic physics in $1T\text{\ensuremath{-}}{\mathrm{TaS}}_{2}$ and other TMD materials.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
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IF 7.2
Hui Zhang,Qiang Fu,Hongyun Qin,Xia Chen,Qicheng Zhang,Zixu Dong,Haoyuan Li,Shoudong Wang,Ming Wang
Hydrogen recovery from ammonia purge gas is a desirable method to relieve the pressure of increasing demand for hydrogen. Metal-organic frameworks (MOFs) are promising adsorbents for the separation of the H 2 –N 2 mixture. However, the separation of the H 2 –N 2 mixture using MOFs remains challenging due to the lack of adsorptive mechanism. Herein, the adsorption mechanism of the H 2 –N 2 mixture in SIFSIX-2-Cu-i has been systematically investigated with the method of a combination of excess adsorption experiments, molecular simulations , and DFT calculations. In the Grand Canonical Monte Carlo (GCMC) simulations, the polarizable force field was first applied to the adsorption of pure H 2 or N 2 and H 2 –N 2 mixture in SIFSIX-2-Cu-i. Ab Initio Molecular Dynamics (AIMD) was performed to investigate the distribution of the guest molecules in the pores of SIFSIX-2-Cu-i. Finally, Density functional theory (DFT) calculations were performed to predict the transfer of charge between MOF and guest molecules. Results revealed two binding sites of H 2 or N 2 in SIFSIX-2-Cu-i. A relatively high thermodynamic adsorption selectivity for N 2 over H 2 has been observed in SIFSIX-2-Cu-i. Furthermore, SIFSIX-2-Cu-i also exhibits a greater affinity with N 2 than with H 2 , which is probably because of the stronger induction interactions between F2 atoms and N 2 molecules. These findings are of significance to guide the design of the new highly selective adsorbents for the separation of H 2 /N 2 .
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Huaiwei Zhang,Yifan Chen,Ying Pan,Liang Bao,Jing-yuan Ge
Environmentally friendly photocatalytic N 2 fixation process has attracted considerable attention. Developing efficient photocatalysts with high electron-hole separation rates and gas adsorption capacities remains quite challenging. Herein, a facile fabrication strategy of Cu-Cu 2 O and multicomponent hydroxide S-scheme heterojunctions with carbon dot charge mediators is reported. The rational heterostructure brings excellent N 2 absorption ability and high photoinduced electron/hole separation efficiency, and the ammonia produced yield reach above 210 µmol·g cal -1 ·h −1 during the nitrogen photofixation process. More superoxide and hydroxyl radicals are generated simultaneously in the as-prepared samples under light illumination. This work offers a reasonable construction method to further develop suitable photocatalysts for ammonia synthesis .
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CATALYSIS LETTERS
·
2023
·
IF 2.8
Sun Wenwen,Guo Ruyue,Shi Chaojie,Li Xuechen,Wu Jiayi,Tian He,Li Huayi,He Jie,Yang Zhengchun,Li Jiahui,Sun Shanfeng
In this study, we prepared carbon quantum dots (CQDs)-modified 26-facet Cu/Cu 2 O composites and investigated their photocatalytic degradation effect on methyl orange (MO). The microstructure and composition of the reduction products were analyzed. The test results validate the successful modification of CQDs on the surface of Cu/Cu 2 O composites. Further, through electrochemical performance analysis among the materials with different thiourea dioxide (TD) contents, 3TD (n × 0.00075 mol of thiourea dioxide is defined as nTD) exhibits the strongest electron transfer ability; thus, 3TD was selected to further combine with CQDs to examine the photocatalytic performance of Cu/Cu 2 O composites. We analyzed the photocatalytic behavior of the composites by monitoring the degradation of the MO solution. Based on the photocatalytic performance test, the CQDs/3TD composite exhibits excellent photocatalytic activity. Following 120 min of visible light irradiation, the degradation rate of MO with the addition of loaded CQDs increased from 25 to 73%. Materials with both adsorption and photocatalytic properties were successfully prepared, which resolved the regeneration of adsorbents to a certain extent and further accelerated the degradation of dyes. Graphical Abstract
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EcoMat
·
2023
·Vol. 5
·期 5
·e12334
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IF 14.6
Juhee Jang,Shangqian Zhu,Ernest Pahuyo Delmo,Tiehuai Li,Qinglan Zhao,Yinuo Wang,Lili Zhang,Hongwen Huang,Jingjie Ge,Minhua Shao
Despite of superior performance of the oxide-derived copper (OD-Cu) in producing valuable hydrocarbons during CO 2 RR, its fabrication process is still ambiguous and complicated. In this work, we develop a simple microwave-assisted method to synthesize the oxide-derived Cu nanosheet (OD-Cu NS) and reveal that the oxidation state of Cu species is controlled by varying the Cu precursor amount. Notably, the simultaneous formation of nano-sized Cu domains influence the surface roughness of OD-Cu NS. The partially oxidized Cu surface exhibits a superior faradaic efficiency (FE) of C 2+ products up to 72%, along with a partial current density of 55 mA cm −2 in a neutral KHCO 3 solution. More importantly, the as-obtained OD-Cu NS shows a synergetic effect on dissociating of CO 2 molecules by the strong binding energy and promoting of C 2+ compounds productivity by the enlarged electrochemical surface area. This work provides a new insight for designing efficient OD-Cu catalysts toward CO 2 RR.
