Small
·
2026
·
IF 11.8
Chuang Liu,Shuai Wu,Mingyu Zhang,Xinyu Ren,Yuqiang Ma,Zhuo Ao,Wenyue Li,Yi Hou
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), yet early diagnosis remains challenging owing to the lack of sensitive and specific approaches for in vivo inflammation visualization, which severely limits accurate diagnosis and effective intervention. To address this limitation, this work reports an inflammation-targeting multiparametric MRI strategy based on a nanoprobe (NPs@PEG-PEP) for real-time visualization of AKI-associated inflammatory responses. NPs@PEG-PEP was modified with functional peptides targeting CD137, which is an activation-induced immune receptor serving as an upstream mediator of inflammatory cascades. This approach enables nanoprobes to selectively target and accumulate surrounding inflammatory cells in AKI-affected kidneys. In addition, constructed from NaGdF 4 nanoparticles, the nanoprobe simultaneously enhances dynamic contrast-enhanced MRI (DCE-MRI) and susceptibility-weighted imaging (SWI) to capture distinct vascular perfusion differences and inflammatory cell infiltration between injured and contralateral kidneys. The inflammatory imaging signal persists for up to 18 h and correlates well with histopathological findings, including H&E staining and CD11b immunofluorescence. Moreover, the biological safety of the nanoprobe is confirmed via cytotoxicity assays, hemolysis tests, and histopathological evaluations. Overall, this work establishes an inflammation-targeting multiparametric MRI platform that enables spatiotemporal mapping of IRI-induced AKI progression, offering a promising strategy for early diagnosis and therapeutic monitoring.
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ACS Applied Nano Materials
·
2026
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IF 5.8
Xin Fu,Yueqi Wu,Sakil Mahmud,Zhixuan Luo,Jinglong Li,Zhuoran Yi,Zhu Wang,Jiahui Peng,Rourou Li,Runhua Liao,Gaosheng Zhang,Zhu Xiong
This study presents a ceramic membrane (MIX-CM, denoting a mixed phase) fabricated through die casting and sintering of heterophase YS-Al2O3 and α-Al2O3 precursors, yielding a hierarchically mesoporous structure with high porosity (60%) and well-balanced mechanical strength (42 MPa). The MIX-CM demonstrates superior chemical stability (<2% mass loss in acidic/alkaline media) and thermal stability up to 1000 °C. Its unique composite microstructure enables dual-function separation via synergistic sieving and adsorption. Under cross-flow filtration (0.5 bar, 25 °C), MIX-CM achieves high rejection of colloids (>98%), humic acid (>96%), and bovine serum albumin (92%), while exhibiting exceptional adsorption of antibiotics─tetracycline hydrochloride (99.6%) and norfloxacin (95.7%)─and selective removal of heavy metals, with Pb2+ reduced from 492 to 3.4 μg L–1 (below WHO limits). In real surface water treatment, the membrane maintains stable UV254 and turbidity removal at 53% and 78%, respectively. NaClO backwashing achieves 96% flux recovery, while a crushing-reconstruction strategy fully restores severely fouled membranes. The MIX-CM is economically viable, with a production cost of ∼113 USD m–2, markedly lower than commercial ceramic membranes (500–3000 USD m–2). These findings position MIX-CM as a scalable, cost-effective, and multifunctional solution for advanced potable water purification.
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Nature Communications
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2026
·Vol. 17
·期 1
·3395
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IF 18.1
Yang Hao-Ran,Hu Shu-Jie,Zhang Meng-Yue,Wu Di,Zheng Lei,She Qianhong,Yuan Zhi-Hua,Zhong Lin-Jiang,Zhao Xuan,Chen Ying,Liu Hong,Xu Lin-Ji,Liu Yuan
Lab-scale wastewater treatment studies, including urine recovery, often rely on oversimplified synthetic wastewater, thereby compromising the reliability of results and data. Here, we systematically evaluate how using full-component versus simplified synthetic urine formulations affects the performance and engineering-economic assessment of bipolar membrane electrodialysis. Our findings reveal that simplification fundamentally alters fouling mechanisms. While urea alone causes significant damage to anion exchange membranes through hydrogen bonding aggregation, natural organic co-components in real urine mitigate fouling via inhibitory interactions—a mechanism confirmed by molecular dynamics simulations and experimental characterization. After seven batches, the full-component formulations showed 29.3% less performance decay and 10–14% higher urea recovery than the simplified formulation. Moreover, the complete removal of organic components disrupts ion-organic co-aggregation pathways on cation exchange membranes, shifting fouling toward mineral crystallization on bipolar membranes. Simplification also distorts the engineering-economic assessment, overestimating cleaning costs by 15.9% and underestimating membrane lifespan by 12.5%. These findings necessitate identifying key wastewater constituents and ensuring experimental integrity to bridge lab-industry gaps, advocating designs comprehensively addressing multi-component interactions.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2026
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IF 2.2
Yaohui Ni,Shicheng Tang,Haiyang Wu,Yufei Zhang,Saijiao Tang,Lexin Chen,Tianjian Lu,Defeng Xu,Hang Hu
Dimethylcurcumin (DMC) is a derivative of curcumin. Studies have shown that DMC can enhance the degradation of androgen receptors (AR), thereby inhibiting AR-related diseases. However, the extremely poor water solubility and fast metabolism in vivo of DMC greatly limit its clinical applications. In the present study, poly(ethylene glycol)-modified liposomes loaded with DMC (DMC@PEG-Liposomes) were prepared by an improved membrane hydration method. The prescription of the liposomes was optimized to obtain DMC@PEG-Liposomes with a particle size between 110 and 150 nm, moderate encapsulation efficiency and good freeze-drying stability. In vitro release studies showed that DMC@PEG-Liposomes displayed Fickian release at pH 7.4 and non-Fickian release at pH 5.0. Compared with free DMC, DMC@PEG-Liposomes were more toxic to 22Rv1 and HepG2 cells in vitro. DMC@PEG-Liposomes also exhibited enhanced AUC0-t as compared to free DMC in in vivo pharmacokinetic studies. These results suggest that DMC@PEG-Liposomes are a promising DMC formulation for anticancer DMC delivery.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Luwei Miao,Ran Li,Ming Gao,Ke Li,Weilong Xiao,Yang Bao,Haiyan Mou,Qiulin Yang,Wenqing Chen
Capacitive deionization (CDI) offers a cost-effective and low-energy method for water desalination. However, the applicability of capacitive deionization (CDI) is often hindered by electrode instability caused by unwanted oxygen reduction reactions (ORR). To overcome it, we propose an innovative capacitive deionization-electro-oxidation (E X -CDI) hybrid system that harnesses ORR for in situ H 2 O 2 generation and micropollutant degradation. Through systematic investigation of the rational operating parameters, this study establishes a quantitative criterion for balancing the competition between capacitive electrosorption and Faradaic degradation, demonstrating that a charge allocation C d /C c ratio of 46.33%–72.59% is critical for sustaining stable desalination. Assisted by Machine Learning (ML), we decoupled the complex influencing factors and identified radical content and H 2 O 2 generation as the dominant governors of stability. The practical efficacy was confirmed through the successful treatment of aquaculture wastewater. Our findings offer a novel pathway for stabilizing CDI via the synergy of Faradaic and non-Faradaic processes, significantly diversifying its potential in advanced water treatment.
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Journal of Soil Science and Plant Nutrition
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2026
·
IF 3.6
Zhao Jiejie,Long Gui,Xia Xintong,Wang Sufen,Zhong Huitao,Teng Xiaowen,Zhang Xiaokai,Liu Dan,Zhang Ying,Zheng Bo,Gustave Williamson,He Lizhi
Heavy metal(loid) contaminated soil is widespread in the word. Exogenous addition of phytohormones have been proved to mitigate Cd toxicity, but the co-application of different phytohormones with Si through plant root or spraying are still limited. It is necessary to investigate an efficient strategy using phytohormones to ensure grain safety in Cd-polluted paddy fields. Three phytohormones (including melatonin [MT], jasmonic acid [JA] and salicylic acid [SA]) were applied alone or in combination with silicon (Si) fertilizer in a hydroponic experiment, screening MT as the best phytohormone on decreasing Cd accumulation and enhancing plant growth. Then a pot experiment was conduced to evaluate the MT application method (root or spraying) and the associated mechanisms. Hydroponic experiment revealed that foliar phytohormone application significantly increased total root length by 97.72–127.40% and improved chlorophyll synthesis. However, root-applied MT exhibited the most notable reduction on Cd accumulation (by 56.96%) and translocation factor (by 64.13%). Consequently, MT was selected for further validation in a soil-pot experiment through foliar and root application. The pot results confirmed that foliar Si and MT co-application was the most effective strategy, reducing Cd concentrations in grains, husks, leaves, shoots, and roots by 37.8%, 74.3%, 72.2%, 45.1%, and 30.3%, respectively. This maybe due to the subcellular sequestration (cell wall fraction increased by 17.3%), and the increased antioxidant protection. This study demonstrates that the co-application of Si and MT is a cost-effective, highly efficient strategy for ensuring grain safety in Cd-polluted paddy fields. Graphical
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2025
·
IF 2.2
Rongyan Zhu,Liu Yang,Yulan Li
Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age and is frequently associated with impaired glucose metabolism. Thioredoxin-interacting protein (TXNIP) plays a critical role in cellular metabolic regulation; however, its involvement in PCOS pathogenesis remains unclear. Bioinformatics analysis revealed significantly increased TXNIP expression in both PCOS patients and mouse ovarian granulosa cells (GCs). In vivo experiments using dehydroepiandrosterone (DHEA)-induced PCOS mouse models showed that TXNIP knockdown restored the expression of glycolysis-related enzymes, including HK2, PFKM, and PKM2. This restoration enhanced glycolytic function by suppressing IRS-1 phosphorylation and activating the PI3K signaling pathway. In vitro, dihydrotestosterone (DHT)treatment elevated TXNIP expression and suppressed glycolytic activity in KGN cells. Silencing TXNIP restored glycolytic metabolites such as pyruvate and lactate and promoted glycolytic flux, while TXNIP overexpression further impaired these functions. Additionally, treatment with the IRS-1 inhibitor NT157 confirmed that TXNIP regulates glycolysis in GCs through the IRS-1/PI3K signaling axis. This study is the first to demonstrate that TXNIP contributes to glycolytic dysfunction in PCOS GCs via the IRS-1/PI3K pathway, highlighting a potential target for PCOS diagnosis and therapy.