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Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Du Jinsong,Chen Guanping,Yuan Xinyi,Yuan Jiang,Li Li
Although the potential of metal-organic framework (MOF) nanoparticles as drug delivery systems (DDS) for cancer treatment has been established by numerous studies, their clinical applications are still limited due to relatively poor biocompatibility. We fabricated a multifunctional Cu-MOFs@Keratin DDS for loaded drug and chemodynamic therapy (CDT) against tumor cells. The Cu-MOFs core was prepared using a hydrothermal method, and then loaded with the anticancer drug DOX and wrapped in human hair keratin. The Cu-MOFs@Keratin was well characterized by transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS). Characterization and pharmacokinetic studies of Cu-MOFs@Keratin were performed in vitro and in vivo. The keratin shell reduced the cytotoxicity and potential leakage of Cu-MOFs to normal cells, and allowed the drug-loaded nanoparticles to accumulate in the tumor tissues through enhanced permeability and retention effect (EPR). The particles entered the tumor cells via endocytosis and disintegrated under the stimulation of intracellular environment, thereby releasing DOX in a controlled manner. In addition, the Cu-MOFs produced hydroxyl radicals (·OH) by consuming presence of high intracellular levels of glutathione (GSH) and H2O2, which decreased the viability of the tumor cells.
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ACS Sustainable Chemistry & Engineering
·
2023
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IF 8.4
Jing Zhao,Lijuan Liu,Ya Yang,Dan Liu,Xiaobo Peng,Shijing Liang,Lilong Jiang
Cu-based bimetallic catalysts have been studied in the electrocatalytic nitrate (NO3–) reduction reaction (NO3–RR) for a long time. However, few studies have focused on horizontal comparison of CuNi, CuCo, and CuFe (abbreviated as CuM) bimetallic catalysts in electrocatalytic NO3–RR for ammonia synthesis. Herein, we prepare the three series of Cu-based bimetallic catalysts, with different atom ratios of Cu/M (Cu/M = 7/3, 5/5, or 3/7) and ordered mesoporous carbon (OMC) as support (denoted as CuM/OMC). The characterization results reveal that the metallic particles of Cu and M components possess an intimate relationship on the CuM/OMC catalysts. The electrocatalytic NO3–RR performance uncovers that the optimal NH3 yield rates of CuM/OMC catalysts at −0.8 V (vs reversible hydrogen electrode (RHE)) follow this order: Cu5Fe5/OMC > Cu5Co5/OMC > Cu7Ni3/OMC > Cu/OMC > Fe/OMC > Co/OMC > Ni/OMC > OMC. The bimetallic CuM/OMC catalysts exhibit higher NH3 yield rates than the monometallic catalysts. This is attributed to strong synergistic effects between the Cu and M components. We expect that these insights can stimulate new developments of bimetallic catalysts in electrocatalysis.