研究领域:
生殖生物学
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代谢病学
·
内分泌学
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ACS Catalysis
·
2025
·
IF 13.1
Linjie Guan,Qicheng Zhang,Mingjun Cen,Bin Chen,Wenchao Peng,Yang Li,Danyun Xu,Xiaobin Fan
MoS2-based catalysts can effectively achieve the hydrodeoxygenation of lipids or fatty acids into biojet fuel, alleviating the energy crisis and environmental problems. Nevertheless, the active sites of MoS2 are predominantly concentrated at the edges or rims, while the more extensive inert plane is deficient in effective catalytic sites. In this study, based on a phase transformation strategy, sulfur atoms in the inert plane are activated through annealing 1T MoS2, generating 2H MoS2 with abundant in-plane sulfur vacancies. Specifically, MoS2(U)-400 achieves 100% conversion of palmitic acid and over 99% hexadecane yield at 2 MPa H2 and 260 °C. This phase transformation-induced active site construction strategy provides a simple and effective catalyst for the hydrodeoxygenation of lipids and fatty acids.
研究领域:
材料科学
·
催化化学
·
能源与环境科学
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高影响因子
Drug Design Development and Therapy
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2025
·
IF 5.1
Hualu Wu,Qian Liu,Yuxin Shen,He Qi,Jiade Zhao,Qiaoying Li,Hailun Xia,Ren-Ai Xu,Lu Shi
Purpose The purpose of this study was to establish an in vitro incubation system and an in vivo model to investigate the potential kinetic interactions of macitentan with imperatorin and curcumin, and to validate the potential inhibitory mechanisms using molecular docking.Methods In vitro, the enzyme kinetic profile of macitentan was explored in rat liver microsomes (RLM) and human liver microsomes (HLM). Furthermore, molecular docking technique was used to study the sites of action of macitentan, imperatorin, and curcumin with CYP 3A4. In vivo, the pharmacokinetic parameters of macitentan were investigated in Sprague-Dawley (SD) rats administered the drug orally, both as a single agent and in combination with imperatorin and curcumin.Results In vitro, the results indicated that imperatorin and curcumin could inhibit the metabolism of macitentan, with IC50 values of 6.58 μM and 10.86 μM in RLM and 6.97 μM and 5.71 μM in HLM, respectively. And in the study of inhibition type, in RLM, the inhibition types of imperatorin and curcumin on macitentan were mixed and non-competitive, respectively; in HLM, the inhibition types of imperatorin and curcumin on macitentan were both mixed. Furthermore, additional molecular docking studies demonstrated that both imperatorin and curcumin occupied the CYP3A4 site. In vivo, the result showed significant increases in AUC(0-t), AUC(0-∞), Tmax, t1/2, and Cmax for macitentan while a decrease in CLz/F when combined with imperatorin. The metabolite ACT-132577 exhibited substantial increases in t1/2, Tmax, and Cmax. Combined with curcumin, the AUC(0-∞) and Tmax of macitentan were significantly increased, while CLz/F was significantly decreased. Conversely, the metabolite ACT-132577 exhibited a substantial decrease in CLz/F, accompanied by notable increases in AUC(0-∞) and Tmax.Conclusion In vitro and in vivo studies revealed that imperatorin and curcumin exhibited inhibitory effects on the metabolism of macitentan. Furthermore, molecular docking revealed that the metabolic inhibition of macitentan by imperatorin and curcumin occurred through binding to the site on CYP3A4. However, further investigation is necessary to ascertain whether this phenomenon will occur in humans.
研究领域:
药理学
·
分子生物学
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PubMed
高影响因子
Cell Reports
·
2024
·
IF 7.5
Zihua Liu,Dongyang Liu,Chu Wang
Itaconate serves as an immune-specific metabolite that regulates gene transcription and metabolism in both host and pathogens. S -itaconation is a post-translational modification that regulates immune response; however, its antimicrobial mechanism under the physiological condition remains unclear. Here, we apply a bioorthogonal itaconate probe to perform global profiling of S -itaconation in living pathogens, including S. Typhimurium, S. aureus , and P. aeruginosa . Some functional enzymes are covalently modified by itaconate, including those involved in the de novo purine biosynthesis pathway. Further biochemical studies demonstrate that itaconate suppresses this specific pathway to limit Salmonella growth by inhibiting the initiator purF to lower de novo purine biosynthesis and simultaneously targeting the guaABC cluster to block the salvage route. Our chemoproteomic study provides a global portrait of S -itaconation in multiple pathogens and offers a valuable resource for finding susceptible targets to combat drug-resistant pathogens in the future.
研究领域:
免疫学
·
微生物学
·
化学生物学
·
病原生物学
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PubMed
高影响因子
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
·
2024
·
IF 1.9
Li Wenjing,Xue Yufan,Zhang Feng,Xiao Ling,Huang Zhu,Li Wenjuan,Zhu Liangliang,Ge Guangbo
Background and Objective Ciclopirox is a widely used antifungal drug, redisposition of which has drawn increasing attentions due to multiple promising activities. The drug undergoes extensive glucuronidation, which acts as a major obstacle in the ongoing novel application and still remains poorly understood. The current study aims to phenotype ciclopirox glucuronidation pathway and as well to decipher the related species differences. Methods Ciclopirox glucuronidation was investigated in liver microsomes from humans (HLM) and various experimental animals. Assays with recombinant uridine diphosphate glucuronosyltransferases (UGTs), enzyme kinetic analyses and selective inhibitors were used to determine the role of individual UGTs in ciclopirox glucuronidation. Results HLM is highly active in ciclopirox glucuronidation with Michaelis–Menten constant ( K m ), maximum velocity ( V max ), and intrinsic clearance (CL int ) values of 139 μM, 7.89 nmol/min/mg, and 56 μL/min/mg, respectively. UGT1A9 displays by far the highest activity, whereas several other isoforms (UGT1A6, UGT1A7, and UGT1A8) catalyze formation of traced glucuronides. Further kinetic analysis demonstrates that UGT1A9 has a closed K m value (167 μM) to HLM. UGT1A9 selective inhibitor (magnolol) can potently inhibit ciclopirox glucuronidation in HLM with the IC 50 value of 0.12 μM. The reaction displays remarkable differences across liver microsomes from mice, rats, cynomolgus monkey, minipig, and beagle dog, with the CL int values in the range of 26–369 μL/min/mg. In addition, ciclopirox glucuronidation activities of experimental animals’ liver microsomes were less sensitive to magnolol than that of HLM. Conclusions Ciclopirox glucuronidation displays remarkable species differences with UGT1A9 as a dominant contributor in humans. It is suggested that the pharmacological or toxicological effects of ciclopirox may be UGT1A9 and species dependent.
研究领域:
药理学
·
生物化学
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高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2024
·
IF 10.8
Xiaofei Li,Mengting Qi,Qiuxuan Li,Boshuang Wu,Yuxuan Fu,Xia Liang,Guoyu Yin,Yanling Zheng,Hongpo Dong,Min Liu,Lijun Hou
Global warming and acidification, induced by a substantial increase in anthropogenic CO2 emissions, are expected to have profound impacts on biogeochemical cycles. However, underlying mechanisms of nitrous oxide (N2O) production in estuarine and coastal sediments remain rarely constrained under warming and acidification. Here, the responses of sediment N2O production pathways to warming and acidification were examined using a series of anoxic incubation experiments. Denitrification and N2O production were largely stimulated by the warming, while N2O production decreased under the acidification as well as the denitrification rate and electron transfer efficiency. Compared to warming alone, the combination of warming and acidification decreased N2O production by 26 ± 4%, which was mainly attributed to the decline of the N2O yield by fungal denitrification. Fungal denitrification was mainly responsible for N2O production under the warming condition, while bacterial denitrification predominated N2O production under the acidification condition. The reduced site preference of N2O under acidification reflects that the dominant pathways of N2O production were likely shifted from fungal to bacterial denitrification. In addition, acidification decreased the diversity and abundance of nirS-type denitrifiers, which were the keystone taxa mediating the low N2O production. Collectively, acidification can decrease sediment N2O yield through shifting the responsible production pathways, partly counteracting the warming-induced increase in N2O emissions, further reducing the positive climate warming feedback loop.
研究领域:
环境科学
·
微生物学
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