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TRIBOLOGY INTERNATIONAL
·
2023
·
IF 6.2
Xiaojing Fu,Shuming Guo,Yong Wan,Changsheng Zheng,Qiang Li,Bingchang Liu
Superlubricity was achieved by the addition of copper nanoparticles (CuNPs) as an additive to glycerol, a sustainable lubricant, which was applied to TiN-coated steel that underwent ball-on-flat reciprocating testing at an average contact pressure of 54.6 MPa. A coefficient of friction of ∼ 0.007 and a wear rate of 2.0 × 10 –8 mm 3 /N m were achieved on the TiN coating when lubricated with glycerol + 0.1 wt% CuNPs at a sliding speed of 120 mm/s. XPS and Raman analysis suggested that a surface tribofilm containing CuNPs and a carbon-based film derived from the degradation of glycerol were deposited onto the contact area of the tribopairs, which effectively prevented the direct asperity contact between the steel ball and TiN-coated steel, enabling ultra-low friction.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2022
·
IF 24.319
Zhizhou Cai,Ning Cao,Fanxing Zhang,Xiangzhou Lv,Ke Wang,Yi He,Yao Shi,Hao Bin Wu,Pengfei Xie
Electrocatalytic CO 2 reduction into ethanol driven by renewable energy represents a promising strategy for energy storage and mitigation of global warming, but it has remained challenging to gain high activity and selectivity of ethanol. Here we take advantage of atomic arrangement in immiscible Ag-Cu composite during annealing and establish hierarchical interfaces in the obtained core-shell catalyst. The atomic Ag-Cu interactions increase electrochemical surface area and expedite charge dynamics, resulting in an unprecedented electrocatalytic performance with the faradaic efficiency of C 2+ products, ethanol as 80.2 %, 52.6 % and the current density of ∼320 mA cm −2 at −1.0 V (versus reversible hydrogen electrode). Moreover, the Ag-Cu catalyst exhibits a notable stability for ∼60 h. Mechanism studies reveal that local CO intermediates preferentially accumulate on the core, then migrate to the continuous Cu surface for C-C coupling energy-favorably toward ethanol. Our work highlights a novel design principle as interface engineering for advanced tandem electrocatalysts.
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高影响因子
LANGMUIR
·
2023
·
IF 3.9
Xingrui Qi,Jiamin Gan,Zhidong Zhao,Nian Li,Yufang Chen,Tao Jin
One of the potential treatments for bacterial wound infections is photodynamic therapy. WO3–x semiconductor materials can generate reactive oxygen species when exposed to light, which can inactivate bacteria. In this work, we improved their photocatalytic performance by doping WO3–x with Cu. The wound dressing was prepared by loading Cu–WO3–x into a highly biocompatible chitosan sponge. The composite sponge dressing showed significant inactivation of Escherichia coli and Staphylococcus aureus, and in vitro toxicity assays on L929 cells demonstrated the biosafety of the dressing. Through in vivo wound healing trials, composite sponge dressings have been shown to accelerate wound healing, and this composite chitosan sponge can be possibly used for photodynamic therapy of bacterial wound infections.
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高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2022
·
IF 6.76
Zhongbo Zhu,Shumei Kang,Hua Chen,Qingping Zhao,Zhaokang Huo,Pengyu Li,Qidong Cao,Chenshuo Lu
In this work, hydrophobized copper powders combined siloxane-modified carbon nanotubes (SHMWCNTs) to obtain intertwined hybrids of carbon nanotubes and copper (CNTs-Cu hybrids), and superhydrophobic CNTs-Cu hybrids/epoxy coatings were prepared on the surface of AH36 carbon steel by drop coating. The surface morphology and wettability of coatings were changed by adjusting the ratios of SHMWCNTs to hydrophobized copper powders. The obtained coating can show a water contact angle of 167.2°, a water sliding angle of 2.9°, a plant oil contact angle of 134.3°, and self-cleaning properties. The coating maintains superhydrophobicity after 300 tape-peeling times, exhibiting excellent mechanical durability. The fouled area percentages of chlorella on the coating and a pure epoxy resin were 0.23(±0.07)% and 12.18(±1.22)%, respectively, displaying anti-biofouling resistances. The coating has excellent corrosion resistance, and its corrosion current density reached 9.55 × 10 -8 A/cm 2 .
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